anytriptaline Posted July 23, 2019 Share Posted July 23, 2019 I'm about to start a slow tapering from amitriptyline after over a decade of use for sleep issues However, the side effects are making being productive virtually impossible, I'm beyond sedated at the moment and I need to be able to hold a full time job and drive a car A doctor I visited claimed all of my issues (and benefits) probably arise from the anticholinergic side effects I've been researching about Bethanechol, a cholinergic agonist that is sometimes used with geriatric patients taking tricyclics . Does anyone have any experience or knowledge about such a combination? Could it cause more harm than good? 2007-2018 25mg-50mg Amitriptyline, 4mg Perphenazine, 500mg Valproic Acid Nov 2018-February 2019 quetiapine, mirtazapine, pregabaline, estazolam, agomelatine, levomepromazine, trazodone, sulpiride March 2019 - 37.5mg Amitriptyline, 4mg Perphenazine, waiting to tapper off slowly February 2023 - Finished taper Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted July 23, 2019 Administrator Share Posted July 23, 2019 Read this: After decades of experience with SSRI withdrawal, it is now quite clear that "cholinergic rebound" does not explain all antidepressant withdrawal symptoms, not even in TCAs. If withdrawal syndrome from TCAs was not solved with cholinergic agonists 30 years ago, they're not the solution now. As a peer support group, we are not in a position to advise on new drug prescriptions. If you would like to experiment with Bethanechol or other cholinergic agonist, please let us know what happens. See https://www.drugs.com/pro/bethanechol.html This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
anytriptaline Posted July 23, 2019 Author Share Posted July 23, 2019 Yeah, but my problems at the moment have nothing to do with withdrawal, it's more like, the meds are working too damn good, they not only make me sleep at night, they keep me asleep all day! I'll talk with my doctor next week, if I hop into them I'll report about it 2007-2018 25mg-50mg Amitriptyline, 4mg Perphenazine, 500mg Valproic Acid Nov 2018-February 2019 quetiapine, mirtazapine, pregabaline, estazolam, agomelatine, levomepromazine, trazodone, sulpiride March 2019 - 37.5mg Amitriptyline, 4mg Perphenazine, waiting to tapper off slowly February 2023 - Finished taper Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted July 23, 2019 Administrator Share Posted July 23, 2019 Please put questions about your personal situation in your Intro topic, we need the context there to answer them. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
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