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Radar: Trintellix / formerly Brintellix / vortioxetine withdrawal


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I’ve been on Trentellix  for almost one month starting at 5 mg and increasing after two weeks to 10 mg.  I’ve been on the 10 mg for one week. The most severe side effects are these increasing headaches and insomnia. The headache started with the 5 mg and continued with the 10 mg and having insomnia with the headaches. My psychiatrist said to just stop taking the Trentellix  all together. I hate to doubt him but I had been on Cymbalta for 6 weeks and it took me two years to get off of it. I am hoping for help from this group.


Edited by ChessieCat
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  • ChessieCat changed the title to Radar: Trintellix / formerly Brintellix / vortioxetine withdrawal

Welcome @Radar

I'm sorry you are struggling, but glad you have found us. To help us better advise you, can you please create a signature with all of the drugs that you are taking and have been taking in the last couple of years. It's important that we know the date you quit Cymbalta, the date you started Trantellix 5mg, the date you started Trantellix 10mg.

How to List Drug History in Signature


Why were you prescribed Trentellix?


When we have a few more details, we will be in a better position to offer support and suggestions.

These are my opinions based on my own experience and what I have learned, not medical advice.


Drug history

2002-2019 Citalopram/Escitalopram, Lamictal
2019 April Escitalopram, quit at 10mg (withdrawal), Oct Escitalopram 10mg reinstated, quit after a few days (adverse reaction)

2019 Oct Lamictal cut from 200mg to 100mg
2019 Dec Lithium 83x2 mg

2020 Aug-Nov Lamictal tapered to 50 mg

2020 Nov 24 Lithium taper started, 30 Jan off Lithium

2021 15. March-31. May Lamictal tapered to 32.5 mg (holding)

2022 10. Jan started taking 25mg+5mg+2mg+0.5 liquid, 22. Jan went back to taking 25mg+5mg+half 5mg

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