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mirapex - phosphorylation


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I was given mirapex early on could not take it but just read it may help protect mitochondra... and came to that old word again phosphorylation... 

here

http://www.alsworldwide.org/documents/EFFECTS... 

 

lead me right back to information Alto put on long ago from an email from a doctor... I can't find the original info and would like to read it if you still have it Alto...

 

apparently it was in an email you received from Dr.Shelton do you still have a copy of this and could I read what he said since it has been deleted from the other site...

 

Sheas post may ring a bell for you 

"SOOOOOOOOOOOO, what exactly does all this mean for someone who does not have the option of ever going back to an SSRI? Is de-phosphorylation inevitable, given enough time? That's what I want to know. I've never had anxiety/panic, prior to withdrawal and I have had trauma in my life. My pre-existing anxiety pathways were not altered by the traumatic experiences I had, which is what Dr. Shelton is saying would happen to those genetically predisposed to respond to trauma in such a profound fashion. Why is it that this trauma would be any different from the others?? The only thing I can surmise is that the lack of the serotonin caused by discontinuation disrupted my body's ability to moderate an alteration to my CNS. I'm feeling a wee-bit unlucky right about now."

 

feeling unlucky myself lately I know how she feels... who is Dr Shelton ?  

can you help me understand this please?

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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" Altostrata for the link, it was interesting and a positive take on the whole thing. i remember reading in your post on magnesium that it has the ability to dephosphorylate receptors, do you have a link for that at all?"

 

A copy and paste while I was looking... is this correct... "magnesium that it has the ability to dephosphorylate receptors"  

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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Please use search on this site to find information about Dr. Shelton and Google to find information about phosphorylation.

 

I believe phosphorylation is a metabolic process that is so far up the chain, so complex and so interactive, I do not aspire to understand it.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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Please use search on this site to find information about Dr. Shelton and Google to find information about phosphorylation.

 

I believe phosphorylation is a metabolic process that is so far up the chain, so complex and so interactive, I do not aspire to understand it.

I did search this site for Dr. Shelton and no results came back... I searched again just now and found only this post.  

 

Is the email from Dr Shelton on here in without his name seems unusual.  

 

It is the search it was not finding him.. but SA in google with  his  name did... 

 

I am making a reference here to the other links so I can keep them in order as I view them.. hope that is ok. 

 

http://survivingantidepressants.org/index.php?/topic/778-shelton-2006-correspondence-from-dr-richard-shelton-about-prolonged-withdrawal-syndrome/

 

http://survivingantidepressants.org/index.php?/topic/822-shelton-2006-the-nature-of-the-discontinuation-syndrome-associated-with-antidepressant-drugs/

 

http://survivingantidepressants.org/index.php?/topic/673-shelton-2001-steps-following-attainment-of-remission-discontinuation-of-antidepressant-therapy/

 

http://survivingantidepressants.org/index.php?/topic/368-papers-about-prolonged-antidepressant-withdrawal-syndrome/

 

http://survivingantidepressants.org/index.php?/topic/4625-protracted-psychiatric-drug-withdrawal-syndrome-chronic-illness-cfs-fibromyalgia-httpwpmep5nnb-9qi/

 

http://survivingantidepressants.org/index.php?/topic/4190-fast-acting-antidepressant/

 

http://survivingantidepressants.org/index.php?/topic/4190-fast-acting-antidepressant/

 

http://survivingantidepressants.org/index.php?/topic/229-my-story-brandon/

 

http://survivingantidepressants.org/index.php?/topic/1987-panic-attacks-already/

 

Ok these are all the references to Dr Shelton that are on SA I will start to read them now.... seems a bit like a needle in a hay stack but I have to start some place I guess. 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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It is there...you can use the search word genomic...I just remember it being in the text

1st round Prozac 1989/90, clear depression symptoms. 2nd round Prozac started 1999 when admitted to dr. I was tired. Prozac pooped out, switch to Cymbalta 3/2006. Diagnosed with bipolar disorder due to mania 6/2006--then I was taken abruptly off Cymbalta and didn't know I had SSRI withdrawal. Lots of meds for my intractable "bipolar" symptoms.

Zyprexa started about 9/06, mostly 5mg. Tapered 4/12 through12/29/12

Wellbutrin. XL 300 mg started 1/07, tapered 1/18/13 through 7/8/13

Oxazepam mostly continuously since 6/06, 30mg since 12/12, tapered 1.17.14 through 8.26.15

11/06 Lithium 600mg twice daily, 2.2.14 400mg TID DIY liquid, 2.12.14 1150mg, 3.2.14 1100mg, 3.18.14 1075mg, 4/14 updose to 1100mg, 6.1.14 900 mg capsules 7.8.14 810mg, 8.17.14 725mg, 8.24.24 700mg...10.22.14 487.5mg, 3.9.15 475mg, 4.1.15 462.5mg 4.21.15 450mg 8.11.15 375mg, 11.28.15 362.5mg, back to 375mg four days later, 3.4.16 updose to 475 (too much going on to risk trouble)

9/4/13 Toprol-XL 25mg daily for sudden hypertension, tapered 11.12.13 through 5.3.14, last 10 days or so switched to atenolol

7.4.14 Started Walsh Protocol

56 years old

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It is there...you can use the search word genomic...I just remember it being in the text

Yes thank you I did find it by searching in SA in google. 

survivingantidepressants.org - " topic you wish to find" 

this is an example for others in case the search here does not bring up the topic you wish to find. 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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http://www.ncbi.nlm.nih.gov/pubmed/8564731 

[Effects of chronic administration of antidepressants on microtubule assembly in rat cerebral cortex].
[Article in Japanese]
Miyamoto S, Asakura M, Sasuga Y.
Author information
Abstract
We examined the effects of chronic treatment with several types of antidepressants on microtubule assembly and phosphorylation of microtubule-associated proteins (MAPs) in the rat cerebral cortex. The microtubule assembly was monitored in turbidity at 350 nm using a spectrophotometer. Chronic but not acute treatment with desipramine (DMI), maprotiline (MPR) or citalopram (CTR) inhibited microtubule assembly, assayed in the presence of protein phosphatase inhibitors (PPI). In contrast, this inhibitory effect was completely nullified in the absence of PPI. The three compounds had no direct effect on microtubule assembly. The phosphorylation of MAPs (MAP2 and tau) was investigated by immunoblotting with monoclonal antibodies (phosphoserine, phosphothreonine and phosphotyrosine) after immunoprecipitation of MAPs. The serine but not threonine or tyrosine phosphorylation of MAP2 was significantly increased after chronic treatment with DMI, MPR or CTR. The phosphorylation of tau was not altered following chronic administration of antidepressants. These results suggest that the inhibition of microtubule assembly observed after chronic antidepressant treatment is attributable to an increase in the phosphorylated MAP2 and this effect may represent a novel and common action of typical and atypical antidepressant agents. Our results show that besides second messengers system, protein phosphorylation might be involved in the therapeutic effects of antidepressants.

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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