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Scientists Recreate Beating Heart, Functional Liver With Microchips In Hopes Of Improving Drug Testing

Mar 7, 2016 12:44 PM By Samantha Olson
 
 
 A research team from the University of Toronto have designed a “person-on-a-chip”— a 3D microchip lined with human cells that mimics the complex organ systems within the body. The study, published in Nature Materials, gives scientists new opportunities to grow human cells outside the body and test for potentially dangerous drug side effects.
 
What sets the AngioChip apart from other synthetic organs is that it can be built to include multiple organs on one chip. The researchers did this with liver cells, which they found could then produce urea, the main compound in urine, as well as metabolize drugs. When this chip was connected to the heart chip, the researchers could watch not only how certain drugs affect each organ but also how they affect both organs at the same time.

"In the last few years, it has become possible to order cultures of human cells for testing, but they're grown on a plate, a two-dimensional environment," Radisic said. "They don't capture all the functional hallmarks of a real heart muscle, for example.”

The AngioChip has the potential to change the way humans test drugs by creating realistic models at a fraction of the cost. On average, it takes roughly $5 billion to develop a drug, and 60 percent of those funds go to research and development of live organ tissue testing. Microchip models would eliminate this expensive approach, and cut the time it takes to bring a new drug to the market. The microchips would also reduce the need for animal testing, which is used to determine any drug side effects.

”It really is multifunctional, and solves many problems in the tissue engineering space,” Radisic said. “It’s truly next-generation.”

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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IF this were taken up by pharma or if they don't want to use it even if the hosp would use it or docs sponsored by gov't we could spare people so much damage there is hope for the future ...IF somebody pushes enough to develop this.

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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