Auto immune diseases triggered by SSRI withdrawal? Mast cell activation?

[Brioche]

https://www.mastzellaktivierung.info/en/therapy_medicaments.html#incompatible

 

Here is one, and with 2 mins of google u find more, ssris are absolutley intolerable on mcas, im wondered youre speaking so much about histamine etc and you do not know the fact that ssris are incompatible? 

 

They killed me with this medicaments, saw my doc this week and she told me that i ll not survive longtime in this state, thats why i say they killed me.

[Altostrata]

If you look at the sole citation for the SSRI entry, you will see it does not support SSRIs being "incompatible" with mast cell disorder. I don't know what the page authors were thinking.

 

On the contrary, other authorities recommend treating mast cell disorder with antidepressants:

 

Selective Serotonin Reuptake Inhibitors Suppress Mast Cell Function

Tamara Haque, John J. Ryan

The Journal of Immunology May 1, 2018, 200 (1 Supplement) 105.8; https://www.jimmunol.org/content/200/1_Supplement/105.8

 

Theoharides TC, Tsilioni I, Ren H. Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?. Expert Rev Clin Immunol. 2019;15(6):639-656. doi:10.1080/1744666X.2019.1596800 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003574/

 

Little is known about mast cell disorders and there is irrational belief that antidepressants are good for everything, so I am dubious about both claims: That antidepressants cause mast cells disorder OR antidepressants are good treatment for mast cell disorders.

 

After years of coping with a MCAS-related condition and having gone through the literature thoroughly, my belief is that just about anything can precipitate a mast cell condition and nobody knows what works for reversing it.

 

Please do your homework before making assertions on this site that other people might take as health-related facts.

[Brioche]

Anyway, i read the opposite if them what youre posting, all medicaments are trigger for mcas. Easy i do not have the force to discuss, good that u found a turnaround forr thid case, whish i could find one too.

[Sicksagittarius]

On 7/17/2018 at 2:46 PM, tryingtosurvive said:

I am now 4 years after CT and 3 years after tapered of the last reinstatement. The 1,5 after tapered of last reinstatement I had immense anxiety, vit D lifted the depression but the anxiety stayed and 1 year after last dose I fell ill in severe mast cell activation during trip to Asia ...Since then I suffer from severe histamine intolerance and it has gotten systemical wandered from somach and lungs to include nerves , vascular and muscelosceletal system now my issues are muscle cramps, crepitus joint pain and laxative joints have had joint luxations, tired and weak the infection Dr suggested ME/CFS  ! Faiting and palpatiations... This despite taking mast cell stabilizing supplements and if needed antihistamines...

WTF! the SSRI (Prozac) has damaged me and my mast cells  for god??????  The issues started already on prozac but sadly since they put me on this **** by default since I felt bad as a teenager then told me to stay on the drug I was on the **** for 14 years WD was worse then I have seen shows ppl coming of heroine...

but thought I made it to the other side but apparantely not free from it since it is still hurting me ??

Investigating possible SIBO/candida and lyme as other causes but from what I understand SSRI can very well sadly be the cause of triggering mast cell activation disorder - right ? and then that MCAS sets of a cascade of symptoms all over in the bodies all system ... 😕

@tryingtosurviveHi there! I have a vast amount of stomach problems from tapering off lexapro including histmaine intolerance, SIBO, candida etc and have to eat low histamine, low fodmap, low inflammatory foods. I was woondering what your main diet consisted of? Also, since we are sensitive to supplements and treatments, what did you do to naturally lower your histamine issues besides just diet? I'm in a hypersensitive state now, I was thinking I could wait a year and then come treat my issues. But I get nervous the longer I let them sit the mroe damage my body will have or maybe if I let my CNS heal, the issues will heal as well? I also have ovarian cysts and hormone imbalances due to the histamine intolerance I believe. I eat just wild caught fish thats flash frozen in a pressure cooker and steamed green vegetables usually. However I'm having a hard time kicking peanut butter because I'm hungry and need a snack food. I was thinking of trying to eat small amounts of starchy veggies like turnips, sweet potatoes but in a limited amt due to fodmaps. Ive been on low fodmap for awhile but still cant tolerate large amts of fodmaps. 

[Ibnabu]

Mast cell activation syndrome

 

Happy new year to every one.

I am almost sure that antidepressant withdrawal is caused by mast cell activation syndrome. Antidepressants were made from antihistamine and they block histamine receptors and affect the mast cells. When the drug is stopped the mast cells  get crazy. Any opinion on this issue?? 

 

Edited December 31, 2021 by ChessieCat
added topic title before merging with existing topic

[ThatOneGirlStitch]

On 12/31/2021 at 12:57 PM, Ibnabu said:

I am almost sure that antidepressant withdrawal is caused by mast cell activation syndrome. Antidepressants were made from antihistamine and they block histamine receptors and affect the mast cells. When the drug is stopped the mast cells  get crazy. Any opinion on this issue?? 

 

 

This came up in the anhedonia thread, read the last few post:

I posted my opinion there but also want to know what you think. We were discussing immune responses and gut health. Also the similarities that WD shares with long covid. But that also begs the question. Wouldn't everyone in WD have to have mast cell activation?

[Junglechicken]

I'm due to see a urologist about "Interstitial Cystitis (IC)/Painful bladder syndrome".

 

Its related to autoimmune disease as it has key "features" but isn't considered to be one?

[peaceandlove]

On 3/7/2022 at 5:42 AM, Junglechicken said:

I'm due to see a urologist about "Interstitial Cystitis (IC)/Painful bladder syndrome".

 

Its related to autoimmune disease as it has key "features" but isn't considered to be one?

Did you end up having Interstitial cystitis? What are your symptoms 

[Finnishgirl]

I just got tested for autoantibodies against protein G and had abnormally high levels on multiple receptors. What this means is that I have some kind of an autoimmune condition going on in my brain attacking certain receptors.  The receptors that had the highest values have been connected with cfs and anhedonia. Fatique and anhedonia are my worst symtoms. I am currently exploring this area and am trying to find ways to help this condition. There is some evidence that gut is the place that might start this chain of events leading  to this reaction so FMT might help. Also, there are some expensive treatments that purify your plasma from these autoantibodies, though am not sure how permanent the results are. Also, there is a drug BC007 (a one time injection) that eliminates the autoantibodies but it is still in development. The drug has had very good results with long covid sufferers. Autoimmunity diet might also help, just ordered a book about that.

[angela9985]

On 12/11/2022 at 7:28 PM, Finnishgirl said:

I just got tested for autoantibodies against protein G and had abnormally high levels on multiple receptors. What this means is that I have some kind of an autoimmune condition going on in my brain attacking certain receptors.  The receptors that had the highest values have been connected with cfs and anhedonia. Fatique and anhedonia are my worst symtoms. I am currently exploring this area and am trying to find ways to help this condition. There is some evidence that gut is the place that might start this chain of events leading  to this reaction so FMT might help. Also, there are some expensive treatments that purify your plasma from these autoantibodies, though am not sure how permanent the results are. Also, there is a drug BC007 (a one time injection) that eliminates the autoantibodies but it is still 

Hi Finnish, could I ask what tests did you order? And I sent you a private message, it would be super grateful if we could discuss there! Thank you so much!

[Kelsears]

I was just diagnosed with hashimoto 6 month into withdrawal/reinstatement (in April). My question is do you treat the autoimmune disease or wait to see if your body repairs itself after withdrawal? 

[Fairsome]

On 12/11/2022 at 1:28 PM, Finnishgirl said:

I just got tested for autoantibodies against protein G and had abnormally high levels on multiple receptors. What this means is that I have some kind of an autoimmune condition going on in my brain attacking certain receptors.  The receptors that had the highest values have been connected with cfs and anhedonia. Fatique and anhedonia are my worst symtoms. I am currently exploring this area and am trying to find ways to help this condition. There is some evidence that gut is the place that might start this chain of events leading  to this reaction so FMT might help. Also, there are some expensive treatments that purify your plasma from these autoantibodies, though am not sure how permanent the results are. Also, there is a drug BC007 (a one time injection) that eliminates the autoantibodies but it is still in development. The drug has had very good results with long covid sufferers. Autoimmunity diet might also help, just ordered a book about that.

Hey, any update about this? What happened?