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Auto immune diseases triggered by SSRI withdrawal? Mast cell activation?

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btdt

Moreover, amiodarone likely played no role in the final illness, having been stopped 17 months previously. The list of drugs implicated in lung injury has grown rapidly during the last decades (12). The exact mechanism of lung injury is uncertain for most drugs. As venlafaxine reduces serotonin reuptake—like anorexic agents—a possible association with pulmonary hypertension has been considered (8). It is unlikely to be a direct effect and is probably a result of biotransformation of the drug in the lung to reactive metabolites and/or oxygen species that damage lung cells (8). The lung is the target for this toxicity because of accumulation of the drug in the lung and/or the presence of a specific biotransformation pathway in the lung.

In hypersensitivity pneumonitis, as in DI-ILD, the first stage consists of an inflammatory process that evolves, over years, inevitably toward pulmonary fibrosis (129). Presumably, in some cases the presence of a fibrotic process reflects presentation at a later stage occurring after a previously overlooked allergic inflammation. Interestingly, Hubbard and coworkers found an association between cryptogenic fibrosing alveolitis and tricyclic antidepressant exposure (10). Therefore, for clinicians an early diagnosis of such pneumonitis is important because early drug cessation will reduce significantly the risk of irreversible fibrosis (210)



Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.200207-739CR#.VSk1TfnF9Ig

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btdt

I read something earlier on Iggys page about mast cells and serotonin.... from Iggy's thread

 

"

Mast cells are the cells in our body that contain histamine, when an allergic reaction happens, these cells break down rapidly and their contents is empied into our bodys and brains....for people who have hayfever or other alleric reactions, hives, sneezing, and at the other end of the scale the anaphilaxis...they are reacting to the high levels of histamine (which as we know is a bucket that once overflowed rovokes reaction) however...histamine is not the only thing contained in mast cells.....yep, you guessed it, its our old buddy serotonin!!!

 

so if pollen is high, mast cells are being broken down and even more serotonin is being pumped into the brain...i know several people in long term recovery who experience a ramping up of symptoms during pollen/hayfever season even though none of the reactions are histamine related...no allergy symptoms at all, but worse akathisia, anhedonia etc....i know last year I suffered tremendously during hayfever season......"

 

Lesson in Mast Cells from Wiki

"mast cell (also known as a mastocyte or a labrocyte[1]) is derived from the myeloid stem cell and a part of the immune system that contains many granules rich in histamine and heparin. Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing and defense against pathogens.[2]

The mast cell is very similar in both appearance and function to the basophil, another type of white blood cell. They differ in that mast cells are tissue resident, e.g., in mucosal tissues, while basophils are found in the blood"

 

Anaphylaxis[edit]

In anaphylaxis (a severe systemic reaction to allergens, such as nuts, bee stings, or drugs), body-wide degranulation of mast cells leads to vasodilation and, if severe, symptoms of life-threatening shock.[citation needed]

Histamine is a vasodilatory substance released during anaphylaxis.[17]

Autoimmunity[edit]

Mast cells may be implicated in the pathology associated with autoimmune, inflammatory disorders of the joints. They have been shown to be involved in the recruitment of inflammatory cells to the joints (e.g., rheumatoid arthritis) and skin (e.g., bullous pemphigoid), and this activity is dependent on antibodies and complement components.[19]

Reproductive disorders[edit]

Mast cells are present within the endometrium, with increased activation and release of mediators in endometriosis.[20] In males, mast cells are present in the testes and are increased in oligo- and azoospermia, with mast cell mediators directly suppressing sperm motility in a potentially reversible manner.[20]

Mast cell disorders[edit]

Mastocytosis is a rare condition featuring proliferation of mast cells. It exists in a cutaneous and systemic form, with the former being limited to the skin and the latter involving multiple organs.[2] Mast cell tumors are often seen in dogs and cats.[21]

Autism[edit]

Research into an immunological contribution to autism suggests that autism spectrum disorder (ASD) children may present with "allergic-like" problems in the absence of elevated serum IgE and chronic urticaria, suggesting non-allergic mast cell activation in response to environmental and stress triggers. This mast cell activation could contribute to brain inflammation and neurodevelopmental problems.[22]

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btdt

Hi everyone, I am in my 7th year of w/d, and most horrible symptoms have gone away, but I have what seems to be fibromyalgia in my upper  leg muscles, can this be a symptom of w/d? :(

7 years hey me too 7.5 now you posted this so long ago and nobody answered you sorry about this must have slipped past everyone... I think you should get the doctor to look at your leg to make sure it is not something serious... it does not hurt to check. It may be something else in general fibro is in more than one place at a time some have it in most limbs others don't.  Necks shoulders legs backs it can be any place but from what I know it is not generally in just one spot so get that leg checked if you have not done that yet. 

peace

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WWWI2

I was on Zoloft for many years. During w/d in 2008 I started to have severe gut pain.  A very long story short was that my gallbladder was removed only to find out that I actually had Lymphocitic Colitis, an autoimmune coliform of colitis that can only be identified with a biopsy during a colonoscopy.  After much research I found that the source of this autoimmune may well be Zoloft.  http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/microscopic-colitis/Pages/facts.aspx

 

So w/d didn't cause this disease, just unmasked it perhaps.

 

However, in 2012 during an extended w/d of benzodiapine, I was diagnosed with Graves' disease, another autoimmune disease.  What I believe is that 1.  Once you are the host of an autoimmune disease, there is a predisposition for additional AI Diseases.  Also,I believe 2. The stress produced from a very traumatic w/d from benzos and the predisposition to other AI Diseases combined with the action that benzo w/d takes on the HPT and HPA Axis were why I have Graves' disease.

 

So I believe there is a strong correlation between AI and Psych drug meds and w/d of those meds.

 

WWWI

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btdt

I was on Zoloft for many years. During w/d in 2008 I started to have severe gut pain.  A very long story short was that my gallbladder was removed only to find out that I actually had Lymphocitic Colitis, an autoimmune coliform of colitis that can only be identified with a biopsy during a colonoscopy.  After much research I found that the source of this autoimmune may well be Zoloft.  http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/microscopic-colitis/Pages/facts.aspx

 

So w/d didn't cause this disease, just unmasked it perhaps.

 

However, in 2012 during an extended w/d of benzodiapine, I was diagnosed with Graves' disease, another autoimmune disease.  What I believe is that 1.  Once you are the host of an autoimmune disease, there is a predisposition for additional AI Diseases.  Also,I believe 2. The stress produced from a very traumatic w/d from benzos and the predisposition to other AI Diseases combined with the action that benzo w/d takes on the HPT and HPA Axis were why I have Graves' disease.

 

So I believe there is a strong correlation between AI and Psych drug meds and w/d of those meds.

 

WWWI

Thanks for the link I took a look found this

What causes microscopic colitis?

The exact cause of microscopic colitis is unknown. Several factors may play a role in causing microscopic colitis. However, most scientists believe that microscopic colitis results from an abnormal immune-system response to bacteria that normally live in the colon. Scientists have proposed other causes, including

  • autoimmune diseases
  • medications
  • infections
  • genetic factors
  • bile acid malabsorption

I have a friend who had had her colon removed after getting colitis from taking an antibiotic. 

 

I did not see antidepressants listed as a cause at that link. 

 

Long long ago when I was often reading pages at the FDA site and many others.  I read that antidepressants affect the immune system for the life of me I could never learn more about it.  It is listed in the FDA side effect pages for Effexor if I remember correctly. 

 

It is odd how many auto immune diseases are caused by drugs lupus too is caused by drugs in many instances bp meds I think. 

 

Where did you link the colitis to zoloft... did I miss something?

  •  

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btdt

Get a load of this an autoimmune drug in early studies seems to work on CFS chronic fatigue syndrome. 

 

https://en.wikipedia.org/wiki/Rituximab

 

In October 2011, a double-blind controlled study was published in PLOS ONE which suggests that rituximab can help patients with chronic fatigue syndrome, leading to a proposed theory relating chronic fatigue syndrome to other autoimmune conditions, however more research is required to verify if such a link exists.[22] A new multi-centre double-blinded trial with 152 patients began in October 2014,[23] after a follow-up open study published in July 2015 suggested a longer acting effect when four maintenance doses were added to the dosing schedule.[24] Two-thirds of the patients responded favorably to the drug, in accordance with previous findings.[25][26][27]

 

SADLY it is a dangerous drug and can kill you

The most dangerous, although among the most rare, side effect is progressive multifocal leukoencephalopathy (PML) infection, which is usually fatal; however only a very small number of cases have been recorded occurring in autoimmune diseases.[9][10]

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icequeen

A doctor - a general practitioner - that I have been in touch with suffered severe withdrawal from Effexor and during the withdrawal he got myositis which I believe is considered an autoimmune disease. He says he is of the opinion that the withdrawal as such may cause autoimmune and other diseases. 

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FeralUrban

Oh dear, hate to read this.

 

I've had occasional high non-specific ANA (autoimmune markers) for the past 10 years.

 

After the last drop in dose (down to 22.22 mg Effexor ER) I've developed what I would think is severe arthritis in my right hand after filling out 10 forms by hand at the Physical Therapists office.

 

Overnight my knuckles are visibly swollen, slightly red, and I can't grasp anything. I can't for instance take the cap off the toothpaste with my right hand. 

 

I'll attempt to double down on my anti-inflammatory diet. (I wander off it from time to time)

 

<big sigh>

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Yubyub65

I am now 45, my first run on Paxil was 26-28 and the summer after coming off I was 29 doing well retuned from a family vacation with fever, then night sweats, hip and ankle pain and a very swollen ankle. All blood work normal except positive ANA and sent for a chest X-ray. The found a mass so followed up with a CT scan and they found Sarcoidosis. It spontaneously remitted in 6 months or so. I can't say Paxil caused it but I am sure withdrawal was one of the straws that broke the camels back as it is a inflammation overreaction of the body. If I did not have this in my medical history any odd symptoms would get poo pooed as somatic so they tend to do more checking with me when I have shown up with symptoms that are most often SSRI related.

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Lexy

My pdoc just told me to see a rheaumatologist dr as he is concerned I might have some kind of lupus.  

I had just finished telling him my physical Symptoms had been getting better:  low grade fevers off and on fast heartbeat, knee pain;Come and go.  He noticed some rash in my leg told me I should be checked out for lupus.  I'm freaking out because after 5 years he's telling me this now?? 

I am microtapering and for the last couple months I have been holding for  longer period and seems to have given me a respite on the symptoms. 

 

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Sheri755

I firmly believe that the shock to my nervous system/endocrine system, etc. resulted in the worsening of Lichen Sclerosis, development of Hashimoto's and tendonitis.  

People are saying that these things happen with age. No, this is too coincidental, not to mention all of the symptoms. 

There is a definite correlation between these drugs (mine/Effexor) and auto immune diseases. 

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Junglechicken

I have reason to believe that I have developed IC (Interstitial cystitis) since being on this AD medication.

 

If PCP doesn't work, I'll pursue the Specialist route to get checked out even if it means cystoscopy etc.,

 

Might also be an idea to look into other autoimmune disease markers - although I don't know how willing my GP would be to do these tests.  NHS doctors/healthcare practitioners are extremely budget conscious and won't do testing unless absolutely necessary so it will have to be private.

 

 

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littleball
On 15/7/2014 at 8:50 PM, NoMeaning25 said:

interstitial Cystitis (Proper diagnosis)

I suspect having this after Effexor.

What did you do to get a diagnosis?

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bruno2016

for what its worth, I went through tons of tests because they thought I had an auto-immune issues since i tested positive on my ANA. I def attribute the immune dysfunction to the SSRIs and the cold turkey. However, I also tested positive ANA after getting sick while traveling in central america in 2014 and i read some infections can raise ANA so its unknown if i have an auto-immune issue or this was all a result of the infection. I am mostly symptom free at this point in my life, but follow a super strict primal type diet--more or less an auto-immune paleo type diet.  

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Butterfly7777
On 2015-05-23 at 10:25 PM, btdt said:

7 years hey me too 7.5 now you posted this so long ago and nobody answered you sorry about this must have slipped past everyone... I think you should get the doctor to look at your leg to make sure it is not something serious... it does not hurt to check. It may be something else in general fibro is in more than one place at a time some have it in most limbs others don't.  Necks shoulders legs backs it can be any place but from what I know it is not generally in just one spot so get that leg checked if you have not done that yet. 

peace

 

Hey there I know you posted this a while ago but I've searching for a couple years and haven't found much on this topic. About two and a half years ago after stopping Zoloft I was taking for depression  I began having symptoms that soon were diagnosed as fibromyalgia. Since then I've been diagnosed with reynaud's disease and interstitial cystitis and by dr. thinks now I could have Sjogrens. Also I'm have scary neurological symptoms not sure yet what that is as I haven't had MRI yet. I hope you read this somehow and know your not alone! My prayers are with you stay strong sister. 

Edited by baroquep

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btdt

bit off topic maybe but 10 years ago I recall talking to lori at pp about all the other drugs we get to treat the side effects of ADs ...auto immune drugs  the biologic type are very expensive...if it turns out to be correct that ADs cause immune dysfunction and disease this would just be one more very profitable type of drug  to add to a long list of drug sales done on the back of the ssri super $$$ extended patent sales...what we have to take in and know is $$$ are the bottom line for these companies...our health or lack of it if every thought of is an after thought.,...unless  they can make more drugs and money off the side effects.

 

the word  parasite comes to mind...

 

you will not find much on any of this unless you are obsessively diligent in your pursuit even then pickings are slim... pharma protects itself well..  That is no reason not to look if your up to it... I am no longer able to do such work.  

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tryingtosurvive

Anyone here who got with Mast cell activation disorder after SSRI use  ?  (Allergies?  Gastro intestinal issues ? Respiratory issues? Pain in joints etc?)

Anyone here who has EDS ( Ehlers-Danlos syndrom ) ?

 

Grateful to all replies!

/Trying to survive

 

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peaceoutofchaos

I feel like my allergies (trees, grass, dust for breathable stuff, stone-fruits, cow-milks protein and soy) started after starting psych-meds, yes

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Toulouse

Big time. Hives mainly. Allergies I never had before. It all started when I was tapering Paxil. 

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brot30

definitely, fell sick with me/cfs, pots, and mcad after withdrawal, it was a more like a process over 4 years, I do not know what caused what, my final "catastrophe" that made me bedbound  to 95% was a Tetanus vaccination, I do realise that this sounds like a freak show, but this is what happened to me, all this diseases are diagnosed by specialists in their field. I am not anti vaccination by the way, I just seem to be pretty unlucky.

 

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Altostrata

brot, your me/cfs, pots, and mcad may in fact be withdrawal syndrome. Did you have any tendency towards allergic reactions before going on psychiatric drugs?

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DaveWales

Hi alto, so you think these things are part of withdrawal and not something else triggered by withdrawal? Did you suffer these problems, if so did you find they eased or disappeared with time? 

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tryingtosurvive
On 4/18/2018 at 7:35 AM, Toulouse said:

Big time. Hives mainly. Allergies I never had before. It all started when I was tapering Paxil. 

it started during your taper ? how long did u taper ? did you get better with the allergies?

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tryingtosurvive
On 4/22/2018 at 8:58 PM, Altostrata said:

brot, your me/cfs, pots, and mcad may in fact be withdrawal syndrome. Did you have any tendency towards allergic reactions before going on psychiatric drugs?

I am now 4 years after CT and 3 years after tapered of the last reinstatement. The 1,5 after tapered of last reinstatement I had immense anxiety, vit D lifted the depression but the anxiety stayed and 1 year after last dose I fell ill in severe mast cell activation during trip to Asia ...Since then I suffer from severe histamine intolerance and it has gotten systemical wandered from somach and lungs to include nerves , vascular and muscelosceletal system now my issues are muscle cramps, crepitus joint pain and laxative joints have had joint luxations, tired and weak the infection Dr suggested ME/CFS  ! Faiting and palpatiations... This despite taking mast cell stabilizing supplements and if needed antihistamines...

WTF! the SSRI (Prozac) has damaged me and my mast cells  for god??????  The issues started already on prozac but sadly since they put me on this **** by default since I felt bad as a teenager then told me to stay on the drug I was on the **** for 14 years WD was worse then I have seen shows ppl coming of heroine...

but thought I made it to the other side but apparantely not free from it since it is still hurting me ??

Investigating possible SIBO/candida and lyme as other causes but from what I understand SSRI can very well sadly be the cause of triggering mast cell activation disorder - right ? and then that MCAS sets of a cascade of symptoms all over in the bodies all system ... :/

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Altostrata

There's no clear relationship between mast cell activation disorder and psychiatric drugs or withdrawal syndrome.

 

Withdrawal syndrome often causes hypersensitivity to a lot of things. But a tendency to mast cell activation seems to be genetic and very much affected by environment.

 

Are people who take psychiatric drugs, get withdrawal syndrome, or have other adverse reactions more susceptible to mast cell activation? We don't know.

 

We have members who have developed mast cell conditions or histamine intolerance, but they might have developed those anyway if they had never taken psychiatric drugs. (I developed histamine intolerance myself, but that was from aspirin damage and food poisoning.)

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tryingtosurvive

Hi, anyone else got MCAS ( Mast cell activation syndrom) during or after using SSRI ?

Grateful to your replies

/Trying...

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Chuck83

I don't know if the Withdrawal can triggered an autoimmune disease, but after an adverse reaction to a pill of 1000mg of paracentamol for a flu with fever at 40°C eight this days ago, my hands and legs are still superfreezing. Today I will go to my doctor to get me to prescribe the analysis and some blood test, probably I contracted some autoimmune diseases like scleroderma, raynaud's syndrome, or syogren's syndrome. I've never had hands and legs so cold like these days in my entire life.
 

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btdt

https://watermark.silverchair.com/znu00507001185.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAkgwggJEBgkqhkiG9w0BBwagggI1MIICMQIBADCCAioGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMn5pTPJDzdTdBeDuFAgEQgIIB-_GZPbmUZveMgxxb06xHher2e7voWooqde4E423xn7Oe6-TYBzPwrNwgHnn0emww-4VtU8kjdhKRmpYzQoVi6KHm_GF56wAf7xkKIhzPC_6E07Tp1EE67RPxmqTAedxnfk1sDcUS0rGn82QTPyIEBVNu5Wvwg-gCyCHNABOcQyvK_vgLGdqbdWMfemrPNGGp-zjpBrhfipJSfT5RCevSFWKzMrJuJkHvsXo1e_Jj1vEyGPU7PKJw7hXI6KweJiN5WqJRPb4m1WkwvEVVgZ4O-aBpPvzBPxq4lBC3pzOFzKyO-Ms4D1aGaAlYG5g5pTrBUaOl2yia2WXyhdhGmfmNz-7aasJIhTwywQa6CLSf8CQot28w2hHLwkUtMQA6H2yQ7gOie6a3zZN7yrNTH8Tb_hY4cZ3EGcPaGQtJ5LoetuDcu0Yy4xHQPw12KdJL6Z1FzwCsx7_O4PHpkd7k98yYVNEg8esSIg9YqG_4Q_6rfhnR6OwAY4PGe_9b5U3_HBj91f8JPTVc_2QvM_mpt5s8kjxJ7fJI1YK1jSdSVUeavHziHZV_HgGUXWVVwp5dyPd95HelQm4StA61zAdltu_esGlVdXODbXyGn5S1cNrnfJ-rxLer7k_zEiyFLhzS5DrDL7j7IoF1QOnos8i0w-4RG6mZkG3p59pIURrLdw

 

TABLE 5 Drugs releasing histamine or inhibiting diamine oxidase Substance class Agent interfering with the histamine metabolism Contrast media Muscle relaxants Pancuronium, alcuronium, D-tubocurarine Narcotics Thiopental Analgetics Morphine, pethidine, nonsteroidal antiinflammatory drugs, acetylsalicylic acid, metamizole Local anesthetics Prilocaine Antihypotonics Dobutamine Antihypertensive drugs Verapamil, alprenolol, dihydralazine Antiarrhythmics Propafenone Diuretics Amiloride Drugs influencing gut motility Metoclopramide Antibiotics Cefuroxime, cefotiam, isoniazid, pentamidin, clavulanic acid, choroquine Mucolytics Acetylcysteine, ambroxol Broncholytics Aminophylline H2-receptor antagonists Cimetidine Cytostatics Cyclophosphamide Antidepressants Amitriptyline

 

found the link to this tidbit in a pdf from this page 

https://www.drbenlynch.com/histamine-intolerance-probiotics/

 

seeking health by ben lynch he has a probiotic and another supplement that increases DAO is that backwards... sorry still messy in the head but it does certainly link medications to histamine issues... of which I have plenty. 

 

I have not taken either of his supplements... so this is not a recommendations I may take them in the near future... I was trying to sort which one would be best to try .. have not sorted it yet. 

 

 

 

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