Jump to content
westcoast

Grubb, 2001 Syncope due to autonomic insufficiency syndromes associated with orthostatic intolerance.

Recommended Posts

westcoast

Rom J Intern Med. 2000-2001;38-39:3-19.

Syncope due to autonomic insufficiency syndromes associated with orthostatic intolerance.

Grubb B1, Dan GA.

 

Abstract (only) at http://www.ncbi.nlm.nih.gov/pubmed/15529568

Recurrent syncope may be either a sign or a symptom and may occur due to a wide variety of very different causes. Extensive investigations into the nature of this disorder soon uncovered that it represents only one aspect of a broad, heterogenous group of disturbances of the autonomic nervous system (ANS) that can result in hypotension, orthostatic intolerance, and often syncope.

 

Disorders of orthostatic regulation may be subgrouped into both primary and secondary forms. In primary autonomic failure syndromes, as opposed to the intermittent periods of hypotension seen in the reflex syncopes, patients could develop orthostatic intolerance due to a failure of the ANS to function under normal circumstances. Chronic autonomic insufficiency has two entities: Pure Autonomic Failure (PAF) and Multiple System Atrophy (MSA).

 

Over the last several years, it has become apparent that a milder form of autonomic insufficiency occurs that is now referred to as the Postural Orthostatic Tachycardia Syndrome (POTS). The secondary forms of autonomic failure occur in association with a particular disease process. One of the most important things to remember are the vast number of pharmacologic agents that may either cause or worsen orthostatic hypotension. The principal feature that all of these conditions share is that normal cardiovascular regulation is disturbed resulting in postural hypotension.

 

The comerstone of evaluation is a detailed history and physical examination. One of the physician's most important tasks is to identify whether hypotensive syncope is primary or secondary in nature, and to determine if there are any potentially reversible causes (i.e., drugs, anemia, volume depletion). It is equally important to educate the patient. Nonpharmacologic therapies are useful. Pharmacotherapy should be used cautiously in selected cases.

 

"One of the most important things to remember are the vast number of pharmacologic agents that may either cause or worsen orthostatic hypotension" is what caught my eye.

 

This was also refreshing: "One of the physician's most important tasks is to identify whether hypotensive syncope is primary or secondary in nature, and to determine if there are any potentially reversible causes (i.e., drugs, anemia, volume depletion). It is equally important to educate the patient. Nonpharmacologic therapies are useful. Pharmacotherapy should be used cautiously in selected cases."

 

Finally, I wonder if "autonomic insufficiency syndromes" relates to autonomic dysfunction and AD use. Here's something that ties the latter two together, with a focus on SNRIs. Sorry I don't have time to post it properly right now. Feel free to if you find it interesting and we don't already have it.

 

Autonomy of autonomic dysfunction in major depression.

Koschke M1, Boettger MK, Schulz S, Berger S, Terhaar J, Voss A, Yeragani VK, Bär KJ.

http://www.ncbi.nlm.nih.gov/pubmed/19779146
 

 

Share this post


Link to post
Share on other sites
Altostrata

Thanks for posting an interesting paper in the Journals format.

Share this post


Link to post
Share on other sites
Barbarannamated

I've had a few episodes of post-micturition syncope (after urinating) in the last 2 months after a year of extreme stress, more weight loss, very low blood pressure.  Prior to this, I've tended toward vasovagal and diaphoretic reactions (since a teen) and dysautonomia since Pristiq sloppy taper in 2011. Usually POTS-like, but have gone in all directions. A few times this happened after eating a banana, so I'm GUESSING that potassium may involved.  

 

A doctor did one cortisol blood level in the afternoon and dx Addison's... again. RXd fludrocortisone which triggered the cortisol awakening response badly...again. Potassium levels were in range.

 

Will I ever learn to not mess with the adrenals?  

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

×

Important Information

By using this site, you agree to our Terms of Use.