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Tips for tapering off Pristiq (desvenlafaxine)


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8 hours ago, Kevman2112 said:

essentially our reason for asking about half life is related to multiple doses per day and what the best time in between is.


That is correct.  If  the half life of pure desvenlafaxine was (for example) 36 hours then we could take powdered Pristiq every 24 hours without being concerned about interdose withdrawal.


8 hours ago, Kevman2112 said:

I have inter-dose withdrawal in the mornings to early afternoon and then 0 symptoms after 2pm (I was taking the full 37.5mg in the morning around 730.  Yesterday I split it up and took 25mg in the morning and 12.5mg right before bed.


It could take up to a week for the drug to reach a consistent level in the blood.


You might start to notice some improvement after a few days.

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Plodding along inch by inch:  12" = 1',  3' =  36 " or 1 yard,  1760 yards  = 63,360" or 1 mile

Current from 17 Apr 2021:  Pristiq 0.2665mg  now holding each dose for 3 weeks

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering Oct 2015 

My tapering program   My Intro (goes to my tapering graph)  My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.

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