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Serdaxin


ajay
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http://pharmalive.com/News/index.cfm?articleid=811952

 

Serdaxin is a new AD in clinical trials. It messes with neurotransmitters in a different way - I believe the mechanism enhances release of Seratonin and dopamine, rather than inhibit their re-uptake. In an 8 week Phase IIb trial, two levels of Serdaxin doseage were not shown to be more effective than a placebo.

 

Dr. Michael Thase, Chairman of the Depression Scientific Advisory Board of Rexahn, stated, “The results of this Phase II trial should be viewed within the historical context of depression clinical trials. The history of drug development in depression has one dominant theme - a notoriously high placebo effect. Six of the blockbuster antidepressant drugs approved between 1987 and 1999 had altogether undergone forty-two clinical trials, many of which were negative. With only one larger clinical trial completed, it may be premature to discount Serdaxin's potential clinical value.”

 

sigh.

 

I believe a separate trial as a treatment for Parkinson's is in progress.

History is approximate; I didn't track my dosages.

 

1995 - started zoloft/sertraline for depression

1995-2008 - sertraline ranged from 100-200mg, may have gone as high as 250mg

2006 - 2009 - added welbutrin/budeprion SR, 150 mg

sometime in 2009-2010 - stopped budeprion c/t

sometime around 2009-2010, Tapered down sertraline w/o guidance to 50 mg, then 25mg.

~ feb 2010, stopped sertraline.

~ Apr 2010, resumed 25mg low dose (really bad business trip)

Oct 2010, stopped sertraline

Jan 2011 - another bad business trip "breaks" my sleep.

 

current issues include insomnia, anxiety, GI distress, depression.

Taking multivitamins, Vitamin D, fish oil, Chinese herbs, ~ 0.5mg melatonin in the evening.

Going to therapy and acupuncture once a week.

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I believe they're bombing out on antidepressant trials all the time.

 

Agonists, which increase production of something, tend to cause dependency.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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In an 8 week Phase IIb trial, two levels of Serdaxin doseage were not shown to be more effective than a placebo.

I believe they're bombing out on antidepressant trials all the time.

LOLz and has this ever been a problem for Pharma? Or PSYCHIATRY?

Been on SSRIs since 1998:

1998-2005: Paxil in varying doses

2005-present: Lexapro.

2006-early '08: Effexor AND Lexapro! Good thing I got off the Effexor rather quickly (within a year).

 

**PSYCHIATRY: TAKE YOUR CHEMICAL IMBALANCE AND CHOKE ON IT!

APA=FUBAR

FDA=SNAFU

NIMH=LMFAO

 

Currently tapering Lexapro ~10% every month:

 

STARTING: 15 mg

11/7/10: 13.5 mg

12/7/10: 12.2 mg

1/6/11: 10.9 mg

2/3/11: 9.8 mg

3/3/11: 8.8 mg

4/1/11: 7.8 mg

4/29/11: 7 mg

5/27/11: 6.4 mg

6/24/11: 5.7 mg

7/22/11: 5 mg

8/18/11: 4.5 mg

9/14/11: 4 mg

10/13/11: 3.6 mg

11/9/11: 3.2 mg

12/7/11: 2.6 mg

1/3/12: 2.1 mg

2/2/12: 1.8 mg

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