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N-acetylcysteine (NAC)


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@TheWayBack I understand NAC helped you in some ways. But did it help your akathisia?

[2013 - 2017] >10 meds and combos (some breaks without meds; last in May-Sep 2016)

[2017] Mar 22 - venlafaxine 150; initially with mianserine 20 which I stopped around June due to serious stomachaches and bloating; 1 month of break in Aug when: duloxetine 60 + esketamine clinical trial)
Sep 05 - venlafaxine 150 + bupropion 150
Oct 11 - tapering off venlafaxine while still on bupro 150; Oct 21 - venla 37,5
Nov 06 - venla 37,5 + bupro 150 + >START buspirone 30>
Nov 20 - venla 12,5 + bupro 150 + buspirone 30;   Nov 29 - [STOP venla]
Dec 01 - [tried to STOP buspi cold turkey] / Dec 03 - HELL unleashed;   Dec 10 - buspi 10;   Dec 17 - buspi 20 (+ still bupro 150); Jan 02 [STOP] bupro;
[2018] Mar 17 - >START quetiapine 50 SR> for tension, restlessness and attacks of fury (buspirone persisting w/d symptom)

Apr 24 - FINALLY STOPPED buspirone (5-month taper; worst in my life) - w/d symptoms continue... Jun 02 - STOP quetiapine
Now taking: mirtazapine 7,5 mg (helps to fall asleep quickly, doesn't help for waking at dawn; didn't tolerate higher doses); for restlessness / akathisia: taurine; antihistamines (small amounts cause still can cause headache and dry mouth even at 12,5 mg of hydroxyzine or promethazine); melatonin 1 mg; omega-3 (330 EPA, 220 DHA); Mg.

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I thought I should let people know that NAC has been only the thing that has made my severe case of SSRI neurotoxity (I follow Shipko in calling it this rather than withdrawal, for reasons that also h

puthappinessfirst

Any other updates on this supplement? Love to give it a go, maybe. 

Celexa 10mg: 2007 to June 2018, stopped CT

No meds: June 2018 to December 2018

PROTRACTED WD-- major depressive episode for 2+ weeks

Lexapro 10mg: December 12, 2018 to January 19, 2019, severe adverse reaction

Celexa 10mg: January 20, 2019

June 24, 2019: 9mg

July 22, 2019: 8.5mg

Jan 8, 2020: 8mg

Aug 25, 2020: 7.2mg

 

Supplements: Magnesium, Fish Oil

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Give it as much go as you like. Say goodbye to the person you know, once you take it.

 

Pray when you try get off of it as well. 

 Cymbalta, Zyprexa, Seroquil, Rispiridone, Valium, Zoloft, Clonazepam,. + 1 other Benzo. Total 11 yrs.

·           April 9th 2018 Hospital. 50mg Zoloft > 0 discontinued. 6mg Clonazepam > 2.5mg over 8 weeks stay.

           October 25th 2019: Hospital:  Clonazepam Bridged 1mg > to 20mg Diazepam.

           

           Anafranil: 90mg

      
  Diazepam (V): 25th October 2019, 20mg. 22 Dec 2019 19mg. 4 April 20: 18mg,  30 September: 17.5mg , 13 November 20: 17mg 01 January 2021: 16mg,

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puthappinessfirst
50 minutes ago, Ryder said:

Give it as much go as you like. Say goodbye to the person you know, once you take it.

 

Pray when you try get off of it as well. 

 

It obviously made you worse, huh?

Celexa 10mg: 2007 to June 2018, stopped CT

No meds: June 2018 to December 2018

PROTRACTED WD-- major depressive episode for 2+ weeks

Lexapro 10mg: December 12, 2018 to January 19, 2019, severe adverse reaction

Celexa 10mg: January 20, 2019

June 24, 2019: 9mg

July 22, 2019: 8.5mg

Jan 8, 2020: 8mg

Aug 25, 2020: 7.2mg

 

Supplements: Magnesium, Fish Oil

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Yes and I reported the doctor for prescribing it. Once I was on it, I started buying other supplements to get off it. 

 

Why would you try something that’ll make you worse than now. Do yourself a favour.

 Cymbalta, Zyprexa, Seroquil, Rispiridone, Valium, Zoloft, Clonazepam,. + 1 other Benzo. Total 11 yrs.

·           April 9th 2018 Hospital. 50mg Zoloft > 0 discontinued. 6mg Clonazepam > 2.5mg over 8 weeks stay.

           October 25th 2019: Hospital:  Clonazepam Bridged 1mg > to 20mg Diazepam.

           

           Anafranil: 90mg

      
  Diazepam (V): 25th October 2019, 20mg. 22 Dec 2019 19mg. 4 April 20: 18mg,  30 September: 17.5mg , 13 November 20: 17mg 01 January 2021: 16mg,

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  • 4 months later...

I just had a few questions for those of you who have used n-acetylcysteine for any extended period?

 

1) Some categorize n-acetylcysteine as a supplement, and others categorize it as a medication? Do you know which it is?

 

2) Do you still use this? And, if so, in what amount?

 

3) When during the day is the ideal time(s) to take this? 

 

4) Is it ok to take around the same time I take my AD?

 

5) Can you become addicted to or dependent on n-acetylcysteine?

 

6) If you stop using it, would you have to taper off it, much like we do ADs?

 

@Altostrata - I'd love to hear your answers to these questions, since you seemed to benefit from n-acetylcysteine for a period of time.

09/2011- 01/2014: 10mg Cipralex / 02/2014: increased to 15mg Cipralex

02/2014 - 10/2016: 15mg Cipralex / 11/2016: reduced to 12.5mg Cipralex (over 2 weeks)

12/2016: reduced to 10mg Cipralex (over 2 weeks) / 01/2017 - 09/2018: 10mg Cipralex

10/2018 - 11/2018: reduced gradually to 7.5mg Cipralex / 12/2018: found SA & first learned about the 10% taper method

01/2019 - 07/2019: held (lots of physical & psychological wd symptoms)

07/19/2019: 7.3mg Cipralex / 08/19/2019: 7.2mg / 09/08/2019: 7.0mg / 09/29/2019: 6.9mg / 03/25/2020: 6.7mg

04/16/2020: 6.6mg (0.084) / 05/10/2020: 6.5mg (0.083) / 06/01/2020: 6.4mg (0.081) / 07/12/2020: 6.3mg (0.079-0.080)

07/26/2020: 6.2mg (0.078-0.0.79) / 09/07/2020: 6.1mg (0.077-0.0.78) / 10/06/2020: 6.0 mg (0.076-0.0.77) /

10/27/2020: 5.9 mg (0.075-0.0.76) / 11/30/2020: 5.8 mg (0.073-0.74) / December-February 22, 2020: 5.4mg  (0.069-0.070) / 02/23/2020: 5.4mg (0.068-0.069) / 03/6/2020: 5.3mg (0.067-0.068) 04/09/2020: 5.3mg (0.066-0.067)

 

Please Note: I am not a medical professional. Consult a knowledgeable

medical professional when making decisions about your medical care. 

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  • Administrator

Everything I know about this supplement is posted in this topic. I took it many years ago. I don't remember the details anymore.

 

Whatever you try, try a very small amount first to see what effect it has. Do not continue if the effect is unpleasant.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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Thanks @Altostrata !

09/2011- 01/2014: 10mg Cipralex / 02/2014: increased to 15mg Cipralex

02/2014 - 10/2016: 15mg Cipralex / 11/2016: reduced to 12.5mg Cipralex (over 2 weeks)

12/2016: reduced to 10mg Cipralex (over 2 weeks) / 01/2017 - 09/2018: 10mg Cipralex

10/2018 - 11/2018: reduced gradually to 7.5mg Cipralex / 12/2018: found SA & first learned about the 10% taper method

01/2019 - 07/2019: held (lots of physical & psychological wd symptoms)

07/19/2019: 7.3mg Cipralex / 08/19/2019: 7.2mg / 09/08/2019: 7.0mg / 09/29/2019: 6.9mg / 03/25/2020: 6.7mg

04/16/2020: 6.6mg (0.084) / 05/10/2020: 6.5mg (0.083) / 06/01/2020: 6.4mg (0.081) / 07/12/2020: 6.3mg (0.079-0.080)

07/26/2020: 6.2mg (0.078-0.0.79) / 09/07/2020: 6.1mg (0.077-0.0.78) / 10/06/2020: 6.0 mg (0.076-0.0.77) /

10/27/2020: 5.9 mg (0.075-0.0.76) / 11/30/2020: 5.8 mg (0.073-0.74) / December-February 22, 2020: 5.4mg  (0.069-0.070) / 02/23/2020: 5.4mg (0.068-0.069) / 03/6/2020: 5.3mg (0.067-0.068) 04/09/2020: 5.3mg (0.066-0.067)

 

Please Note: I am not a medical professional. Consult a knowledgeable

medical professional when making decisions about your medical care. 

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  • 7 months later...
On 2/9/2019 at 3:08 AM, Ryder said:

Can I just say, I took NAC about 2.5 years ago. I was on Zoloft and Clonazepam and i was able to drive.

 

Once i started NAC, yes it really took the burden off my withdrawal symptoms. But, I eventually stopped driving because of it. I wouldn't wish NAC on anybody my cognition and concentration just went funny.

 

Also it has a really short half life, I took it up to 3xtimes in a day at one stage, that is including before bed.

Do you recall what dosage you took?  

 

2016-Aug-Prescribed 2 mg Ativan & 10 mg Ambien; Oct-c/o from 20 mg Lexapro to 60 mg Cymbalta; Nov-Dec-Tapered off 10 mg Ambien    

2017-Jan-Feb c/o from 1.75 mg Ativan to 13 mg Valium & begin daily liquid micro taper; May-taper Cymbalta 60 mg to 48 mg with severe withdrawals.  Begin 11 month Cymbalta hold.

2018-Jan 11 completed Valium taper; Apr-Resume Cymbalta taper.  Interval dose progress: Apr 43 mg; May 40 mg; Jul 35 mg; Sep 29 mg; Dec 21 mg; 

2019- Apr 14 mg; Jun 11 mg; Aug 9 mg; Oct 7 mg; Nov 6 mg

2020-Jan 5.2 mg; Feb 4.8 mg; Mar 4.3 mg; Apr 3.9 mg; May 3.5 mg; Jun 3.3 mg; Jul 2.9 mg; Aug 2.7 mg; 28 Sep 2.4 mg/12 beads; 25 Oct 2.2 mg/11 beads; 22 Nov 2.0 mg/10 beads; 20 Dec 1.8 mg/9 beads

2021- 17 Jan 1.6 mg/8 beads; 14 Feb 1.4 mg/7 beads; 18 Mar 1.2 mg/6 beads; 18 Apr 1.0 mg/5 beads 

 

 

 

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  • 2 months later...

Ok you guys, I tried NAC again due to seeing a naturopath and having allergic conjunctivitis during winter. I lasted 2.5 months before coming off about a week ago. Here is my take 

 

1) Some categorize n-acetylcysteine as a supplement, and others categorize it as a medication? Do you know which it is? NOPE

 

2) Do you still use this? And, if so, in what amount? It was Biomedica NAC, and I was taking about 1/3 measuring spoon that came with the jar. The measuring spoon was pretty small, so I reckon I was taking 1/4 of a teaspoon, twice a day. Almost a large pinch. 

 

3) When during the day is the ideal time(s) to take this? Morning and lunchtime. 

 

4) Is it ok to take around the same time I take my AD? I have been off AD for 2-3 years now. 

 

5) Can you become addicted to or dependent on n-acetylcysteine? No. I came off completely overnight and it was fine. 

 

6) If you stop using it, would you have to taper off it, much like we do ADs? No. I came off about a week ago when I started reacting to it on a sustained basis, with scalp eczema (which was weeping and not healing despite having cortisone pour on it every night) and increasing anxiety. Saying that, it did kill my sugar cravings as well as help me work ALOT better. Now I am back to feeling slightly down here and there, but the eczema is almost 80-90% healed. It also helped with the allergic conjunctivitis initially. So for me, I saw initial benefits, then it went backwards such that the reactions outweigh the benefits. Back to just cold-turkeying sugar (lol) and putting some music on when I feel down...

Prescribed Lexapro in 2003 and switched to Cipramil (5-10mg per day) 2004 with Lamictal.

Stopped Lamictal cold turkey with no withdrawals in 2014 with support of a Paleo diet. 

2003-2015 Cipramil only: 5mg 21 Dec 15: 2.5mg 28 Dec 15: 2.25mg 4 Jan 16: 1.575mg 10 Jan 16: 1.1025 11 Jan 16: 0.7875 25 Jan 16: 0.9, 1 Feb: 0.8, 8 Feb 0.75, 15 Feb 0.5, 29 Feb 0.25, 21 March 0.17, 4 April: 0.10, 25 April 0.05, 8 May 2016 0.05, 15 May 2016 NIL 21 June 2016 0.1, 5 Sep 16: 0.2 7 Sep 16: 0.15 16 Sep 16: 0.075 3 Oct 16: 0.015 17 October: 0.015, 14 Nov 2016: Reinstate 0.005, 26 Dec 16 0.0045, 2 Jan 17 0.004, 20 Feb 17 0.003, 3 Apr 17 0.002, 22 May 17 NIL. 

Supplements/Lifestyle: Paleo/AIP protocol, daily exercise, low histamine and salicylate diet. Church/mediation all the time! No supplements from March 2021 post pregnancy in Oct 2020. 

 

 

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  • 8 months later...
Patti2057

@Ryderwhat did NAC do to you ?

 

Nardil 1985-1988
Paxil ?-1998

Effexor150  1998-November 2018 

Bupoprion150 2002-November 2018

Fluoxetine approximately 1/4 mg trial for WD symptoms December 2020. Took for 3 days but  it seemed to compound the dizziness significantly so I had to discontinue the trial. 

 

Current Medications: Levothyroxine, Acyclovir 

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ChessieCat

@Patti2057

 

Here is the link to Ryder's Intro topic:

 

ryder-zoloft-to-clomipramine

 

NEW!!!     INTERVIEW with Altostrata, SA's founder    NEW!!! 

 

Plodding along inch by inch:  12" = 1',  3' =  36 " or 1 yard,  1760 yards  = 63,360" or 1 mile

Current from 17 Apr 2021:  Pristiq 0.2665mg  now holding each dose for 3 weeks

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering Oct 2015 

My tapering program   My Intro (goes to my tapering graph)  My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.

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Patti2057

Thanks @ChessieCat 

Nardil 1985-1988
Paxil ?-1998

Effexor150  1998-November 2018 

Bupoprion150 2002-November 2018

Fluoxetine approximately 1/4 mg trial for WD symptoms December 2020. Took for 3 days but  it seemed to compound the dizziness significantly so I had to discontinue the trial. 

 

Current Medications: Levothyroxine, Acyclovir 

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  • 3 weeks later...

Fairly new study says NAC might reduce neuronal degeneration (lobotomy) from antipsychotics (Olanzapine):

https://www.nature.com/articles/s41598-020-75356-3

A week of oxazepam 10mg with 1 day of zopiclone 7.5mg and concurrent Zyprexa totalling: 10mg 25 days , 7.5mg 18 days, 5mg 14 days, 2.5mg 11 days,  10x0mg + 4x1mg. Very bad condition reinstated: zyprexa 7.5mg zopiclone 8.5mg, 25mg Propiomazine. Next day 5mg Z. Then 6 months taper to nothing but Zyprexa and 0.0mg again. 6 days 0mg. Reinstated 0.12mg x2 days. 23 june: 0.25mg. 29 june: 0.12mg. 8th and 9th july 2020 also tried 0.375mg Melatonin. 9 july 0.16mg. Made an error of judgement in august and was forced on various drugs in hospital mainly landing on: Abilify injections + pills for a daily total of 5-15 mg (for 2½ month) + zyprexa 3 days of 10mg mostly 2.5mg but started cheating. 14 oct 2020 only zyprexa and due to cheating earlier able to go 0.31mg! 30 oct 0.21mg, 13 nov 0.14mg, 28 nov 0.10mg, 14 dec 0.07mg, 04 jan 2021 0.035mg, 25 jan 0.017mg, 4 feb 2021 0.000 mg

 

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