ToothDoc Posted February 18, 2015 Share Posted February 18, 2015 Science behind commonly used anti-depressants appears to be backwards, researchers say The science behind many anti-depressant medications appears to be backwards, say the authors of a paper that challenges the prevailing ideas about the nature of depression and some of the world's most commonly prescribed medications. The authors of the paper, posted by the journal Neuroscience & Biobehavioral Reviews, combed existing research for evidence to support the theory that has dominated nearly 50 years of depression research: that depression is related to low levels of serotonin in the gaps between cells in the brain. The low-serotonin theory is the basis for commonly prescribed anti-depressant medications called selective serotonin re-uptake inhibitors, or SSRIs, which keep the neurotransmitter's levels high by blocking its re-absorption into the cells that release it. http://www.sciencedaily.com/releases/2015/02/150217114119.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 2000-2004 Celexa 75mg,Klonopin 1mg qd2004-2014 Effexor XR 75mg, Klonopin 1mg qdEffexor taper begun June 2014. Currently at ~50% reduction Reinstated Effexor 75mg qd July 2014..... Contemplating another taper. Link to comment Share on other sites More sharing options...
Konjo Posted February 18, 2015 Share Posted February 18, 2015 Here is another one: http://www.neuroscientistnews.com/research-news/science-behind-commonly-used-anti-depressants-appears-be-backwards-researchers-say Link to comment Share on other sites More sharing options...
westcoast Posted February 18, 2015 Share Posted February 18, 2015 Good to know. Makes sense. Maybe the tide is turning. 2009: Cancer hospital said I had adjustment disorder because I thought they were doing it wrong. Their headshrinker prescribed Effexor, and my life set on a new course. I didn't know what was ahead, like a passenger on Disneyland's Matterhorn, smiling and waving as it climbs...clink, clink, clink. 2010: Post surgical accidental Effexor discontinuation by nurses, masked by intravenous Dilaudid. (The car is balanced at the top of the track.) I get home, pop a Vicodin, and ... Whooosh...down, down, down, down, down...goes the trajectory of my life, up goes my mood and tendency to think everything is a good idea.2012: After the bipolar jig was up, now a walking bag of unrelated symptoms, I went crazy on Daytrana (the Ritalin skin patch by Noven), because ADHD was a perfect fit for a bag of unrelated symptoms. I was prescribed Effexor for the nervousness of it, and things got neurological. An EEG showed enough activity to warrant an epilepsy diagnosis rather than non-epileptic ("psychogenic") seizures. 2013-2014: Quit everything and got worse. I probably went through DAWS: dopamine agonist withdrawal syndrome. I drank to not feel, but I felt a lot: dread, fear, regret, grief: an utter sense of total loss of everything worth breathing about, for almost two years. I was not suicidal but I wanted to be dead, at least dead to the experience of my own brain and body. 2015: I began to recover after adding virgin coconut oil and organic grass-fed fed butter to a cup of instant coffee in the morning. I did it hoping for mental acuity and better memory. After ten days of that, I was much better, mood-wise. Approximately neutral. And, I experienced drowsiness. I could sleep. Not exactly happy, I did 30 days on Wellbutrin, because it had done me no harm in the past. I don't have the DAWS mood or state of mind. It never feel like doing anything if it means standing up. In fact, I don't especially like moving. I'm a brain with a beanbag body. Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted February 19, 2015 Administrator Share Posted February 19, 2015 We have several papers by Paul Andrews in the Journals and Media forums -- all worth reading. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
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