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Tips for tapering off lurasidone (Latuda)


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ADMIN NOTE Also see Dose Equivalents for Second-Generation Antipsychotics


Lurasidone is a new generation atypical antipsychotic, with the usual adverse effects, including obesity and tardive dyskinesia.
General FDA information about Latuda: http://www.drugs.com/pro/latuda.html
Latuda is predominantly metabolized by the liver enzyme identified as P450 CYP3A4. Taking other drugs that are processed through this enzyme may cause drug-drug interactions. If you are taking multiple drugs of any type, you may wish to check interactions here http://www.drugs.com/drug_interactions.html
Half-life is about 18 hours.

Tablets are available in these dosages:

  • 20 mg
  • 40 mg
  • 60 mg
  • 80 mg
  • 120 mg

According to this Madison, Wisconsin health insurance company, the tablets can be split:
Reduce by 10% per month to start
Like all psychiatric drugs, if you take lurasidone regularly for a month or more, you are at risk for withdrawal symptoms when you go off. We recommend a gradual taper as with other psychiatric drugs: Reduce by 10% per month, calculated on the last dosage. (The amount of the reduction gets progressively smaller.) Read Why taper by 10% of my dosage?

Tapering by cutting up tablets

According to this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440099/


Aripiprazole and lurasidone are optimal agents for tablet splitting.

See How to cut up tablets or pills (using a pill cutter)
For precise measurements of small amounts, you may wish to weigh the fragments see Using a digital scale to measure doses

Using a liquid is much more convenient when tapering by tiny amounts.


Use a combination of tablet dosages to taper
You may wish to get all or part of your prescription filled with the 20mg tablets, then split them into quarters to taper by 5mg at a time. This will stay within the 10% guideline until you get to 45mg.
After 45mg, you may wish to combine a 20mg tablet and take the rest of your dosage by

When you reach 20mg, you may wish to halve the tablet, then take the rest in measured amounts as above, until you get to 10mg, at which point you probably will wish to take the entire dosage in a liquid you can easily titrate.


To get prescriptions covered by insurance for two dosages of a tablet, your doctor probably has to specify "divided doses."

You will probably find using a liquid to be much more convenient when tapering by amounts smaller than 10mg.

Make a liquid yourself from tablets or capsules
While lurasidone is only slightly soluble in water, you can make a liquid suspension, see How to make a liquid from tablets or capsules

Use an oral syringe to precisely measure out doses as small as .01mg.


Additional information about chemistry of making a lurasidone liquid http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381388/


Other data http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=88a244d1-eddb-499c-bee2-e1f49056e78f


Drugbank http://www.drugbank.ca/drugs/DB08815

Edited by Altostrata

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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  • 3 years later...

Lurasidone has a fairly short halflife of about 18 hours or 20-24 hours, depending on where you look.  Thus its concentration can vary quite a bit throughout the day.  At smaller dosages (e.g., around 5mg), this variation can lead to drastically different rates of receptor occupancy throughout the day.  I am concerned that this may be difficult to go through.  Has anyone thought about dealing with this through splitting administration into two doses daily of a smaller amount rather than dosing once a day?

Previously: Lithium (incorrectly diagnosed bipolar although I never had a manic or hypomanic episode)(taken during summer/fall 2020); Olanzapine (taken from late spring 2020 until late December 2020); Abilify (briefly for a couple of weeks in 2016, caused akethesia); Risperidone (2014-2016); Fluoxetine (two weeks in 2020); various sleep aids, e.g., Ativan, trazadone, mirtazapine and other antihistaminics (winter through summer of 2021).  I don't remember most of the dosages and am leaving them blank.


Currently: Latuda (40mg) (hoping to taper). 

Other: I do not smoke, do not drink, have only one cup of coffee in the morning, and don't use anything else.  I exercise 3-4 times per week and watch my diet. 


My posts do not include any medical advice and I am not trained in medicine. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

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