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Researchers doubt the abnormal brain-network theory of psychiatric disorders


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After coining the word "pathoconnectomics," researchers find brain imaging "inconclusive" evidence for the "abnormal brain network" theory.

 

http://www.improbable.com/2013/11/19/its-a-mess-attempt-to-connect-the-messy-dots-of-messy-hard-to-define-phenomena/

It’s a Mess: Attempt to Connect the Messy Dots of Messy, Hard-to-Define Phenomena

What happens when you try to use new technological tools to measure and map things that are tough to define — so tough to define that people go half-crazy if they try to agree on the details of any of the definitions?

The results can be messy, this paper suggests. Very messy:
 

“Fledgling pathoconnectomics of psychiatric disorders,” Mikail Rubinov [pictured here] and Ed Bullmore, Trends in Cognitive Science, epub November 15, 2013. The authors, at the University of Cambridge, UK, explain:

“Pathoconnectomics, the mapping of abnormal brain networks, is a popular current framework for the study of brain dysfunction in psychiatric disorders. In this review we evaluate the conceptual foundations of this framework, describe the construction and analysis of empirical models of brain networks or connectomes, and summarize recent reports of the large-scale whole-brain connectome organization of two candidate brain-network disorders, schizophrenia and autism. We consider the evidence for the abnormal brain-network nature of psychiatric disorders and find it inconclusive.

 

....

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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Inconclusive, perhaps. But is it profitable? I think imaging involves some very pricey equipment. That will be the true test of the validity of this theory.

 

snark

Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease". Long story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything. Amitryptiline, Prozac, bupropion, buspirone, flurazepam, diazepam, alprazolam, Paxil, citalopram, lamotrigine, gabapentin...probably more I've forgotten. 

Started multidrug taper in Feb 2010.  Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 10 2014:   62 Lamictal    1.1 Celexa         0.135 Xanax    1.8 Valium

Feb 10 2015:   50 Lamictal      0.875 Celexa    0.11 Xanax      1.5 Valium

Feb 15 2016:   47.5 Lamictal   0.75 Celexa      0.0875 Xanax    1.42 Valium    

2/12/20             12                       0.045               0.007                   1 

May 2021            7                       0.01                  0.0037                1

Feb 2022            6                      0!!!                     0.00167               0.98                2.5 mg Ambien

 

I'm not a doctor. Any advice I give is just my civilian opinion.

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After coining the word "pathoconnectomics,"

 

 

....researchers realized it had already been defined under the heading of "phrenology".

I am not a medical professional and nothing I say is a medical opinion or meant to be medical advice, please seek a competent and trusted medical professional to consult for all medical decisions.

 

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:lol: !!!!

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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