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Prozac and Tamoxifen and Other Breast Cancer Prevention Drugs


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Wondering if anyone tapering slowly off an SSRI -- especially fluoxetine -- has been told they are at high risk for breast cancer and should take Tamoxifen for disease prevention? I've read that fluoxetine compromises Tamoxifen metabolism and makes the drug less effective.

 

Have also read about drugs similar to Tamoxifen -- such as Raloxifene -- and aromatase inhibitors, which aid in BC prevention but aren't contraindicated with SSRIs. Problem comes in if Tamoxifen, due to its side-effect profile vs. alternatives, is doctor's recommendation for me.

 

Any experience or insight appreciated. I had never heard of this issue!

Prozac 20 mg/daily since 1995

July 19, 2013, initial cut to 15 mg; Aug. 2 updosed to 18 mg; Aug. 19, to 16.2 mg
Held at 2.52 ml/day Jan. 11-April 16, 2014
April 16, 2014, cut to 2.40 ml/day
Dec. 29, 2014, 1.84 ml/day, and held there almost six months
June 23, 2015, 1.75ml/day; July 21, 2015, 1.70 ml/day
Aug. 13, 2015, 1.60 ml/day

Feb. 7, 2016, .7 ml/day; April 26, 2016, .6 ml/day

 

Taking anastrozole (estrogen blocker)
 
Successfully completed long, slow Klonopin taper November 2011. :ph34r:

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Have you had breast cancer? See http://www.uptodate.com/contents/medications-for-the-prevention-of-breast-cancer-beyond-the-basics

 

Yes, tamoxifen and Prozac do not mix well http://www.breastcancer.org/research-news/20100208

 

However, you're taking such a small amount, the drug-drug conflict is probably reduced.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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Alto: Thanks for responding. No, I have not been diagnosed with breast cancer (further biopsy soon), but am at high risk due to benign breast condition. Tamoxifen and similar drugs are often given to high-risk, post-menopausal women. Yes, dose is small, and I'll ask doc about it. Will read links you posted.

Prozac 20 mg/daily since 1995

July 19, 2013, initial cut to 15 mg; Aug. 2 updosed to 18 mg; Aug. 19, to 16.2 mg
Held at 2.52 ml/day Jan. 11-April 16, 2014
April 16, 2014, cut to 2.40 ml/day
Dec. 29, 2014, 1.84 ml/day, and held there almost six months
June 23, 2015, 1.75ml/day; July 21, 2015, 1.70 ml/day
Aug. 13, 2015, 1.60 ml/day

Feb. 7, 2016, .7 ml/day; April 26, 2016, .6 ml/day

 

Taking anastrozole (estrogen blocker)
 
Successfully completed long, slow Klonopin taper November 2011. :ph34r:

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