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Glucocorticoids receptors


John
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In Central Nervous System structures, the glucocorticoid receptor is gaining interest as a novel representative of neuroendocrine integration, functioning as a major component of endocrine influence - specifically the stress response - upon the brain. The receptor is now implicated in both short and long-term adaptations seen in response to stressors and may be critical to the understanding of psychological disorders, including some or all subtypes of depression.[12]Indeed, long-standing observations such as the mood dysregulations typical of Cushing's disease demonstrate the role of corticosteroids in regulating psychologic state; recent advances have demonstrated interactions with norepinephrine andserotonin at the neural level.[13]

 

Interestingly, emerging research suggests that certain psychoactive drugs, like those used to treat anxiety and depression, may stabilize mood not only by acting upon neurotransmitter levels, but by modulating the action of glucocorticoids receptors within the brain (Anacker 2011). These new findings strongly support the idea that in order to alleviate mood disorders, controlling stress response is an important aspect of treatment. Indeed, several genetic and epidemiological studies have linked excessive stress, and the inability to efficiently adapt to stress, to increased rates of anxiety and depression (Strohle 2003; Binder 2010).

 

 

So theoretically if some people are going through withdrawal or even the AD might of been atrophying the glucocorticoid receptors which is like the theory of it atrophying the serotonin receptors, then possibly this is why some people have very high cortisol because it prevented the receptors from reuptaking the cortisol?

On Venlafaxine XR 75mg > 20 years, because a general MD decided to try these new "calming pills" taken from his sample closet because my pulse was a little high since I get nervous going to the doctor.

 

June 2010 - Cold turkey

September 2010 - Sudden onset of EXTREME anxiety, constant terror and fear that got marginally better at night.  I had no idea what or why this was; had no idea it was the quitting of Effexor.  (I was never in my life even remotely like this)

December 2010 - reinstated 75mgs Effexor XR, felt no better months later

January 2011 - Began 5% taper every month

2012 - Anxiety began improving by had many windows and waves

January 2014 - Fell back into sudden onset of same anxiety, fear as in 2010; realized I was tapering too quickly.  I was not allowing withdrawal effects to dissipate before another taper.  Began 2% taper every 6 to 8 months

2016 - Fear, anxiety began to wane

2017, 18 & 19 - Constant Fear & anxiety stopped, just occasional minor bouts that lasted 3 days or so

December 2020 - Now at ~40mgs Effexor XR, 2.5mgs Crestor (Cutting 5mg pill in half due to sudden palpitations or PVCs)

 
 
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http://www.sciencedaily.com/releases/2011/04/110412065800.htm

 

This is a writeup on the discovery that depressive patients have a slowdown of hypocampus neurogenesis of glucocortisoid receptors, and how this discovery can lead to new treatments.  This also explains how current antidepressants work in some people, since they also work on glucocortisoid receptors in about 50% of people.  Also while there check at the right hand column where theres other concerning topics like "taking ADs can cause more harm than good.", and "ADs might increase your relapse rate."

On Venlafaxine XR 75mg > 20 years, because a general MD decided to try these new "calming pills" taken from his sample closet because my pulse was a little high since I get nervous going to the doctor.

 

June 2010 - Cold turkey

September 2010 - Sudden onset of EXTREME anxiety, constant terror and fear that got marginally better at night.  I had no idea what or why this was; had no idea it was the quitting of Effexor.  (I was never in my life even remotely like this)

December 2010 - reinstated 75mgs Effexor XR, felt no better months later

January 2011 - Began 5% taper every month

2012 - Anxiety began improving by had many windows and waves

January 2014 - Fell back into sudden onset of same anxiety, fear as in 2010; realized I was tapering too quickly.  I was not allowing withdrawal effects to dissipate before another taper.  Began 2% taper every 6 to 8 months

2016 - Fear, anxiety began to wane

2017, 18 & 19 - Constant Fear & anxiety stopped, just occasional minor bouts that lasted 3 days or so

December 2020 - Now at ~40mgs Effexor XR, 2.5mgs Crestor (Cutting 5mg pill in half due to sudden palpitations or PVCs)

 
 
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This is interesting in the context of HPA dysregulation and autonomic dysfunction and problems with cortisol during withdrawal. Less so, to me, in the context of how ADs "work," since the stats show that they actually mostly don't work better than placebo, except in cases of severe depression. (In all my years working on withdrawal forums I can count on the fingers of one hand the number of people I've encountered who were initiated on ADs due to severe depression. Maybe half the fingers come to think of it.)

Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease". Long story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything. Amitryptiline, Prozac, bupropion, buspirone, flurazepam, diazepam, alprazolam, Paxil, citalopram, lamotrigine, gabapentin...probably more I've forgotten. 

Started multidrug taper in Feb 2010.  Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 10 2014:   62 Lamictal    1.1 Celexa         0.135 Xanax    1.8 Valium

Feb 10 2015:   50 Lamictal      0.875 Celexa    0.11 Xanax      1.5 Valium

Feb 15 2016:   47.5 Lamictal   0.75 Celexa      0.0875 Xanax    1.42 Valium    

2/12/20             12                       0.045               0.007                   1 

May 2021            7                       0.01                  0.0037                1

Feb 2022            6                      0!!!                     0.00167               0.98                2.5 mg Ambien

Oct 2022       4.5 mg Lamictal    (off Celexa, off Xanax)   0.95 Valium    Ambien, 1/4 to 1/2 of a 5 mg tablet 

 

I'm not a doctor. Any advice I give is just my civilian opinion.

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  • Moderator Emeritus

John, do you have an intro thread in Introductions and Updates? If not, it would be great if you'd start one--people are more likely to find you there and that's where we generally keep up with each other and give advice and follow each others' progress.

 

I only looked down the first page so if you have one it's probably just on another page.

Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease". Long story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything. Amitryptiline, Prozac, bupropion, buspirone, flurazepam, diazepam, alprazolam, Paxil, citalopram, lamotrigine, gabapentin...probably more I've forgotten. 

Started multidrug taper in Feb 2010.  Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 10 2014:   62 Lamictal    1.1 Celexa         0.135 Xanax    1.8 Valium

Feb 10 2015:   50 Lamictal      0.875 Celexa    0.11 Xanax      1.5 Valium

Feb 15 2016:   47.5 Lamictal   0.75 Celexa      0.0875 Xanax    1.42 Valium    

2/12/20             12                       0.045               0.007                   1 

May 2021            7                       0.01                  0.0037                1

Feb 2022            6                      0!!!                     0.00167               0.98                2.5 mg Ambien

Oct 2022       4.5 mg Lamictal    (off Celexa, off Xanax)   0.95 Valium    Ambien, 1/4 to 1/2 of a 5 mg tablet 

 

I'm not a doctor. Any advice I give is just my civilian opinion.

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John, please post links to all quotations.

 

You will often find announcements of researchers discovering this or that neurotransmitter or receptor and theorizing this might be the key to some enormous breakthrough in psychiatry. Currently, researchers are looking for the next brain drug blockbuster treating Alzheimer's or dementia.

 

This has been going on for decades. 30 years ago, the breathless announcements were about serotonin. You know where that led.

 

Take all such information with a grain of salt. There are dozens if not hundreds of neurohormones that act on the brain and nervous system. None of them are single-purpose. They all work in concert for our health. Jiggering any one of them often causes unanticipated consequences, usually to the detriment of the autonomic nervous system.

 

While you might find such information interesting, there is no one in the world who can say what it might mean in your particular case, and certainly no one on this site who can do so.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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There are links there.  What i'm wondering is if someone who is not depressed takes these pills, and it grows additional cortisol receptors, and cortisol is increased and the brain is absorbing more cortisol, if it would make one more anxious than ever.

On Venlafaxine XR 75mg > 20 years, because a general MD decided to try these new "calming pills" taken from his sample closet because my pulse was a little high since I get nervous going to the doctor.

 

June 2010 - Cold turkey

September 2010 - Sudden onset of EXTREME anxiety, constant terror and fear that got marginally better at night.  I had no idea what or why this was; had no idea it was the quitting of Effexor.  (I was never in my life even remotely like this)

December 2010 - reinstated 75mgs Effexor XR, felt no better months later

January 2011 - Began 5% taper every month

2012 - Anxiety began improving by had many windows and waves

January 2014 - Fell back into sudden onset of same anxiety, fear as in 2010; realized I was tapering too quickly.  I was not allowing withdrawal effects to dissipate before another taper.  Began 2% taper every 6 to 8 months

2016 - Fear, anxiety began to wane

2017, 18 & 19 - Constant Fear & anxiety stopped, just occasional minor bouts that lasted 3 days or so

December 2020 - Now at ~40mgs Effexor XR, 2.5mgs Crestor (Cutting 5mg pill in half due to sudden palpitations or PVCs)

 
 
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