Jump to content
Phil

N-acetylcysteine (NAC)

Recommended Posts

BinxBolling

No, I don't take potassium, but will try that.  Magnesium does seem to help, and I do take fish oil but have never noticed a direct impact.  I shouldn't actually say that it's worse at night, because it also gets bad (and more distinctly uncomfortable) when I push myself mentally or when I exercise.

 

I wasn't suggesting that I'm atypical, just that autonomic dysfunction doesn't seem to tell the whole story.  But perhaps no one has ever said that.  I do think it's also unusual that my withdrawal symptoms didn't become acute until a full 2 months after I stopped the medication---I basically had no symptoms for a month; insomnia and cogntive problems started about 6 weeks in.  But perhaps that's not uncommon---I don't keep up with all the postings here. 

 

I suppose I'm still chasing the dream of figuring out some underlying pathology that might clarify treatment protocols, especially when it comes to cognition.  Your glumate theory seems like the best thing going---and I'm grateful for the knowledge and insight that constructed it, and don't think its a stretch to say that you are probably the person who has the most knowledge about this condition in the world---but it seems to be based largely on one animal study that wasn't really exploring the unsual condition that we all suffer from, and buttressed by the that fact that lamotrigine helped you.  It's not even entirely clear to me that the people that have severe, protracted problems can be said to have the same thing that people that have the brief withdrawal problems do, just in a more amplified and protracted form.  I have friends who have been on high doses of SSRI's, and have had upon discontinuation, say, brain zaps and other unpleasant symptoms for about a week, and then are completely fine; no hypersensitivity, etc.  That's obviously not novel information to anyone, but my point is: can what we have really be considered just an intensified and protracted version of this same phenomenon?  I had no brain zaps, no nausea, no temperature sensitivity, and no real symptoms of "withdrawal" for weeks.  This is why it makes more sense to me to talk about neurotoxity or "tardive" phenomena as thoughtful physicians like Healy and Shipko do.  There are some decent scientific theories about what causes, say, tardive dyskinesia or akathisia, and some decent treatments for those conditions.  And, terrible as those phenomena must be, they don't seem to be as horrifically systemic or comprehensive as our problems (in other words, my sense is that you can have tardive dyskinesia and the rest of your neurological functioning can be completely normal).  It almost makes me wish that there could be some systematic scientific investigation of our brains, tedious as that would be for us participants.

 

Sorry for the abstract discourse.  I know that most of us (myself included) are mostly just trying to get on with our lives and get what little relief we can from magnesium, fish oil, etc.  But I'm an academic by training and temperament, and every few months I just get the itch to understand better what's happened.  Hence these posts.  So for instance, what is our hypersensitivity?  Allergists know what hypersensitivity means in their context.  Pain specialists have some sense of what "central sensitization" is, but neither of these is as physiologically comprehensive as our experiences.  As far as I know, this is the only medical condition where people aren't able to take medications to help them feel better, including other difficult to theorize conditions like fibromyalgia or CFS.  When one takes a step back, it's a bizzare thing to realize, and surely there's some sort of general pathology that explains this fairly uniform experience.  I'm not so naive that I think that even understanding the pathology would lead to a clear treatment.  I think everyone who's been afflicted by this and has tried to do amateurish research has discovered how little anyone knows about the brain.  But I can't help but feel that understanding the pathology would at least be a step in the right direction. 

 

I hope this isn't taken as quarrelsome or difficult---it isn't meant to be.  It probably should be in a letter to my Congressman or something.

 

Oh yeah, and the pragmatic question: what did you mean by testing for inflammation?

Share this post


Link to post
Share on other sites
Altostrata

There are some general blood tests for inflammation which can indicate if you have an underlying organic condition.

 

You are correct, no one knows exactly what's going on. If you read up on autonomic instability, you may find the best model for iatrogenic dysregulation. No one knows exactly what's going on there, either.

 

The normal functions of the body are extremely complex and interdependent. This is denied by psychiatry's "chemical imbalance" model, which held, erroneously, that psychiatric drugs correct hormonal abnormalities in the brain and disregarded any systemic effects.

 

Psychiatric drugs affect the entire body. (The very common side effect of sexual dysfunction is evidence of this.) If you're lucky, the effects are so subtle, you won't notice them. They alter hormonal functioning of every kind. The body adjusts to their presence with normal mechanisms to maintain homeostasis. The autonomic nervous system is a network of these feedback loops.

 

But, upon discontinuing, those homeostatic mechanisms can be overwhelmed. Long-term chemical interference may have weakened them. The complex network may wobble imperceptibly for a while, then dominoes start to fall as it fails in various areas. This is why noticeable symptoms are sometimes delayed.

 

Still, the body struggles to regain a natural balance, and this is why you have waves and windows and changing symptoms. Because it is a complex system, it can't repair itself all at once, it heals in patches which finally coalesce in noticeable improvement. And because its stability is tenuous, only very gentle interventions can be used to support healing or we experience what we sense as paradoxical reactions or other destabilization.

 

(See http://survivingantidepressants.org/index.php?/topic/749-andrews-2011-blue-again-perturbational-effects-of-antidepressants/

I had extensive correspondence with the author, Giovanni Fava, and Robert Whitaker about whether the homeostatic mechanisms were broken or only temporarily malfunctioning. Since we do see improvement over time, temporary malfunction seems more likely.)

 

It's pretty clear these symptoms are neurological, and not due to organic injury. To my knowledge, hundreds of people with withdrawal syndrome have had various tests and scans and nothing physical has shown up. This would be consistent with a problem of autonomic nervous system dysregulation.

 

(There is other evidence for glutamatergic disinhibition in the Journals section. After 6 years of research, I got tired of writing a PhD dissertation every week, so the source material is there but not summarized.)

Share this post


Link to post
Share on other sites
BinxBolling

Thanks, Alto.  I understand that you've explained yourself to death over the years.  I think I understand the basic theory of autonomic dyregulation, and it makes perfect sense.  I guess what I still don't understand is the way in which autonomic dysregulation can affect cognition.  I get how it would cause sensory and affective problems---pain, insomnia, anxiety, depression---but it's less clear to me how it could cause, say, visuo-spatial problems.  (Though as I write this I've just found a pubmed abstract suggesting that the ANS can impact cognition more than we think, so perhaps there's my answer: http://www.ncbi.nlm.nih.gov/pubmed/8725968

 

One of my biggest frustrations early on with the doctors, including my brother, was the repeated claim that my cognition was bad because I was depressed or anxious.  (It's amazing how this wooly, catch-all abstraction, "major depressive disorder"---how do you know you have it?: you sleep too much... or too little; you eat too much.... or too little---becomes reified into a cause of anything else wrong with you.)  I knew very well that this was not the case, and that much of my depression and anxiety was actually caused by the fact that I was having to try to continue my academic performance with seriously compromised cognition.  The neuropsych testing finally validated this.  Do you have any theories as to how autonomic dysregulation impacts cogntition?  Is it as simple as the fact that everything in body or nervous system is connected?  It's easiest for me to understand how it might impact attention, slightly harder to understand how it could impact memory, and perhaps the most difficult to understand how things like visuo-spatial processing would be affected.  No need to respond to this if you feel like you've been over this ground before.

Edited by Altostrata
fixed link

Share this post


Link to post
Share on other sites
Altostrata

Autonomic dysregulation could impact cognition in any number of ways as it affects circulation and timing of all hormonal releases. You'll have to do more research on its effect on cognition; please share your findings in a new topic here.

 

It could also be a problem in the Krebs energy cycle (NAC facilitates this) http://www.ncbi.nlm.nih.gov/pubmed/19821517

 

Those of us suffering withdrawal syndrome often find our brains and senses are not working as we expect. This causes a great deal of anguish. It could be that when you reach, cognitively, and find nothing but fog, an emotional reaction plays a role, too.

 

Also, your own assessment of your functioning might not be what others see. You might be able to pass as much higher functioning than you feel. In your situation, where there probably is a lot of competition to display brilliance, you are wise to lay low in a less-demanding job. Little by little, your cognitive capacity will come back.

Share this post


Link to post
Share on other sites
compsports

I just placed an order for this after reading it might protect against reactions from anesthesia, particular ones of an ototoxic nature which I would be a sitting duck for due to my hearing loss and tinnitus.  I do intend to make sure what I am going to be given isn't known for ototoxic  properties.   But that still doesn't totally protect me.

 

And thankfully, it  is not forbidden to take before surgery.  Yeah!

 

I will keep folks posted.

 

CS

Share this post


Link to post
Share on other sites
compsports

Thanks, Alto.  I understand that you've explained yourself to death over the years.  I think I understand the basic theory of autonomic dyregulation, and it makes perfect sense.  I guess what I still don't understand is the way in which autonomic dysregulation can affect cognition.  I get how it would cause sensory and affective problems---pain, insomnia, anxiety, depression---but it's less clear to me how it could cause, say, visuo-spatial problems.  (Though as I write this I've just found a pubmed abstract suggesting that the ANS can impact cognition more than we think, so perhaps there's my answer: http://www.ncbi.nlm.nih.gov/pubmed/8725968

 

One of my biggest frustrations early on with the doctors, including my brother, was the repeated claim that my cognition was bad because I was depressed or anxious.  (It's amazing how this wooly, catch-all abstraction, "major depressive disorder"---how do you know you have it?: you sleep too much... or too little; you eat too much.... or too little---becomes reified into a cause of anything else wrong with you.)  I knew very well that this was not the case, and that much of my depression and anxiety was actually caused by the fact that I was having to try to continue my academic performance with seriously compromised cognition.  The neuropsych testing finally validated this.  Do you have any theories as to how autonomic dysregulation impacts cogntition?  Is it as simple as the fact that everything in body or nervous system is connected?  It's easiest for me to understand how it might impact attention, slightly harder to understand how it could impact memory, and perhaps the most difficult to understand how things like visuo-spatial processing would be affected.  No need to respond to this if you feel like you've been over this ground before.

Binx Bolling, blaming cognitive issues on depression and anxiety greatly angers me.  I know someone who experienced a memory loss from anesthesia and that is exactly what she dealt with during the 6 years she was trying to find a doctor to take her seriously.   Several suggested antidepressants.

 

I am glad you received validation from neuropsych testing.   My only concern is as one who had it several years ago is that many of them also believe that psych meds are wonderful.   So you have to be careful about that.

 

I hope things improve for you.

 

CS

Share this post


Link to post
Share on other sites
compsports

Well, I took a 600mg capsule this morning and it seemed to affect my eye pressure which was judged to be high by an optometrist recently.  Yes, I do have an appointment with an opthalmologist although due it possibly being too soon after my surgery, I may have to reschedule it.

 

May try it one more time just to see if it happens again.

 

CS

Share this post


Link to post
Share on other sites
pennygracie

I started taking NAC a few weeks ago to hopefully combat obsessive skin picking. Since then, I've been spotting randomly and feeling kind of moody. My roommate also tried the supplement and started her period the next day. This is definitely messing with our hormones. Is this normal?

Share this post


Link to post
Share on other sites
Altostrata

I've never heard of that. Try Googling and let us know what you find.

Share this post


Link to post
Share on other sites
Nadia

Thought I'd update this thread with my latest experience with NAC. I bought a bottle of the Now brand NAC 600mg with Selenium and Molybdenum about a year ago, and I have taken it occasionally when I have morning anxiety or early waking. (I don't take anything regularly because it will either stop working or go paradoxical, and these days I can sleep OK and have no major anxiety over half the time.) I usually take it at the same time as l-arginine, but I've had trouble recently with cold sores because of too much l-arginine (after years of not having them), so this morning I took it by itself.

 

I took one capsule (600mg) when I woke pre-dawn with anxiety, and I was able to go back to sleep... until 9:45am! It was a disturbed, dream-filled sleep, but it was sleep nonetheless. I feel almost drugged every time I take NAC, like my blood pressure lowers (but I have no evidence for that). It stopped my heart from pounding and I felt sleepy and calm in my body, and yet somehow there was still worry somewhere in me because the dread affected my dreams and was still there. Once I got out of bed, though, I felt good. Even now I feel more calm and collected... almost slow and lazy, which feels fantastic!

When I have taken it at night I feel like I sleep more deeply, but wake earlier, so  I prefer to reserve it for early morning or mid-night waking. If I take it more than two or three days in a row, though, it does nothing or I get worse. Even though it's not a "magic bullet", I plan on using it again sporadically when my morning anxiety rears its ugly head again (less and less these days). I think it's best not to take ANYTHING, but sometimes disrupting the down-spiral can help me interrupt the build of anxiety... in my experience that is when you start worrying about the anxiety itself and it feeds back into itself and makes it worse.

Share this post


Link to post
Share on other sites
Olivia

 I wish I would have known of NAC to take during Benzo Withdrawal. I did and still do take Chelated Magnesium

 which also contains the amino acids glycine and lysine. Very beneficial as a supplement during and after Benzo tapering.

 

Question on the NAC, I do have "residual" Benzo withdrawal symptoms that come and go. Adding NAC sounds like a good idea

for the anxiousness, nervousness, which occasionally rears its head. But reading further, it can be stimulating?

 

Would like to hear more from others in regards to this.

 

Thank you

Olivia

Share this post


Link to post
Share on other sites
Nadia

Yes... Alto provided an excellent explanation earlier in the thread.

 

I took another one at night to see what would happen, and I had a terrible night. I felt like the NAC was provoking a deeper sleep, and my mind fought against it. I kept waking up gasping like I was losing control... my mind was afraid to let go into the state the NAC was creating. This is something that used to happen to me regularly before, and one of the reasons I think things go "paradoxical"... whatever you are trying to do to calm down can alert your system to danger!

So... I might just reserve NAC for early AM anxiety. I'm still thinking it's best not to take anything at all, but I don't always have the willpower to "tough it out"!

Share this post


Link to post
Share on other sites
compsports

Have had amazing results from this supplement.  I have gotten more done in a few days than I have in months.   And today, even t though my sleep was horrible last night, got more done than usual today.

 

I sure hope though it wasn't the cause of my having a higher than normal apnea index last night and causing a wakening after an hour on the machine due to a choking dream.   I will be horribly upset if the remedy is doing that but hopefully, it wasn't the cause of what happened last night.

Share this post


Link to post
Share on other sites
Altostrata

That's good news, cs. Perhaps you can also add in the dietary ways to boost glutathione?

Share this post


Link to post
Share on other sites
Altostrata

Ha! Had asparagus last night.

 

Looks like ingesting glutathione precursors, our old pals the cruciferous veggies, are the best way to increase glutathione.

 

Interesting that black cumin seed (nigella sativa) is on the list. GiaK has written about it regarding histamine intolerance, as a natural antihistamine.

Share this post


Link to post
Share on other sites
alwayslookup

I am really thinking about trying this to take it during the day. I did try avocado as it is also very high in glutathione. I can not remember if it had a huge effect but I will try again.

 

I can get hold of l-cysteine easier than NAC. As I understand they are very similar, it seems that NAC converts to l-cysteine and then to glutathione. So will it have the same effect? 

 

 

from wikipedia:

 

 

Acetylcysteine serves as a prodrug to L-cysteine which is a precursor to the biologic antioxidant, glutathione and hence administration of acetylcysteine replenishes glutathione stores.[5] L-cysteine also serves as a precursor to cystinewhich in turn serves as a substrate for the cystine-glutamate antiporter on astrocytes hence increasing glutamate release into the extracellular space. This glutamate in turn acts on mGluR2/3 receptors, and at higher doses of acetylcysteine, mGluR5.[56][57] Glutathione also modulates the NMDA receptor by acting at the redox site.[36][58] Acetylcysteine also possesses some anti-inflammatory effects possibly via inhibiting NF-κB and modulating cytokine synthesis.[36]

Share this post


Link to post
Share on other sites
MatGMax

1+ for NAC for me.

500 mg has a day has helped he a lot.

But I will have to give it 2 months to be sure.

It has only been a week. And I tend to go up and down in waves.

 

Cheers

 

Damien

Share this post


Link to post
Share on other sites
Laura1981

Hey Damien,

 

I was just curious how the NAC experiment is going. What symptoms did it help with? 

 

I'm always careful with new supplements now, but I still have annoying brain zaps, fatigue, headaches and tingling feeling in the brain, so I am still curious to give it a try.

 

Cheers,

 

Laura

Share this post


Link to post
Share on other sites
MatGMax

Hi Laura,

I still take it though it isn't a magic cure.

It has some great advantages.

Virtually no side effects.

Cheap.

 

If I was guessing it probably helps about 10% better/healthier.

 

It doesn't help any specific wd symptoms that I can tell except a small boost to energy levels.

 

Cheers

 

Damien

Share this post


Link to post
Share on other sites
Laura1981

Hi Damien,

 

thanks a lot! I'll give it a try. I tried 100mg yesterday. I have the feeling the headache and brain zaps are less.

 

But that could be down to the spa-day I had yesterday as well ;-P

 

Cheers,

 

Laura

Share this post


Link to post
Share on other sites
starcontrol2

Been taking 500mg every morning for maybe a month. Not sure if I notice anything either way.

Share this post


Link to post
Share on other sites
Faithgrl

Just want to put in my experience with NAC - tried two different brands from iHerb and it didn't work for me and I got REALLY anxious and even more depressed and my brain wouldn't shut up.

 

-1 from me...

 

I do take glutathione and it has worked really well for me. I have a bottle at work and I take it when I get over-anxious at work.

Share this post


Link to post
Share on other sites
Festus

The reason such high doses are needed is because not enough gets into your intestines to be absorbed because the stomach acids destroy it. Try taking the recommended dosage along with two ginger pills. The ginger pushes the stomach contents through rapidly allowing more in your intestines. Or also find a brand that has a capsule or coating that is resistant to hydrochloric acid

Share this post


Link to post
Share on other sites
downtongirl

I have had some genetic testing done by an integrative medicine doctor and I have a double mutation strain of the MTHFR mutation and am ABSENT for the COMT enzyme and the dr. has suggested for me to take NAC, L Methyl folate, and L glutamine.....I guess I should try....anyone else have these mutations and these supplements help them?

Share this post


Link to post
Share on other sites
Henosis

 

What's confusing about this is that it should increase Glutathione which modulates NDMA receptors (hence its use in treating OCD) which could in theory alleviate the glutamatergic over activation that leads to anxiety/panick in withdrawal. However, L-cysteine also serves as a precursor to cystine which in turn serves as a substrate for the cystine-glutamate antiporter on astrocytes which increases glutamate release into the extracellular space, which we would theoretically want to avoid during glutamergic over activation. Perhaps the former outweighs the latter effect?

 

Good to hear from you, Binx, and good to hear NAC has been helpful.

 

I agree, autonomic dysfunction is highly various. The autonomic nervous system controls so many functions, the permutations are endless.

 

Don't worry about the "silver star" error -- many make it! It takes a bit to get used to the layout of the posts.

 

The neuropathic pain is an autonomic symptom (fibromyalgia is also thought to have an autonomic component). I had it for about 1.5 years in my hands, arms, and shoulders. It seemed to resolve with acupuncture.

 

The autonomic nervous system controls muscle tension, blood vessel dilation, nerve conduction and other subtle operations that might be the source of your neuropathic pain. Inflammation might also be involved (did you get tested for this?)

 

NAC is a precursor of glutathione http://www.jissn.com/content/2/2/38

Glutathione is involved in many immune system cell repair functions. (It's sometimes called an antioxidant, but that doesn't explain everything it does.)

 

From the paper abstract at http://www.sciencedirect.com/science/article/pii/S0163725813001952

N-acetyl-l-cysteine (NAC) has long been used therapeutically for the treatment of acetaminophen (paracetamol) overdose, acting as a precursor for the substrate (l-cysteine) in synthesis of hepatic glutathione (GSH) depleted through drug conjugation. Other therapeutic uses of NAC have also emerged, including the alleviation of clinical symptoms of cystic fibrosis through cysteine-mediated disruption of disulfide cross-bridges in the glycoprotein matrix in mucus.

 

....

This review seeks to re-evaluate the mechanism of action of NAC as a precursor for GSH synthesis in the context of its activity as an “antioxidant”. Results from recent studies are examined to establish whether the pre-requisites for effective NAC-induced antioxidant activity (i.e. GSH depletion and the presence of functional metabolic pathways for conversion of NAC to GSH) have received adequate consideration in the interpretation of the data. A key conclusion is a reinforcement of the concept that NAC should not be considered to be a powerful antioxidant in its own right: its strength is the targeted replenishment of GSH in deficient cells and it is likely to be ineffective in cells replete in GSH.

Curr Opin Pharmacol. 2007 Aug;7(4):355-9. Epub 2007 Jun 29.

N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency.

Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA.

 

Abstract at http://www.ncbi.nlm.nih.gov/pubmed/17602868 Full text at http://www.mediafire.com/view/3tyroedsbc6f6bf/07_Atkuri_n-acetylcysteiine.pdf

 

Glutathione (GSH) deficiency is associated with numerous pathological conditions. Administration of N-acetylcysteine (NAC), a cysteine prodrug, replenishes intracellular GSH levels. NAC, best known for its ability to counter acetaminophen toxicity, is a safe, well-tolerated antidote for cysteine/GSH deficiency. NAC has been used successfully to treat GSH deficiency in a wide range of infections, genetic defects and metabolic disorders, including HIV infection and COPD. Over two-thirds of 46 placebo-controlled clinical trials with orally administered NAC have indicated beneficial effects of NAC measured either as trial endpoints or as general measures of improvement in quality of life and well-being of the patients.

 

Mark Hyman's opinion

Glutathione: The Mother of All Antioxidants

http://www.huffingtonpost.com/dr-mark-hyman/glutathione-the-mother-of_b_530494.html

 

Whey protein isolate also boosts glutathione production. Both NAC and whey protein isolate are often recommended for chronic fatigue syndrome, another mysterious condition with an autonomic component, the symptoms of which overlap with withdrawal syndrome. See paper at http://www.ncbi.nlm.nih.gov/pubmed/11703165

 

 

I have no idea if your benefit from NAC is because of the glutathione connection or something else. These reactions are so complex. But whatever works, works, and thanks for telling us about this.

 

...I did notice after I quit it that it contains a sulfa component. I was always wondering about the color of the material. It definitely is orange. Long story short, I've had a sulfa allergy my whole life. I wasn't sure that was the reason for the reaction I had to it.....

NAC does NOT contain sulfa; it is a sulfur compound -- sulfa and sulfur are entirely different!

Share this post


Link to post
Share on other sites
Ryder
On 4/12/2014 at 5:20 AM, Nadia said:

I feel almost drugged every time I take NAC, like my blood pressure lowers (but I have no evidence for)

 

I feel exactly the same way. I was on and off it for about a year and when I raised my concerns with my Naturopath Doc, she simply stated it cannot be harmful because it is not classed as a drug. I was prescribed L-Carneteine and CoQ10 to go with NAC and the first two are ok. They take away some of the neorological back and neck pain. I will only take a quarter teaspoon of NAC like others have said before bed if I just want to get some sleep.

 

As of 2017, I have a really bad feeling about NAC and would rather just stick to a tried and tested SSRI. What is the consensus ?

Share this post


Link to post
Share on other sites
neurotransmission

This thing works in a different way. there is a sweet spot and titration that should be done is different person to person. its effect can dissapear after weeks. But in some person just popping high doses can immidiately improve some ssri withrawall issues and wellbutrin-adderal-ritalin withrawalls. It can give some guys sedative eeffect when you are above sweet spot. its stabilizing dopamine and preventing dopamine receptor upregulation. There is a lot of guys using it for using less ritalin,adderal for adhd even using less cocaine,mdma for recreational abuse.

on the sweet spot, you can get:

less anxiety from coffee and other stimulans and more motivation, alertness.

it can cure some type of OCD which is ressistant to ssri/antipsycotic combos. BTW Memantine is a far more potent agent which is working from the same pathway for ocd.

it can potentiate ssris and speed up onset action, (getting 10mg effect from 5mg lexa)

if you use it for weeks and start ritalin again you get can what you are getting from 10 mg  only from 2.5 ritalin like me.

it can prevent or reduce anxiety from stimulants and stimulant like antidepressants.

it is also very beneficial for humidity problems in nose after radiofrequency turbinate reduction for me.

 

 

Share this post


Link to post
Share on other sites
TheWayBack

Anybody has some results for akathisia with this? I found some positive comments on other forums from people saying it helped them very much with akathisia even when on neuroleptics. I asked Dr Shipko about it today too. Waiting on his reply. Probably going to try it one of the coming days.

I have brutal akathisia from morning until noon, and a bit less in the afternoon, and mostly gone in the evening. So I'm going to take it in the morning. I'll post my progress. Propranolol 20mg takes the edge of the akathisia now, but I'd rather not increase this.

 

 

 

 

Share this post


Link to post
Share on other sites
TheWayBack

NAC so far after a couple of days:

 

600mg in the morning and 600mg in the evening - Take it with food in the morning, otherwise too hard on the stomach (and I have never had stomach issues!)

 

Mood more stable, less WD symptoms. Overall good impression, so far the best supplement I have tested. Fishoil and magnesium doesn't do much for me.

 

 

 

 

 

 

 

 

Share this post


Link to post
Share on other sites
thinkpink

Would be okay to try NAC whilst taking a magnesium supplement? Has anyone tried taking both? 

Share this post


Link to post
Share on other sites
thinkpink

Thank you Chessie Cat

Share this post


Link to post
Share on other sites
asdf

I have used NAC occasionally for UTI and had no serious side effects. But this time things got out of hand, I think it triggered me into a nasty zopiclone withdrawal ( https://www.survivingantidepressants.org/topic/11607-asdf-zopiclone-tolerance-crossover-to-benzodiazepine/?do=findComment&comment=406239 )

 

 

Not sure I understand how NAC works. If I take NAC with medications, which increase GABA (diazepam and zopiclone) and the dose of NAC is wrong, is it possible it has the same effect than withdrawal of these medications?

 

 

 

 

 

Share this post


Link to post
Share on other sites
Ryder

Can I just say, I took NAC about 2.5 years ago. I was on Zoloft and Clonazepam and i was able to drive.

 

Once i started NAC, yes it really took the burden off my withdrawal symptoms. But, I eventually stopped driving because of it. I wouldn't wish NAC on anybody my cognition and concentration just went funny.

 

Also it has a really short half life, I took it up to 3xtimes in a day at one stage, that is including before bed.

Share this post


Link to post
Share on other sites
asdf

I have never used NAC regularly, only for UTI. But I think I felt it`s short half life, when I took a very small dose on wednesday, just to see if it affects me. It relieved my anxiety a little and the effect lasted for 2 hours. 

 

I am just trying to find out what happened. I feel like I am in zopiclone interdose withdrawal, is it possible that taking NAC may have caused this?  And if so, what can I do? 

Last time I started crossover to diazepam and reduced the dose of zopiclone and it helped with acute withdrawal symptoms. But I could not complete the crossover, because at some point it became impossible to reduce zopiclone. 

 

 

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.


×
×
  • Create New...