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Tips for tapering off Pristiq (desvenlafaxine)


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8 hours ago, Kevman2112 said:

essentially our reason for asking about half life is related to multiple doses per day and what the best time in between is.


That is correct.  If  the half life of pure desvenlafaxine was (for example) 36 hours then we could take powdered Pristiq every 24 hours without being concerned about interdose withdrawal.


8 hours ago, Kevman2112 said:

I have inter-dose withdrawal in the mornings to early afternoon and then 0 symptoms after 2pm (I was taking the full 37.5mg in the morning around 730.  Yesterday I split it up and took 25mg in the morning and 12.5mg right before bed.


It could take up to a week for the drug to reach a consistent level in the blood.


You might start to notice some improvement after a few days.

 MISSION ACCOMPLISHED:    13 November 2021 -  0mg Pristiq      

Woohoo!!!  Finally off Pristiq   

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering from Oct 2015 - 13 Nov 2021   LAST DOSE 0.0025mg

My full tapering program     My Intro (goes to my tapering graph)    My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.  I do not provide tapering advice via PM.  Please post questions in your Introduction topic.  Please do not tag me for any reason.  I am an unpaid volunteer and assist members if I am able to and when I have the time.  Thank you for your understanding.

Mid Nov 2021 changed to low carb diet due to diabetes & cholesterol.  Lost 1/16 body weight, BP has reduced a lot. 

Links to my exercises and weights.  I also do 3 x 5.5 min with HIIT on exercise bike with 20 secs/min as fast as I can cycle.

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  • 3 months later...

I have been having interdose withdrawal when taking 2x per day, 2.125mg in the morning and 2.125mg later in the day.  Hoping someone can provide advice on 3 doses per day.


My current schedule is:

7:30am- 2.215mg.  Withdrawal symptoms until around 12-1pm

If I take my next dose at 3pm I feel better for the evening but have worse symptoms the next morning.  If I take my next dose between 4-5pm, I feel horrible in the evening but the next morning isn’t so bad. 

I assume I am not getting good coverage with this 2x per day method.


my question is, if I go to 3x per day, what should the split be?  If I go by peak plasma levels I would take it every 7 hours, essentially 7:30am, 2:30pm, 9:30pm.  Does this sound reasonable to anyone?


thanks in advance.

Multiple drugs for my teen years.  ~10 years on Pristiq 100mg.  
January 2021: 50mg Pristiq to 43.75. Stopped Viibryd at 10mg.February 2021: 37.5mg 

March 2021: holding at 37.5mg.
April 2021: 25mg.  May 2021: 18.75 to 12.5.  
June 2021: 12.5 to (accidentally) 4.29mg.  Updose to 6mg using compounded Pristiq

July 2020: 5mg

August 2020: Crashed at day 35 of 5mg. Updose to 6mg

September 2020: 5.5mg from 6 after 38 days

10/2021: 5mg

Planning on 10% reduction every 4-6 weeks



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