Jump to content

Drug-induced phospholipidosis


btdt
 Share

Recommended Posts

http://www.sciencedirect.com/science/article/pii/S0014579306010325

 

"Drug-induced phospholipidosis is characterized by intracellular accumulation of phospholipids with lamellar bodies, most likely from an impaired phospholipid metabolism of the lysosome. Organs affected by phospholipidosis exhibit inflammatory reactions and histopathological changes. Despite significant advances in the understanding of drug-altered lipid metabolism, the relationship between impaired phospholipid metabolism and drug-induced toxicity remains enigmatic. Here we review molecular features of inheritable lysosomal storage disorders as a molecular mimicry of drug-induced phospholipidosis for an improved understanding of adverse drug reaction."

 

". Essentially, drug-induced phospholipidosis is characterized by phospholipid accumulation in affected tissue of which lung, liver, brain, kidney, cornea and others have been reported [3].

So far, more than 50 novel chemical entities have been identified to induce phospholipidosis. These include antibiotics, antidepressants, antipsychotics, antimalarial and antiarrythmic drugs. Many of these are cationic amphiphilic drugs (CADs) and share particular physical properties resulting from a chemical structure containing a hydrophilic ring and hydrophobic regions. Several of these drugs display severe adverse effects, such as acute pneumonitis or hepatitis as observed under amiodarone treatment [4]. However, the relationship between drug-induced phospholipidosis and adverse drug effects remains unexplained. Specifically, the onset of phospholipidosis may or may not be associated with clinical symptoms, including inflammatory reactions and histopathological changes, such as macrophagic infiltration or fibrosis. Clinically relevant phospholipidosis has been observed under administration of amiodarone, fluoxetine, gentamicin, perhexiline and 4.4′-dieethylaminoethoxyhexestrol [5].

The term drug-induced phospholipidosis ascribes to a condition that has been defined by the appearance of intracellular accumulation of phospholipids and lamellar bodies. Beyond this definition, each CAD induces its own specific phospholipid composition and selectively targets organs. There are species differences in drug-induced phospholipidosis and the presence of lamellar bodies may not always signify drug-induced phospholipidosis [6]. Animal models and cell culture systems have been used to study induction of lamellar bodies in response to several cationic amphiphilic drugs [7]. Essentially, the lysosome seems to be the primary target for drug-induced phospholipidosis and may serve as a storage organelle for phospholipid accumulation as well. Inhibition of lysosomal enzymes by CADs decreases phospholipid degradation thereby rendering lipid-drug particles indigestible [5]. As of today, drug-induced phospholipidosis remains an unresolved issue due to unclear molecular causes, and its sporadic relationship with adverse drug reactions. Indeed, the biological consequences of phospholipid accumulation in targeted organs such as liver or kidney remain, at least in part, speculative. Here we focus on drug-induced phospholipidosis, the origin of the lamellar bodies and its relationship to organ toxicity. Notably, some basic understanding on the various causes of phospholipidosis have been reviewed elsewhere [7] and [8]."

 

Sounds like a maybe I wonder if anyone has done more recent research??? 

only posted a bit as I know there are rules... about too much. 

 

Calling all smart people and those with smart friends... 

ideas.. 

 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

Link to comment
Share on other sites

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

Link to comment
Share on other sites

 Share

×
×
  • Create New...

Important Information

Terms of Use Privacy Policy