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Auto immune diseases triggered by SSRI withdrawal? Mast cell activation?

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btdt

Moreover, amiodarone likely played no role in the final illness, having been stopped 17 months previously. The list of drugs implicated in lung injury has grown rapidly during the last decades (12). The exact mechanism of lung injury is uncertain for most drugs. As venlafaxine reduces serotonin reuptake—like anorexic agents—a possible association with pulmonary hypertension has been considered (8). It is unlikely to be a direct effect and is probably a result of biotransformation of the drug in the lung to reactive metabolites and/or oxygen species that damage lung cells (8). The lung is the target for this toxicity because of accumulation of the drug in the lung and/or the presence of a specific biotransformation pathway in the lung.

In hypersensitivity pneumonitis, as in DI-ILD, the first stage consists of an inflammatory process that evolves, over years, inevitably toward pulmonary fibrosis (129). Presumably, in some cases the presence of a fibrotic process reflects presentation at a later stage occurring after a previously overlooked allergic inflammation. Interestingly, Hubbard and coworkers found an association between cryptogenic fibrosing alveolitis and tricyclic antidepressant exposure (10). Therefore, for clinicians an early diagnosis of such pneumonitis is important because early drug cessation will reduce significantly the risk of irreversible fibrosis (210)



Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.200207-739CR#.VSk1TfnF9Ig


WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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btdt

I read something earlier on Iggys page about mast cells and serotonin.... from Iggy's thread

 

"

Mast cells are the cells in our body that contain histamine, when an allergic reaction happens, these cells break down rapidly and their contents is empied into our bodys and brains....for people who have hayfever or other alleric reactions, hives, sneezing, and at the other end of the scale the anaphilaxis...they are reacting to the high levels of histamine (which as we know is a bucket that once overflowed rovokes reaction) however...histamine is not the only thing contained in mast cells.....yep, you guessed it, its our old buddy serotonin!!!

 

so if pollen is high, mast cells are being broken down and even more serotonin is being pumped into the brain...i know several people in long term recovery who experience a ramping up of symptoms during pollen/hayfever season even though none of the reactions are histamine related...no allergy symptoms at all, but worse akathisia, anhedonia etc....i know last year I suffered tremendously during hayfever season......"

 

Lesson in Mast Cells from Wiki

"mast cell (also known as a mastocyte or a labrocyte[1]) is derived from the myeloid stem cell and a part of the immune system that contains many granules rich in histamine and heparin. Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing and defense against pathogens.[2]

The mast cell is very similar in both appearance and function to the basophil, another type of white blood cell. They differ in that mast cells are tissue resident, e.g., in mucosal tissues, while basophils are found in the blood"

 

Anaphylaxis[edit]

In anaphylaxis (a severe systemic reaction to allergens, such as nuts, bee stings, or drugs), body-wide degranulation of mast cells leads to vasodilation and, if severe, symptoms of life-threatening shock.[citation needed]

Histamine is a vasodilatory substance released during anaphylaxis.[17]

Autoimmunity[edit]

Mast cells may be implicated in the pathology associated with autoimmune, inflammatory disorders of the joints. They have been shown to be involved in the recruitment of inflammatory cells to the joints (e.g., rheumatoid arthritis) and skin (e.g., bullous pemphigoid), and this activity is dependent on antibodies and complement components.[19]

Reproductive disorders[edit]

Mast cells are present within the endometrium, with increased activation and release of mediators in endometriosis.[20] In males, mast cells are present in the testes and are increased in oligo- and azoospermia, with mast cell mediators directly suppressing sperm motility in a potentially reversible manner.[20]

Mast cell disorders[edit]

Mastocytosis is a rare condition featuring proliferation of mast cells. It exists in a cutaneous and systemic form, with the former being limited to the skin and the latter involving multiple organs.[2] Mast cell tumors are often seen in dogs and cats.[21]

Autism[edit]

Research into an immunological contribution to autism suggests that autism spectrum disorder (ASD) children may present with "allergic-like" problems in the absence of elevated serum IgE and chronic urticaria, suggesting non-allergic mast cell activation in response to environmental and stress triggers. This mast cell activation could contribute to brain inflammation and neurodevelopmental problems.[22]


WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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btdt

Hi everyone, I am in my 7th year of w/d, and most horrible symptoms have gone away, but I have what seems to be fibromyalgia in my upper  leg muscles, can this be a symptom of w/d? :(

7 years hey me too 7.5 now you posted this so long ago and nobody answered you sorry about this must have slipped past everyone... I think you should get the doctor to look at your leg to make sure it is not something serious... it does not hurt to check. It may be something else in general fibro is in more than one place at a time some have it in most limbs others don't.  Necks shoulders legs backs it can be any place but from what I know it is not generally in just one spot so get that leg checked if you have not done that yet. 

peace


WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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btdt

If Chronic fatigue syndrome is an auto immune disorder... nobody seems to know anything about it for sure... then it makes sense to me. 

 

this link should probably be merged here

 

http://survivingantidepressants.org/index.php?/topic/6256-phopholipidosis-and-antidepressants%E2%80%8F/


WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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WWWI2

I was on Zoloft for many years. During w/d in 2008 I started to have severe gut pain.  A very long story short was that my gallbladder was removed only to find out that I actually had Lymphocitic Colitis, an autoimmune coliform of colitis that can only be identified with a biopsy during a colonoscopy.  After much research I found that the source of this autoimmune may well be Zoloft.  http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/microscopic-colitis/Pages/facts.aspx

 

So w/d didn't cause this disease, just unmasked it perhaps.

 

However, in 2012 during an extended w/d of benzodiapine, I was diagnosed with Graves' disease, another autoimmune disease.  What I believe is that 1.  Once you are the host of an autoimmune disease, there is a predisposition for additional AI Diseases.  Also,I believe 2. The stress produced from a very traumatic w/d from benzos and the predisposition to other AI Diseases combined with the action that benzo w/d takes on the HPT and HPA Axis were why I have Graves' disease.

 

So I believe there is a strong correlation between AI and Psych drug meds and w/d of those meds.

 

WWWI


Paxil 10 mg 4/15 to 7/30/17 crossed over to 20 mg prozac

 

10 years 4mg Ativan.  3 year taper completed 

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btdt

I was on Zoloft for many years. During w/d in 2008 I started to have severe gut pain.  A very long story short was that my gallbladder was removed only to find out that I actually had Lymphocitic Colitis, an autoimmune coliform of colitis that can only be identified with a biopsy during a colonoscopy.  After much research I found that the source of this autoimmune may well be Zoloft.  http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/microscopic-colitis/Pages/facts.aspx

 

So w/d didn't cause this disease, just unmasked it perhaps.

 

However, in 2012 during an extended w/d of benzodiapine, I was diagnosed with Graves' disease, another autoimmune disease.  What I believe is that 1.  Once you are the host of an autoimmune disease, there is a predisposition for additional AI Diseases.  Also,I believe 2. The stress produced from a very traumatic w/d from benzos and the predisposition to other AI Diseases combined with the action that benzo w/d takes on the HPT and HPA Axis were why I have Graves' disease.

 

So I believe there is a strong correlation between AI and Psych drug meds and w/d of those meds.

 

WWWI

Thanks for the link I took a look found this

What causes microscopic colitis?

The exact cause of microscopic colitis is unknown. Several factors may play a role in causing microscopic colitis. However, most scientists believe that microscopic colitis results from an abnormal immune-system response to bacteria that normally live in the colon. Scientists have proposed other causes, including

  • autoimmune diseases
  • medications
  • infections
  • genetic factors
  • bile acid malabsorption

I have a friend who had had her colon removed after getting colitis from taking an antibiotic. 

 

I did not see antidepressants listed as a cause at that link. 

 

Long long ago when I was often reading pages at the FDA site and many others.  I read that antidepressants affect the immune system for the life of me I could never learn more about it.  It is listed in the FDA side effect pages for Effexor if I remember correctly. 

 

It is odd how many auto immune diseases are caused by drugs lupus too is caused by drugs in many instances bp meds I think. 

 

Where did you link the colitis to zoloft... did I miss something?

  •  

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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btdt

Get a load of this an autoimmune drug in early studies seems to work on CFS chronic fatigue syndrome. 

 

https://en.wikipedia.org/wiki/Rituximab

 

In October 2011, a double-blind controlled study was published in PLOS ONE which suggests that rituximab can help patients with chronic fatigue syndrome, leading to a proposed theory relating chronic fatigue syndrome to other autoimmune conditions, however more research is required to verify if such a link exists.[22] A new multi-centre double-blinded trial with 152 patients began in October 2014,[23] after a follow-up open study published in July 2015 suggested a longer acting effect when four maintenance doses were added to the dosing schedule.[24] Two-thirds of the patients responded favorably to the drug, in accordance with previous findings.[25][26][27]

 

SADLY it is a dangerous drug and can kill you

The most dangerous, although among the most rare, side effect is progressive multifocal leukoencephalopathy (PML) infection, which is usually fatal; however only a very small number of cases have been recorded occurring in autoimmune diseases.[9][10]


WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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btdt

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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icequeen

A doctor - a general practitioner - that I have been in touch with suffered severe withdrawal from Effexor and during the withdrawal he got myositis which I believe is considered an autoimmune disease. He says he is of the opinion that the withdrawal as such may cause autoimmune and other diseases. 

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FeralUrban

Oh dear, hate to read this.

 

I've had occasional high non-specific ANA (autoimmune markers) for the past 10 years.

 

After the last drop in dose (down to 22.22 mg Effexor ER) I've developed what I would think is severe arthritis in my right hand after filling out 10 forms by hand at the Physical Therapists office.

 

Overnight my knuckles are visibly swollen, slightly red, and I can't grasp anything. I can't for instance take the cap off the toothpaste with my right hand. 

 

I'll attempt to double down on my anti-inflammatory diet. (I wander off it from time to time)

 

<big sigh>


2002 to 2016 Venlafaxine ER 225mg.  2013 TMS treatments triggered nerve pain in face, arm, back.  2016 TMS round ending Feb 1 Central Nerve Pain and and sub-acute serotonin toxicity compounded by Imitrex.  April-June tapered over 3 months from 225 to 0. Reinstated 6/20/16 21.5 nonER 2x day. 7/7/16-37.5mg; 7/17/16-36.6; 7/22/16-33.75; 8/22/16 32.6mg, 9/11/16-28.9mg, 9/25/16-25mg, 12/3/16-19.4mg, 12/18/16-18.5 holding.  OTHER DAILY PHARMACEUTICALS:   *Oxcarbazepine 150 mg 2x/day since mid 2015, *Naproxen 220mg 3x/day as an antidepressant and for pain since 2012, *Levothyrozine 75mcg since 2008 (hypothyroid), *Levothyronine 5 mpg 2x/day since 2012 (hypothyroid) *montelukast SOD 10 mg for asthma since 2014, Advair 250/50 2x daily, [DX 11/16 Felodopine 5mg since 2006,DX combivent 8/1/16] *MEDICAL MARIJUANA for neuropathic pain:CBD oil 25 mg 3-4 x day, THC tincture a few drops: 1/4 tsp 0-3x/day, vaporize CBD for breakthrough pain, CBD concentrate for severe pain.  PRN MEDS *Valium 5 mg PRN up to 4/day for muscle spasms, usually 1-2 x/ day. *Low dose Ketamine nasal spray for severe pain, and also finding 1 dose calms bad WD quickly. HERBAL TINCTURES: burdock, lobelia, turmeric, white willow. CURRENT SUPPLEMENTS:  *Methylated B vitamins, *Vitamin D 5000 iu, Alpha Lipoid Acid, Neti pot. [DX 6/13/16 promethazine suppository + 2 OTC Benadryl for severe pain N Acetyl Cytine for asthma1992-2002, over 20 different psych meds. 2012-2016 Eliminated 7 meds 1 at a time DX Plaquenil DX Spironolactone DX Lunesta, DX Ativan,  + others

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Yubyub65

I am now 45, my first run on Paxil was 26-28 and the summer after coming off I was 29 doing well retuned from a family vacation with fever, then night sweats, hip and ankle pain and a very swollen ankle. All blood work normal except positive ANA and sent for a chest X-ray. The found a mass so followed up with a CT scan and they found Sarcoidosis. It spontaneously remitted in 6 months or so. I can't say Paxil caused it but I am sure withdrawal was one of the straws that broke the camels back as it is a inflammation overreaction of the body. If I did not have this in my medical history any odd symptoms would get poo pooed as somatic so they tend to do more checking with me when I have shown up with symptoms that are most often SSRI related.


GAD, Panic, Severe Health Anxiety/Somatization Disorder

SSRIs (Paxil and Lexapro) and Klonpin at various doses since late 90s

Alcohol abuse got bad 2008 Quit everything in summer 2009.

Fall 09 still alcohol free but reinstate messy got hospitalized at McClean for 10 days

March 2012 relapsed on drinking.  Two years pretty bad drinking on my Lexapro.

Still slipping into 2016 with some good patches.  Dropped to 10mg Lexapro in late summer.

November 4th stopped drinking but days later all hell broke loose.  

Dec 4th 0.5mg Klonopin added (I know not a good idea this early into not drinking)

 

 

 

 

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Lexy

My pdoc just told me to see a rheaumatologist dr as he is concerned I might have some kind of lupus.  

I had just finished telling him my physical Symptoms had been getting better:  low grade fevers off and on fast heartbeat, knee pain;Come and go.  He noticed some rash in my leg told me I should be checked out for lupus.  I'm freaking out because after 5 years he's telling me this now?? 

I am microtapering and for the last couple months I have been holding for  longer period and seems to have given me a respite on the symptoms. 

 


Started Effexor August 2012 Sept'12-150mg=extreme anxiety Oct'12 cut half-75mg severe wds

Feb 2013 68.5mg. Mar'13- 65mg. Apr'13-59mg. May'13-57mg. June '13-52mg Aug'13 49.75mg.

Sep'13-48.75. Nov'13-47mg Dec'13-45..5mg

May 2014 42mg. Jun'14 40mg (depressive mood started). Aug'14 -40mg/ started brintellix 2.5mg

Oct '14 -39 Nov'14 36.89 Dec'14 34.45

Jan 2015- 31 Feb'15 29mg. Mar'15 26.72. Apr'15 24.48. May'15 22.31mg. Jun'15 20.30mg

Aug'15-18.89. Oct'15 16.96. Nov/16- 16.10. Dec/15- 15mg

Jan 2016-14.22. May'16 11.45. Aug'16-9.60. Sep/16- 8.88mg. Oct/16- 8.39mg. Nov/16- 8.13. Dec/16- 7.89

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Sheri755

I firmly believe that the shock to my nervous system/endocrine system, etc. resulted in the worsening of Lichen Sclerosis, development of Hashimoto's and tendonitis.  

People are saying that these things happen with age. No, this is too coincidental, not to mention all of the symptoms. 

There is a definite correlation between these drugs (mine/Effexor) and auto immune diseases. 


Effexor XR 300 (brand) mg & various SSRIs 15 yrs (Effexor XR 300 mg past 10 yrs

Clonazepam, 1.0 mg. am, .5 mg pm. - 15 yrs, 7-17-16- Began .5 three times a day

Vyvanse 60 mg, - 2 yrs, Cut to 50 mg for 6 mths, Cut to 30 mg. on 4-1-16. Tapering.

Approx. 4-1-15 began Effexor XR 300 taper, very slowly for a year. Held at 37.5 for about 3 mths. Cut to 18 mg for 2 wks to 0. WD began 2 wks later. Depression, anxiety, paranoia, low appetite, nausea.

7-14-16-Reinstated 5 beads Effx after 4 mths misery.Pooped out 10 days.

9-12-16-to present- Wide eyed terror, bedridden fear, no appetite/feeling of being full.

10-30-16- Began 15% liquid tapering of 30 mg Vyvanse. (25 mg)

11-13-16- Liquid Vyvanse 22 mg,11-27-16- Liquid 15 mg, 12-12-16- Vyvanse 12.5 for 5 days. 12-16 - 12-29, 15 mg.

11-20-16- Switched back to 1.0 clonazepam am & .5 bedtime

12-30-16- Moved to 15 mg COMPOUNDED Vyvanse.Current 4/11-4/25 7.5 mg.(10% ev 2 wks) Off Vyvanse

Current meds:Effexor XR- 3 Beads, Clonazepam-1.0 mg am, .5 mg bedtime,Vyvanse-(tapering) Estradiol- 2

mg,Progesterone 200 mg,Testosterone 30 mg/ml,Nature Throid- 48.75 mg.(12-21-16-65 mg.) (4-18-17-81.25 mg) Current supplements: Fish Oil-1360 mg, Curamin- 2706 mg.

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Junglechicken

I have reason to believe that I have developed IC (Interstitial cystitis) since being on this AD medication.

 

If PCP doesn't work, I'll pursue the Specialist route to get checked out even if it means cystoscopy etc.,

 

Might also be an idea to look into other autoimmune disease markers - although I don't know how willing my GP would be to do these tests.  NHS doctors/healthcare practitioners are extremely budget conscious and won't do testing unless absolutely necessary so it will have to be private.

 

 


Dose History: 19 Feb 2014 - Escitalopram 10mg daily June 2015 - Started taper, 5mg every other day July 2015 - 5mg every 2 days August 2015 - 5mg every 3 days September 2015 - 5mg every 4 days Sept 14th - Completed tapering, but at 7 weeks "drug free" I suffered serious WD symptoms as a consequence of "incorrect" tapering. Nov 25 2015 - Re-instated Cipralex @ 2.5mg daily. WD symptoms faded. Held at this dose and experienced "windows and waves". 12 Oct 2017 Reduced dose to 1.25mg. 13 Mar 2018 Reduced dose to 0.625mg (approx.). 16 April 2018 0mg. Windows and waves triggered by stress (IBS/reflux, headaches, sinus issues) Aug 2019 Mirena coil fitted 6 Jan 2020 MAJOR Wave hit 19 months following last dose (protracted WD).  Symptoms listed below Mar 2020 Mirena coil removal.

Therapy: Nov 15th 2016 Re-started therapy Jan 19th 2017 Started CBT Dec 2017 Started listening to Hypnotherapy CD (self-esteem). Nov 2019 Started couples therapy.

Supplements: "Bioglan" Biotic Balance Ultimate Flora 10 billion CFU, live Bacteria, Probiotic, suitable for Vegetarians, with Lactobacillus Acidophilus, Lactobacillus Rhamnosus, Bifidobacterium Longum"Pukka" Vitalise a unique blend of 30 energising botanicals.

Diet: 16 April 2018 Detox cleanse / anti-candida for 90 days. Jan 2020 Started "small plate" diet (i.e child size portions).

Exercise: Stretching, Yoga, Pilates, Spinning, Elliptical/upper body workout, walking.

Medical Test Results: 4 Jan 2017 Homeopathic Treatment starts 24 Feb 2017 Started weight loss program 24 Mar 2017 Naturopathic Treatment + anti-Candida diet started due to suspected Candida Related Complex (CRC). DETOXED for 7 weeks to "re-set" gut. April 2017 "Genova Diagnostics" Comprehensive Stool Analysis NEGATIVE; Full Blood Count (Normal) / Blood Cholesterol: 5.6 (Borderline) / Blood Sugar (Normal) / 28 Jun 2017 FSH 8.2 / 14 Nov 2017 FSH 17.7 Dec 2017 Blood Cholesterol: 3.9 (Normal) / Kidney Function (Normal) / Blood Sugar (Normal). December 2017 "Genova Diagnostics" Food panel allergy (bloodwork) analysis - a few "VERY LOW/VL" allergens; Mar 2018 "Genova Diagnostics" SIBO urine analysis: High Level of Yeast/fungal markers found in small intestine but NO SIBO.  April 2018 Thyroid (Normal) / Full Blood Count (Normal) / FSH (Normal). 16 April 2018 Started anti-Candida diet - 3 month protocol.   25 March 2020 All test results "Normal". CRP" 5 mg/L (normal range to 0-5 mg/L).

Symptoms:  Flu-like symptoms, anxiety, anhedonia, sinus headaches right-side (severe), IBS issues/reflux (severe)**, tinnitus, fatigue, inner tremor, nausea, chills/hot flushes, pounding heart, muscular issues including stiff left hip flexor, intense anger, PSSD (ongoing).  **Histhamine intolerance (suspected).

 

Major Life Events: 

Re-located to UK from Canada: Jan 2016

My father died: 5:05pm, Monday 5 Feb 2018 Last Lexapro dose: 16 April 2018 (its now been over a year since I quit ADs)

Moved house: Friday 23rd February 2018  "Divorced" toxic Mother: Monday 26 March 2018 Starting working again: 19 November 2018

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littleball
On 15/7/2014 at 8:50 PM, NoMeaning25 said:

interstitial Cystitis (Proper diagnosis)

I suspect having this after Effexor.

What did you do to get a diagnosis?


November 2014 - September 2015: Zoloft 50 mg, Trilafon 4mg, clonazepam 1mg
October 2015 - September 2016: Effexor 75 mg
September 2016 - January 2017: Effexor 150 mg
Stopped Effexor in March 2017 after tapering under medical supervision
The doctor I've now found is an expert in withdrawal from ADs
Persistent withdrawal syndrome since July 2017: Prozac 10 mg, clonazepam 0.5 mg, to cope with it.
December 2017 -  withdrawing from Prozac, 10 mg every 2 days
Drug free since January (?) 2018
 
Symptoms: pins and needles, burning skin sensations, PSSD, OCD, mood swings (a lot), malaise (a lot), muscle spasms, voice in my conscience. 

Doing not so bad, but I want to be the person I was. 

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bruno2016

for what its worth, I went through tons of tests because they thought I had an auto-immune issues since i tested positive on my ANA. I def attribute the immune dysfunction to the SSRIs and the cold turkey. However, I also tested positive ANA after getting sick while traveling in central america in 2014 and i read some infections can raise ANA so its unknown if i have an auto-immune issue or this was all a result of the infection. I am mostly symptom free at this point in my life, but follow a super strict primal type diet--more or less an auto-immune paleo type diet.  


Various SSRIs/SNRIs 7- 1/2 years

Went Cold Turkey from Celexa 2011, Stayed Off

Psych Drug Free and Loving Life (over 6 years and counting)

 

How I Stay Well: Diet, exercise, meditation, supplements, etc

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Butterfly7777
On 2015-05-23 at 10:25 PM, btdt said:

7 years hey me too 7.5 now you posted this so long ago and nobody answered you sorry about this must have slipped past everyone... I think you should get the doctor to look at your leg to make sure it is not something serious... it does not hurt to check. It may be something else in general fibro is in more than one place at a time some have it in most limbs others don't.  Necks shoulders legs backs it can be any place but from what I know it is not generally in just one spot so get that leg checked if you have not done that yet. 

peace

 

Hey there I know you posted this a while ago but I've searching for a couple years and haven't found much on this topic. About two and a half years ago after stopping Zoloft I was taking for depression  I began having symptoms that soon were diagnosed as fibromyalgia. Since then I've been diagnosed with reynaud's disease and interstitial cystitis and by dr. thinks now I could have Sjogrens. Also I'm have scary neurological symptoms not sure yet what that is as I haven't had MRI yet. I hope you read this somehow and know your not alone! My prayers are with you stay strong sister. 

Edited by baroquep

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btdt

bit off topic maybe but 10 years ago I recall talking to lori at pp about all the other drugs we get to treat the side effects of ADs ...auto immune drugs  the biologic type are very expensive...if it turns out to be correct that ADs cause immune dysfunction and disease this would just be one more very profitable type of drug  to add to a long list of drug sales done on the back of the ssri super $$$ extended patent sales...what we have to take in and know is $$$ are the bottom line for these companies...our health or lack of it if every thought of is an after thought.,...unless  they can make more drugs and money off the side effects.

 

the word  parasite comes to mind...

 

you will not find much on any of this unless you are obsessively diligent in your pursuit even then pickings are slim... pharma protects itself well..  That is no reason not to look if your up to it... I am no longer able to do such work.  


WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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tryingtosurvive

Anyone here who got with Mast cell activation disorder after SSRI use  ?  (Allergies?  Gastro intestinal issues ? Respiratory issues? Pain in joints etc?)

Anyone here who has EDS ( Ehlers-Danlos syndrom ) ?

 

Grateful to all replies!

/Trying to survive

 


fluoxetine since 13years followed doctors advice tapered 40 mg to 0mg in 4 months july 2015 august crasched in panic attacks etc end of september akatisia , nausea, crying alot no one told me it could be something called withdrawal I read it and also about going back to last dose No one knew if it was worth it. tried reinstate autumn 2014 5 mg prozac then 10mg since 29/11-2014 feel only worse sucidal for real, tried antihistamine 10 mg or oxascand (benso) 5 mg or valerian for anxiousness but sick feeling taking this. 6mg prozac to taper slowly down since 15/2-2014 (30ml out of 100ml water with 20 mg pill) tapered 10-20% per month until June 2015 super anxious depressed tired. Got Buspar may 2015 5mg 10mg 15mg headache etc
June 2015: 10mg buspar plus around 3 mg prozac quit this cold turkey in July 2015. One week later crying spells and suicidal. Tried 5htp.magnesium omega 3 until September. October 2015 tested vit D was 17 . Since October 2015 ONLY Vit D and magnesium . nov 2016 can laungh again! but still too anxious ,depressed or lethargic in waves can't focuS, Crying spells , scared, social fobia, bitterness. .. . Did not reinstate prozac again . Trying to survive ....

july 2016-troathpain /reflux starts...

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peaceoutofchaos

I feel like my allergies (trees, grass, dust for breathable stuff, stone-fruits, cow-milks protein and soy) started after starting psych-meds, yes


On a combination of antidepressants, antipsychotics and ADHD meds since I was 16, my 21st birthday is September 19 (2017) 
Meds that did not work for me and that I took in the past:
citalopram, venlafaxine, risperidon, abipiprazole, methylphenidate IR/concerta/telekinet


As of July I'm on 25 mg Quetiapine (IR) 
I currently take 125 mg Quetiapine as of March 29 2018 (Highest dose: 300 XR, 100 mg IR. A total of 400 mg)

I also take fluoxetine 40 mg and dexamfetamine 10 mg 3 times a day. I'm not tapering anything besides Quetiapine


I've never had psychosis to begin with, and I'm experiencing lots of side effects because of the AP, which made me decide to quit. I'm slowly feeling a bit more like myself again.
 

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Toulouse

Big time. Hives mainly. Allergies I never had before. It all started when I was tapering Paxil. 


Been on Paxil 14 years. 40mg for the bulk of those.

20mg in 2014

10mg March of 2015 - then tapered to 5mg

Then to 2.5 to 1.5 - to 1mg, from Mar-August.

As of August 23 2015, I am flying without a net.  Paxil free!

WD symptoms since tapering mid- 2015:

Short temper, hostile. Brain zaps. Bruxism. Wild vivid dreams  Hives Food intolerance Lump in throat, . Joint pain. Knees, elbows.  Pain in feet. Numbness in hands. Shaking, like I'm cold. Trembling. Tremors, muscle twitches all over. Facial tics. Eye, lips. Head.  Floaters in my eyes. Severe Insomnia (between months 4-5)  then returned from March-October 2016. I'm sleeping better now. Dreams have returned to normal (month 7) High levels of anxiety when around large crowds or in large rooms. Intestinal spasms, heartburn.  Dizzy spells.  Panic/Anxiety Attacks suddenly developed months 8 out.  4 years out, 98% feeling back to normal.  (October 9 2019)

 

 

 

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brot30

definitely, fell sick with me/cfs, pots, and mcad after withdrawal, it was a more like a process over 4 years, I do not know what caused what, my final "catastrophe" that made me bedbound  to 95% was a Tetanus vaccination, I do realise that this sounds like a freak show, but this is what happened to me, all this diseases are diagnosed by specialists in their field. I am not anti vaccination by the way, I just seem to be pretty unlucky.

 

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Altostrata

brot, your me/cfs, pots, and mcad may in fact be withdrawal syndrome. Did you have any tendency towards allergic reactions before going on psychiatric drugs?


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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DaveWales

Hi alto, so you think these things are part of withdrawal and not something else triggered by withdrawal? Did you suffer these problems, if so did you find they eased or disappeared with time? 


Intro - 

  • On Paroxetine (Paxil / Seroxat) 20mg since 1999 (age 18). Tapered off over 8 weeks on Dr's advice 2016 - Crashed massively (acute withdrawal) September '16 and reinstated on doc's advice. Found this site and started getting real answers! Currently doing a very slow withdrawal. 

 

Taper progress - 

  • September '16 - 40mg / December'16 - 30mg / Feb '17 - 20 mg / March '17 - 18mg / April '17 - 15mg - became paranoid / May '17-  upped dose to 20mg (kindled - developed chemical sensitivities and neuropathy in legs). 2 month hold. July '17 - 19.5mg / Aug'17 - 18.5mgSept '17 - 17.5mg / October '17 - 17mg / Nov '17 - 16mg / Dec '17 - 15.5mg / Jan '18 - hold / Feb '18 - 14.5mg / April '18 - 13mg / June '18 - 11.5mg / Aug '18 - 10mg (half way hold of approx 2 months) / Nov '18 - 9mg / Dec '18 - 8mg. (tapering too fast, having anxiety / paranoia, so having a 6 week extra hold) / April 19 - still holding at approx 7.5mg

 

Points of interest - 

  • Average seroxat 20mg pill weights 0.355g 
  • Using AWS Gemini 20 scales (seem reasonable for about £20)

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tryingtosurvive
On 4/18/2018 at 7:35 AM, Toulouse said:

Big time. Hives mainly. Allergies I never had before. It all started when I was tapering Paxil. 

it started during your taper ? how long did u taper ? did you get better with the allergies?


fluoxetine since 13years followed doctors advice tapered 40 mg to 0mg in 4 months july 2015 august crasched in panic attacks etc end of september akatisia , nausea, crying alot no one told me it could be something called withdrawal I read it and also about going back to last dose No one knew if it was worth it. tried reinstate autumn 2014 5 mg prozac then 10mg since 29/11-2014 feel only worse sucidal for real, tried antihistamine 10 mg or oxascand (benso) 5 mg or valerian for anxiousness but sick feeling taking this. 6mg prozac to taper slowly down since 15/2-2014 (30ml out of 100ml water with 20 mg pill) tapered 10-20% per month until June 2015 super anxious depressed tired. Got Buspar may 2015 5mg 10mg 15mg headache etc
June 2015: 10mg buspar plus around 3 mg prozac quit this cold turkey in July 2015. One week later crying spells and suicidal. Tried 5htp.magnesium omega 3 until September. October 2015 tested vit D was 17 . Since October 2015 ONLY Vit D and magnesium . nov 2016 can laungh again! but still too anxious ,depressed or lethargic in waves can't focuS, Crying spells , scared, social fobia, bitterness. .. . Did not reinstate prozac again . Trying to survive ....

july 2016-troathpain /reflux starts...

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tryingtosurvive
On 4/22/2018 at 8:58 PM, Altostrata said:

brot, your me/cfs, pots, and mcad may in fact be withdrawal syndrome. Did you have any tendency towards allergic reactions before going on psychiatric drugs?

I am now 4 years after CT and 3 years after tapered of the last reinstatement. The 1,5 after tapered of last reinstatement I had immense anxiety, vit D lifted the depression but the anxiety stayed and 1 year after last dose I fell ill in severe mast cell activation during trip to Asia ...Since then I suffer from severe histamine intolerance and it has gotten systemical wandered from somach and lungs to include nerves , vascular and muscelosceletal system now my issues are muscle cramps, crepitus joint pain and laxative joints have had joint luxations, tired and weak the infection Dr suggested ME/CFS  ! Faiting and palpatiations... This despite taking mast cell stabilizing supplements and if needed antihistamines...

WTF! the SSRI (Prozac) has damaged me and my mast cells  for god??????  The issues started already on prozac but sadly since they put me on this **** by default since I felt bad as a teenager then told me to stay on the drug I was on the **** for 14 years WD was worse then I have seen shows ppl coming of heroine...

but thought I made it to the other side but apparantely not free from it since it is still hurting me ??

Investigating possible SIBO/candida and lyme as other causes but from what I understand SSRI can very well sadly be the cause of triggering mast cell activation disorder - right ? and then that MCAS sets of a cascade of symptoms all over in the bodies all system ... :/


fluoxetine since 13years followed doctors advice tapered 40 mg to 0mg in 4 months july 2015 august crasched in panic attacks etc end of september akatisia , nausea, crying alot no one told me it could be something called withdrawal I read it and also about going back to last dose No one knew if it was worth it. tried reinstate autumn 2014 5 mg prozac then 10mg since 29/11-2014 feel only worse sucidal for real, tried antihistamine 10 mg or oxascand (benso) 5 mg or valerian for anxiousness but sick feeling taking this. 6mg prozac to taper slowly down since 15/2-2014 (30ml out of 100ml water with 20 mg pill) tapered 10-20% per month until June 2015 super anxious depressed tired. Got Buspar may 2015 5mg 10mg 15mg headache etc
June 2015: 10mg buspar plus around 3 mg prozac quit this cold turkey in July 2015. One week later crying spells and suicidal. Tried 5htp.magnesium omega 3 until September. October 2015 tested vit D was 17 . Since October 2015 ONLY Vit D and magnesium . nov 2016 can laungh again! but still too anxious ,depressed or lethargic in waves can't focuS, Crying spells , scared, social fobia, bitterness. .. . Did not reinstate prozac again . Trying to survive ....

july 2016-troathpain /reflux starts...

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Altostrata

There's no clear relationship between mast cell activation disorder and psychiatric drugs or withdrawal syndrome.

 

Withdrawal syndrome often causes hypersensitivity to a lot of things. But a tendency to mast cell activation seems to be genetic and very much affected by environment.

 

Are people who take psychiatric drugs, get withdrawal syndrome, or have other adverse reactions more susceptible to mast cell activation? We don't know.

 

We have members who have developed mast cell conditions or histamine intolerance, but they might have developed those anyway if they had never taken psychiatric drugs. (I developed histamine intolerance myself, but that was from aspirin damage and food poisoning.)


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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tryingtosurvive

Hi, anyone else got MCAS ( Mast cell activation syndrom) during or after using SSRI ?

Grateful to your replies

/Trying...


fluoxetine since 13years followed doctors advice tapered 40 mg to 0mg in 4 months july 2015 august crasched in panic attacks etc end of september akatisia , nausea, crying alot no one told me it could be something called withdrawal I read it and also about going back to last dose No one knew if it was worth it. tried reinstate autumn 2014 5 mg prozac then 10mg since 29/11-2014 feel only worse sucidal for real, tried antihistamine 10 mg or oxascand (benso) 5 mg or valerian for anxiousness but sick feeling taking this. 6mg prozac to taper slowly down since 15/2-2014 (30ml out of 100ml water with 20 mg pill) tapered 10-20% per month until June 2015 super anxious depressed tired. Got Buspar may 2015 5mg 10mg 15mg headache etc
June 2015: 10mg buspar plus around 3 mg prozac quit this cold turkey in July 2015. One week later crying spells and suicidal. Tried 5htp.magnesium omega 3 until September. October 2015 tested vit D was 17 . Since October 2015 ONLY Vit D and magnesium . nov 2016 can laungh again! but still too anxious ,depressed or lethargic in waves can't focuS, Crying spells , scared, social fobia, bitterness. .. . Did not reinstate prozac again . Trying to survive ....

july 2016-troathpain /reflux starts...

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Chuck83

I don't know if the Withdrawal can triggered an autoimmune disease, but after an adverse reaction to a pill of 1000mg of paracentamol for a flu with fever at 40°C eight this days ago, my hands and legs are still superfreezing. Today I will go to my doctor to get me to prescribe the analysis and some blood test, probably I contracted some autoimmune diseases like scleroderma, raynaud's syndrome, or syogren's syndrome. I've never had hands and legs so cold like these days in my entire life.
 


2001, Amisulpride (deniban) - 3 months, I taper in some weeks

2001, Seroquel, 4 weeks - quit cold turkey, 2001. Efexxor,  one pill adverse reaction

2002. Amitryptaline (mutabon mite) - 4 months, I taper really faster in some weeks

around more 10 years drug free

4 December 2013, 7 drops of citalopram , adverse reaction

December    2013, Italian supplement called serenplus with tryptophan, 9 pills adverse reaction, quit cold turkey.

After December 2013, Im drug free.

 

 

 

 

 

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Chuck83

2001, Amisulpride (deniban) - 3 months, I taper in some weeks

2001, Seroquel, 4 weeks - quit cold turkey, 2001. Efexxor,  one pill adverse reaction

2002. Amitryptaline (mutabon mite) - 4 months, I taper really faster in some weeks

around more 10 years drug free

4 December 2013, 7 drops of citalopram , adverse reaction

December    2013, Italian supplement called serenplus with tryptophan, 9 pills adverse reaction, quit cold turkey.

After December 2013, Im drug free.

 

 

 

 

 

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btdt

https://watermark.silverchair.com/znu00507001185.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAkgwggJEBgkqhkiG9w0BBwagggI1MIICMQIBADCCAioGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMn5pTPJDzdTdBeDuFAgEQgIIB-_GZPbmUZveMgxxb06xHher2e7voWooqde4E423xn7Oe6-TYBzPwrNwgHnn0emww-4VtU8kjdhKRmpYzQoVi6KHm_GF56wAf7xkKIhzPC_6E07Tp1EE67RPxmqTAedxnfk1sDcUS0rGn82QTPyIEBVNu5Wvwg-gCyCHNABOcQyvK_vgLGdqbdWMfemrPNGGp-zjpBrhfipJSfT5RCevSFWKzMrJuJkHvsXo1e_Jj1vEyGPU7PKJw7hXI6KweJiN5WqJRPb4m1WkwvEVVgZ4O-aBpPvzBPxq4lBC3pzOFzKyO-Ms4D1aGaAlYG5g5pTrBUaOl2yia2WXyhdhGmfmNz-7aasJIhTwywQa6CLSf8CQot28w2hHLwkUtMQA6H2yQ7gOie6a3zZN7yrNTH8Tb_hY4cZ3EGcPaGQtJ5LoetuDcu0Yy4xHQPw12KdJL6Z1FzwCsx7_O4PHpkd7k98yYVNEg8esSIg9YqG_4Q_6rfhnR6OwAY4PGe_9b5U3_HBj91f8JPTVc_2QvM_mpt5s8kjxJ7fJI1YK1jSdSVUeavHziHZV_HgGUXWVVwp5dyPd95HelQm4StA61zAdltu_esGlVdXODbXyGn5S1cNrnfJ-rxLer7k_zEiyFLhzS5DrDL7j7IoF1QOnos8i0w-4RG6mZkG3p59pIURrLdw

 

TABLE 5 Drugs releasing histamine or inhibiting diamine oxidase Substance class Agent interfering with the histamine metabolism Contrast media Muscle relaxants Pancuronium, alcuronium, D-tubocurarine Narcotics Thiopental Analgetics Morphine, pethidine, nonsteroidal antiinflammatory drugs, acetylsalicylic acid, metamizole Local anesthetics Prilocaine Antihypotonics Dobutamine Antihypertensive drugs Verapamil, alprenolol, dihydralazine Antiarrhythmics Propafenone Diuretics Amiloride Drugs influencing gut motility Metoclopramide Antibiotics Cefuroxime, cefotiam, isoniazid, pentamidin, clavulanic acid, choroquine Mucolytics Acetylcysteine, ambroxol Broncholytics Aminophylline H2-receptor antagonists Cimetidine Cytostatics Cyclophosphamide Antidepressants Amitriptyline

 

found the link to this tidbit in a pdf from this page 

https://www.drbenlynch.com/histamine-intolerance-probiotics/

 

seeking health by ben lynch he has a probiotic and another supplement that increases DAO is that backwards... sorry still messy in the head but it does certainly link medications to histamine issues... of which I have plenty. 

 

I have not taken either of his supplements... so this is not a recommendations I may take them in the near future... I was trying to sort which one would be best to try .. have not sorted it yet. 

 

 

 


WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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btdt

 

 

link is for myself for when I come back wondering when all these odd body movements started to come down I can look here should link it to my page in case 


WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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Junglechicken

Oh boy does reading all this give me that, oh so UN warm and fuzzy feeling ☹️

 

Getting bloodwork done this week to check for Celiac disease, and other nasties.

 

Still struck down with sinus headaches and a general feeling of crappiness.

 

I'm certain the coil triggered this wave/histamine intolerance.


Dose History: 19 Feb 2014 - Escitalopram 10mg daily June 2015 - Started taper, 5mg every other day July 2015 - 5mg every 2 days August 2015 - 5mg every 3 days September 2015 - 5mg every 4 days Sept 14th - Completed tapering, but at 7 weeks "drug free" I suffered serious WD symptoms as a consequence of "incorrect" tapering. Nov 25 2015 - Re-instated Cipralex @ 2.5mg daily. WD symptoms faded. Held at this dose and experienced "windows and waves". 12 Oct 2017 Reduced dose to 1.25mg. 13 Mar 2018 Reduced dose to 0.625mg (approx.). 16 April 2018 0mg. Windows and waves triggered by stress (IBS/reflux, headaches, sinus issues) Aug 2019 Mirena coil fitted 6 Jan 2020 MAJOR Wave hit 19 months following last dose (protracted WD).  Symptoms listed below Mar 2020 Mirena coil removal.

Therapy: Nov 15th 2016 Re-started therapy Jan 19th 2017 Started CBT Dec 2017 Started listening to Hypnotherapy CD (self-esteem). Nov 2019 Started couples therapy.

Supplements: "Bioglan" Biotic Balance Ultimate Flora 10 billion CFU, live Bacteria, Probiotic, suitable for Vegetarians, with Lactobacillus Acidophilus, Lactobacillus Rhamnosus, Bifidobacterium Longum"Pukka" Vitalise a unique blend of 30 energising botanicals.

Diet: 16 April 2018 Detox cleanse / anti-candida for 90 days. Jan 2020 Started "small plate" diet (i.e child size portions).

Exercise: Stretching, Yoga, Pilates, Spinning, Elliptical/upper body workout, walking.

Medical Test Results: 4 Jan 2017 Homeopathic Treatment starts 24 Feb 2017 Started weight loss program 24 Mar 2017 Naturopathic Treatment + anti-Candida diet started due to suspected Candida Related Complex (CRC). DETOXED for 7 weeks to "re-set" gut. April 2017 "Genova Diagnostics" Comprehensive Stool Analysis NEGATIVE; Full Blood Count (Normal) / Blood Cholesterol: 5.6 (Borderline) / Blood Sugar (Normal) / 28 Jun 2017 FSH 8.2 / 14 Nov 2017 FSH 17.7 Dec 2017 Blood Cholesterol: 3.9 (Normal) / Kidney Function (Normal) / Blood Sugar (Normal). December 2017 "Genova Diagnostics" Food panel allergy (bloodwork) analysis - a few "VERY LOW/VL" allergens; Mar 2018 "Genova Diagnostics" SIBO urine analysis: High Level of Yeast/fungal markers found in small intestine but NO SIBO.  April 2018 Thyroid (Normal) / Full Blood Count (Normal) / FSH (Normal). 16 April 2018 Started anti-Candida diet - 3 month protocol.   25 March 2020 All test results "Normal". CRP" 5 mg/L (normal range to 0-5 mg/L).

Symptoms:  Flu-like symptoms, anxiety, anhedonia, sinus headaches right-side (severe), IBS issues/reflux (severe)**, tinnitus, fatigue, inner tremor, nausea, chills/hot flushes, pounding heart, muscular issues including stiff left hip flexor, intense anger, PSSD (ongoing).  **Histhamine intolerance (suspected).

 

Major Life Events: 

Re-located to UK from Canada: Jan 2016

My father died: 5:05pm, Monday 5 Feb 2018 Last Lexapro dose: 16 April 2018 (its now been over a year since I quit ADs)

Moved house: Friday 23rd February 2018  "Divorced" toxic Mother: Monday 26 March 2018 Starting working again: 19 November 2018

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NoMoreLexapro

I"ve been in WD for 6 mths.  Lots of Drs keep wanting to believe this is autoimmune or related to tick-borne disease. 


Was on Lexapro for 66 days starting in early January.  5mg for a week, 10mg for 3, 7.5 for 3 days, then 5mg and 2.5mg for approx two weeks after.  

Was on Lithium for 60 days starting in late January. 1 300mg ER pill a day.  Stopped CT

Was given a .5 ativan script in early Jan.  Took it maybe 20x total from early Jan to beg of June, 2020.

 

-Fall of 2019:  had two vertigo attacks for the first time with no warning, each followed by 4-5 days of morning dizziness.

-Last Friday of 2019:  had first ever, out of the blue, panic attack.  Went to ER- didn't know what was happening.  Was diagnosed w/GAD, even though had never had anxiety or depression problems before.  Basically no health problems at all prior to this, and in very good shape emotionally, physically, and mentally.

-4 days after panic attack given lexapro.  That's when the hell began.  Was on it 66 days.  Reacted badly to it.  Gave me suicidal ideation 4 wks after starting it, plus exhaustion, off the charts anxiety, dizziness, and fatigue.  Did a fast taper over 5 wks.  Was on it 66 days total.

-been off lexapro completely since mid-March, 2020.  First 3 weeks I got better and better.  Then, week 4 into WD got slammed.  Since then, over 64 side effects/symptoms.  Can't drive.  At times, barely surviving.

-since Jan., have been to the e r 16x.

-was given lithium after experienced SI from lexapro to as a "mood stabilizer".  Never really noticed anything from it, nor anything after stopping it, except for a few days of heightened depression about a week after.

-was given low dosage ativan script 2nd week into lexapro to deal with the anxiety/panic spike caused by the lexapro.  Took it perhaps 20x between Jan and June, 2020.  Always made me feel better, but last time it was taken (early June) experienced intrusive thoughts after so stopped it.  Didn't feel any negative reaction from stopping it, perhaps b/c it was taken so infrequently and the dosage was so low. 

 

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