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Daveguy2015

Does SSRI withdrawal last longer than the withdrawal from heroin or cocaine?

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Daveguy2015

I don't know if this is the right place to post this but I'm curious to know why does SSRI withdrawal last longer than that from heroine or cocaine?

 

Heroine or cocaine withdrawal can last a few months where as SSRI withdrawal can take years. This just doesn't seem right to me.

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AlexKidd

In a nutshell - legal drugs are more dangerous than illegal drugs!

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MostlyWater

SSRI's cause more changes to happen or the changes that happen are more significant.. that seems to be the only logical answer.

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antidepressantsNoMore

Withdrawals may last longer but what about the psychological effects of drugs on the brain? Yes, I know a/d can cause other psychologically effect but just bare with me for a second and think...

 

I abused pot for 4 years and alcohol for nearly 8 and I'm only 26.

For four years after stopping pot and really cutting back on alcohol to the point where I just drink a few beers, my mind, body and spirit were messed up.

 

I psychologically am recovering from this still. I even experience psychosis on a few occasions associated with major depression and probably the re-wiring of the brain caused by drugs. A lot of people say pot being a psychoactive drug can psychologically mess you up more than alcohol and is more associated with psychosis but I disagree. Alcohol abuse is associated with psychosis as well. Alcohol is a depressant and can fry the GABA receptors. Anxiety runs in my family so I never should have touched either.

 

So the withdrawals of a/d may last longer but the psychologically effects of drugs may last longer. Again, I'm just typing freely, I may not be 100 percent accurate but I know from experience, drugs will screw up your mind BAD!

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Daveguy2015

So do you believe the psychosis you had was caused by the pot and alcohol, or the a/d's?

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antidepressantsNoMore

So do you believe the psychosis you had was caused by the pot and alcohol, or the a/d's?

 

Mine was caused by the pot and alcohol abuse because there was a long time when I was not on any a/d.

 

I will never smoke pot again, you couldn't pay me to smoke that crap anymore. As for drinking, I can drink a few beers and just relax in a social setting. I don't overdo it anymore and if I do, my anxiety is horrible the next day.

 

I'm not telling you what to do and I'm not going to preach to you but drugs CAN and many times WILL mess you up to the point of a psychological break. So take care of yourself.

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MatGMax

DaveGuy2015,

 

I feel for you.

I just doesn't see right (or fair).

 

But yet for some of us it is true.

 

Cheers

 

Damien

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Fresh

I don't know why either Daveguy , but I reckon that ssri's alter the way the brain functions in different ways than heroin , pot or alcohol.

 

Would be good if there was a warning on ssri packaging:   THESE DRUGS ARE TOUGHER TO KICK THAN HEROIN  would make people notice , lol

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WiggleIt

Because pharmaceutical companies are pieces of sh*t.

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helpless

Its completly wanted to make you suffer for years, you also dont get any brainzaps, after taking MDMA, its made to torture people, so they take that useless **** again or comite suicide, or killing other people... they are made to kill you sooner or later, in that time you paying for it...

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Daveguy2015

It's very frustrating that these drugs can mess you up more than heroine or cocaine. Alto do you have any ideas as to why SSRI withdrawals last longer?

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WiggleIt

I was going to suggest that perhaps it has something to do with the fact that antidepressants are meant to be cumulative in the body, therefore meaning that the damage would be cumulative later on also, as opposed to drugs that make you high whose effects are only meant to last for a brief time. That theory sounds sort of reasonable, but it doesn't explain the long term damage of benzodiazepines.

 

Considering that we don't even know how or why the medications work in the first place, I don't think we have a chance of understanding why they leave people so damaged afterwards. But it is criminal that they are continually manufactured, prescribed, and sold.

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Altostrata

What makes you think it's easy to go off heroin or cocaine?

 

Addiction detox programs have a very high rate of recidivism. It's very common that people go back on the substances.

 

Withdrawal symptoms post-discontinuation are very common as well. That is why heroin addicts are given heroin substitutes such as methadone instead.

 

The prolonged withdrawal syndrome after going off addictive drugs is called Post-Acute Withdrawal Syndrome, or PAWS.

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MostlyWater

SSRIs change the brain in a way heroine and cocaine do not. SSRIs seem to work by changing how the brain operates in the long term, thats why it takes a month to "work" or take effect.. heroine and cocaine change the brain in the short term. 

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antidepressantsNoMore

All these drugs are bad, both illegal and prescription drugs.

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Oceanrat

All drugs are bad yes. But I've been sober 18 years! I detoxed, opiates, cocaine, pot, alcohol, etc back then. I have helped detox people on heroin, etc. There is NO comparison to this Ssri and benzo garbage, not even close. The suffering and detox from the other drugs leaves you very sick, for a short time in comparison! This process has no limits and no end in sight. We received very poor info when starting these terrible things. This process is like no other!

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oskcajga

I'm not exactly sure why they do what they do, but if I had to guess I'd say its more complicated than most realize.  Serotonin affects virtually all bodily functions, and the mechanism of reuptake inhibition apparently causes many downstream effects that are more complicated than the mechanism of action from many street drugs.  Because serotinin is linked to MANY bodily functions (do a search on 5-HT receptors, and serotonin receptors), and MANY central nervous system functions, if something goes wrong metabolically, or even at the protein synthesis level (i.e., at the gene level - yes these drugs affect your DNA basically), you can have some serious long term complications on your hands.  The fact that people take this medication EVERY SINGLE DAY for many years, probably causes much more profound alterations and adaptations in the brain than someone who does street drugs several times a week at varying doses.

 

One mechanism that is likely is a downregulation of serotinin receptors (this is the main mechanism that "street drugs" utilize resulting in the tolerance that opiate abusers and benzo abusers are familiar with), and its also possible that there is cell death of dendrites that occurs, similar to the effects of ecstacy on the brain.  Serotonin also affects hormone feedback loops, as does norepinephrine, which may explain why some people going through withdrawals have hormone levels that are all out of whack.

 

I've also read that SSRI's actually cause the twisting of the neurons in the brain, affecting their shape, and thus their connectivity patterns.  They may also affect blood cell density in the brain regions, and likely affect the way that the various brain regions connect to one another.  I'm sure that there are published papers on the subject, you just have to do some extensive searching on google scholar. 

 

Overall, these drugs are at the very least just as damaging in the long run as street drugs, but because the doses are much lower and spread out over many years, people just don't realize the damage that is taking place until its too late.  If someone were to smoke, lets say, crack, every single day for 5 years, I'm certain that they would experience similar problems.  The major difference between daily users of street drugs and daily users of ssris is that the street drug users are fully aware of the fact that they are destroying their brain, but don't stop for one reason or another - while the SSRI users are deceived into believing that the drugs are safe and couldn't possibly cause any damage.

 

Pharmaceutical medication is designed to be VERY specific in its effect, while many of the drugs that existed prior to big pharma (i.e., prior to the second half of the 20th century), had much less affinity to a specific mechanism and therefore caused less profound neuronal adaptations.  Basically, we're trying to play God by synthesizing such specific drugs, and creating chemicals that don't naturally occur on Earth, so our ancestors had no way of developing a defense mechanism to their effects.  For example, the closest analog to SSRIs that I can think of is something like St. John's Wort, which is just a ridiculously ineffective version of an SSRI, but that's what our brains are basically adapted to handle.  

 

I'm not sure if any of this makes sense, but this is, in my opinion why pharmaceutical medications are as effective at damaging neurons as we have all discovered them to be.

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Altostrata

Oceanrat, you are 18 years older than you were when you went off those other drugs, and probably not as resilient.

 

oskcajga, I agree with you that the synthesized so-called "targeted" drugs are probably very strong compared to "natural" substances such as heroin.

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BlueLeader

I've thought about this a lot the past year and have not come to a comprehensive answer as of yet.

What I can say is SSRIs and Benzos change the brain chemistry and your whole body functions in ways Heroine and Cocaine cannot even dream of.

Whether it is crossing the blood/brain barrier or a specific target of certain areas as Altostrata wrote, they are incredibly damaging.

 

The worst part is you don't even know damage is being done all months/years you are on them.

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ladybug

I have always wondered this myself. I have said many times I would much rather have been addicted to heroin than Paxil. Heroin may have an awful acute WD but that lasts a couple of weeks at the most (I'm sure there are exceptions) and then you seem ok. I assume it's the psychological addiction that causes many to relapse.

 

I was a HEAVY pot user for 15 years and I essentially cold turkeyed and didn't experience any WD symptoms. If I did I didn't notice because I was already in the midst of an awful rough patch due to Paxil, despite the fact that I was tapering very slowly. I never experienced any psychotic episodes as a result and I don't believe I have any lingering issues from it either. Although, I do wonder if it was my use of weed as a teen that caused my anxiety to get worse which then led me to Paxil. I started smoking weed at 16 and then went on Paxil at 18.

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Altostrata

Addictive drugs are very difficult to quit. It's to the benefit of detox clinics to make it seem they have methods that are effective and don't take very long.

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FatPaxiller

I think that it would vary individually. I am 12 months into a Cold Turkey, after 8 months on Paroxetine, 4/5 months Citalopram prior to that and 4.5 years Prozac prior to that (with a little break). I would say that I have minimal withdrawal

I feel a little more depressed, but in my opinion that's because the root cause was never addressed.

People go through withdrawal for years with SSRI'S and I expect other drugs that can have withdrawal to be the same for some people.

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btdt
Post-acute-withdrawal syndrome - Wikipedia, the free ...
https://en.wikipedia.org/wiki/Post-acute-withdrawal_syndrome
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Post-acute-withdrawal syndrome (PAWS), or the terms post-withdrawal ... after withdrawal from alcohol, opiates, benzodiazepines, antidepressants and other  ...
Signs and symptoms - ‎Cause - ‎Treatment - ‎See also
Antidepressants Post Acute Withdrawal Syndrome
toxicantidepressants.fr/english/.../post-acute-withdrawal-syndrome.html
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  •  

Without saying anything he prescribed me an antidepressant and told me to take a half of ... Unfortunately, the withdrawal symptoms turned out to be too severe.

 

I think it may depend to some extend how long your took a drug there are brain zaps from Ecstacy if you use too much or roll too hard as they call it on Blue Light a illegal drug withdrawal form I found when I first looked up electric zaps in my head.. years ago before I found anything about it on a AD wd site...I found it there first.  Most people don't take MDMA every day but if they do they may get zaps when they stop. Not all heroine users take it every day some dabble... some need it every day and are addicted from the first hit... I have looked all over any place that may give me a clue as to how to get well.  It seems to me from my own research of all sorts of sites that the length of time the drug was used and the dose taken has an effect on the sort of fallout or withdrawal people will have.  

 

There was once an article about this but like many other missing science articles I cannot find it now .. it was posted on both pp and effexor topix 

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