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Tips for tapering off trazodone (Desyrel)


Altostrata
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34 minutes ago, ChessieCat said:

 

I went to the Success Stories and typed trazadone in the search bar and clicked on Forum.  This is the link:

 

https://www.survivingantidepressants.org/search/?q=trazadone&type=forums_topic&nodes=28

 

Thank you.  I didn't think to try searching for that misspelling of 'Trazodone'.  Unfortunately the search results from your link are uninspiring—not a single success story as far as I can tell.  😞

 

  • 2019-01-16 50 mg of Trazodone 2x/week
  • 01-23 up to 100 mg, various frequencies and dosages
  • 05-03 100 mg
  • 05-10 90 mg
  • 05-16 Starting tapering by 2.5 mg/day
  • 05-30 50 mg
  • 05-31 65 mg
  • 06-07 75 mg
  • 06-15 67.5 mg
  • 06-17 75 mg
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  • Moderator Emeritus

You could try searching for trazadone (try both spellings 😉) in the main Introduction forum and look for members who have a sun symbol ☼

 VIDEO:   Antidepressant Withdrawal Syndrome and its Management

 

MISSION ACCOMPLISHED:    (6 year taper)      0mg Pristiq      on 13th November 2021

Woohoo!!!  Finally off Pristiq    Post 0 updates start here

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering from Oct 2015 - 13 Nov 2021   LAST DOSE 0.0025mg

My full tapering program     My Intro (goes to my tapering graph)    My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.  Please DO NOT TAG me - thank you.

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Thanks for that tip!  After 20 minutes of searching I found two:

 

☼-sharkface-enduring-a-long-taper-hang-in-there

 

and

 

On 3/1/2016 at 11:01 AM, marie123 said:

Hi Sharkface,

 

I got off Trazadone 2 months ago with a nice slow taper of 11 months. I'm glad to rid of it.

 

Marie

 

marie123's Introduction topic

 

 

Edited by ChessieCat
fixed up links and added marie's intro topic link
  • 2019-01-16 50 mg of Trazodone 2x/week
  • 01-23 up to 100 mg, various frequencies and dosages
  • 05-03 100 mg
  • 05-10 90 mg
  • 05-16 Starting tapering by 2.5 mg/day
  • 05-30 50 mg
  • 05-31 65 mg
  • 06-07 75 mg
  • 06-15 67.5 mg
  • 06-17 75 mg
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Has anyone figured out what the SERT transporter occupancy relationship is for Trazodone?  I've become curious after reading the table for Citalopram in the Horowitz paper.

 

  • 2019-01-16 50 mg of Trazodone 2x/week
  • 01-23 up to 100 mg, various frequencies and dosages
  • 05-03 100 mg
  • 05-10 90 mg
  • 05-16 Starting tapering by 2.5 mg/day
  • 05-30 50 mg
  • 05-31 65 mg
  • 06-07 75 mg
  • 06-15 67.5 mg
  • 06-17 75 mg
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  • Moderator

There is a lot more to trazodone than just SERT loading, but the following paper talks a lot about it around page 26.

 

https://kclpure.kcl.ac.uk/portal/files/92011077/Evaluating_the_dose_dependent_SETTIMO_Published15January2018_GREEN_AAM.pdf

20 years on Paxil starting at 20mg and working up to 40mg. Sept 2011 started 10% every 6 weeks taper (2.5% every week for 4 weeks then hold for 2 additional weeks), currently at 7.9mg. Oct 2011 CTed 15oz vodka a night, to only drinking 2 beers most nights, totally sober Feb 2013.

Since I wrote this I have continued to decrease my dose by 10% every 6 weeks (2.5% every week for 4 weeks and then hold for an additional 2 weeks). I added in an extra 6 week hold when I hit 10mg to let things settle out even more. When I hit 3mgpw it became hard to split the drop into 4 parts so I switched to dropping 1mgpw (pill weight) every week for 3 weeks and then holding for another 3 weeks.  The 3 + 3 schedule turned out to be too harsh so I cut back to dropping 1mgpw every 4 weeks which is working better.

Final Dose 0.016mg.     Current dose 0.000mg 04-15-2017

 

"It's also important not to become angry, no matter how difficult life is, because you can loose all hope if you can't laugh at yourself and at life in general."  Stephen Hawking

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The Horowitz SERT occupancy theory can be taken as a metaphor for all psychopharmacological relationships being hyperbolic; the techique of exponential reduction is likely to apply to any target no matter what it is.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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On 6/15/2019 at 3:44 PM, brassmonkey said:

There is a lot more to trazodone than just SERT loading, but the following paper talks a lot about it around page 26.

 

https://kclpure.kcl.ac.uk/portal/files/92011077/Evaluating_the_dose_dependent_SETTIMO_Published15January2018_GREEN_AAM.pdf

 

Thank you!

 

  • 2019-01-16 50 mg of Trazodone 2x/week
  • 01-23 up to 100 mg, various frequencies and dosages
  • 05-03 100 mg
  • 05-10 90 mg
  • 05-16 Starting tapering by 2.5 mg/day
  • 05-30 50 mg
  • 05-31 65 mg
  • 06-07 75 mg
  • 06-15 67.5 mg
  • 06-17 75 mg
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  • 2 weeks later...

So this is why I experienced some severe muscle symptoms during my last benzo tapering procedure even after I had jumped benzo! I reported to different doctors about this life-threatening event and they said “Don’t worry, it’s just because you are too anxious “🙄

 

On 7/20/2012 at 12:40 PM, Altostrata said:

Unnecessary polypharmacy
If your doctor has given you a benzo to help with adverse effects caused by trazodone, mCPP, or drug interactions, you are taking two medications to counter the adverse effects of another drug: Trazodone to counter insomnia from the antidepressant and a benzo to counter the effects of trazodone.

 

Edited by ChessieCat
removed blasphemy

Xanax 0.4mg on and off only for bedtime occasionally from 2015

2019.6 Xanax Inter-dose withdraw after 8 weeks continuous usage 

2019.6.3 100mg Zoloft

2019.6.27 CT 0.4mg Xanax cross over to 7.14mg Valium 75mg Trazodone

2019.8.29 Jumped Valium at 0.5mg

2019.12.15 Jumped Zoloft at 4mg

2020.1.4 Jumped Trazodone at 5mg

2020.6.1 95% healed with no symptoms and sleep very well

2021.4.6 Reinstated 1mg Zoloft and 10mg x3 Tandospirone for anxiety setback from antibiotics 2021.4.25 0.5mg Zoloft and 10mg x3 Tandospirone 2021.5.7 Jumped Zoloft at 0.25mg as adverse effects 2021.6.2Tapered and jumped Tandospirone as mild serotonin syndrome Couldn’t take Seremind (Lavender oil) neither it could also cause the serotonin syndrome 2021.6.13 1mg Cyproheptadine before bed and got better and better 2021.8.13 Bad wave don’t know if triggered by chocolate ice cream

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  • 3 months later...

Trazodone is only available as a capsule in the UK. It was easy to empty the capsule into water and pull it up with an oral syringe. The fact it is sparingly soluble means it has to be shaken before you take it and also stirred before you draw it up for the first time after emptying the cap. This avoids issues like crushing tablets and losing 10% of it or more to waste.

Dx: complex PTSD

Discontinuation/taper history: sertraline, trazodone, prazosin, mirtazapine, diazepam

Took 200mg quetiapine for 0.5 years and 150mg for 1.5 years until 01/2020. Now microtapering daily at an overall rate of 12.5mg/month.

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  • Administrator

Thanks, @lxjuice , for that useful information.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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17 hours ago, lxjuice said:

Trazodone is only available as a capsule in the UK. It was easy to empty the capsule into water and pull it up with an oral syringe. The fact it is sparingly soluble means it has to be shaken before you take it and also stirred before you draw it up for the first time after emptying the cap. This avoids issues like crushing tablets and losing 10% of it or more to waste.

Thanks @lxjuice

 

I've got lots and lots of 100 mg tablets since I've never taken more than half the prescribed amount. Even using a slow taper I'm going to have tabs leftover so ... but thanks.

 

I'll probably just take the dry powder and wash it down with water rather than make a suspension unless there's a reason I shouldn't do it that way.  These are immediate release tabs so no coatings.  

1994  Venlafaxine XR 300mg, 2003 tapered, 2004 off briefly back to 37.5 then 75mg, held, June 2019 up to  150mg, Aug.12 tapered down to 112.5mgs, Oct. 21, 2019 96mg;  Dec. 8, 2019  90mg, Jan. 8 2020 81mg, Feb. 4, 75mg;

2003/2004? Diazepam 10mg/bedtime

2013 Lyrica 300mg to 25mg; April 6, 2020 17mg; April 28, <5mg; May 7, 2020 Lyrica 0 mg!

2013 Tramadol 50mg tablets, 200mg/day divided

2005? Trazodone 50mg bedtime, Feb. 12, 2020 40mg, March 7, 25mg; Oct 1 20mg

2009? Zolpidem 5mg at bedtime. Nov. 9, 2019 Zolpidem 0 mg! 

1990? Omeprazole 20mg in morning.

2010? Levothyroxine 75mcg morning

2011? Liothyronine 5mcg morning

1999? Buspirone 30mg twice a day  August 2019 15mg once a day,  Oct.21, 2019 2.5mg evening  Oct. 25, 2019 Buspirone 0 mg!

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