Freeby60: this month is the 24th anniversary of getting on ADs - 24 years!

[Freeby60]

On 11/30/2021 at 4:08 PM, Altostrata said:

 

What drug are you tapering? How long have you been at this dose?

 

Exactly what drugs are you taking now, at what times o'clock and dosages?

 

Did you ever address potential problems of drug interactions with your doctor? Any TD is more likely related to Seroquel, or an interaction of Seroquel with your other drugs that would increase plasma levels of Seroquel.

Hi Alto-

I am tapering lex since 2018

 

AM - lex - 0.13 ml/mg (since 11/28)

clonazapam - 0.05 mg 

duloxetine - 60 mg

probiotic

 

PM - seroquel 25 mg 

Multi Vit

Omegas

 

Yes, TD is related to Seroquel. My GP says clonazepam is the only Med that can cause Positive Histone Antibodies and she wants me to taper when I can.

 

Drug interactions in the drug checker all moderate. 
 

The benzo, Seroquel, and duloxetine all added during psych hospital stay in 2018 Nov. When I asked pdoc about all the drugs, he was unconcerned about polydrugging. 

[Altostrata]

As requested, please post a link to your drug interactions report.

 

How long did your increased symptoms last after your last decrease of Lexapro?

 

On 12/1/2021 at 4:01 PM, Freeby60 said:

Yes, TD is related to Seroquel. My GP says clonazepam is the only Med that can cause Positive Histone Antibodies and she wants me to taper when I can.

 

Drug interactions in the drug checker all moderate. 

 

Many drugs can cause Positive Histone Antibodies. I got it from terbinafine. If I were you, I would stop taking statements from my doctors as the final word on anything. GPs know very little about adverse effects of psychiatric drugs.

 

from https://emedicine.medscape.com/article/1065086-overview#a5

Quote

 

Etiology

DILE may be induced by medications or caused by other compounds in the environment. The most common drugs that cause drug-induced SLE are hydralazine (rate roughly 20%), procainamide (rate roughly 20%, 5-8% if taken for 1 y), quinine, isoniazid, and minocycline.

 

Drugs most commonly associated with drug-induced SCLE include calcium-channel blockers, angiotensin-converting enzyme inhibitors, thiazide diuretics TNF-alpha antagonists. [18] 

 

Several broad drug categories have been linked to DILE, including those described below.

 

Antacids

Histamine H2 receptor antagonists include the following:

Ranitidine (discontinued) [7, 19] 

Proton pump inhibitors include the following [19, 20] :

Esomeprazole [19, 3, 21] 

Lansoprazole [3, 7, 12, 19, 22] 

Omeprazole (SCLE) (DISCLE) [3, 19, 23] 

Pantoprazole [3, 19, 22] 

Anti-inflammatories

Antirheumatics include the following:

Penicillamine [2, 10, 12, 24] 

NSAIDs include the following:

Aspirin [20] 

Naproxen [3, 7, 12, 19, 22] 

Piroxicam [3, 7, 12, 19, 22, 25] 

Phenylbutazone [2, 10, 12] 

Sulfasalazine [2, 10, 12, 24] 

Antiarrhythmics

Antiarrhythmics include the following:

Amiodarone [26] 

Disopyramide [10, 12] 

Procainamide [1, 2, 6, 10, 12, 27] 

Propafenone [10, 12] 

Tocainide [2] 

Quinidine [1, 2, 10, 12, 27] 

Antibiotics

Antibiotics include the following:

Amoxicillin + clavulanic acid [2, 19, 25] 

Cefepime [28] 

Ciprofloxacin [2, 19] 

Doxycycline [2, 29] 

Isoniazid [2, 10, 12] 

Minocycline [1, 2, 10, 12, 30, 31] 

Nitrofurantoin [3, 10, 12] 

Norfloxacin [3] 

Para-amino-salicylic acid [2] 

Penicillin [2] 

Rifabutin [32] 

Rifampin [2] 

Rifamycin [33] 

Streptomycin [2] 

Tetracycline [2] 

Anticonvulsants

Anticonvulsants include the following:

Carbamazepine [2, 3, 7, 10, 12, 25, 34] 

Diphenylhydantoin [2] 

Ethosuximide [2, 10, 12] 

Lamotrigine [3, 35, 36] 

Phenytoin [2, 3, 7, 10, 12] 

Primidone [2, 10, 12] 

Trimethadione [2, 10, 12] 

Valproate [2] 

Zonisamide [2] 

Anticoagulants

Anticoagulants include the following:

Ticlopidine [3, 7, 12, 22] 

Antifungals

Antifungals include the following:

Griseofulvin [2, 3, 7, 12, 22] 

Terbinafine [2, 3, 7, 12, 22, 37] 

Antihistamines

Antihistamines include the following:

Brompheniramine [3, 7, 19] 

Cinnarizine + thiethylperazine [3, 7, 19] 

Antihypertensives

Antihypertensives include the following:

Clonidine [2, 10, 12] 

Methyldopa [2, 10, 12] 

Olmesartan [38] 

Reserpine [2] 

ACE inhibitors include the following [39] :

Captopril [2, 3, 7, 10, 12, 19] 

Cilazapril [3, 7, 12, 19, 22] 

Enalapril [3, 7, 10, 12, 19, 25] 

Lisinopril [2, 3, 19] 

Ramipril [3, 19, 25] 

Beta-blockers include the following:

Acebutolol [2, 3, 7, 10, 12, 19, 22] 

Atenolol [2, 10, 40] 

Labetalol [2, 10, 12] 

Metoprolol [2] 

Ophthalmic timolol [2, 10] 

Oxprenolol [3, 7] 

Pindolol [2, 10, 12] 

Prazosin [10, 12] 

Propranolol [2] 

Calcium channel blockers include the following:

Amlodipine [3] 

Diltiazem [1, 3, 7, 12, 22, 27] 

Nifedipine [3, 7, 12, 22] 

Nitrendipine [3, 7, 22, 25] 

Verapamil [3, 7, 12, 22] 

Diuretics include the following:

Chlorothiazide [3, 7] 

Chlorthalidone [10, 12] 

Hydrochlorothiazide + triamterene [3, 7] 

Hydrochlorothiazide [2, 3, 7, 10, 12, 19, 22, 41] 

Spironolactone (DISCLE) [3] 

Vasodilators include the following:

Hydralazine [1, 2, 6, 9, 10, 12, 27] 

Minoxidil [10, 12] 

Antipsychotics

Antipsychotics include the following:

Chlorpromazine [2, 10, 12, 27] 

Chlorprothixene [10, 12] 

Lithium carbonate [10, 12] 

Antidepressants include the following:

Bupropion [3, 7, 12, 22] 

Citalopram [3] 

Lithium [2] 

Phenelzine [10, 12] 

Sertraline [42] 

Antithyroid agents

Antithyroid agents include the following:

Iodine I 131 [3] 

Methimazole (bullous SLE) [2, 43] 

Propylthiouracil [2, 10] 

Thiamazole [2] 

Benzodiazepines

Benzodiazepines include the following [20] :

Clobazam [2] 

Clozapine [2, 44] 

Biologics

Biologics include the following:

Abatacept [19] 

Bevacizumab [3] 

Efalizumab [3, 7, 12, 22] 

Golimumab (SCLE) [3, 45] 

Interferons (alpha, beta, gamma) [2, 3, 7, 10, 12, 16, 22, 46] 

Interleukins (IL-2) [2, 12] 

Ranibizumab [3] 

Rituximab [3, 47] 

Secukinumab [19] 

Ustekinumab [19] 

TNF-alpha inhibitors include the following [11, 12, 13, 15, 17, 18, 22, 47, 48, 49] :

Adalimumab [3, 12, 13, 14, 22, 49] 

Etanercept [2, 3, 7, 12, 13, 22, 25] 

Infliximab (Remicade) [2, 3, 10, 12, 13, 22, 49] 

Checkpoint inhibitors include the following:

Ipilimumab [50] 

Nivolumab [1, 50] 

Chemotherapy agents

Chemotherapy agents include the following:

Anastrozole [2, 7, 19] 

Atezolizumab [1] 

Capecitabine [3, 7, 51] 

Doxorubicin (DISCLE) [3, 19, 39] 

Doxorubicin + cyclophosphamide [3, 39] 

Gemcitabine [3, 19, 52, 51] 

Hydroxyurea [2] 

Imiquimod (DISCLE) [3, 19] 

Masitinib [19] 

Mitotane [3, 19] 

Nivolumab [1, 19] 

Palbociclib [19] 

Pazopanib [3] 

Pembrolizumab [1, 19] 

Tamoxifen [3, 7, 12, 19, 22] 

Fluorouracil agents include the following:

Fluorouracil [2, 3, 19, 53] 

Tegafur [2] 

Uracil-tegafur [2, 19] 

Taxanes include the following [51] :

Cabazitaxel (DISCLE) [41] 

Docetaxel [3, 7, 19, 22, 39, 41, 51] 

Paclitaxel [3, 7, 51] 

Cholesterol-lowering agents

Cholesterol-lowering agents include the following:

Atorvastatin [12] 

Fluvastatin [2, 12] 

Gemfibrozil [2] 

Lovastatin [2, 10, 12] 

Pravastatin [3, 7, 12] 

Simvastatin [2, 3, 7, 12] 

Gold salts  [2] 

Hormonal therapy

Hormonal therapies include the following:

Aminoglutethimide [10] 

Estrogens [2] 

Leuprolide acetate [2, 7] 

Oral contraceptives [2] 

Immunomodulators include the following:

Hydroxychloroquine [3, 25] 

Leflunomide [3, 7, 12, 22, 25, 4] 

Inhalers

Inhalers include the following:

Tiotropium bromide inhaler [3, 7, 54] 

Miscellaneous

Miscellaneous agents include the following:

Allopurinol [2, 19, 25] 

Hay with fertilizer [7] 

Intravenous immunoglobulin [19] 

Levodopa [10] 

Lipstick [7] 

Ultraviolet light therapy [3, 7] 

Zafirlukast [2] 

Stool softeners  [19] 

Sulfonylureas

Sulfonylureas include the following:

Glyburide (DISCLE) [3] 

....

Other causes may induce DILE in certain individuals for no apparent reason, such as sensitivity to the following:

Insecticide compounds

Certain metallic compounds

Fluorescent acid dye found in some lipsticks

Drugs that cause flares of SLE are as follows:

Cimetidine

Golimumab [45] 

Hydralazine

Hydrochlorothiazide

Mesantoin

Omeprazole [23] 

Para-aminobenzoic acid (PABA)

Penicillin

Phenylbutazone

Sulfonamides

Terbinafine [37]

 

 

[Freeby60]

3 hours ago, Altostrata said:

 

As requested, please post a link to your drug interactions report

 

Sorry- don’t see where you asked for it, here it is: https://www.drugs.com/interactions-check.php?drug_list=1013-0,1979-1274,703-0,949-0,1510-0,1749-15936,3205-15943&consumer=1&types[]=major&types[]=minor&types[]=moderate&types[]=food&types[]=therapeutic_duplication

 

3 hours ago, Altostrata said:

How long did your increased symptoms last after your last decrease of -check.php?drug_list=1013-0,1979-1274,703-0,949-0,1510-0,1749-15936,3205-15943&consumer=1&types[]=major&types[]=minor&types[]=moderate&types[]=food&types[]=therapeutic_duplication

My increased symptoms lasted 2 months. I appear to have TMJ which appeared a year ago (not confirmed by doc). This also increases symptoms like chewed up inner cheeks and clenching. I held my dose for August through October. 

 

3 hours ago, Altostrata said:

Many drugs can cause Positive Histone Antibodies. I got it from terbinafine. If I were you, I would stop taking statements from my doctors as the final word on anything. GPs know very little about adverse effects of psychiatric drugs.

 

 

I’m aware of the number of medications and more that can cause PHA. I wrote what my doc says here for your information, not as the “final word”. Please let me know if you need anything else. 
 

 

[Altostrata]

The reason I point out that many drugs may cause elevated ANA is that I suggest you taper clonazepam last. It may assist in masking withdrawal symptoms from  going off the other drugs.

 

Any of your drugs may be causing your elevated ANA. It's too bad the ANA did not resolve with Lexapro reduction.

 

The TD is most likely caused by Seroquel, Cymbalta is the second most likely.  

 

All of your drugs are going to be difficult to taper, and after you finish with Lexapro, I might reduce Seroquel next, in the hopes of reducing the ANA and TD.

 

Depending on how you feel physically now, you may wish to accelerate the taper, if your current symptoms are equal or worse than the risk of withdrawal. Have you had liver and kidney panels recently? The results would be important to this decision.

 

What times o'clock do you take your drugs?

On 12/1/2021 at 4:01 PM, Freeby60 said:

AM - lex - 0.13 ml/mg (since 11/28)

clonazapam - 0.05 mg 

duloxetine - 60 mg

probiotic

 

PM - seroquel 25 mg 

Multi Vit

Omegas

 

Do you take Lexapro, duloxetine, and clonazepam at the same time in the morning? Why do you do that?

 

I might notify the hospital of the outcome of the drug treatment you initiated as an inpatient in 2018.

 

 

 

[Freeby60]

1 hour ago, Altostrata said:

Have you had liver and kidney panels recently? The results would be important to this decision.

Yes, both negative. My symptoms have subsided since my first post. I am not wedded to tapering my Benzo and not feeling rushed.

 

1 hour ago, Altostrata said:

Do you take Lexapro, duloxetine, and clonazepam at the same time in the morning? Why do you do that?

 

I might notify the hospital of the outcome of the drug treatment you initiated as an inpatient in 2018.

I take them at the same time. There is no reason (I used to take clonazepam at bed with the Seroquel, but that made me uncomfortably dead to the world so I gradually moved it up). Just convenience, I guess. Do you suggest otherwise?

 

1 hour ago, Altostrata said:

What times o'clock do you take your drugs?

On 12/1/2021 at 7:01 PM, Freeby60 said:

AM - lex - 0.13 ml/mg (since 11/28)

clonazapam - 0.05 mg 

duloxetine - 60 mg

probiotic

 

PM - seroquel 25 mg 

Multi Vit

Omegas

I forgot to indicate the PM times. Vitamins and Omegas at dinner Seroquel is at 9 PM.

 

Thank you for suggesting I notify the hospital. I wouldn’t have thought of that. I think I will.

 

Thank you.

 

 

 

 

[Altostrata]

2 hours ago, Freeby60 said:

My symptoms have subsided since my first post.

 

What symptoms do you mean?

 

Please make it easy for me: In a simple list form, what are the times o'clock you take each of your drugs, with their dosages? 

 

Quote

2016-2017 Effexor, Lamotrigine, Nortriptyline, Abilify, Cymbalta, Klonopin, Seroquel, Lexapro- slow taper 2016

 

Are those all unsuccessful short-term trials of Effexor, Lamotrigine, Nortriptyline, Abilify, Cymbalta, Klonopin, Seroquel, Lexapro? "slow taper 2016" What was it that you tapered? Do you mean 2017? 

 

What happened between 2017 and when you were hospitalized in 2018? Why were you hospitalized then?

 

It looks like you've been on and off clonazepam for years. Why was clonazepam prescribed in 2018?

 

Was 25mg Seroquel prescribed for any particular reason? 

[Freeby60]

8 minutes ago, Altostrata said:

2 hours ago, Freeby60 said:

My symptoms have subsided since my first post.

 

What symptoms do you mean?

 

I'm sorry, I am not being very clear. The oral TD symptoms were aggravated by something, and it seemed to occur after a cut, although it was also during the same period that I had a low grade fever for several weeks that led to the tests that found the positive ANAs. These are the events that may have increased symptoms in my tongue and jaw that have subsided now. In general, my tongue and jaw movements are mildly noticeable to others, mostly when I talk. I was concerned that my tongue was beginning to push against my teeth (rather than side-to-side) and out my mouth. My tongue is no longer pushing against my teeth, but I am not saying that the TD is gone. It has returned to its usual milder state.

 

20 minutes ago, Altostrata said:

Please make it easy for me: In a simple list form, what are the times o'clock you take each of your drugs, with their dosages? 

8 AM 

Lex - 0.13 lm/mg

Duloxetine - 60 mg

Clonazepam - 0.5 mg

probiotic

 

6 PM

Magnesium 1000 mg

Multi-V

Omegas 

9 PM 

Seroquel 25 mg

 

27 minutes ago, Altostrata said:

Quote

2016-2017 Effexor, Lamotrigine, Nortriptyline, Abilify, Cymbalta, Klonopin, Seroquel, Lexapro- slow taper 2016

 

Are those all unsuccessful short-term trials of Effexor, Lamotrigine, Nortriptyline, Abilify, Cymbalta, Klonopin, Seroquel, Lexapro? "slow taper 2016" What was it that you tapered? Do you mean 2017? 

 

Yes. When I was last here in 2016, I was experiencing horrific withdrawal from tapering 50% of the Lexapro. My doctor reinstated back to original dose which made it worse. We tried to add Wellbutrin again, and that was worse. That was when he prescribed the Lexapro in liquid so I could titrate off. I was still desperate and felt the only thing I could do was find a new medication, even if it meant kicking the can down the road and making things worse. I felt I could not let my world fall down around me and I had to survive. So, my doctor and I started trying to find something to take the edge off so I would survive. We didn't find anything that would help. I suffered from suicide ideation and would think of ending my life constantly. Not because I wanted to die, but because it was unbearable to be alive. The 2016 date is correct. I was hospitalized in November 2017, NOT 2018, as I wrote above- my apologies. All medications on the list above, except the Lexapro, were prescribed in hospital.

 

40 minutes ago, Altostrata said:

It looks like you've been on and off clonazepam for years. Why was clonazepam prescribed in 2018?

 

Was 25mg Seroquel prescribed for any particular reason? 

 

Yes, I was given a prescription for Clonazepam after having postpartum anxiety. About 3 months after that the psychiatrist added Zoloft and Clonazepam on an as needed basis, which I rarely needed. The, about 6 or 7 years into taking an antidepressants (1997ish), I started having squirrly feelings in my legs. My GP didn't find anything wrong. I noticed that I also felt agitated and that it happened mostly at night, and I would take a low dose to ease it and sleep. 

 

Seroquel was given in the hospital for panic attacks at night. When I got out of the hospital, I was a shell of my former self. I also had ECT which did nothing. My pdoc told me to keep taking everything, and I was in no place to challenge anyone about anything.

 

I hope this is clearer. Thank you, again.

[Altostrata]

Okay. Please keep daily notes of times o’clock you take your drugs, their dosages, and your symptoms throughout the day. We need to know how you feel before and after taking each drug, and your symptoms in between. Post 24 hours of notes at a time in this topic, in a simple list format with time o’clock on the left and notation (symptom or drug and dosage) on the right.

 

This can show if your symptoms are adverse effects from one of your drugs. With some small changes, such as changing the schedule for the clonazepam, you may be able to go off that last bit of Lexapro and start on Seroquel.

[Freeby60]

43 minutes ago, Altostrata said:

With some small changes, such as changing the schedule for the clonazepam, you may be able to go off that last bit of Lexapro and start on Seroquel.

Thank you 🙏🏻 I will keep diligent notes and look forward to next steps when we are are ready.

[Freeby60]

On 12/3/2021 at 6:29 PM, Altostrata said:

Please keep daily notes of times o’clock you take your drugs, their dosages, and your symptoms throughout the day. We need to know how you feel before and after taking each drug, and your symptoms in between. Post 24 hours of notes at a time in this topic, in a simple list format with time o’clock on the left and notation (symptom or drug and dosage) on the right.

12/3

7:45 pm lip sucking

9:00 pm Seroquel 25 mgs

10:00 pm jaw clenching, headache at jaw joint

10:30 pm sleep w/ slight headache at jaw joint

Slept 9 hours

12/4

9 am

Duloxetine 60 mgs

Clonazepam 0.5

Escitalopram .13 ml/mgs

Probiotic 

6 pm headache around eyes, tongue sucking

6:23 pm jaw clenching 

6:45 pm bit inside cheek

7pm omegas, magnesium chloride 1000mg, multi vitamin.

-tongue pushing around mouth while scrubbing pot - strong repetitive arm motions trigger this

9 pm 

Quetiapine Fumarate 25 mgs 

9:24 mild anxiety 

9:30 pm jaw clenching, slight tenderness in area

10 pm sleep - Slept 9 hours

[Altostrata]

4 hours ago, Freeby60 said:

Escitalopram .13 ml/mgs

 

How much escitalopram are you taking in milligrams? Please always give your dosage in milligrams, not milliliters.

 

Do the mouth and jaw symptoms always appear in the early evening?

 

You might get a bite guard to use at night, it could ease some of the pressure on your jaw.

[Freeby60]

3 hours ago, Altostrata said:

 

8 hours ago, Freeby60 said:

Escitalopram .13 ml/mgs

 

How much escitalopram are you taking in milligrams? Please always give your dosage in milligrams, not milliliters.

 

Lex 0.13 ml/0.13 mg - I’ll write it this way going forward.

 

3 hours ago, Altostrata said:

Do the mouth and jaw symptoms always appear in the early evening?

 

You might get a bite guard to use at night, it could ease some of the pressure on your jaw.

Honestly, I’m not sure. There are times when I come down from my office at the end of the work day and I notice that I chewed my cheeks up while I was working. I’m usually unaware of it until it hurts or is super active. I think I feel it mostly in the evening because I’m tired and hurting. I guess tracking will flesh that out. The guard is a good idea. Thank you. 

[Freeby60]

12/5

8:30 am - wake up w/ headache

9 am - Duloxetine 60 mgs, Clonazepam 0.5, Escitalopram .13 ml/13 mgs, Probiotic.

2 pm - headache, chills

3:30 pm - headache resolved after meditation 

9 pm - Quetiapine Fumarate 25 mgs

11 pm slept 9 hours

12/6

8:00 am - wake up with mild anxiety which passes

8:15 am - Duloxetine 60 mgs, Clonazepam 0.5, Escitalopram .13 ml/13 mgs, Probiotic

9:40 am mild teeth grinding, mild anxiety, both pass. 

2 pm tired, not focused, need to nap 2 hrs - could’ve been more 

5 pm - 7:30 pm mild teeth grinding

9 pm - Seroquel 25 mgs, continue mild teeth grinding, headache

10 pm - sleep 10 hours

[Altostrata]

4 hours ago, Freeby60 said:

8:15 am - Duloxetine 60 mgs, Clonazepam 0.5, Escitalopram .13 ml/13 mgs, Probiotic

 

It looks to me like this very dumb combination of drugs at 8:15 a.m. every morning causes problems some hours later. Since the escitalopram dose is so small, the other 2 are the more likely culprits.

 

How do you feel in the morning before you take this batch at 8:15? We need to know how you feel before and after taking your drugs. Please include this in your daily notes.

 

When did you last reduce escitalopram, from what dosage to what dosage, and what happened after that?

 

 

 

[Freeby60]

11 minutes ago, Altostrata said:

How do you feel in the morning before you take this batch at 8:15? We need to know how you feel before and after taking your drugs. Please include this in your daily notes.

I usually wake up feeling symptom-free, unless I've had a busy jaw and then I might feel a headache. After a cut of the escitalopram, I sometimes experience mild anxiety in the morning, but it usually resolves as I start moving around. I will include in daily notes.

 

15 minutes ago, Altostrata said:

When did you last reduce escitalopram, from what dosage to what dosage, and what happened after that?

 

My last reduction was 11/28 from .14 ml/.14 mgs to .13 ml/.13 mgs. Usually within a week I experience mild anxiety that is short lived, and emotional lability that comes and goes and doesn't usually interfere with my functioning. Symptoms used to last longer and be more troublesome but this was relieved when I added the magnesium.

[Altostrata]

Is your bruxism at its worst overnight?

[Freeby60]

3 minutes ago, Altostrata said:

Is your bruxism at its worst overnight?

 

Honestly, it's hard to tell because I am experience such a deep sleep. But that is my impression.

[Freeby60]

12/7

8 am - woke up no headache or anxiety

8:15 am - Duloxetine 60 mgs, Clonazepam 0.5, Escitalopram .13 ml/13 mgs, Probiotic. 

Throughout the day my tongue quivers and I am unaware of it. It is visible when I talk or when I put on lipstick I can see it in the mirror. The times I indicate tongue movements is when I notice it because it pushes against my mouth and teeth. I didn’t notice much tongue movements today or other symptoms.

5:30 pm - tongue movements while making dinner

9 pm - Seroquel 

9:40 pm - jaw feels tired, indigestion

10:30 pm - noticing tongue movements - sleep 9.5 hrs

 

[Altostrata]

@Freeby60 since you're taking 4 drugs, yours is a complex situation.

 

The Seroquel is the prime suspect for the tongue movements, which are not a good sign. I would prepare for tapering Seroquel. 

 

See Tips for tapering off quetiapine (Seroquel)

 

An initial test reduction of 10% is a way to see how tapering Seroquel will go. It's possible you might be able to get down to 12.5mg Seroquel without affecting your sleep. Then you can finish up the escitalopram taper.

 

Please continue to post daily notes. Please include the dosage with all your drugs.

 

 

[Freeby60]

Thank you, Alto! I’ll continue to post daily notes on symptoms, and read about tapering quetiapine.

[Freeby60]

12/8

7:40 am - wake up with mild anxiety which passes, mild jaw movements

8:15 am - Duloxetine 60 mgs, Clonazepam 0.5, Escitalopram .13 ml/13 mgs, Probiotic. 

10:30 am - jaw clenching, lip sucking

1 pm - light tongue movements against teeth

5 pm - tongue movements 

6:30 pm - omegas, magnesium chloride 1000mg, multi vitamin.

7:30 pm - tongue and jaw movements.

9 pm - Quetiapine fumarate 25 mgs

10 pm sleep 9 hours

[Altostrata]

How do you want to taper Seroquel? Your first reduction would be to 22.5mg.

[Freeby60]

2 hours ago, Altostrata said:

How do you want to taper Seroquel? Your first reduction would be to 22.5mg.

I was thinking I would make a suspension- assuming I understood what I read and that’s possible. I stopped Wellbutrin that way and it worked fine. 

[Altostrata]

Time to start tapering Seroquel. Please let us know how you're doing.

[Freeby60]

1 hour ago, Altostrata said:

Time to start tapering Seroquel. Please let us know how you're doing.

Wooo whooo! I will keep posting my symptoms. Thank you. 

[Freeby60]

7:20 am - woke up, no symptoms.

8 am - Duloxetine 60 mgs, Clonazepam 0.5, Escitalopram .13 ml/13 mgs, Probiotic. 

11:30 am - tired and decide to get back into bed. Sleep 3 hours - didn’t set alarm or expect to sleep that long (I attribute the periodic need to go back to bed during the day to being over medicated).

6:30 pm - omegas, magnesium chloride 1000 mgs

7:30 pm jaw clenching 

9 pm - Quetiapine fumarate 22.5 mgs 

9:40 pm - drowsy

10:10 pm - irritable - mild

10:30 pm - sleep 8 hrs. Woke during the night a few times (not usual). Fell back to sleep easily. 

[Freeby60]

Hi 👋 Thanks for all you do! Can someone please tell me how to update the tags on my intro to reflect current drugs?

[Altostrata]

Please don't worry about the tags.

[Freeby60]

1 hour ago, Altostrata said:

Please don't worry about the tags.

Okey dokey!

[Freeby60]

12/10

6:40 am- wake no symptoms.

7:45 am - Duloxetine 60 mgs, Clonazepam 0.5, Escitalopram .13 ml/13 mgs, Probiotic. 

11 am - tongue sucking 

1:30 pm - brain fog

5:30 pm - tongue movements. Spasm of upper soft palate in mouth twice.*** this is new. It started 12/9 BEFORE the Seroquel cut. I didn't realise what it was until it happened again today. 

6:30 pm - omegas, magnesium chloride 1000 mgs 

8:30 pm - spasms again inside roof of the mouth

9:40 pm - Quetiapine fumarate 22.5 mgs *hits faster than taking the tablet

10:30 pm- sleep 9 hours

[Freeby60]

2 hours ago, Freeby60 said:

5:30 pm - tongue movements. Spasm of upper soft palate in mouth twice.*** this is new. It started 12/9 BEFORE the Seroquel cut. I didn't realise what it was until it happened again today. 

This new symptom is disturbing me a lot. It's beginning to look like oromandibular dystonia to me. Is it worth it to get a diagnosis from a neurologist? 

[Freeby60]

12/11

7:30 am - wake, no symptoms but rapid tongue movements while making coffee

8 am - Duloxetine 60 mgs, Clonazepam 0.5, Escitalopram .13 ml/13 mgs, Probiotic. 

9:30 am - oral spasm 2x

12:30 pm - feel tongue against teeth roof of mouth and resting between teeth

5:45 pm - bit tongue on the side while eating - crooked jaw

6:30 pm - omegas, magnesium chloride 1000 mgs

7 pm - mild anxiety passes

8-10 pm - tongue rests between teeth pushing against roof of mouth but behind lips

11:30pm - sleep 9.5 hrs

[Altostrata]

Please be sure to include all drugs and dosage in your daily notes. How much Seroquel are you taking now?

[Freeby60]

1 hour ago, Altostrata said:

Please be sure to include all drugs and dosage in your daily notes. How much Seroquel are you taking now?

Oops! Still 22.5 mgs

[Freeby60]

12/12

7:30 am - wake, no symptoms but rapid tongue movements while making coffee

8 am - Duloxetine 60 mgs, Clonazepam 0.5, Escitalopram .13 ml/13 mgs, Probiotic

1:10 pm - roof of mouth spasms

6:30 pm - omegas, magnesium chloride 1000 mgs

7-11 pm - head and jaw ache, eyes sensitive to light

11 pm - Quetiapine fumarate 22.5 mgs* 

12 am - sleep 9 hours

* I try to take meds at the same time each night, but we were out until late.

[Freeby60]

12/13

8:45 am - wake with mild anxiety that passes

9 am - Duloxetine 60 mgs, Clonazepam 0.5, Escitalopram .13 ml/13 mgs, Probiotic

12:30 pm - anxiety, not mild. Hit hard - did some deep breathing/ mindfulness and it passed.

6:30 pm - omegas, magnesium chloride 1000 mgs

7-10 pm - Jaw clenching, soreness

9:30 pm- Quetiapine fumarate 22.5 mgs *hits faster than taking the tablet

10:30 pm - slept 9 hours