btdt Posted June 30, 2017 Share Posted June 30, 2017 https://www.snpedia.com/index.php/Rs2032583 Navigation Page Discussion Edit with form Edit History Have questions? Visit https://www.reddit.com/r/SNPedia rs2032583 Orientation minus Stabilized minus Geno Mag Summary (C;C) 1.9 7x more likely to respond to certain antidepressants. (C;T) 1.9 7x more likely to respond to certain antidepressants. (T;T) 2 7x less likely to respond to certain antidepressants. Reference GRCh38 38.1/142 Chromosome 7 Position 87531245 Gene ABCB1 is a snp is mentioned by dbSNP rs2032583 ClinGen rs2032583 ebi rs2032583 HLI rs2032583 Exac rs2032583 Varsome rs2032583 Map rs2032583 PheGenI rs2032583 hapmap rs2032583 1000 genomes rs2032583 hgdp rs2032583 ensembl rs2032583 gopubmed rs2032583 geneview rs2032583 scholar rs2032583 google rs2032583 pharmgkb rs2032583 gwascentral rs2032583 openSNP rs2032583 23andMe rs2032583 23andMe all rs2032583 SNP Nexus SNPshot rs2032583 SNPdbe rs2032583 MSV3d rs2032583 GWAS Ctlg rs2032583 GMAF 0.1318 Max Magnitude 2 ? (C;C) (C;T) (T;T) 28 rs2032583 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which encodes a protein that transports certain molecules across the blood-brain barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of certain drugs and thus their efficacy or potential for adverse side effects. rs2032583 is one of 9 SNPs found within a tight linkage block (r2 >= 0.8 ) such that the minor allele at any one of them predicts (with ~80%+ accuracy) that the other SNPs will also be the minor allele. The list of the 9 SNPs is shown below. When treated for depression with substrates of the protein encoded by ABCB1, carriers of one or two minor alleles at these ABCB1 SNPs have been reported to respond better than non-carriers. The antidepressant drugs that are known to be substrates include citalopram, paroxetine, amitriptyline, and venlafaxine. The relative odds of better response for rs2032583(C) carriers is 7.72 (CI: 2.8-21.3, p=0.000065) based on a study of ~400 primarily Caucasian patients.10.1016/j.neuron.2007.11.017 The 9 SNPs in the linkage block identified are 10.1016/j.neuron.2007.11.017: rs2235067 rs4148740 rs2032583 rs4148739 rs11983225 rs2235040 rs12720067 rs7787082 rs10248420 [PMID 19107781] rs10248420 and rs2032583 associated with colonic disease Neighbor rs2032582 Distance 57 [PMID 15197162] Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene. [PMID 18424454] ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence. [PMID 19844206] Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. [PMID 21172166] Pharmacogenetics of antidepressant response. [PMID 21827404] The clinical impact of ABCB1 polymorphisms on the treatment of psychiatric diseases. [PMID 21987299] Associations between variants in the ABCB1 (MDR1) gene and corticosteroid dependence in children with Crohn's disease. [PMID 22641028] ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder. GET Evidence rs2032583 aa_change aa_change_short impact pharmacogenetic qualified_impact Insufficiently evaluated pharmacogenetic overall_frequency 0.14505 summary [PMID 22672924] Polymorphisms of the drug transporter gene ABCB1 predict side effects of treatment with cabergoline in patients with PRL adenomas [PMID 23093106] Detection of frequent ABCB1 polymorphisms by high-resolution melting curve analysis and their effect on breast carcinoma prognosis Categories: I am 7 x less likely to respond... according to 23 and me test results ran thru the Promethease program for a big five bucks. their report looks like this rs2032583(T;T) 7x less likely to respond to certain antidepressants. This version of a blood brain barrier protein blocks many common antidepressants from entering the brain, including: amitriptyline (Elavil), citalopram (Celexa), paroxetine (Paxil), and venlafaxine (Effexor). That makes those antidepressants 7 times less effective. rs2032583 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which encodes a protein that transports certain molecules across the blood-brain barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of certain drugs and thus their efficacy or potential for adverse side effects. rs2032583 is one of 9 SNPs found within a tight linkage block (r<sup>2</sup> >= 0.8 ) such that the minor allele at any one of them predicts (with ~80%+ accuracy) that the other SNPs will also be the minor allele. The list of the 9 SNPs is shown below. When treated for depression with substrates of the protein encoded by ABCB1, carriers of one or two minor alleles at these ABCB1 SNPs have been reported to respond better than non-carriers. The antidepressant drugs that are know... more info they have a presellected list of drugs you can check. including specific antidepressants... with different causes of reaction or reasons they don't work or do work for you. peace WARNING THIS WILL BE LONG Had a car accident in 85 Codeine was the pain med when I was release from hosp continuous use till 89 Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above. One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking. As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/ There is a crack in everything ..That's how the light gets in Link to comment Share on other sites More sharing options...
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