Should I take this psychoactive drug?

[phoenix7]

[NSI-189] What do you think about it? Studies show that it promotes neurons regeneration (that goes on even after discontinuation) and can potenitally grow the size of the hippocampus.

 

It's proposed for major depressive disorder but also brain injury. hence the reason i am posting this here, to discuss if it could help for the damage that pych drugs have done to us.

 

P.S.: It's not officially out for the public,still in clinical trials (phase 3 now i beleive) but hundreds of people have already used it with very good results to report..

 

P.S.#2: i can understand the "new unresearched chemical too dangerous to use" but please don't give me the "non FDA approved" **** cause i can quicly name 3 FDA approved poisons ,that come to my mind, used for years and still going on strong: paxil, prozac and risperdal

 

Also all the people used this reported limited to zero side effects and no withdrawals upon discontinuation

Edited May 30, 2017 by Altostrata
added name of drug

[phoenix7]

What do you think about it? Studies show that it promotes neurons regeneration (that goes on even after discontinuation) and can potenitally grow the size of the hippocampus.

 

It's proposed for major depressive disorder but also brain injury. hence the reason i am posting this here, to discuss if it could help for the damage that pych drugs have done to us.

 

P.S.: It's not officially out for the public,still in clinical trials (phase 3 now i beleive) but hundreds of people have already used it with very good results to report..

 

P.S.#2: i can understand the "new unresearched chemical too dangerous to use" but please don't give me the "non FDA approved" **** cause i can quicly name 3 FDA approved poisons ,that come to my mind, used for years and still going on strong: paxil, prozac and risperdal 

 

Also all the people used this reported limited to zero side effects and no withdrawals upon discontinuation

 

[JanCarol]

Regeneration for someone in withdrawal is exactly the opposite of what you want to do.

 

If you are starting from a healthy baseline and want to play "nootropic" with your brain, then fine.

 

But if you are suffering symptoms, I have every reason to believe that seeking "nerve regeneration" and growth will increase your symptoms.

 

The reason withdrawal symptoms are so extreme is that - the drugs change the way your neurotransmitters receive their "keys" in their "locks."

 

Over time, these neurotransmitters up-regulate (make more neurons) or down-regulate (make fewer neurons) to compensate for what the drug does.  This is called Homeostasis.

 

When you withdraw from the drugs, these neurons which were previously bathed in chemical soup, are exposed.  In the case of up-regulation, you have too many neurons and your brain will need to trim them, to achieve homeostasis.  This results in extreme sensitivity - and you don't want to grow new neurons.

 

In the case of down-regulation (different drugs cause different effects in order to achieve homeostasis, I won't go into that here), when the soup is removed, there are not enough neuron receptors, and new ones must be grown.  These baby neurons are extremely sensitive, and cause symptoms too.  So you don't want to hasten the growth of neurons in this case, either.

 

All the people who used this were not people in withdrawal from SSRI's.  They were likely healthy test subjects.  My objections have nothing to do with FDA - more to do with how psych drugs work, and why it is dangerous to play with your neurons when in a state of withdrawal and symptoms.

Again - if you, from a healthy baseline, want to fiddle your neurons (and I can't help but to wonder if your brain will compensate for this drug, too, but up-regulating or down-regulating receptors) that's fine.

 

But I don't recommend it for people in withdrawal or who are having symptoms. 

[Terry4949]

Unfortunately there are a lot of new antidepressants being made and the professionals are shouting from the roof tops how good they are , alks5641 , and av101 are two new drugs that are being fast tracked through their phases , and are reportedly showing promise in treating depression how ever these won't help us that are all ready damaged from previous medication , our cns is damaged and more meds will only confuse matters , it is a big gamble to try these new drugs , as to people reporting no side effects when withdrawing that's a good marketing strategy, they said that about ssri,s , if there was a magic pill that would regrow our brains back to normal we would all jump at the chance to do it , but it's our cns that needs addressing

[tryingtosurvive]

Any one with experience of using amitripyline for reflux /pain /hypersensitivity?

Very grateful to your responses

/trying to survive

[fj929]

I disagree with the statements above. If drugs will never help the damage then nothing will. Many of us are severly damaged and there is no way after still being this ill after 5 years that I will ever get back to the way I was on it's own. Drugs are the only hope and of all the drugs NSI 189 holds the most potential.

[fj929]

Who used this? The drug is not out yet and is only in phase 2. I hope your not talking about those fools on longecity that had "NSI made" by chinese labs. I have alot of hope for this drug but place no faith at all in the longecity fools.

[TikkiTikki]

.

Mod note:  Please see this post

_________________________________________________________________

 

Hi all,

 

Anyone ever used modafanil?

 

I took to using it now and then (unprescribed), and then fairly regular, when I was taking 40mg Celexa. I found it made me focused, energetic, eager to get things done, more social and brighter in mood.

 

I had read that some people use it as an AD, or an adjunct, and it did seem to counter some of the lousy effects of ADS (inertia, indifference, carb-stuffing etc).

 

Tolerance is the main issue, so I've stopped using it on back-to-back days, only now and then to get work done, but I do miss it as an all-round 'brightener' of mood, outlook and energy.

 

Tikki

Edited May 28, 2017 by ChessieCat
Added mod note

[Webhead21]

Modafinil got me into this mess... I research it thinking it could be a safe study drug, but ended up in withdrawal after short term use. That lead me to antidepressants from my doctor how thought it would fix me, which open the gates of hell instead. B12 never used to do the trick, although now it gives my a energy throughout the day. Try B-12 vitamin.

[TikkiTikki]

Thanks Webhead, I'll try that.

 

Yeah, I had researched and thought modafanil sounded pretty safe too. My main trouble was the tolerance, and that I tended to stay up later and not get as much sleep and so inevitably developed a sleep debt. But I rarely use it now, and I tolerate it fine when I do.

[Newbeginning]

I used Nuvigil, which is similar but longer half life. This was *before* tapering and withdrawal. It helped a LOT with energy and apathy caused by antidepressants. I never used it daily. Neurologist said to use it just few times a week when I needed to work, etc. Otherwise it could cause issues (like tolerance, brain changes).

 

When I started tapering and getting withdrawal, I tried it again and I was not reacting the same. Even when I was stable during my taper (no withdrawal), I would get the side effects (insomnia), but not the same amount of benefit in energy and motivation. It still helps me stay awake even after a sleep deprived night and it helps cognitive focus/some sharpness, but it doesn't touch mood or motivation anymore.

 

I have never tried it in withdrawal and would not dare to because if coffee gives me anxiety in withdrawal, Nuvigil would probably give me severe anxiety. It has strong stimulating effects, after all. 

[powerback]

Modafinil got me into this mess... I research it thinking it could be a safe study drug, but ended up in withdrawal after short term use. That lead me to antidepressants from my doctor how thought it would fix me, which open the gates of hell instead. B12 never used to do the trick, although now it gives my a energy throughout the day. Try B-12 vitamin.

 

hi web I've started b12 at 500mg what dose u taking ,I will double this dose soon .  

[Zeldazonk]

I have never tried it in withdrawal and would not dare to because if coffee gives me anxiety in withdrawal, Nuvigil would probably give me severe anxiety. It has strong stimulating effects, after all. 

 

Hi New, my psych wants me to take Modafinil for chronic fatigue but also for a hyper-aroused / wired problem I have...

Isn't it supposed to have a paradoxical effect re the anxiety?

 

Zel.

[Webhead21]

hi web I've started b12 at 500mg what dose u taking ,I will double this dose soon .

I'm only 100mcg, but there is a good thread with a lot of advice on B12 doseages.

[Webhead21]

 

I have never tried it in withdrawal and would not dare to because if coffee gives me anxiety in withdrawal, Nuvigil would probably give me severe anxiety. It has strong stimulating effects, after all.

 

Hi New, my psych wants me to take Modafinil for chronic fatigue but also for a hyper-aroused / wired problem I have...

Isn't it supposed to have a paradoxical effect re the anxiety?

 

Zel.

If I were you I wouldn't take anything from the doctor. Modafinil is a very new drug with little research it really did work that will anyway... Don't put more chemicals in your already altered brain. Eat very well, excerise, natural solutions. Modafinil, from my experience, need in a antidepressants like withdrawal state for weeks. In the ER twice to get answers, which was all bullsh*t, honestly if I waited for another week of 2 maybe in could I been okay. Unfortunately, I took 2 antidepressants, doctor advice, and now I have PSSD, Emotional dullness, a numbing body, and my leg the worst because of muscle loss. Now here I am... Doctors and the drug they have for mental health are not working, not for me. It's all experimental, hit or miss.

[powerback]

I'm only 100mcg, but there is a good thread with a lot of advice on B12 doseages.

 

cheers ile have a look for it

[brassmonkey]

W can not recommend that people take this drug, modafanil, for dealing with effects of ADWD. Firstly because we do not recommend taking any prescription drugs and in many countries this is a controlled substance for dealing with WD symptoms.  Secondly because it has psychotropic actions by adjusting levels of a variety of neurotransmitters, making it in effect one of the drugs we are all trying to get off of. Please refrain from recommending prescription drugs in the future. 

[TikkiTikki]

Hey, sorry Brassmonkey and everyone. I wasn't meaning to recommend it, just wanted more info. I suspected it was not a good idea.

[brassmonkey]

No problem TikkiTikki-- some members tend to take even mentioning a drug as a recommendation, so we have to keep a real eye out  possible situations.  There is a lot of good information out there on the web, but it takes some digging to get past the hype.  Modafanil appears to be a very popular nootropic or "smart drug" used by "mind hackers" for "improving intelligence".  There is a lot of miss information being spread by their sites about it's lack of side effects and general safety.  Once you get past the hype you'll find that it is a psychotropic very similar to the ones we are dealing with, but it affects multiple neurotransmitters instead just the one or two we usually work with.  It claims to be non addictive, but so do ADs and the people using it on a regular basis are in for a rude surprise when they try to stop.

 

Please don't hesitate to ask about any drug that comes up, we've seem them all.  The best thing is to do a google search of the site, something like "survivingandidepressants.com modafinil".

[Altostrata]

Many doctors will attempt to help you with various drugs that act on the nervous system. It's up to you whether you want to become an experimental subject.

 

We would tell you immediately if we knew of something that worked. As it is, we're not in a position to recommend or prescribe drugs to treat withdrawal.

[Why]

It seems to me it is the last bullsh*t study they put out to promote their next branded molecule to gain some millions $/€.

Before depression was caused by lack of serotonin (never proved) , now it's all about neurogenesis.

The truth we have almost no idea on how the brain works as whole. They will try to sell every new **** but you can decide not to be their guinea pig.

Sorry for language

[Newbeginning]

On 5/27/2017 at 6:56 PM, Zeldazonk said:

 

Hi New, my psych wants me to take Modafinil for chronic fatigue but also for a hyper-aroused / wired problem I have...

Isn't it supposed to have a paradoxical effect re the anxiety?

 

Zel.

 

Hi Zel.

 

Sorry for the delay in responding. Didn't see your post until today. The main use for Modafinil is as a waking agent. It is prescribed for narcolepsy or people who need to be up during the night for their job. I don't see how it could decrease anxiety when it has a stimulating effect in most people. 

 

In withdrawal, it probably has an even more stimulating effect, since many people seem to have an overreactive nervous system. 

 

Hope this helps.

[ANR]

On 4/6/2017 at 0:08 PM, JanCarol said:

Regeneration for someone in withdrawal is exactly the opposite of what you want to do.

 

If you are starting from a healthy baseline and want to play "nootropic" with your brain, then fine.

 

But if you are suffering symptoms, I have every reason to believe that seeking "nerve regeneration" and growth will increase your symptoms.

 

The reason withdrawal symptoms are so extreme is that - the drugs change the way your neurotransmitters receive their "keys" in their "locks."

 

Over time, these neurotransmitters up-regulate (make more neurons) or down-regulate (make fewer neurons) to compensate for what the drug does.  This is called Homeostasis.

 

When you withdraw from the drugs, these neurons which were previously bathed in chemical soup, are exposed.  In the case of up-regulation, you have too many neurons and your brain will need to trim them, to achieve homeostasis.  This results in extreme sensitivity - and you don't want to grow new neurons.

 

In the case of down-regulation (different drugs cause different effects in order to achieve homeostasis, I won't go into that here), when the soup is removed, there are not enough neuron receptors, and new ones must be grown.  These baby neurons are extremely sensitive, and cause symptoms too.  So you don't want to hasten the growth of neurons in this case, either.

 

All the people who used this were not people in withdrawal from SSRI's.  They were likely healthy test subjects.  My objections have nothing to do with FDA - more to do with how psych drugs work, and why it is dangerous to play with your neurons when in a state of withdrawal and symptoms.

Again - if you, from a healthy baseline, want to fiddle your neurons (and I can't help but to wonder if your brain will compensate for this drug, too, but up-regulating or down-regulating receptors) that's fine.

 

But I don't recommend it for people in withdrawal or who are having symptoms. 

I think this is what happened to me. I was doing good after 2 years of escitalopram withdrawal and was recovering slowly. Then I took DHA supplement which supposedly "resensitizes serotonin receptors" and now I am feeling even worse than before. After escitalopram I could function at least and even work. Now after DHA I'm crippled and have lost my job.