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armide: Amitryptilline withdrawal with burning feet and hands and facial. Flushing


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Since gradually tapering amitryptilline I was on it for migraine since January 2019 from 25 mg to 2.5 mg ... a burning sensation over my right forearm  which did not let me sleep that day it was 2 April I said I am gonna stop since I am on 2.5 mg....I had some melatonin so I can be able to sleep ... little I know I opened the door to hell the very next night I reinstated amitryptilline to10 mg then I was fine for a month  but I thought that burning feeling was because of the melatonin and then I after a month I was again at 2.5 mg I cutting the 10 mg pill in 4 small pieces it so I guess it was not really 2.5 mg since some of those were less or more ... since May 15 I was gone into swirl of symptoms from burning feet burning skin burning trunk and back itchy scalp and severe anxiety and incapacitating insomnia  I went though a battery of test from mri ultrasound Nerve conduction test all kind of autoimmune test let alone got problems and fast weightloss... but the problem of burning skin tingling stinging doesn’t seem to go away it lessened ain’t but I comes in waves days worse than others I wonder for how long what’s is the best treatment to alllievatr all this .//:I can not wear shoes anymore thin socks and flip flops.  And  the skin of my palms and soles became thin dry and super red my whole body skin backs flaky itchy tender to touch 

any similar experience 

I was on amitryptilline since August 2017 on 25 kGs but I was dropping to 10 mg every now and then. When my headaches were not coming back but it is since January 2019 that I decided to drop 10 mg all th way 2.5 mgs until April 2019  and then I got. Burning sensation in my left forearm then I went back to 10 mg for few days and then back to 5 mg and then 2.5 mg in less than a month and exactly on 15 of May burning sensation started in my feet and palms I was so terrified by my physical symptoms I started having anxiety and zero sleep at night intried 2 weeks ago to reinstate to 25 mgs recommendation from my neurologist but I got 10’” times worse so I stopped totally since 4 weeks

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  • Moderator Emeritus

Hello, Armide, and welcome to SA.  The symptoms you describe are withdrawal symptoms due to too-fast tapers of Amitryptiline and frequent changes of dose.  Your central nervous system needs stability, especially when withdrawing from a psychiatric drug, such as the tricyclic antidepressant, Amitryptiline. 

The rule of 3KIS: Keep it simple. Keep it slow. Keep it stable.

 So that we're clear on your dose changes, please review the following and supply information requested.


Jan. 2019 UNTIL WHAT DATE?  Tapered Amitryptiline from 25mg to 2.5mg.

WHAT DATE?  Reinstated to 10mg.

STARTED WHAT DATE UNTIL WHAT DATE?  Tapered from 10mg to 2.5mg  ARE YOU STILL ON 2.5mg?


 Please put this  information in your drug signature, which will appear with all your posts and is very helpful to the moderators. 


Account Settings – Create or Edit a signature.  Please also include all supplements, including dosage of Melatonin


At this point it is important to let your central nervous stabilize, which means making no further changes to your Amitryptiline dosage (assuming you're still on 2.5mg).  

If after you stabilize, which can take several months,  you wish to taper off the Amitryptiline, let us know and we will advise you.  We recommend tapering no more than 10% of current dose every four weeks.


Why taper by 10% of my dosage?


The symptoms you describe are typical psychiatric drug withdrawal symptoms.  Unfortunately, doctors know little or nothing about antidepressant withdrawal or slow tapering.  Here is some information on withdrawal.


You'll find many, if not all, of your symptoms on this list:
Ups and downs as well as symptoms coming and going is typical of withdrawal. 


When we take medications, the CNS (central nervous system) responds by making changes over the months and years we take the drug(s). When the medication is discontinued, the CNS has to undo all the changes it made. Rebuilding the neurotransmitter production and reactivating the receptor and transporter cells takes time -- during that rebuilding process symptoms occur.  
This explains it really well:


Burning hands and feet are common psychiatric drug withdrawal symptoms, as is tingling.
We don't recommend a lot of supplements on SA, as many members report being sensitive to them due to our over-reactive nervous systems, but two supplements that we do recommend are magnesium and omega 3 (fish oil). Many people find these to be calming to the nervous system. 




Please research all supplements first and only add in one at a time and at a low dose in case you do experience problems.
This is your Introduction topic, the place for you to ask questions, provide updates and connect with other members. 




Gridley Introduction


Lexapro 20 mg since 2004.  Begin Brassmonkey Slide Taper Jan. 2017.   

End 2017 year 1 of taper at 9.25mg 

End 2018 year 2 of taper at 4.1mg

End 2019 year 3 of taper at 1.0mg  

Oct. 30, 2020  Jump to zero from 0.025mg.  Current dose: 0.000mg

3 year, 10 month taper is 100% complete.


Ativan 1 mg to 1.875mg 1986-2020, two CT's and reinstatements

Nov. 2020, 7-week Ativan-Valium crossover to 18.75mg Valium

Feb. 2021, begin 10%/4 week taper of 18.75mg Valium 

End 2021  year 1 of Valium taper at 6mg

End 2022 year 2 of Valium taper at 2.75mg 

End 2023 year 3 of Valium taper at 1mg

Jan. 24, 2024: Hold at 1mg and shift to Imipramine taper.

Taper is 95% complete.


Imipramine 75 mg daily since 1986.  Jan.-Sept. 2016 tapered to 14.4mg  

March 22, 2022: Begin 10%/4 week taper

Aug. 5, 2022: hold at 9.5mg and shift to Valium taper

Jan. 24, 2024: Resume Imipramine taper.  Current dose as of June 28: 5mg

Taper is 93% complete.  


Supplements: multiple, quercetin, omega-3, vitamins C, E and D3, magnesium glycinate, probiotic, zinc, melatonin .3mg, iron, serrapeptase, nattokinase, L-Glutamine

I am not a medical professional and this is not medical advice but simply information based on my own experience, as well as other members who have survived these drugs.

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  • ChessieCat changed the title to armide: Amitryptilline withdrawal with burning feet and hands and facial. Flushing

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