Jump to content
Sign in to follow this  
Cookson

speed of recovery from withdrawal genetic?

Recommended Posts

Cookson

Am interested In anyone's experience of speed/severity of their recovery from anti depressants correlating to their blood related family who also took them. 

 

So was anyone's speed/severity of withdrawal similar as their family relatives who also took them? 

Share this post


Link to post
Share on other sites
ladybug

I remember when I was little hearing my mother talk about how she had participated in a clinical trial for an antidepressant and how it had screwed her up for years afterward. I should have taken it as a sign. Because of that she was against me starting Paxil, but I was a couple a months away from my 18th birthday anyway and I told her I would do it with or without her permission. What an idiot I was. I am surely paying the price for it now. Hands down the biggest mistake of my life. I am doing the slowest taper of anyone on any forum and I am still having a hard time. Bad genetics? Who knows. There is no one else in my immediate family, but I have had aunts and cousins who have taken AD's for a short time and were able to get off without a problem.

Share this post


Link to post
Share on other sites
Altostrata

No doubt the variability in the way drugs affect people is genetically determined. But there are so many genetic and environmental influences, any individual's response cannot be determined.

 

Yes, I would think your mother might have been very sensitive to SSRIs, ladybug. It's possible you inherited this tendency.

Share this post


Link to post
Share on other sites
ladybug

No doubt the variability in the way drugs affect people is genetically determined. But there are so many genetic and environmental influences, any individual's response cannot be determined.

 

Yes, I would think your mother might have been very sensitive to SSRIs, ladybug. It's possible you inherited this tendency.

I believe she participated in this study in the 70's so I'm not sure if they were testing out SSRI's at that time.  I should note that I had no problems starting Paxil, and I started right away at 20mg. I believe I am one of those "lucky" people whose brain adapted to the drug strongly and right away. I remember having strong WD symptoms after missing two doses only a couple months after starting.

Share this post


Link to post
Share on other sites
Cookson

It does look like their could be a possible correlation between you ladybug and your mothers sensitivity with ssri's.

Was your mother subsidised in the clinical trial? Not being administered commercially as that time was it considered to be 'safe'

How did she feel about taking the drug?

 

The optimist in me likes to think that my father's 2 year period of taking citalopram-and his subsequent cold turkey withdrawal with full recovery In a matter of weeks be reflected in me in his success of a quick recovery.

Share this post


Link to post
Share on other sites
ladybug

Ok, I just talked to my mom and apparently I was wrong. She says she participated in a clinical trial for an AD in the mid 80's (so it WAS most likely a SSRI) for a month and then it was over. She says she didn't have any problems from it, just that it didn't do anything for her. She may have been on the placebo, I don't know if they tell you that when the trial is over or not. I don't know why I remember her saying she had problems from it while I was growing up, but I do. Well, it just goes to show you memory isn't very reliable. Incidentally, my mother has a cousin who goes off and on Paxil EVERY YEAR! She has done this for several years with no problem. Yet here I am unable to get off this poison even after tapering for 6 years. What a world.

Share this post


Link to post
Share on other sites
Altostrata

None of this is predictive. You yourself can have gone on and off psychiatric drugs many times before with no problem, then finally have great difficulty in going off the last one.

Share this post


Link to post
Share on other sites
ladybug

Who me? I've only ever been on Paxil.

Share this post


Link to post
Share on other sites
Cookson

Alto is talking figuratively.

Share this post


Link to post
Share on other sites
Zoe

My mom got off paxil in 3 weeks with no problem ( had been on it about 6 mths) Also stopped Neurotin cold turkey - no problem. I wish I would take after her in that regard! I was fine for 10 days, now feel as bad as ever. This up & down business is nuts!

Share this post


Link to post
Share on other sites
Cookson

Oh dear :/

 

Very much what I'm reading and experiencing myself contradicts my original hypothesis of their being a genetic correlation for WD symptoms.

 

I find it appalling and equally frightening how little research has be done on the true mechanisms of action of these drugs-and the effect they have on ourselves.

 

We have unknowingly volunteered ourselves into a world wide experiment and we are all the test subject participants.

 

Far more reliable and ethical then any of big pharms clinical trials.

 

And I'm not even receiving compensation for my ailments!

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
Sign in to follow this  

×
×
  • Create New...

Important Information

Terms of Use Privacy Policy