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Tips for tapering off Pristiq (desvenlafaxine)

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ChessieCat

Observations about returning emotions at lower Pristiq doses:

 

31 minutes ago, Andie said:

My emotions came roaring back at about 15 mg mark and are becoming stronger.  Its like someone suddenly turned the volume up. I am very shocked at how numbed out I have been. I didn’t think it was even possible.  I was a plank of wood. I would rarely get emotional about things but I would get very irritable and angry. A few people in my life pointed out to me that I didn’t seem ‘right’ and that I had changed.  I thought I was just standing up for myself and had gained more confidence. I didn’t believe them. 

 

58 minutes ago, ChessieCat said:

The lower our dose gets the less numbed our emotions are.

 

April 2017 I bought a new car when I was at 25mg Pristiq.  In October/November 2017 I was at 19mg.  I got very excited when I unexpectedly saw some whales when we were checking out a car that my daughter was looking at and the seller's house was on the coast.  I even jumped up and down on the spot which I noticed because I had been having trouble raising my legs high enough to step up the gutter (this has slowly improved).  I realised then that when I got my car it was a dulled excitement.

 

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ChessieCat

Spoke to my compounder and he said he can make capsules of any dose.  When I get my next batch I will need to provide 50mg tablets instead of 100mg because he said it will be easier for him.  I didn't even think about that.

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Altostrata

You're handling this Pristiq taper brilliantly, Chessie.

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ChessieCat

Thanks Alto.  I'm very thankful for what I have learned from here about the no more than 10% reduction every 4 weeks.  It's been a bit fiddly having to work with the various capsule doses to create a similar reduction timeline to SA's protocol, but what I'm doing seems to be working okay.  I think once I stopped being concerned about the length of time it's going to take and just working it out the best I can keeping the reduction under the 10% has helped.  I also decided right from the start that I was not going to change to venlafaxine or generic.

 

I've already worked out my reductions for the next section of the taper (will calculate required capsules closer to when I need them).  But the one after that is going to be a bit trickier.  Instead of going down by 0.125 each time it would be 0.0625 so I might go to 0.06 or even 0.05 just to make it easier.  I'll just need to do it when my brain is fairly clear.  And not leave it until the last minute and have to do it in a panic.

 

Edited by ChessieCat

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ChessieCat

Getting off Pristiq is achievable!!!  😊

 

Depending on your compounding pharmacist, you might be able to get your Pristiq compounded in the dose you need to make a 10% reduction and get 28 capsules made up for a 4 week hold.  My compounder makes capsules in dose batches of 100 so I have had to adjust my tapering to suit the capsules.

 

I thought it might be helpful for other members tapering Pristiq to know what doses and length of holds I've done using compounded capsules.  In Australia we can only get 50mg and 100mg tablets.  In some other places 25mg tablets are available so you can use 50mg and 25mg tablets combined with capsules whenever possible.  I got my Pristiq compounded in the largest amount (eg 40mg, 30mg, 10mg) and then use 5mg, 2mg, 1mg, 0.5mg and 0.25mg to make up the full dose.  In the table I've included how I have already tapered on the right (doses from lowest to highest) and on the left is my proposed taper to 1.25mg (doses from highest to lowest).  Obviously if issues arise I will hold for longer.

 

I did a long hold of about 3 months on 50mg (a tablet dose so convenient) and about 7 weeks at 20mg (I had extra 20mg capsules available so I took the opportunity to hold).  I accidentally reduced my dose by half going from 9.5mg to 4.5mg instead of to 9mg for 5 days when I used the 0.5mg bottle of capsules instead of 5mg (yes, my anxiety did increase for a while).  I held for longer because of the error.  I also held for an extra week at 8mg.  I had dental issues from May 2018 and the accidental dose reduction mentioned.  And there might be info in my Intro topic for the other hold times which aren't 21 or 28 days:  chessiecat-so-im-not-the-only-one

 

When I got to 8.5mg I started taking a smaller part of the dose in the evening.  The amount varies, depending on what dose I am taking.  For example when taking 6mg I took 1mg at night (dose made up of 5mg and 1mg capsules) and at 5.5mg I took 0.5mg at night.  I'm now down to 5mg but my dose is made up of 4mg and 1mg capsules so I take 1mg at night.  Member Andie has just started taking 4mg capsules 3 times a day for his her 12mg dose.  (Andie has informed me that they are a girl - sorry Andie)

 

Sorry it's blurry.  It's not bolded but came out that way.  I tried but couldn't create a JPG and had to use PNG and this is how it turned out.  EDIT:  Thanks to my daughter's suggestion of using the "snip tool" to create this is now clearer.

 

1928954101_Doneandplan2018.PNG.e034c1db7885072d6e4e81fb878c7cff.PNG

 

 

Edited by ChessieCat
changed gender of Andie/changed table

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ChessieCat

I've just done a quick google search and found this here https://www.rxlist.com/pristiq-drug.htm#indications

 

(10 mg doses?  Must have been made specially for the clinical studies.)

DOSAGE AND ADMINISTRATION

General Instruction For Use

The recommended dose for PRISTIQ is 50 mg once daily, with or without food. The 50 mg dose is both a starting dose and the therapeutic dose. PRISTIQ should be taken at approximately the same time each day. Tablets must be swallowed whole with fluid and not divided, crushed, chewed, or dissolved.

 

In clinical studies, doses of 10 mg to 400 mg per day were studied. In clinical studies, doses of 50 mg to 400 mg per day were shown to be effective, although no additional benefit was demonstrated at doses greater than 50 mg per day and adverse reactions and discontinuations were more frequent at higher doses.

 

The 25 mg per day dose is intended for a gradual reduction in dose when discontinuing treatment. When discontinuing therapy, gradual dose reduction is recommended whenever possible to minimize discontinuation symptoms [see Discontinuing PRISTIQ and WARNINGS AND PRECAUTIONS].

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