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apoe4 gene


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Has anyone considered the apoe4 gene being a problem with those that get WD? I started reading it's implications in neuronal repair with head injuries and such, and it seems that it might have something to do with people who heal and who do not?

I would love others ideas on this topic, before I go down another rabbit hole..


med history: 17 years total

Concerta: 2 yrs - cold turkey, brought on first "depression" 

Short trials of Zoloft and Effexor: 1-3 years - multiple cold turkey's brought on OCD intrusive thoughts for the first time

Lexapro 15-20 mg (16 yrs)  - tried to quit once, cold turkey, worst WD ever, had to go on to 20mg to stop WD

Welbutrin 150mg (8-ish yrs) NO w/d symptoms from CT

Adderall 5-7.5mg (8-10-ish yrs) quit CT, brought on many WD symptoms, but manageable. 


Begin taper March 2018 Currently on 4.4 mg lexapro - down from 20mg


Symptoms depression, horrible intrusive thoughts and urges, new onset PMS/PMDD, constant extreme irritation and anger, visual hallucinations, irrational thinking patterns, panic, nausea, dizzy, intolerance to working out, chemical sensitivities, noise sensitivities, memory issues, heart palps, etc. 

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I was tested and was APO3, the most common variant.  My doc just did it as part of a panel, not related to WD

1st round Prozac 1989/90, clear depression symptoms. 2nd round Prozac started 1999 when admitted to dr. I was tired. Prozac pooped out, switch to Cymbalta 3/2006. Diagnosed with bipolar disorder due to mania 6/2006--then I was taken abruptly off Cymbalta and didn't know I had SSRI withdrawal. Lots of meds for my intractable "bipolar" symptoms.

Zyprexa started about 9/06, mostly 5mg. Tapered 4/12 through12/29/12

Wellbutrin. XL 300 mg started 1/07, tapered 1/18/13 through 7/8/13

Oxazepam mostly continuously since 6/06, 30mg since 12/12, tapered 1.17.14 through 8.26.15

11/06 Lithium 600mg twice daily, 2.2.14 400mg TID DIY liquid, 2.12.14 1150mg, 3.2.14 1100mg, 3.18.14 1075mg, 4/14 updose to 1100mg, 6.1.14 900 mg capsules 7.8.14 810mg, 8.17.14 725mg, 8.24.24 700mg...10.22.14 487.5mg, 3.9.15 475mg, 4.1.15 462.5mg 4.21.15 450mg 8.11.15 375mg, 11.28.15 362.5mg, back to 375mg four days later, 3.4.16 updose to 475 (too much going on to risk trouble)

9/4/13 Toprol-XL 25mg daily for sudden hypertension, tapered 11.12.13 through 5.3.14, last 10 days or so switched to atenolol

7.4.14 Started Walsh Protocol

56 years old

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