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Delayed onset of withdrawal symptoms

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reachingforthestars

I'm also very curious about determining the causation of this. In my case it was complicated as i didn't experience any withdrawal symptoms during fast tapering or the three months after quiting high dose paroxetine. It ended up only arising upon major CNS disruption from a suboxone withdrawal. I was left assuming it was the suboxone withdrawal causing all the problems, but ultimately determined it was almost purely SSRI related once I re-instated (relief within 24 hours). Complex indeed.

 

Maybe in your case the onset of WD symptoms 6 weeks later was due to long half life of Paxil? But I cannot understand how come in some cases WD symptoms can start an year later?? Really mysterious... Can other people have stored SSRI in their liver or in fat tissue which is reabsorbing to bloodstream little by little and once they run out of stored SSRI the WD start? I wonder can SSRI accumulate the same way than heavy metals in liver and in other organs?

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coldturkmama

I went cold turkey in October and didn't start WD symptoms until some time in December.

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Henosis

 

I'm also very curious about determining the causation of this. In my case it was complicated as i didn't experience any withdrawal symptoms during fast tapering or the three months after quiting high dose paroxetine. It ended up only arising upon major CNS disruption from a suboxone withdrawal. I was left assuming it was the suboxone withdrawal causing all the problems, but ultimately determined it was almost purely SSRI related once I re-instated (relief within 24 hours). Complex indeed.

Maybe in your case the onset of WD symptoms 6 weeks later was due to long half life of Paxil? But I cannot understand how come in some cases WD symptoms can start an year later?? Really mysterious... Can other people have stored SSRI in their liver or in fat tissue which is reabsorbing to bloodstream little by little and once they run out of stored SSRI the WD start? I wonder can SSRI accumulate the same way than heavy metals in liver and in other organs?

Paxil actually has one of the shortest half lives, but ends up disrupting its own metabolism in the liver. My theory rests on liver enzyme inhibition or (what a well known doc told me) is actually a tardive (delayed) effect akin to tardive dyskinesia with antipsychotics.

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reachingforthestars

 

 

I'm also very curious about determining the causation of this. In my case it was complicated as i didn't experience any withdrawal symptoms during fast tapering or the three months after quiting high dose paroxetine. It ended up only arising upon major CNS disruption from a suboxone withdrawal. I was left assuming it was the suboxone withdrawal causing all the problems, but ultimately determined it was almost purely SSRI related once I re-instated (relief within 24 hours). Complex indeed.

Maybe in your case the onset of WD symptoms 6 weeks later was due to long half life of Paxil? But I cannot understand how come in some cases WD symptoms can start an year later?? Really mysterious... Can other people have stored SSRI in their liver or in fat tissue which is reabsorbing to bloodstream little by little and once they run out of stored SSRI the WD start? I wonder can SSRI accumulate the same way than heavy metals in liver and in other organs?

Paxil actually has one of the shortest half lives, but ends up disrupting its own metabolism in the liver. My theory rests on liver enzyme inhibition or (what a well known doc told me) is actually a tardive (delayed) effect akin to tardive dyskinesia with antipsychotics.

 

 

I also believe that the liver enzymes has a lot to do with how much one get damaged by SSRI and how long the half life of SSRI is individually. Of course it sound logic that these drugs can accumulate more if one has slow metabolism. Is this what you mean?

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Waiting12

Exactly what happened to me. I quit Zoloft 25 mg ct in February 2015 after being on it 4 years. I had some brain zaps for a few weeks and felt not too bad (looking back there were some wd symptoms like fatigue but nothing debilitating). A year later, feb 2016 I got slammed with dizziness, derealization, headaches, nausea. I had no idea what it was. I wish I would have known then what I do now. I didn't know it was delayed wd and eventually tried many different ssris with terrible adverse reactions to everything and now am in a world of hurt. I understanding now that this is going to be a long journey, but at least I know what it is.

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Petunia

Delayed withdrawal probably happens much more often than people realize. In my case, it wasn't until I stumbled onto withdrawal forums, that I realized my symptoms might be connected with drugs I had stopped taking 30 months earlier.

 

After an initial acute phase, after my 2 month 'taper', I felt relatively well for several months. So when new and strange symptoms started arising, I didn't make a connection and like most people, thought it was  a new illness or an old one manifesting in a new way.

 

This pattern of delayed withdrawal probably accounts for a lot of people believing they can come off antidepressants fairly easily, but then the delayed withdrawal gets misdiagnosed as something else, for which more medication is prescribed, and the cycle continues.

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IrishMonkey92

I quit Citalopram cold turkey from 40mg - 0mg within 4 weeks - August 2015.

 

I had shooting pains in my head here and there and a restless leg some nights for a few months. Didn't attribute it to withdrawal. Thought it was stress.

 

Then 5 months later, January 2016 - after a heavy night of drinking - BAM - woke up to a massive panic attack - thought I was dying. That's when my main symptom started - floaty boat/swaying/rocking. I have it 12 months now. The anxiety has calmed down a good bit. It was much much worse. Recovery from health anxiety big time.

 

I wonder if I never touched drink, would I have been fine?

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TikkiTikki

Glad I found this topic!

 

Delayed withdrawal - that's what I experienced, and just thought it was relapse so reinstated Citalopram (which took 7 weeks to work and they were HELL).

 

IT seems that many people have done a short (less than 6 month) taper or CTed, and then been hit months after. Has it happened to anyone after a taper of 2+ years?

 

A very slow taper seems to be the best strategy (which feels strange when you don't have any WD symptoms during taper).

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Lorin

I quit Citalopram cold turkey from 40mg - 0mg within 4 weeks - August 2015.

 

I had shooting pains in my head here and there and a restless leg some nights for a few months. Didn't attribute it to withdrawal. Thought it was stress.

 

Then 5 months later, January 2016 - after a heavy night of drinking - BAM - woke up to a massive panic attack - thought I was dying. That's when my main symptom started - floaty boat/swaying/rocking. I have it 12 months now. The anxiety has calmed down a good bit. It was much much worse. Recovery from health anxiety big time.

 

I wonder if I never touched drink, would I have been fine?

how long you took lexapro?

did you had insomnia in wd time?

when the things go better?

thank you

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RainbowDbc
On 2/11/2013 at 0:29 PM, Altostrata said:

Reasons why withdrawal symptoms may not be immediately apparent:

 

  • "Washout," related to drug half-life, takes some time; minute amounts of drug in the body holding off withdrawal symptoms (particularly with long half-life drugs such as Prozac, where washout takes weeks).

     

  • Outright misdiagnosis and mistreatment of withdrawal symptoms, causing worsening of condition.

     

  • Symptoms are attributed to something else, such as the flu or situational stress.

     

  • Symptoms may be mild initially and the person doesn't pay any attention to them.

     

  • Symptoms of nervous system instability might initially be very mild with the homeostasis gradually deteriorating over time, producing more severe, noticeable symptoms.

     

  • Other ???

This might be a dumb observation but. Wouldnt it be possible that the stronger your systems.and brain get the more aggressive it becomes weeks and months later? You may not feel much initially because your brain is sedated and damaged...once it wakes up and..recognizes what it has to heal it starts to do this aggressively? 

My first withdrawal attempt felt this way. I would feel.an agonizing over activity all day the next day I felt my cognition was better and I was self aware of it. But it took me 3.months to see drastic changes...?

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IrishMonkey92
On 14/5/2017 at 4:31 PM, Lorin said:

how long you took lexapro?

did you had insomnia in wd time?

when the things go better?

thank you

Never took Lexapro. 

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Dalalea

I had been on Sertraline for several years. I tapered off of it June/July 2017. I was very busy planning a big trip at the time and a bit of insomnia was all I remember having. 

I left for Europe in mid August thinking that it was much easier to get off the med than I first feared. I felt wonderful the whole time. 

3 days after getting home and working through some jet lag, I had a night with extremely cold feet. Next morning, they felt a little numb. I thought it must be my lower back acting up. I still have it on and off after 3 months. With in a month I was experiencing more severe depression than I’d ever known! 

It wasn’t until I started researching and found this site that I realized what was happening to me. I’ve never heard of a delayed response to withdrawal but now  I’m sure my many and ever-changing symptoms can be explained by this! 

My theory is that I was running on adrenaline due to the constant change of scenery at that time and the jet lag weekened me. Or, maybe it really was just a delay and I was very lucky to get home before it started. 

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GUL123
On 10/21/2015 at 11:19 PM, Sampo said:

I had been 3 months without Sertraline when withdrawal symptoms really started. When I ended it first time it took maybe 4 months to get PSSD.

I have the same symptoms. The same happened to me. I wish I could talk to u more on this topic

 

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dj2010
17 hours ago, Dalalea said:

I had been on Sertraline for several years. I tapered off of it June/July 2017. I was very busy planning a big trip at the time and a bit of insomnia was all I remember having. 

I left for Europe in mid August thinking that it was much easier to get off the med than I first feared. I felt wonderful the whole time. 

3 days after getting home and working through some jet lag, I had a night with extremely cold feet. Next morning, they felt a little numb. I thought it must be my lower back acting up. I still have it on and off after 3 months. With in a month I was experiencing more severe depression than I’d ever known! 

It wasn’t until I started researching and found this site that I realized what was happening to me. I’ve never heard of a delayed response to withdrawal but now  I’m sure my many and ever-changing symptoms can be explained by this! 

My theory is that I was running on adrenaline due to the constant change of scenery at that time and the jet lag weekened me. Or, maybe it really was just a delay and I was very lucky to get home before it started. 

was almost exactly 3 months for me also if you read my intro, months 5, 6 and 7 were worse, month 8 things improving a lot, over last month things seem to be improving a lot more

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Dalalea

 Hi dj,

I’m starting month 6. Lots of trouble with waking too early on most mornings. I’m hoping by month 8 I can say I’m improving that much, also! 

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dj2010
1 hour ago, Dalalea said:

 Hi dj,

I’m starting month 6. Lots of trouble with waking too early on most mornings. I’m hoping by month 8 I can say I’m improving that much, also! 

my sleep is far from normal but much improved now especially since having epsom salt baths every night, still waking usually 2 - 3 times in the night but now usually getting 7 or more hours of sleep in total, except for last few days as had a flu type bug and havent been able to breath while in bed so very poor sleep, started running and swimming again over the last month which was not possible before so definitely improvements recently, take good care of yourself, try do lots of walking and eat very clean and I am sure you will be fine with time,

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Dalalea

Thanks for the encouragement, dj! Good luck to you!

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GUL123
On 1/18/2014 at 6:42 AM, Hexal said:

Is it common to have delayed withdrawal symptoms or is it something of a rarity?

 

I noticed no problems whatsoever when I was tapering off Sertraline and was a bit surprised by it. 2 1/2 months had gone by before the symptoms slowly started emerging and they have continued to evolve ever since.

 

This delay makes it even harder to convince my doctor in any way about this stuff (probably an exercise in futility, anyway). Even friends and family are asking me; are you sure this is not just stress or anxiety expressing itself in a weird way? Why would the drug start causing these problems months after stopping?

 

Sorry if this topic has been discussed already.

Don't know whether u will see this comment or not. This is exactly what happened to me. 

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Dalalea

Yes! The only thing that keeps me from worrying more about it is that others have had the same thing happen! This forum has already helped me so much! Thank you for sharing this!

How are you doing, now?

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GUL123
On 1/5/2018 at 11:54 PM, Dalalea said:

Yes! The only thing that keeps me from worrying more about it is that others have had the same thing happen! This forum has already helped me so much! Thank you for sharing this!

How are you doing, now?

I am tapering my meds now (bupropion and alprazolam) my anxiety has subsided now and I feel clear headed but my sexual dysfunction has not improved (zero libido and poor errection) and I feel reduced emotional range. Thank u dear

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WantoffVen
Posted (edited)

I know no one knows the answer but I'm a little fearful because initially I went from 225MG VenlafaxineXR to 187.50 to 150 to 112.50 within a 3 month period. At 112.5 I had minimal withdrawal symptoms and found this site. Since then  have been doing the recommended 10% taper, but I have no way of knowing if my initial dropping so quickly will catch up with me. I think I am dwelling on it too much. I am really doing well. But then I read about people falling flat on their faces a few months later and it scares me. I think one can use this site helpfully but you can also scare yourself. I'm probably foolishly worrying about what might happen down the road instead of staying in the moment. I think I am typing this so no one else worries when they are doing well.

Edited by Gridley

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Gridley

"worrying about what might happen down the road instead of staying in the moment. I think I am typing this so no one else worries when they are doing well."

 

You have it figured out, WantofVen.  No one can tell what's going to happen, so you're much ahead assuming it's going to be okay.  Worrying uses up valuable energy that you need for healing.

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India
On 1/18/2014 at 9:57 AM, rapunzel2 said:

I ended zoloft within a few months, and then also had a very good period - totally well and grounded. after it started going bad - at first with wild fluctuations (waves), until I totally crashed, big time. the crash came about 4-5 months after the quit.

 

brain accostumes to taking SSRI by reducing it's serotonin receptors and reducing their sensitivity. if drug is removed, it has to restore the receptors and start working in a totally different way. the pace of this restoration is slow, and it probably just runs into havoc after trying and trying to gain some new equilibrium. 

I tapered from 10mg to zero in 4 weeks . The first month I did ok, with a few symptoms but I managed them. I even felt a bit high from the thought that I had gotten off the drugs and was managing. Little did I know the full fury of WD would hit me around the 4 week mark and stuck around too. Every symptom expect for brain zaps ( i suppose I must be grateful for that). The worst have been derealization and memory problems. The deterioration was rapid. I've been quite ill ever since. I would NOT recommend a fast withdrawal, you take a huge risk.

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Jansin

I was on Zoloft for four years, starting in late 2013 and ending in late 2017 when I CTed. 
 

Nothing happened to me, not for the first three weeks, not for the first five months after. I just slowly became more and more depressed as 2018 began and went on and also noticed some short term memory problems, but nothing debilitating.

Until finally in September I wake up one day and notice my vision was different, and then health anxiety soon followed after that, then crying episodes came into play very soon after.

 

Then in October I noticed the ringing in my ears is a bit louder than usual

 

But to this day I barely have any symptoms, and honestly after all that I have read on this site: The lack of symptoms is honestly starting to concern me.

Is there anyone else here that only experienced mental symptoms? Or anyone else that CTed without any immediate reaction? 

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FarmGirlWorks

I almost CT'd from Zoloft (4 week "taper") and what you said above kind of tracks with my first 5-6 months. Increasing depression week by week until month 6 or so and then I've had cog fog, akathisia, extreme anxiety, leaky eyes, light sensitivity, head pressure, debilitating headaches. I had tinnitus before from a head surgery but it has gotten worse in WD. I see that you were able to reinstate so perhaps that has waylaid any physical symptoms. Everybody's recovery is different. That is great though that you were able to reinstate which, as I understand it, can arrest WD symptoms while your CNS heals.

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trenace

Im always hesitant to reply to stuff like this because it scares me to read about others but my cold turkey from zoloft gave me mental symptoms for a year and then full blown withdrawal started and knocked me for 6. My withdrawal seems to be completely all over the place in terms of symptoms. I don't think there's a pattern at all tbh. 

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Jansin
On 11/27/2018 at 7:42 AM, trenace said:

Im always hesitant to reply to stuff like this because it scares me to read about others but my cold turkey from zoloft gave me mental symptoms for a year and then full blown withdrawal started and knocked me for 6. My withdrawal seems to be completely all over the place in terms of symptoms. I don't think there's a pattern at all tbh. 


How long were you on zoloft? and what dosage?

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trenace

100mg just under a year can't remember exactly. I fought heightened anxiety and insomnia for a year and then at roughly the year mark I developed almost every symptom. 

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VincentV
On 11/24/2018 at 4:17 AM, Jansin said:

Is there anyone else here that only experienced mental symptoms? Or anyone else that CTed without any immediate reaction? 

 

It took six weeks for my withdrawal to hit me and I've pretty much only had mental symptoms: Mostly depression (which is severe), really obsessive health anxety (only the first month or so, so far) constant general anxiety, agitation (which has very occasionally been akathisia like) , depersonalisation and this weird unsettling/dissociated/foggy feeling and various oher weird feelings. I have almost total anhedonia too, but on reflection that had that for years. 

 

 

On 12/2/2018 at 1:07 PM, trenace said:

100mg just under a year can't remember exactly. I fought heightened anxiety and insomnia for a year and then at roughly the year mark I developed almost every symptom. 

 

Did you take anything other than sertraline? 

 

 

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trenace
14 minutes ago, VincentV said:

 

It took six weeks for my withdrawal to hit me and I've pretty much only had mental symptoms: Mostly depression (which is severe), really obsessive health anxety (only the first month or so, so far) constant general anxiety, agitation (which has very occasionally been akathisia like) , depersonalisation and this weird unsettling/dissociated/foggy feeling and various oher weird feelings. I have almost total anhedonia too, but on reflection that had that for years. 

 

 

 

Did you take anything other than sertraline? 

 

 

Yes fluanxol for only a few months and cold turkeyd that too then cold turkeyd the sertraline after. 

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Altostrata

Merged similar topics.

 

How many of you had very minor symptoms shortly after quitting the drug, maybe you thought it was a cold or something else?

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ChessieCat
26 minutes ago, Altostrata said:

How many of you had very minor symptoms shortly after quitting the drug, maybe you thought it was a cold or something else?

 

Or an upset stomach?

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VincentV

Oh I did get stomach issues a week after coming off my brief stint on mirtazapine. Insomnia for two or three days and an over sensitivity to histimines which I'd already forgotten about. These seemed to clear up very quickly, and actually felt like how Drs tell you a withdrawal ought to be... Aside from the mental horror of my lived experience ofcourse. Sertraline and Mirtazapine have rendered my mind a Somme-like wasteland. 

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bubbles
10 hours ago, Altostrata said:

Merged similar topics.

 

How many of you had very minor symptoms shortly after quitting the drug, maybe you thought it was a cold or something else?

 

Well, I haven't quit quite yet ;) but I am having, err, gastrointestinal symptoms that are rather annoying.

 

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