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endocrine system /exocrine affects of ssri treatment


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http://en.wikipedia.org/wiki/Endocrine_system

 

http://en.wikipedia.org/wiki/Endocrine_system

 

A bit from Healy 

http://www.madinamerica.com/2012/07/theres-something-about-mary/

 

"It is far more likely that the risk of birth defects in women who have stopped their SSRI is mediated through some enduring epigenetic change or effect on the endocrine system brought about by previous treatment than it is that these birth defects are caused by untreated nerves. If this is the case, it means we do not know how long women have to stop SSRIs and other serotonin reuptake inhibiting antidepressants before it is safe for them to conceive." 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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It seems to me digestion which is a big issue for many of us here has been affected according to this 

http://en.wikipedia.org/wiki/Endocrine_system

even more so this

http://www.cram.com/flashcards/gi-tract-exocrine-glands-1665814

 

we are talking about the exocrine system which I have not heard a word about. 

I know I read a long time ago about how ssri drugs affect one of these 

 

Pancreas is part of this system as you can see... I would like to start a conversation about this and maybe we call all learn some things that will help our digestion.  

peace

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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what are the seven substances that exocrine glands or secretory cells of the GI tract secrete into the GI lumen?

 

digestive enzymes, mucus, HCL, water, electrolytes, intrinsic factor and bile

 

this will be the focus of this thread 

 

what two secretion sources excrete the most amount of substance daily? what is the amount?

 

Gastric mucosa and pancreas. 2000 mls

 

Good starting place:

erotonin is best known as a neurotransmitter in the brain. Released by one neuron and picked up by another, it regulates mood and aggression. Many antidepressants, and the party drug Ecstasy, increase serotonin stimulation. But it is found outside the central nervous system as well, including in the pancreas, specifically in the beta cells that release insulin to regulate blood glucose levels. Serotonin was discovered in beta cells over 30 years ago, and researchers have been trying to figure out what it's doing there ever since. In a new study, Nils Paumann, Diego Walther, and colleagues show that serotonin plays a key role in controlling insulin secretion and that its absence leads to diabetes. Even more surprisingly, it does so through a completely different mechanism than that used in the brain—it acts within, not between, cells and, rather than forming brief and weak liaisons with a receptor, makes long-lasting covalent bonds with an enzyme.

When released from the pancreas, insulin helps other cells in the body take up sugar from the bloodstream, feeding the cells and bringing blood sugar levels down again. Diabetes, in its several forms, arises when the system goes awry. Before its release, insulin is stored in beta cells in secretory granules. These granules also store serotonin, which is released along with insulin. (In fact, when cell biologists want to track insulin release, they often measure serotonin instead because it's easier to monitor.)

Prior studies have offered some clues to serotonin's activities in other tissues in the body's periphery. In platelet-forming cells called thrombocytes, it links up to a group of signaling enzymes called GTPases, triggering the release of vesicle contents by exocytosis. Unlike the fleeting connections it makes to receptors within the brain, serotonin covalently bonds to the GTPase, a reaction called “serotonylation,” which is catalyzed by a transglutaminase enzyme. Intriguingly, GTPases also help regulate insulin secretion in the pancreas, and lack of transglutaminase leads to glucose intolerance, both suggesting that the same system may be at play in the pancreas.

To test this directly, the authors examined mice lacking tryptophan hydroxylase, a key enzyme in serotonin synthesis, rendering the mice unable to make serotonin outside the central nervous system. The mice exhibited classic signs of diabetes—elevated blood glucose and decreased insulin secretion. They were also resistant to the effects of pargyline, a chemical that in normal mice causes insulin release, suggesting that the absence of serotonin blocked this effect. Infusion of serotonin normalized secretion in mice unable to make their own.

The authors found that serotonin in pancreatic cells bound directly to GTPase enzymes, and by blocking transglutaminase, blocked this reaction, reducing insulin secretion. The authors identified two specific GTPases that are known to play a role in insulin secretion as targets for serotonylation. But, based on the large amount of protein-bound serotonin they saw, they suggest serotonin likely links up with multiple other proteins as well, suggesting a host of other interactions yet to be discovered.

The model that emerges from this study suggests that by binding to GTPases, serotonin promotes insulin release in response to elevated glucose. In addition to solving the puzzle of what a brain neurotransmitter is doing in the pancreas, the study has some important clinical implications. The condition that developed in the mice lacking tryptophan hydroxylase most resembled the human form of disease known as “maturity onset diabetes of the young,” raising the intriguing prospect that this disease may be linked to mutation of the tryptophan hydroxylase gene, a possibility that will require further study. Whether or not this is so, the serotonin pathway provides an avenue for intervention in multiple forms of diabetes, since it directly influences the amount of insulin secreted. Given the medical importance of diabetes—it affects almost 200 million people worldwide, and requires chronic treatment—it is a good bet that serotonin modulation will soon be a target for drug development.

Paulmann N, Grohmann M, Voigt J-P, Bert B, Vowinckel J, et al. (2009) Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation. doi:10.1371/journal.pbio.1000229

http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1000227

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells.

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are antidepressants used for the treatment of mood and anxiety disorders. Here, we demonstrate that incubation (2 h) of murine islets or Min6 β cell line with the SSRIs paroxetine, fluoxetine, or sertraline inhibited insulin-induced Tyr phosphorylation of insulin receptor substrate (IRS)-2 protein and the activation of its downstream targets Akt and the ribosomal protein S6 kinase-1 (S6K1). Inhibition was dose-dependent with half-maximal effects at ∼15-20 μM. It correlated with a rapid dephosphorylation and activation of the IRS kinase GSK3β. Introduction of GSK3β siRNAs eliminated the inhibitory effects of the SSRIs. Inhibition of IRS-2 action by 30 μM SSRI was associated with a marked inhibition of glucose-stimulated insulin secretion from murine and human pancreatic islets. Secretion induced by basic secretagogues (KCl and Arg) was not affected by these drugs. Prolonged treatment (16 h) of Min6 cells with sertraline resulted in the induction of inducible nitric oxide synthase; activation of endoplasmic reticulum stress, and the initiation of the unfolded protein response, manifested by enhanced transcription of ATF4 and C/EBP homologous protein. This triggered an apoptotic process, manifested by enhanced caspase 3/7 activity, which resulted in β cell death. These findings implicate SSRIs as inhibitors of IRS protein function and insulin action through the activation of GSK3β. They further suggest that SSRIs inhibit insulin secretion; induce the unfolded protein response; activate an apoptotic process, and trigger β cell death. Given that SSRIs promote insulin resistance while inhibiting insulin secretion, these drugs might accelerate the transition from an insulin-resistant state to overt diabetes.

PMID:   23275337   [PubMed - indexed for MEDLINE]    PMCID:   PMC3581374    Free PMC Article

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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class dismissed till the typist can figure out what this much means if you already know please tell me.. 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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Share on other sites

The effect of acute bilateral adrenalectomy on serotonin-induced inhibition of gastric acid secretion and acute gastric mucosal injury in rats.

Dokuz Eylut University, Medical Faculty, Department of Pharmacology, Balcova, Izmir, Turkey.
International Journal of Experimental Pathology (Impact Factor: 2.05). 09/1996; 77(4):163-6. DOI: 10.1046/j.1365-2613.1996.d01-216.x
Source: PubMed

ABSTRACT Serotonin (5-hydroxytryptamine, 5-HT) produces many changes in gastric functional parameters, including the inhibition of gastric acid secretion and changes in mucosal blood flow. Exogenous 5-HT has also been shown to induce gastric erosion. The influence of adrenalectomy on experimental lesions in the rat gastric mucosa remains controversial. The aim of this study was to see the effects of adrenalectomy on pentagastrin stimulated gastric acid secretion in anaesthetized male Wistar rats. Gastric acid was collected via cannulae placed in the stomach. 5-HT (3.5 mumol/kg, i.v.) inhibited pentagastrin stimulated acid output by 54% and produced haemorrhagic gastric lesions with a mean ulcer index of 2 +/- 0.3. Adrenalectomy prevented both 5-HT induced inhibition of gastric acid secretion and mucosal injury. The results suggest that the effects of 5-HT require an intact adrenal gland.

 

 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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Word from above I did not know... 


 


Pentagastrin (trade name Peptavlon) is a synthetic polypeptidethat has effects like gastrin when given parenterally.[2] It stimulates the secretion of gastric acidpepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.


Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. When given intravenously it may cause panic attacks.[3]


Pentagastrin's IUPAC chemical name is "L-Phenylalaninamide, N-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl".



Pentagastrin stimulation test[edit]

Pentagastrin is also used as a stimulation test to elevate of several hormones, such as serotonin. It provokes flushing and is useful in evaluating patients who describe flushing, but have normal or only marginally elevated biochemical markers for carcinoid syndrome.


It has been used to stimulate ectopic gastric mucosa for the detection of Meckels diverticulum by nuclear medicine.


It is used to stimulate calcitonin release from residual parafollicular cell C-cells after total thyroidectomy for medullary thyroid carcinoma.


WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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  • 3 months later...

This is a fascinating thread and I wish we knew what it all means!

 

Based on my own hell of ssri withdrawal and having recently been diagnosed with an unknown "endocrine disorder" I feel like it is this big mystery and we are left trying to put the puzzle pieces together.

 

What I know is that my thyroid, adrenals, sex hormones (amenorrhea), and gut are all deeply imbalanced right now. Candida keeps getting thrown around, but I wonder how much of it is more related to insulin resistance from the ssri/pancreas connection. And that's not even considering my brain.

 

50 years from now I imagine that there will be textbooks written on the true mechanisms of ssris and we have all been the unpaid experimental participatants.

HISTORY: Lexapro 10mg (current and for approximately 7 years; Prozac 20mg for 5 years and Zoloft 50mg for 5 years)

Lexapro (too fast taper) 9mg 09/13; 8mg 10/13; 7mg 12/13; 6mg  02/14; 5mg  04/14; 4mg 06/14 2.5mg 08/29/14 2.25 mg 12/04/14;

 

Re-instatement - 2.5mg 12/17/14; 03/01/15 3.0 mg; 04/01/15 - 5mg;  05/01/15  6mg; 5/15/15 6.5mg 6/01/15 7.5mg

 

2nd attempt at micro taper: starting dose is 7.5mg using liquid compounded rx: 12/16/17 - 7mg;  02/05/18 - 6.75mg 04/06/18 - 6.5ml  05/31/18 re-instate back to 6.75mg 

 

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I completely agree except I don't think they will be writing anything in books as pharma does not have to expose any of it proprietary secrets they can keep all this information to themselves.   The better to jerks us around some more us and the next generations. We will stay clueless just as they like us as there is a law saying they don't have to tell us squat. 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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But what if enough of us "citizen scientists" suffer enough for long enough and we can figure out the underlying mechanisms? That is my hope.

 

I spoke w a dr. Last week who said she has seen more and more endocrine disorders due to ssri showing up in her practice. I think there are some healthcare practitioners who are catching on.

 

My fantasy is that 50 years from now, ssris will be viewed like cigarettes. The general public will be well informed of the true dangers instead of being mislead that they are benign. And then there will still be people who chose to take ssris even though they know they are slowing killing themselves.

 

This site has already revealed some of the pieces that we were not told by mainstream medicine (that they boost serotonin). So now we know they disrupt cortisol, the endocrine system, the enteric nervous system, and the autonomic nervous system.

HISTORY: Lexapro 10mg (current and for approximately 7 years; Prozac 20mg for 5 years and Zoloft 50mg for 5 years)

Lexapro (too fast taper) 9mg 09/13; 8mg 10/13; 7mg 12/13; 6mg  02/14; 5mg  04/14; 4mg 06/14 2.5mg 08/29/14 2.25 mg 12/04/14;

 

Re-instatement - 2.5mg 12/17/14; 03/01/15 3.0 mg; 04/01/15 - 5mg;  05/01/15  6mg; 5/15/15 6.5mg 6/01/15 7.5mg

 

2nd attempt at micro taper: starting dose is 7.5mg using liquid compounded rx: 12/16/17 - 7mg;  02/05/18 - 6.75mg 04/06/18 - 6.5ml  05/31/18 re-instate back to 6.75mg 

 

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It is possible I guess that 50 years will make a difference we can always hope :) what you see on this site is rarely seen by any people who are not in wd so the main stream will not have a clue about any of it. I know we think this is an very popular site and it is for wd but those  not in wd will never lay eyes on it. We are far fringe. 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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To continue this discussion, check out this article:

 

http://chriskresser.com/is-a-low-carb-diet-ruining-your-health/

 

Specifically the part on how a low carb diet can increase cortisol and wreck havoc on hormones.

 

I've been faithfully following paleo and eliminated most carbs from my diet at the urging of a naturopath for withdrawal and now I'm questioning if that is the best approach for the endocrine system. I had no idea. I'm not suggesting going carb crazy, as refined sugar is the devil but I do think I personally need more healthy carbs for recovery...

HISTORY: Lexapro 10mg (current and for approximately 7 years; Prozac 20mg for 5 years and Zoloft 50mg for 5 years)

Lexapro (too fast taper) 9mg 09/13; 8mg 10/13; 7mg 12/13; 6mg  02/14; 5mg  04/14; 4mg 06/14 2.5mg 08/29/14 2.25 mg 12/04/14;

 

Re-instatement - 2.5mg 12/17/14; 03/01/15 3.0 mg; 04/01/15 - 5mg;  05/01/15  6mg; 5/15/15 6.5mg 6/01/15 7.5mg

 

2nd attempt at micro taper: starting dose is 7.5mg using liquid compounded rx: 12/16/17 - 7mg;  02/05/18 - 6.75mg 04/06/18 - 6.5ml  05/31/18 re-instate back to 6.75mg 

 

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I have tried a lot of different things... and lately say the last year or so have been sick a lot.. yesterday I actually ate a chocolate bar and you know what it did not kill me... seems I needed to just have something.. and I did.  Will I pay later who knows I think I am too kind of out of myself to notice most things just now... I don't know if that is understandable or not... but it is how it is today.

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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To continue this discussion, check out this article:

 

http://chriskresser.com/is-a-low-carb-diet-ruining-your-health/

 

Specifically the part on how a low carb diet can increase cortisol and wreck havoc on hormones.

 

I've been faithfully following paleo and eliminated most carbs from my diet at the urging of a naturopath for withdrawal and now I'm questioning if that is the best approach for the endocrine system. I had no idea. I'm not suggesting going carb crazy, as refined sugar is the devil but I do think I personally need more healthy carbs for recovery...

 

I imagine if you looked, you'd find someone who said the exact opposite of this. That's the problem with following someone's ideas of what's right. I think the most important thing to pay attention to is how one feels when you eat a certain way.

 

I was forced to stop eating many carbs due to issues with histamine. I couldn't tolerate rice, potatoes, wheat, any dried or sweet fruit, sugar or honey,  and only limited amounts of things like quinoa or oats. I could do gluten free bread once or twice a week and the occasional rice cake. I felt better eating less carbs and lost a lot of weight. But once I started exercising more, I needed to add more carbs back in...which has been a challenge, given my dietary limitations. I listen to my body, rather than following what anyone else thinks.

 

Doctors, dieticians, alternative practitioners take on some kind of stance and cling to it. I think there are huge variations from one person to the next in terms of needs and what is right...as well as profound changes within one person.

Remeron for depression. Started at 7.5 mg. in 2005. Gradual increases over 8 years, up to 45 mg. in 2012.Began tapering in June 2013. Went from 45 to 30 mg in the first 3-4 months. Held for a couple of months.Started tapering by 3.75 mg every month or 2, with some longer holding periods. Eventually went down to 3.75 mg. about April 2014. Stopped taking Remeron August 2014. Developed issues with histamine a week after stopping--symptoms reduced through diet and a few supplements. Currently having issues with a few foods. Most of the histamine intolerance has resolved or is at least, in remission.

Current Medications:

Current Supplements: Cannabis (CBD and THC), Vitamin C, D, Quercetin, CoQ10, Tart Cherry, Probiotic, Phytoplankton oil, magnesium, Methyl B. What has helped me most: spending time in nature, qi gong, exercise, healthy diet, meditation, IV vitamins, homeopathy, massage, acupuncture, chiropractic, music, and cuddling my cats..

My introduction: http://survivingantidepressants.org/index.php?/topic/8459-mirtazapine-withdrawal-freespirit/#entry144282

Please note: I am not a therapist or medical practitioner. Any suggestions offered come solely from my personal experience in recovering from childhood trauma, therapy, and AD use. Please seek appropriate care for yourself.

 

“After a cruel childhood, one must reinvent oneself. Then re-imagine the world.”
Mary Oliver
 

 

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  • 6 months later...

Earlier this year I went to see an endocrinologist. I was on quite a few different meds and my family doctor didn't feel I needed all these meds anymore so she sent me to see her to get a second opinion. I had a bunch of blood work done and she found my hormones to be all out of whack. Specifically my Cortisol and Testosterone, she said my testosterone was incredibly low, and and not sure exactly she found with my cortisol but also found it to be concerning, so I went for a bunch more blood tests and nothing came up, so I'm booked for an MRI of my pituitary gland sometime in 2016, My question is I have been on Lexapro since I was 14, starting at 10mg and a few years later going to 20 mg where I stayed until now, Could the Lexapro be resulting in my endocrine system going out of whack?  and have any of you experienced this?

2009 - started lexapro 10mg for anxiety/panic disorder, switched to 20 mg ~4 years later.

nov 2015 - immediate stop of lexapro 20 mg - followed by switching to 50 mg pristiq next day (horrible withdrawals for 2-3 days, once pristiq entered system withdrawals went away)

dec 2015 - felt worse on pristiq than I did lexapro 20mg - saw dr said I may have adhd - prescribed "test" dose of adderall for 20 days.

dec 2015 - immediate stop of pristiq 50mg - followed by 10mg adderall - horrible withdrawals for 1.5 weeks

jan 2016 - immediate stop of adderall - reinstate lexapro 10 mg - withdrawal symptoms gone. switched to 5 mg few days later, currently taking 5mg and hoping to be drug free within the next month.

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how many years were you on lexapro? I was on lexapro for 1 year and 2 on fluoxetine, but lexapro gave me the worse debilitating symptoms, which can have to do with your similar issues. Specially the low sex drive and demotivation can be due to low testosterone no? best luck

1/12: 20 mg Prozac.


6/14: Doc decides to switch me to Lexapro in may. The switch consisted in overlaping fluoxetine and half lexapro for 2 weeks, then stop fluoxetine and go on 10mg Lexapro, I was a week on 10mg lexapro and stopped as I was feeling bad then went on 3mg and taper from it .After that I learned from withdrawal and all that.


7/14: 2.5mg Lexapro for 1 year.


7/15: cold turkeyed from 2.5 mg.

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I'm very interested in this so please report back with your findings. Good luck.

 

Namaste. DC

1997 - 2001 Seroxat 10mg

2001 - 2013 Escitalopram 10mg

Gradual taper from 10mg to 5mg over 2.5 years (between 2011 - 2013)

Last taper from 5mg to 0 under advice from doctor done in 1 month (too damn fast!) - included missing out days.

Have been drug free since Oct 2013.  - Yep 5 years drugs free

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  • 4 weeks later...

how many years were you on lexapro? I was on lexapro for 1 year and 2 on fluoxetine, but lexapro gave me the worse debilitating symptoms, which can have to do with your similar issues. Specially the low sex drive and demotivation can be due to low testosterone no? best lu

 

 

Like 7 years, if you are talking to me that is

2009 - started lexapro 10mg for anxiety/panic disorder, switched to 20 mg ~4 years later.

nov 2015 - immediate stop of lexapro 20 mg - followed by switching to 50 mg pristiq next day (horrible withdrawals for 2-3 days, once pristiq entered system withdrawals went away)

dec 2015 - felt worse on pristiq than I did lexapro 20mg - saw dr said I may have adhd - prescribed "test" dose of adderall for 20 days.

dec 2015 - immediate stop of pristiq 50mg - followed by 10mg adderall - horrible withdrawals for 1.5 weeks

jan 2016 - immediate stop of adderall - reinstate lexapro 10 mg - withdrawal symptoms gone. switched to 5 mg few days later, currently taking 5mg and hoping to be drug free within the next month.

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Share on other sites

 

To continue this discussion, check out this article:

 

http://chriskresser.com/is-a-low-carb-diet-ruining-your-health/

 

Specifically the part on how a low carb diet can increase cortisol and wreck havoc on hormones.

 

I've been faithfully following paleo and eliminated most carbs from my diet at the urging of a naturopath for withdrawal and now I'm questioning if that is the best approach for the endocrine system. I had no idea. I'm not suggesting going carb crazy, as refined sugar is the devil but I do think I personally need more healthy carbs for recovery...

 

I imagine if you looked, you'd find someone who said the exact opposite of this. That's the problem with following someone's ideas of what's right. I think the most important thing to pay attention to is how one feels when you eat a certain way.

 

I was forced to stop eating many carbs due to issues with histamine. I couldn't tolerate rice, potatoes, wheat, any dried or sweet fruit, sugar or honey,  and only limited amounts of things like quinoa or oats. I could do gluten free bread once or twice a week and the occasional rice cake. I felt better eating less carbs and lost a lot of weight. But once I started exercising more, I needed to add more carbs back in...which has been a challenge, given my dietary limitations. I listen to my body, rather than following what anyone else thinks.

 

Doctors, dieticians, alternative practitioners take on some kind of stance and cling to it. I think there are huge variations from one person to the next in terms of needs and what is right...as well as profound changes within one person.

 

I had to resort to extreme diets at different times in wd the thing is it changes or did for me.  

 

Taking bits from all things I have tried and knowing when I need each one seems to be the answer kind of so far.  

 

As for hormones which another person mentioned ... mine were all over the map when I was running to different docs in different cities I ended up with duplicate testing ...over 6 months 6 different hormone tests showed my hormones to be in constant flux I was everything a woman can be from pre pubescent to pregnant to post menopausal pre menopausal normal one of them must have be a duplicate but I don't recall which one.  

 

This was early on in the first 8 months after cold turkey before I knew there was such a thing as withdrawal from Ads I thought I was seriously ill and kept looking for an answer.  

 

About this thread I was obviously doing well and in a great window when I started sometimes I can really think well for awhile... once the shift comes I forget all I started and forgot about this one too... and I don't recall what I was looking for or why I would have to start all over again at the beginning and I am not well enough and can't think well enough now to do that so if anybody else sees a pattern or a glimpse of daylight thru this thread by all means pick it up and carry one. 

peace all

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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