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Chronic use of common sedative (benzo) linked to Alzheimer's risk


EternalOptimist
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1989-2004 low doze Xanax nightly.

2004 w/d in hospital c/t with 3 other meds, (trazadone, phenobarbital, risperdal)

Tapered off those meds in 7 months.

2010- bad anxiety so tried Valium and klonopin, back to hospital, came home on nothing, got much better.

12-23-2013- hospital for anxiety, depression,insomnia...used low dose lamictal 12 days with mitrazapine.

Came home on 15 mg mitrazapine, down to c. 10 mg mitrazapine in c. 3weeks, 7.5 mg in 32 days..

Tapered off mitrazapine March 6, 2014.

Took .75 mg April 20 and 1.05 mg April 21st.

Ended taper March 6, 2014.

Take supplements tho not all daily: fish oil, Vit. C., Vit. D, cal/mag, little multi, mag at night,

Been taking homeopathic remedy since June, 2014 via a Homeopathic M.D. (Trained in psychiatry)1-12, 2018 put on 60 mg cymbalta; 150 lyrica for anxiety and 50 mg trazadone. Tapered of trazadone after 3 months on it and tapered off of lyrica in about 9 months. As of March, 2019, only on 60 mg cymbalta.

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That link led to a different article for me, but a quick Google found this:

http://www.breakingnews.ie/world/benzodiazepines-raises-alzheimers-risk-641553.html

 

Great. Just what I need.

Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease". Long story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything. Amitryptiline, Prozac, bupropion, buspirone, flurazepam, diazepam, alprazolam, Paxil, citalopram, lamotrigine, gabapentin...probably more I've forgotten. 

Started multidrug taper in Feb 2010.  Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 10 2014:   62 Lamictal    1.1 Celexa         0.135 Xanax    1.8 Valium

Feb 10 2015:   50 Lamictal      0.875 Celexa    0.11 Xanax      1.5 Valium

Feb 15 2016:   47.5 Lamictal   0.75 Celexa      0.0875 Xanax    1.42 Valium    

2/12/20             12                       0.045               0.007                   1 

May 2021            7                       0.01                  0.0037                   1

 

I'm not a doctor. Any advice I give is just my civilian opinion.

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Bad news for millions.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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SHUDDER.... Very very scary. I kind of knew this, but the validation feels like just one more nail. According to Ashton, Klonopin is especially bad on memory because of the anesthetic action. I've been aware of this almost from the beginning of my first taper in 2011, and the knowledge has weighed me down since.

 

This effect is one of the reasons I'm so against the use of benzos for anything other than short term use, and none at all if there are any other options. I know the side effect profile for ADs involves more symptoms, but some of the long term effects from benzos are really bad. The one positive here is this sort of info might finally bring physicians to be more cautious about prescribing the poisons.

As always, LISTEN TO YOUR BODY! A proud supporter of the 10% (or slower) rule.

 

Requip - 3/16 ZERO  Total time on 25 years.

 

Lyrica: 8/15 ZERO Total time on 7 or 8 yrs.

BENZO FREE 10/13 (started tapering 7/10)  Total time on 25 years.

 

Read my intro thread here, and check the about me section.  "No matter how cynical you get, it's almost impossible to keep up." Lily Tomlin

 

 

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SHUDDER.... Very very scary. I kind of knew this, but the validation feels like just one more nail. According to Ashton, Klonopin is especially bad on memory because of the anesthetic action. I've been aware of this almost from the beginning of my first taper in 2011, and the knowledge has weighed me down since.

 

This effect is one of the reasons I'm so against the use of benzos for anything other than short term use, and none at all if there are any other options. I know the side effect profile for ADs involves more symptoms, but some of the long term effects from benzos are really bad. The one positive here is this sort of info might finally bring physicians to be more cautious about prescribing the poisons.

Nah, they will just prescribe Seroquel instead, particularly if insomnia is the issue.   If someone held a gun to my heard and forced me to pick a med, I would take a benzo any day over Seroquel.

 

CS

Drug cocktail 1995 - 2010
Started taper of Adderall, Wellbutrin XL, Remeron, and Doxepin in 2006
Finished taper on June 10, 2010

Temazepam on a PRN basis approximately twice a month - 2014 to 2016

Beginning in 2017 - Consumption increased to about two times per week

April 2017 - Increased to taking it full time for insomnia

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I'm so screwed. :(

Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormonesLitigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.<p>2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc).

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  • 2 weeks later...

I agree with the Benzos. I have used them many times short term. The longest was about 6 months. They do affect my short term memory. After I taper them, my memory returns.

 

I use tranxene though. It is very weak compared to Klonopin.

Prozac 1999-2009 quit semi cold turkey.

 

2012 Placed on Seroquel 25 mg, Tranxene (Clorezepate) 3.75 mg 3x a day, Remeron 30 mg for anxiety/akathesia.

 

Weaned off Seroquel and Tranxene .to Remeron 15 Mg.

In May 2014 tried quitting Remeron at its lowest dose. Had severe withdrawals.Reinstated Remeron at 30 mg by doctor. August 5 2014 entered hospital. Doctor pulled the Remeron and bridged it to Pamelor (Nortriptyline) 40mg and Zyprexa 2.5mg.After removing the Remeron all my bad symptoms went away and I am stable.

 

9/11/14 - 7.5 mg tranxene, 40mg Pamelor, Zyprexa 2.5mg

12/29/14 -  20mg Pamelor, 1/6/15,  7/31/15 3.5mg, 8/10/15 3.2 mg, 9/15/15 2.2mg, 10/15/15 1.8mg

(Feb 2016 - 1.4mg Pamelor only -  OFF OF TRANXENE AND ZYPREXA SINCE DEC 2014 BENZO FREE Since 2014. Nortrityline (Pamelor) .8mg Aug 2016

March 2017 DRUG FREE

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While I am no fan of benzos, I don't think this is a high quality study. To get good data, you would need to do an intent--to-treat study where patients are selected as being appropriate for benzo treatment, then separated between a group receiving benzo treatment and a group not receiving benzos, and followed for years. Which will never happen. But it is possible some of the wounding of the brain is from anxiety, depression, whatever, and especially that suboptimal self-care leads to anxiety, depression, drugs, and eventual loss of focus and memory. There is risk in psychotropic drugs and there is risk in untreated disease.

1st round Prozac 1989/90, clear depression symptoms. 2nd round Prozac started 1999 when admitted to dr. I was tired. Prozac pooped out, switch to Cymbalta 3/2006. Diagnosed with bipolar disorder due to mania 6/2006--then I was taken abruptly off Cymbalta and didn't know I had SSRI withdrawal. Lots of meds for my intractable "bipolar" symptoms.

Zyprexa started about 9/06, mostly 5mg. Tapered 4/12 through12/29/12

Wellbutrin. XL 300 mg started 1/07, tapered 1/18/13 through 7/8/13

Oxazepam mostly continuously since 6/06, 30mg since 12/12, tapered 1.17.14 through 8.26.15

11/06 Lithium 600mg twice daily, 2.2.14 400mg TID DIY liquid, 2.12.14 1150mg, 3.2.14 1100mg, 3.18.14 1075mg, 4/14 updose to 1100mg, 6.1.14 900 mg capsules 7.8.14 810mg, 8.17.14 725mg, 8.24.24 700mg...10.22.14 487.5mg, 3.9.15 475mg, 4.1.15 462.5mg 4.21.15 450mg 8.11.15 375mg, 11.28.15 362.5mg, back to 375mg four days later, 3.4.16 updose to 475 (too much going on to risk trouble)

9/4/13 Toprol-XL 25mg daily for sudden hypertension, tapered 11.12.13 through 5.3.14, last 10 days or so switched to atenolol

7.4.14 Started Walsh Protocol

56 years old

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meimei, those questions about the study are addressed in this NY Times article today http://newoldage.blogs.nytimes.com/2014/09/24/study-links-anxiety-drugs-to-alzheimers-disease/

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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Thank you! That is pretty compelling.

1st round Prozac 1989/90, clear depression symptoms. 2nd round Prozac started 1999 when admitted to dr. I was tired. Prozac pooped out, switch to Cymbalta 3/2006. Diagnosed with bipolar disorder due to mania 6/2006--then I was taken abruptly off Cymbalta and didn't know I had SSRI withdrawal. Lots of meds for my intractable "bipolar" symptoms.

Zyprexa started about 9/06, mostly 5mg. Tapered 4/12 through12/29/12

Wellbutrin. XL 300 mg started 1/07, tapered 1/18/13 through 7/8/13

Oxazepam mostly continuously since 6/06, 30mg since 12/12, tapered 1.17.14 through 8.26.15

11/06 Lithium 600mg twice daily, 2.2.14 400mg TID DIY liquid, 2.12.14 1150mg, 3.2.14 1100mg, 3.18.14 1075mg, 4/14 updose to 1100mg, 6.1.14 900 mg capsules 7.8.14 810mg, 8.17.14 725mg, 8.24.24 700mg...10.22.14 487.5mg, 3.9.15 475mg, 4.1.15 462.5mg 4.21.15 450mg 8.11.15 375mg, 11.28.15 362.5mg, back to 375mg four days later, 3.4.16 updose to 475 (too much going on to risk trouble)

9/4/13 Toprol-XL 25mg daily for sudden hypertension, tapered 11.12.13 through 5.3.14, last 10 days or so switched to atenolol

7.4.14 Started Walsh Protocol

56 years old

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  • 8 months later...

Alzheimer

 

Calcification[edit]

The pineal gland is often seen in skull X-rays, when it is calcified (in old age).[26]

Calcification of the pineal gland is typical in adults, and has been observed in children as young as 2. Calcification rates vary widely by country and correlate with an increase in age, with calcification occurring in an estimated 40% of Americans by their 17th year.[26] Calcification of the pineal gland is largely associated with corpora arenacea also known as "brain sand".

It seems that the internal secretions of the pineal gland inhibit the development of the reproductive glands, because, in cases where it is severely damaged in children, the result is accelerated development of the sexual organs and the skeleton.[27] In animals, the pineal gland appears to play a major role in sexual development, hibernation, metabolism, and seasonal breeding.[28]

Some recent studies show that the degree of pineal gland calcification is significantly higher in patients with Alzheimer's disease vs. other types of dementia.[29]

Pineal gland calcification may also contribute to the pathogenesis of Alzheimer's disease and may reflect an absence of crystallization inhibitors.[29]

Calciumphosphorus,[14] and fluoride deposits in the pineal gland have been correlated with aging, showing that, as the brain ages, more deposits collect.[30]

 

Few more links if your into this subject

http://survivingantidepressants.org/index.php?/topic/6753-brain-insulin-resistance-causing-alzheimers/

 

  • Ecstasy use causes damage similar to Alzheimers study ...
    www.3news.co.nz/.../ecstasy-use-causes-damage-similar-to-alzheimers--st...
    •  
    •  
    Jul 26, 2012 - Ecstasy can ruin both your long and short-term memory in a similar way to Alzheimers according to a new study.
  • Long-term ecstasy use 'raises risk of brain damage and ...
    www.theguardian.com › Society › Drugs
    •  
    •  
    Apr 6, 2011 - Dutch researchers find that the hippocampus of long-term ecstasy users is ... Long-term ecstasy use 'raises risk of brain damage and Alzheimer's' ... 'No Diet Coke for you': Islamophobia at 30,000 feet leads to viral United  ...
  • Ecstasy associated with chronic change in brain function ...
    news.vanderbilt.edu/2011/05/ecstasy-change-brain-function/
    •  
    •  

    May 5, 2011 - Recreational Ecstasy use is associated with a chronic change in brain function, ... in fMRI studies of individuals at risk for, or with early, Alzheimer's disease.... or not the drug is causing long-term brain damage,” Cowan said.

     

    I have read previously that Effexor and Ecstacsy were similar I know we will never see a study saying effexor causes this as nobody will do it ..makes me worry.

     

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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