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L.A. Times: Antidepressants rapidly alter brain architecture, study finds


Brandy
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The following contains brief excerpts only from the news article (link to full article below).

 

FYI - Articles in the L.A. Times are only on the website for a finite period of time, though archived contents usually appear after an interval of time. So if you're interested, read it soon (or google in the future).

 

I'm too burnt out on these things to comment on the stated directions they take this research, etc. I'm sure we all have similar opinions about that and that others will take up the slack for me lol.

 

So posting this fwiw re the findings from this study:

 

 

http://www.latimes.com/science/sciencenow/la-sci-sn-antidepressants-brain-structure-20140918-story.html

 

Los Angeles Times

 

Antidepressants rapidly alter brain architecture, study finds

 

A single dose of SSRI antidepressants such as Fluoxetine, shown here, can change the brain's functional connectivity within three hours, a new study found. (Joe Raedle / Getty Images)

 

By Geoffrey Mohan

 

  • No bummer: antidepressants work faster than we think they do, study suggests
  • Drugs tinker with brain connections within three hours, study of antidepressants says

September 18, 2014, 2:26 PM

A single dose of a popular class of psychiatric drug used to treat depression can alter the brain’s architecture within hours, even though most patients usually don’t report improvement for weeks, a new study suggests.

 

More than 1 in 10 adults in the U.S. use these drugs, which adjust the availability of a chemical transmitter in the brain, serotonin, by blocking the way it is reabsorbed. The so-called Selective Serotonin Reuptake Inhibitors, or SSRIs, include Prozac, Lexapro, Celexa, Paxil and Zoloft...

 

Researchers at the Max Planck Institute in Leipzig, Germany, used a magnetic resonance imaging machine to compare connections in the gray matter of those who took SSRIs and those who did not...

 

When more serotonin was available, this resting state functional connectivity decreased on a broad scale, the study found. This finding was not particularly surprising -- other studies have shown a similar effect in brain regions strongly associated with mood regulation.

 

But there was a two-fold shock: Some areas of the brain appeared to buck the trend and become more interdependent. And all the changes were evident only three hours after the single dosage.

 

“It was interesting to see two patterns that seemed to go in the opposite direction,” Sacher said. “What was really surprising was that the entire brain would light up after only three hours. We didn’t expect that.”

 

...

I was "TryingToGetWell" (aka TTGW) on paxilprogress. I also was one of the original members here on Surviving Antidepressants

 

I had horrific and protracted withdrawal from paxil, but now am back to enjoying life with enthusiasm to the max, some residual physical symptoms continued but largely improve. The horror, severe derealization, anhedonia, akathisia, and so much more, are long over.

 

My signature is a temporary scribble from year 2013. I'll rewrite it when I can.

 

If you want to read it, click on http://survivingantidepressants.org/index.php?/topic/209-brandy-anyone/?p=110343

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Have only briefly glanced at it but the powers to be are seeing this as a good thing and want to do more studying to see who is a quick responder to ADS.   I am sure all of us have a totally opposite point of view if the drugs are acting that quickly.   God only knows what happens over many years.

Drug cocktail 1995 - 2010
Started taper of Adderall, Wellbutrin XL, Remeron, and Doxepin in 2006
Finished taper on June 10, 2010

Temazepam on a PRN basis approximately twice a month - 2014 to 2016

Beginning in 2017 - Consumption increased to about two times per week

April 2017 - Increased to taking it full time for insomnia

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I am sure we have enough people here and in the world that have been on these drugs for years and years if they want to know they could take a look at out brains ... I am sure what we are feeling inside is reflected in our brains if only somebody would ask they could look at my brain all day... would have liked them to look when I could not walk without dragging my foot when my head was dropping to my chest for no apparent reason when I was constantly lost and could not find my way home... when I could not form a sentence ... 

nobody asked 

One can only assume nobody wants to know... or I assume they don't want to know the damage that has been done quick sweep that under the rug... and be done with it. 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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