Nadia Posted July 19, 2011 Share Posted July 19, 2011 (edited) Full article: http://www.ncbi.nlm.nih.gov/pubmed/17617388 There are a few other articles on pubmed about curcumin in relation to depression and neurogenesis. Abstract Curcuma longa is a major constituent of Xiaoyao-san, the traditional Chinese medicine, which has been used to effectively manage stress and depression-related disorders in China. As the active component of curcuma longa, curcumin possesses many therapeutic properties; we have previously described its antidepressant activity in our earlier studies using the chronic unpredictable stress model of depression in rats. Recent studies show that stress-induced damage to hippocampal neurons may contribute to the phathophysiology of depression. The aim of this study was to investigate the effects of curcumin on hippocampal neurogenesis in chronically stressed rats. We used an unpredictable chronic stress paradigm (20 days) to determine whether chronic curcumin treatment with the effective doses for behavioral responses (5, 10 and 20 mg/kg, p.o.), could alleviate or reverse the effects of stress on adult hippocampal neurogenesis. Our results suggested that curcumin administration (10 and 20 mg/kg, p.o.) increased hippocampal neurogenesis in chronically stressed rats, similar to classic antidepressant imipramine treatment (10 mg/kg, i.p.). Our results further demonstrated that these new cells mature and become neurons, as determined by triple labeling for BrdU and neuronal- or glial-specific markers. In addition, curcumin significantly prevented the stress-induced decrease in 5-HT(1A) mRNA and BDNF protein levels in the hippocampal subfields, two molecules involved in hippocampal neurogenesis. These results raise the possibility that increased cell proliferation and neuronal populations may be a mechanism by which curcumin treatment overcomes the stress-induced behavioral abnormalities and hippocampal neuronal damage. Moreover, curcumin treatment, via up-regulation of 5-HT(1A) receptors and BDNF, may reverse or protect hippocampal neurons from further damage in response to chronic stress, which may underlie the therapeutic actions of curcumin. Edited September 25, 2011 by Altostrata corrected link '94-'08 On/off ADs. Mostly Zoloft & Wellbutrin, but also Prozac, Celexa, Effexor, etc.6/08 quit Z & W after tapering, awful anxiety 3 mos. later, reinstated.11/10 CTed. Severe anxiety 3 mos. later & @ 8 mos. much worse (set off by metronidazole). Anxiety, depression, anhedonia, DP, DR, dizziness, severe insomnia, high serum AM cortisol, flu-like feelings, muscle discomfort.9/11-9/12 Waves and windows of recovery.10/12 Awful relapse, DP/DR. Hydrocortisone?11/12 Improved fairly quickly even though relapse was one of worst waves ever. 1/13 Best I've ever felt. 3/13 A bit of a relapse... then faster and shorter waves and windows. 4/14 Have to watch out for triggers, but feel completely normal about 80% of the time. Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted July 19, 2011 Administrator Share Posted July 19, 2011 Also see http://survivingantidepressants.org/index.php?/topic/395-curcumin-helps-neurons-to-recover/page__p__4014__hl__curcumin__fromsearch__1#entry4014 (Nadia, the link you posted for the full article is broken.) This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
Moderator Emeritus Rhiannon Posted July 19, 2011 Moderator Emeritus Share Posted July 19, 2011 Nice! My doctor is Ayurvedic and although I don't really follow that tradition I do take turmeric, which she recommended. Mostly she's wonderful because she supports my weird slow taper and writes my prescriptions and says she will continue to do so without any problems for as long as I need to taper. Turmeric is a good source of cucurmin. So, cool. Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease". Long story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything. Amitryptiline, Prozac, bupropion, buspirone, flurazepam, diazepam, alprazolam, Paxil, citalopram, lamotrigine, gabapentin...probably more I've forgotten. Started multidrug taper in Feb 2010. Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea. Feb 15 2010: 300 mg Neurontin 200 Lamictal 10 Celexa 0.65 Xanax and 5 mg Ambien Feb 10 2014: 62 Lamictal 1.1 Celexa 0.135 Xanax 1.8 Valium Feb 10 2015: 50 Lamictal 0.875 Celexa 0.11 Xanax 1.5 Valium Feb 15 2016: 47.5 Lamictal 0.75 Celexa 0.0875 Xanax 1.42 Valium 2/12/20 12 0.045 0.007 1 May 2021 7 0.01 0.0037 1 Feb 2022 6 0!!! 0.00167 0.98 2.5 mg Ambien Oct 2022 4.5 mg Lamictal (off Celexa, off Xanax) 0.95 Valium Ambien, 1/4 to 1/2 of a 5 mg tablet I'm not a doctor. Any advice I give is just my civilian opinion. Link to comment Share on other sites More sharing options...
compsports Posted July 19, 2011 Share Posted July 19, 2011 Sorry to be the voice of negativity but unfortunately when I took curcumin, it led to blood in the stools. I took a minimal amount. My system also felt like it was on fire. Once I stopped, everything cleared up. CS Drug cocktail 1995 - 2010 Started taper of Adderall, Wellbutrin XL, Remeron, and Doxepin in 2006 Finished taper on June 10, 2010 Temazepam on a PRN basis approximately twice a month - 2014 to 2016 Beginning in 2017 - Consumption increased to about two times per week April 2017 - Increased to taking it full time for insomnia Link to comment Share on other sites More sharing options...
Nadia Posted July 20, 2011 Author Share Posted July 20, 2011 Sorry about that, the correct link is: http://www.ncbi.nlm.nih.gov/pubmed/17617388 As for reactions, I'm sure this will vary person to person. '94-'08 On/off ADs. Mostly Zoloft & Wellbutrin, but also Prozac, Celexa, Effexor, etc.6/08 quit Z & W after tapering, awful anxiety 3 mos. later, reinstated.11/10 CTed. Severe anxiety 3 mos. later & @ 8 mos. much worse (set off by metronidazole). Anxiety, depression, anhedonia, DP, DR, dizziness, severe insomnia, high serum AM cortisol, flu-like feelings, muscle discomfort.9/11-9/12 Waves and windows of recovery.10/12 Awful relapse, DP/DR. Hydrocortisone?11/12 Improved fairly quickly even though relapse was one of worst waves ever. 1/13 Best I've ever felt. 3/13 A bit of a relapse... then faster and shorter waves and windows. 4/14 Have to watch out for triggers, but feel completely normal about 80% of the time. Link to comment Share on other sites More sharing options...
Nadia Posted July 20, 2011 Author Share Posted July 20, 2011 Also, sorry that I hadn't seen this had been posted already under symptoms and what helps! '94-'08 On/off ADs. Mostly Zoloft & Wellbutrin, but also Prozac, Celexa, Effexor, etc.6/08 quit Z & W after tapering, awful anxiety 3 mos. later, reinstated.11/10 CTed. Severe anxiety 3 mos. later & @ 8 mos. much worse (set off by metronidazole). Anxiety, depression, anhedonia, DP, DR, dizziness, severe insomnia, high serum AM cortisol, flu-like feelings, muscle discomfort.9/11-9/12 Waves and windows of recovery.10/12 Awful relapse, DP/DR. Hydrocortisone?11/12 Improved fairly quickly even though relapse was one of worst waves ever. 1/13 Best I've ever felt. 3/13 A bit of a relapse... then faster and shorter waves and windows. 4/14 Have to watch out for triggers, but feel completely normal about 80% of the time. Link to comment Share on other sites More sharing options...
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