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Gaba Reuptake Inhibitors GRIs Gabitril (Tiagabine)


chicken
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Anyone had any experience tapering Gaba reuptake inhibitors like Gabatril?

 

I looked online and didn't find a lot on them about withdrawal.

 

My mom was just prescribed one for pain yesterday. I had never heard of them until yesterday.

I don't think she should take it, but she is desperate for something to ease her chronic pain and nothing has really helped so far.

 

Doc told her to taper slowly off it when the time comes. That tells me it's a trouble drug.

Prozac 1999-2009 quit semi cold turkey.

 

2012 Placed on Seroquel 25 mg, Tranxene (Clorezepate) 3.75 mg 3x a day, Remeron 30 mg for anxiety/akathesia.

 

Weaned off Seroquel and Tranxene .to Remeron 15 Mg.

In May 2014 tried quitting Remeron at its lowest dose. Had severe withdrawals.Reinstated Remeron at 30 mg by doctor. August 5 2014 entered hospital. Doctor pulled the Remeron and bridged it to Pamelor (Nortriptyline) 40mg and Zyprexa 2.5mg.After removing the Remeron all my bad symptoms went away and I am stable.

 

9/11/14 - 7.5 mg tranxene, 40mg Pamelor, Zyprexa 2.5mg

12/29/14 -  20mg Pamelor, 1/6/15,  7/31/15 3.5mg, 8/10/15 3.2 mg, 9/15/15 2.2mg, 10/15/15 1.8mg

(Feb 2016 - 1.4mg Pamelor only -  OFF OF TRANXENE AND ZYPREXA SINCE DEC 2014 BENZO FREE Since 2014. Nortrityline (Pamelor) .8mg Aug 2016

March 2017 DRUG FREE

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That's a new one to me.

 

I think pretty much any drug that alters neurotransmitter function is going to produce a similar effect, where the brain changes itself to adapt to the drug, then you can't just yank the drug out without causing problems.

Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease". Long story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything. Amitryptiline, Prozac, bupropion, buspirone, flurazepam, diazepam, alprazolam, Paxil, citalopram, lamotrigine, gabapentin...probably more I've forgotten. 

Started multidrug taper in Feb 2010.  Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 10 2014:   62 Lamictal    1.1 Celexa         0.135 Xanax    1.8 Valium

Feb 10 2015:   50 Lamictal      0.875 Celexa    0.11 Xanax      1.5 Valium

Feb 15 2016:   47.5 Lamictal   0.75 Celexa      0.0875 Xanax    1.42 Valium    

2/12/20             12                       0.045               0.007                   1 

May 2021            7                       0.01                  0.0037                1

Feb 2022            6                      0!!!                     0.00167               0.98                2.5 mg Ambien

 

I'm not a doctor. Any advice I give is just my civilian opinion.

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I recognized the name of this med because it's an anticonvulsant. I have a seizure disorder but have refused to take this, so no personal experience with it. But I read that it is sometimes prescribed off-label for neuropathic pain, especially to augment the effects of other meds (including SSRIs etc. used for pain).

 

I sympathize with your mother's need for pain relief, but I would suggest reading up on it (it's spelled gabitril) and that she get at least a second opinion about the cause and treatment options of her pain, if she hasn't already.

I was "TryingToGetWell" (aka TTGW) on paxilprogress. I also was one of the original members here on Surviving Antidepressants

 

I had horrific and protracted withdrawal from paxil, but now am back to enjoying life with enthusiasm to the max, some residual physical symptoms continued but largely improve. The horror, severe derealization, anhedonia, akathisia, and so much more, are long over.

 

My signature is a temporary scribble from year 2013. I'll rewrite it when I can.

 

If you want to read it, click on http://survivingantidepressants.org/index.php?/topic/209-brandy-anyone/?p=110343

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Thanks Brandy for your input.

 

She has been to so many pain clinics and doctors. I let her know what you said but she says that she going to try it anyway.

 

She has already had a bad reaction to a newer pain drug, Opana but got over it. I guess at her age she just wants some kind of quality of life. She is on Zoloft. She did taper down but says that she does not want to quit that.

 

If she is happy with the drugs I guess it is best to not push her to stop them.

Prozac 1999-2009 quit semi cold turkey.

 

2012 Placed on Seroquel 25 mg, Tranxene (Clorezepate) 3.75 mg 3x a day, Remeron 30 mg for anxiety/akathesia.

 

Weaned off Seroquel and Tranxene .to Remeron 15 Mg.

In May 2014 tried quitting Remeron at its lowest dose. Had severe withdrawals.Reinstated Remeron at 30 mg by doctor. August 5 2014 entered hospital. Doctor pulled the Remeron and bridged it to Pamelor (Nortriptyline) 40mg and Zyprexa 2.5mg.After removing the Remeron all my bad symptoms went away and I am stable.

 

9/11/14 - 7.5 mg tranxene, 40mg Pamelor, Zyprexa 2.5mg

12/29/14 -  20mg Pamelor, 1/6/15,  7/31/15 3.5mg, 8/10/15 3.2 mg, 9/15/15 2.2mg, 10/15/15 1.8mg

(Feb 2016 - 1.4mg Pamelor only -  OFF OF TRANXENE AND ZYPREXA SINCE DEC 2014 BENZO FREE Since 2014. Nortrityline (Pamelor) .8mg Aug 2016

March 2017 DRUG FREE

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What about gentle physical therapy?  I was diagnosed with chronic pain, which is why I was put on meds, but it turned out to be a misdiagnosis.  Too bad I'd already been given four years of psych meds by the time I found a specialized physical therapist who figured out the location of my pain… It was all muscular.

Sometimes you have to cruise a BUNCH of physical therapists.

*I'm not a doctor and don't give medical advice, just personal experience
**Off all meds since Nov. 2014. Mentally & emotionally recovered; physically not
-Dual cold turkeys off TCA & Ativan in Oct 2014. Prescribed from 2011-2014

-All meds were Rxed off-label for an autoimmune illness.  It was a MISDIAGNOSIS, but I did not find out until AFTER meds caused damage.  All med tapers/cold turkeys directed by doctors 

-Nortriptyline May 2012 - Dec 2013. Cold turkey off nortrip & cold switched to desipramine

-Desipramine Jan 2014 - Oct. 29, 2014 (rapid taper/cold turkey)

-Lorazepam 1 mg per night during 2011
-Lorazepam 1 mg per month in 2012 (or less)

-Lorazepam on & off, Dec 2013 through Aug 2014. Didn't exceed 3x a week

-Lorazepam again in Oct. 2014 to help get off of desipramine. Last dose lzpam was 1 mg, Nov. 2, 2014. Immediate paradoxical reactions to benzos after stopping TCAs 

-First muscle/dystonia side effects started on nortriptyline, but docs too stupid to figure it out. On desipramine, muscle tremors & rigidity worsened

-Two weeks after I got off all meds, I developed full-blown TD.  Tardive dystonia, dyskinesia, myoclonic jerks ALL over body, ribcage wiggles, facial tics, twitching tongue & fingers, tremors/twitches of arms, legs, cognitive impairment, throat muscles semi-paralyzed & unable to swallow solid food, brain zaps, ears ring, dizzy, everything looks too far away, insomnia, numbness & electric shocks everywhere when I try to fall asleep, jerk awake from sleep with big, gasping breaths, wake with terrors & tremors, severely depressed.  NO HISTORY OF DEPRESSION, EVER. Meds CREATED it.

-Month 7: hair falling out; no vision improvement; still tardive dystonia; facial & tongue tics returned
-Month 8: back to acute, incl. Grand Mal seizure-like episodes. New mental torment, PGAD, worse insomnia
-Month 9: tardive dystonia worse, dyskinesia returned. Unable to breathe well due to dystonia in stomach, chest, throat
-Month 13: Back to acute, brain zaps back, developed eczema & stomach problems. Left leg no longer works right due to dystonia, meaning both legs now damaged
-7 years off: Huge improvements, incl. improved dystonia

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What about gentle physical therapy?  I was diagnosed with chronic pain, which is why I was put on meds, but it turned out to be a misdiagnosis.  Too bad I'd already been given four years of psych meds by the time I found a specialized physical therapist who figured out the location of my pain… It was all muscular.

 

Sometimes you have to cruise a BUNCH of physical therapists.

Wiggle,

She has been through everything including surgeries. She had a fall some years back that damaged her nerves. She also had a log roll from the top of a barn on to her as well as having lower disks that are severely damaged. Meds are about the only thing that his helping her now.

Prozac 1999-2009 quit semi cold turkey.

 

2012 Placed on Seroquel 25 mg, Tranxene (Clorezepate) 3.75 mg 3x a day, Remeron 30 mg for anxiety/akathesia.

 

Weaned off Seroquel and Tranxene .to Remeron 15 Mg.

In May 2014 tried quitting Remeron at its lowest dose. Had severe withdrawals.Reinstated Remeron at 30 mg by doctor. August 5 2014 entered hospital. Doctor pulled the Remeron and bridged it to Pamelor (Nortriptyline) 40mg and Zyprexa 2.5mg.After removing the Remeron all my bad symptoms went away and I am stable.

 

9/11/14 - 7.5 mg tranxene, 40mg Pamelor, Zyprexa 2.5mg

12/29/14 -  20mg Pamelor, 1/6/15,  7/31/15 3.5mg, 8/10/15 3.2 mg, 9/15/15 2.2mg, 10/15/15 1.8mg

(Feb 2016 - 1.4mg Pamelor only -  OFF OF TRANXENE AND ZYPREXA SINCE DEC 2014 BENZO FREE Since 2014. Nortrityline (Pamelor) .8mg Aug 2016

March 2017 DRUG FREE

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Well, she took the first GRI last night. Said that it helped with the pain but she thinks it may cause her to start "drawing" again.

 

She had a reaction to a new pain med, Opana about 6 months ago that caused her to suddenly draw from one side to the other and fall. She stopped the Opana and the "drawing" and falling stopped after a few months.

 

She thinks that the Gaba re-uptake inhibitor may cause this as she felt it slightly last night.  She wants to try it a little longer.  I told her to not stay on it more than a week if she has any symptoms.

 

She is still taking the older pain meds with no problems.

Prozac 1999-2009 quit semi cold turkey.

 

2012 Placed on Seroquel 25 mg, Tranxene (Clorezepate) 3.75 mg 3x a day, Remeron 30 mg for anxiety/akathesia.

 

Weaned off Seroquel and Tranxene .to Remeron 15 Mg.

In May 2014 tried quitting Remeron at its lowest dose. Had severe withdrawals.Reinstated Remeron at 30 mg by doctor. August 5 2014 entered hospital. Doctor pulled the Remeron and bridged it to Pamelor (Nortriptyline) 40mg and Zyprexa 2.5mg.After removing the Remeron all my bad symptoms went away and I am stable.

 

9/11/14 - 7.5 mg tranxene, 40mg Pamelor, Zyprexa 2.5mg

12/29/14 -  20mg Pamelor, 1/6/15,  7/31/15 3.5mg, 8/10/15 3.2 mg, 9/15/15 2.2mg, 10/15/15 1.8mg

(Feb 2016 - 1.4mg Pamelor only -  OFF OF TRANXENE AND ZYPREXA SINCE DEC 2014 BENZO FREE Since 2014. Nortrityline (Pamelor) .8mg Aug 2016

March 2017 DRUG FREE

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Hi Chicken, we don't yet have a topic on Gabitril/Tiagabine, but like all anticonvulsants, if your mom takes it for more than a few days, it will need to be tapered when she wants to stop taking it. 

 

The most common side effects are dose related and include impaired concentration, nervousness, nausea, weakness and tremor,  abnormal skin sensations; diarrhea; dizziness; drowsiness; increased appetite; irritability; lack of energy; lightheadedness;   shakiness; sore throat; stomach pain; trouble sleeping; and vomiting.

 

More information can be found here:

 

http://livertox.nih.gov/Tiagabine.htm and here:   http://www.drugs.com/cdi/tiagabine.html

 

You might want to put all of her medications into the interactions checker here:

 

http://www.drugs.com/drug_interactions.html

 

       

I'm not a doctor.  My comments are not medical advise. These are my opinions based on my own experience and what I've learned. Please discuss your situation with a medical practitioner who has knowledge of tapering and withdrawal...if you are lucky enough to find one.

My Introduction Thread

Full Drug and Withdrawal History

Brief Summary

Several SSRIs for 13 years starting 1997 (for mild to moderate partly situational anxiety) Xanax PRN ~ Various other drugs over the years for side effects

2 month 'taper' off Lexapro 2010

Short acute withdrawal, followed by 2 -3 months of improvement then delayed protracted withdrawal

DX ADHD followed by several years of stimulants and other drugs trying to manage increasing symptoms

Failed reinstatement of Lexapro and trial of Prozac (became suicidal)

May 2013 Found SA, learned about withdrawal, stopped taking drugs...healing begins.

Protracted withdrawal, with a very sensitized nervous system, slowly recovering as time passes

Supplements which have helped: Vitamin C, Magnesium, Taurine

Bad reactions: Many supplements but mostly fish oil and Vitamin D

June 2016 - Started daily juicing, mostly vegetables and lots of greens.

Aug 2016 - Oct 2016 Best window ever, felt almost completely recovered

Oct 2016 -Symptoms returned - bad days and less bad days.

April 2018 - No windows, but significant improvement, it feels like permanent full recovery is close.

VIDEO: Where did the chemical imbalance theory come from?



VIDEO: How are psychiatric diagnoses made?



VIDEO: Why do psychiatric drugs have withdrawal syndromes?



VIDEO: Can psychiatric drugs cause long-lasting negative effects?

VIDEO: Dr. Claire Weekes

 

 

 

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She took it for about 4 days and has stopped it 2 days ago. She has been sleeping better now that she if off of it. She said it caused insomnia and itching.

Prozac 1999-2009 quit semi cold turkey.

 

2012 Placed on Seroquel 25 mg, Tranxene (Clorezepate) 3.75 mg 3x a day, Remeron 30 mg for anxiety/akathesia.

 

Weaned off Seroquel and Tranxene .to Remeron 15 Mg.

In May 2014 tried quitting Remeron at its lowest dose. Had severe withdrawals.Reinstated Remeron at 30 mg by doctor. August 5 2014 entered hospital. Doctor pulled the Remeron and bridged it to Pamelor (Nortriptyline) 40mg and Zyprexa 2.5mg.After removing the Remeron all my bad symptoms went away and I am stable.

 

9/11/14 - 7.5 mg tranxene, 40mg Pamelor, Zyprexa 2.5mg

12/29/14 -  20mg Pamelor, 1/6/15,  7/31/15 3.5mg, 8/10/15 3.2 mg, 9/15/15 2.2mg, 10/15/15 1.8mg

(Feb 2016 - 1.4mg Pamelor only -  OFF OF TRANXENE AND ZYPREXA SINCE DEC 2014 BENZO FREE Since 2014. Nortrityline (Pamelor) .8mg Aug 2016

March 2017 DRUG FREE

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  • 6 months later...

I just wanted to comment on Tiagabine Hydrochloride‎ used for pain. I have MS, Myasthenia Gravis, PTSD, and Fibromyalgia. I had to quit working due to the extreme pain I was in, and it seemed no one could help. After years on Fentanyl patches, a miracle happened. I changed my primary care doctor and he suggested I try Tiagabine and combine it with a good multi-vitamin, and magnesium. My first thought was YEAH RIGHT a drug that is suppise to control seizures is going to help. I had been taking strong muscle relaxers and major heavy duty narcotics and it didnt even touch the pain. He ask me to give it two weeks.

I am over joyed to say, The Fibromyalgia is gone, hardly any MS symptoms at all, the only Myasthenia Gravis symptoms I have is blurred vision and my eyesite, i don't think it was just the Tiagabine but a combination of the 3 taken together. I did this for 3 months. Now if the pai starts to come back I take the combo for 3 days. It has been 6 months since I really hurt bad enough to stay in bed. But be warned, i had hurt so long. I actually thought something was wrong because my body did not know how to deal with no pain. It literly took me about 2 weeks to realize the feeling I was having WAS NO PAIN AT ALL.

Currently i take 1 small muscle relaxer at night so my muscles dont get stiff. The dr was completely shocked that all the pain had disappeared. It is so sad that I suffered 9 years in so much pain when a small tablet. 1/2 the size of a baby asprin 2mg and 2 vitamins could make that much difference.

I have shared this info with several friends who also suffered sever fibromyalgia and after taking it 3 moths almost all are compketely pain free.

So please at least give it a try, it has truly given me my life back.

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