circle of drugs - buprenorphine is coming

[btdt]

http://www.madinamerica.com/2015/06/the-medical-model-discovers-heroin-addiction/

 

The Medical Model Discovers Heroin Addiction

Opiate Agonists Are Very Dangerous Drugs

At first glance this may appear unrelated to this site keep in mind there is only one brain one body for phrama to sell to there is a point where everything overlaps... as side effects reactions not understood lead to multiple drugs to treat side effects.  From opiates side effects treated by psych drugs psych drug induced pain treated by opiates.. benzos to treat all related wd sdr and side effects.  It is a vicious circle and many are trapped more are headed our way after the big lie of oxy are not addictive and they are coming to use after being told Ads are not addictive.  Pharma is using up and killing off it's customer base - they know we know it. This makes me want to keep a more steady on the young as they are the next set of customers.. they will be targeted earlier to treat longer.  This article discusses the revolving door from one brain system to the next it would seem ignoring the fact this is all one brain one body it is all related.

a tease from the article:
 

Methadone and buprenorphine compete for the same enzymes as many antibiotics, antidepressants, and antipsychotics for their metabolism (removal from the body). As such the effective dose of methadone is much higher than when people are not on these other medications.  In addition, methadone can result in cardiac arrhythmias because of a change in electrical conduction in the heart (QTc prolongation), although buprenorphine is supposed to be a safe on this outcome.  However, many antidepressants and antipsychotics can also increase QTc prolongation.  With regard to danger associated with cardiac arrhythmias, the probability of an adverse event increments with each additional drug.  Studies of opiate overdoses find that antidepressants, benzodiazepines, and antipsychotic drugs are associated with lethal overdoses.  The SAMSHA guidelines recommend screening for co-occurring disorders.  The Tip 43 guidelines do mention those medications which compete for the same enzymes as methadone but don’t discuss risks associated with multiple medications that increase risk of cardiac arrhythmias.

The electrical effects of these drugs are not often discussed like those who have issues post use they tend to be ignored tho we know there is an electrical system working within our bodies research funds are not going to this area while it is ignored the relation to drugs induced eletrical conduction issues are not understood and those who have these problems shuffled off to get more psych drugs sometimes leading to their death.  As always the not well known or understood issues are not real and created by the patients broken psyche. 

A new drug to treat depression: this from a comment on the article. There's a new drug in town.

 The development of buprenorphine as an antidepressant scares me. It’s formulation in ALKS-5461 is essentially another chemical version of Suboxone. I think of it as the coming of a depression apocalypse. now people treating their depression will develop a dependency to a Schedule III opioid.

Turns out that buprenorphine not only interacts with the mu-receptor but also another protein called a “Regulator of G-protein Signaling” which turns off activity at the mu-receptor.  The problem is that tissues and brain areas vary in terms of whether the neuron contains the “Regulator of G-protein Signaling.”  As such, buprenorphine will only demonstrate an effect on some outcome measures but not on others.  Thus it will be a “partial agonist” on some measures but not on others. The case has been made that buprenorphine is less likely to produce an overdose via respiratory depression than other opiates.  However, all bets are off if buprenorphine is used with another drug.  Many people on buprenorphine die when they combine “bup” with alcohol.

You have to love this once your addicted then they tell you how dangerous your addiction is but not a word before your an addict before your and addict mums the word. 

" This all seemed ironic to me, because if given a pain patient is indeed an addict, then the protocol is to refer to methadone or buprenorphine treatment for addiction.  Once the patient becomes a methadone or buprenorphine patient, doctors are to “educate” the patient about the dangers of ever trying to become abstinent.  "

Then there is naloxone: for fat people to make them sad AD needing fat people God forbid a fat person could be happy!

"  Drug addicts are not going to crave their drug(s) of choice when taking naloxone.  The problem is that with naloxone patients aren’t going to want anything else either, such as food, going to work, etc.  (Yes, naloxone has been considered as a potential treatment for obesity.)  Of course the drug companies don’t include measures such as lethargy and apathy when they publish the drug trials, but the impact is clear in the animal literature."

"Given that buprenorphine is now in a clinical trial to treat medication resistant depression, we’re probably going to have a lot of people taking opiates.  Then we’ll have many dilemmas over what to do if the patient escalates the “bup” dose without permission or uses an unapproved medication.  Physician may wonder whether they need parole officer training.  But, whatever the outcome for the patient, more money will be spent on drugs, monitoring, and auxiliary personnel.  Thus, the U.S. is embarking on another big experiment with the drug companies and another big increase in the cost of medical care in this country"