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Simon47: Lost and feeling out of hope


Simon47

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im 47. Since 1992 I’ve been on all the so called anti depressants at some point . Amitriptline in 92 after a major car accident , for 4 years , then duloxetine for a couple of years , then citalopram switched to eicitalopram , then to fluoxetine , then to Effexor ( which actually was only one that helped apart from gave me non alcoholic fatty liver ) then switched to sertraline for 2 years , then next was venlafaxine 75 mg generic , then dr switched me about very quickly to roboxetine , which had me climbing the walls for 3 weeks , then at end of 2019 swapped me straight from robixetine to mirtazpine 30 mg along side venlafaxine 37.5mg .

 

By. Early 2020, I felt like someone had put my brain to sleep . Did not have the get up and go mentally to do anything really . No interest in me life wife kids , just flat . Knew this had to be the mirtazpine . Dr said cut it in half , so 15mg for a week then stop . I said no , and dropped from 30 to 22.5mg . Felt very low for three months . But seemed to settle . But still felt mentally screwed . No Drive no excitement no anger no anything . I stayed put for rest of 2020.in 2021, I had to close my new business as I didn’t have it in me to run it . Bookkeeping . I then declared myself bankrupt .


In June 2021,my mother passed away sadly . I had been caring for her when I could for 4 years . I hit a massive void . I have been out of work so I could be there to help her when needed . I was 3 weeks in to a too large reduction (33%) of my 37.5 venlalic when she passed away . I ended up in A and E convinced that I was dying .

 

Drs increased venlafaxine to 75mg Effexor . I didn’t want it but I needed some immediate help . And it did. A bit . I began to taper slowly in august from mirt by 10%  or less . I was on 22.5mg in august , I am now on 18.5mg . My last reduction of only .5mg ( 2.5%) two weeks ago.

 

I have severe joint and muscle and tendon aches and cramps . I seem to have become intolerant to histamine ( if I eat a banana in am , 4 hours later I feel like I’m going to pass out ) but this only happens in morning . 


is this really all possible ? The pains in my joints are if I am100 years old . I’m 47 . And this has all come about since reducing mirtazpine ? Why is this at such small reductions ? How please can I get round this ?? I have crohnes disease and had a bowel resection 20 years ago . This has now flared up , no doubt due to the histamine and stress issues ? I can’t touch cod liver oil or vitamins as it makes me feel hot and anxious ?? What can I do ? No one is listening at the Drs or anywhere ?

 

To add , since June ( at that point I was on 37.5mg venlalic and 22.5mg mirtazpine)

 

I changed from tablet venlalic 37.5 to venlablue capsule in June with three tablets inside , and then tried to reduce this by 1 of the tablets , ( so, 33% for 3 weeks ) failed, so put back to tablet venlalic at 37.5mg.

 

I was also diagnosed adhd 8 months ago . In July , they started me on various stimulants , elvanse 30mg for a week then 50mg for a week. I stopped as didn’t like how I felt . So they put me on dexamphetamin 5mg twice a day , and told me to start to also take the venlalic in eve with mirtazpine , so I switched the venlalic to eve straight away . Went through 2 weeks of feeling proper rough . Stopped the adhd meds as too anxious . Mid July  So then I am back to the 37.5 Venlalic in a.m. 22.5mg mirt in eve .

 
started to slowly reduce mirt 22.5 to 20mg. 

Got real bad due to grief and all, Drs upped venlafaxine to 75mg Effexor capsule in around September .

 

since then done 2 more small mirt cuts so now on 18.5mirt and 75mg Effexor .

 

im hurting . I’m aching everywhere . I can’t eat certain foods with histamine .

 

have I gone wrong ? 

 

Edited by ChessieCat
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  • ChessieCat changed the title to Simon47: Lost and feeling out of hope
  • Moderator

Welcome @Simon47

I am sorry you are going through this and are suffering, but relieved you have found us. This forum is run by others like you who have been through and survived, or are surviving, the negative effects of psychiatric drugs. Hang in there.

 

Personally, I would disregard the ADHD diagnosis. Going on and off psychiatric drugs can cause symptoms that are interpreted as disorders, but are in fact effects of the drugs.

 

What is withdrawal syndrome?

Dr. Joseph Glenmullen's withdrawal symptom checklist

 

As these threads show you are not alone in your symptoms:

Overwhelmed, demotivated, apathetic? Cannot get going on interest or action

Tension, pain, twitches, excruciating spasms in muscles and joints

 

Since your symptoms have gotten worse after you reduced Mirtazapine, I recommend not reducing any further until you are feeling better.

Keep it simple, slow and stable

 

Once you are stable you can considering tapering more following these guidelines:

Why taper by 10% of my dosage?

Why taper? Importance of gradual change in plasma concentration  (This explains why you are struggling with small reductions.)

Taking multiple psych drugs? Which drug to taper first?

Tips for tapering off mirtazapine (Remeron)

Tips for tapering off venlafaxine (Effexor)

About going off mirtazapine plus venlafaxine (Effexor) aka "California rocket fuel"

 

What date did you start taking 18.5mg

Mirtazapine? What dose where you on before that and for how long?

 

To give members the best information, we ask them to summarize their drug history in a signature. Please make it clear what dates you have been reducing Mirtazapine, the doses, what other drugs you are currently taking, as well as what drugs you have taken and the date you quit them the past two years.

How to List Drug History in Signature

This is your Introductory topic, where you can ask questions and connect with other members.  We're glad you found your way here.

Please stay in touch and let us know how you are doing.

These are my opinions based on my own experience and what I have learned, not medical advice.

 

Drug history

2002-2019 Citalopram/Escitalopram, Lamictal
2019 April Escitalopram, quit at 10mg (withdrawal), Oct Escitalopram 10mg reinstated, quit after a few days (adverse reaction)

2019 Oct Lamictal cut from 200mg to 100mg
2019 Dec Lithium 83x2 mg

2020 Aug-Nov Lamictal tapered to 50 mg

2020 Nov 24 Lithium taper started, 30 Jan off Lithium

2021 15. March-31. May Lamictal tapered to 32.5 mg (holding)

2022 10. Jan started taking 25mg+5mg+2mg+0.5 liquid, 22. Jan went back to taking 25mg+5mg+half 5mg

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  • 8 months later...

Tolerance withdrawals or mixed side effects

 

Anyone help ? 48 years old . Crohn’s disease . Half bowel removed 25 years ago . On off antidepressants since 1992 . Recently diagnosed adhd and ASD .

 

most current medication since 2020 mirtazpine and Effexor xl.

 

in Jan 2020 dr added 30mg mirtazpine to 37.5mg venlafaxine .

 

after couple months , could feel the mirtazpine was no good for me , so dropped from 30mg to 22.5mg in one go . Because suicidal . So dropped no more ( despite dr saying I could just quit it ). During next year I lost mum and business . In July 2021 I began cutting the mirtazpine pill by 10% each month , but it was hit and miss as scales not so accurate . During this time , I seem to then develop histamine intolerance and extreme anxiety especially in morning . Then weirdly , every morning when i took mu 37.5mg venlafaxine , 4 hours later , I started to get very thick headed and dizzy , this lasts for about 1 hour . Every day . It’s quite scary . After much back and forth with useless Drs and mental health people , they suggested as things were hard for me , to up their venlafaxine to 75mg Effexor xl. After a week or so , the issue in the morning where I felt faint etc 4 hours after taking , went away . 


min January of this year , I continued the withdrawal very slowly of mirtazapine, and it’s very painful and makes me so so anxious and panicky and raising thoughts , all negative . In may of 2022 dr agreed to give me the liquid mirtazpine . I’m currently down to 13.5mg mirtazapine . Over last month though , the issue where after I’ve taken Effexor xl, 4 hours later my head becomes very thick and spaced out has returned . No one seems to know why , but it is scary . It’s like each day , I’ve taken the first Effexor again and it hits my head hard .

 

ivr had brain scans , other scans , all bloods , was picked up having low 11am cortisol , but on future tests it is fine . I’m at my wits end and feel something is wrong . Someone has mentioned tolerance withdrawals , I don’t know Much about that . I do know the mirtazapine has given me many issues with foods that effect me , and histamine issues , can’t really eats sugar bread yeast products processed foods , as all make me feel spun Out . Could the Effexor be causing histamine problems ?! Anyone any ideas please . I no longer can take any supplements as all make my head very thick and dizzy . Help .

 

Edited by ChessieCat
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  • Moderator Emeritus
On 11/12/2021 at 8:21 AM, Kiasofia said:

To give members the best information, we ask them to summarize their drug history in a signature. Please make it clear what dates you have been reducing Mirtazapine, the doses, what other drugs you are currently taking, as well as what drugs you have taken and the date you quit them the past two years.

How to List Drug History in Signature

 

As requested previously (above), please create your drug signature.

 

 

 VIDEO:   Antidepressant Withdrawal Syndrome and its Management

 

MISSION ACCOMPLISHED:    (6 year taper)      0mg Pristiq      on 13th November 2021

Woohoo!!!  Finally off Pristiq    Post 0 updates start here

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering from Oct 2015 - 13 Nov 2021   LAST DOSE 0.0025mg

My full tapering program     My Intro (goes to my tapering graph)    My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.  Please DO NOT TAG me - thank you.

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  • Administrator

Hello, @Simon47

 

Please stop any drug changes at this point, until your symptom pattern is sorted out. 

 

On 8/6/2022 at 5:03 AM, Simon47 said:

In may of 2022 dr agreed to give me the liquid mirtazpine . I’m currently down to 13.5mg mirtazapine . Over last month though , the issue where after I’ve taken Effexor xl, 4 hours later my head becomes very thick and spaced out has returned .

 

Have you accidentally forgotten to take Effexor, or changed your dosing schedule of your drugs, in the last several months?

 

Are you taking any other drugs? What times o'clock do you take your drugs, with their dosages? Please put ALL your drugs in this Interactions Checker and post the report or a link to it in this topic.

 

As @ChessieCat requested, Please summarize your drug and withdrawal history in your signature You may need to use a computer to do this.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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