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Benazzi, 1998 Fluoxetine for serotonin reuptake inhibitor discontinuation syndrome.


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J Psychiatry Neurosci. 1998 Sep;23(4):241-2.
Fluoxetine for serotonin reuptake inhibitor discontinuation syndrome.
Benazzi F.
Full text at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188942/?page=1


Selective serotonin reuptake inhibitor(SSRI) discontinuation syndrome includes dizziness, paresthesia, lethargy, nausea, depressed mood, anxiety, agitation, iritability, insomnia, vivid dreams and headache. It may be caused by a sudden synaptic serotonin drop and is most common with short- half-life SSRIs. It has also been reported with venlafaxine. The cases of 5 patients are reported here. Each was unable to discontinue an SSRI because of withdrawal symptoms but all were able to discontinue it by adding the long-half-life SSRI fluoxetine. A MEDLINE search found only 1 similar report about venlafaxine.



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