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Drug or Withdrawal Induced Small Fiber Neuropathy vs Autoimmune Neuropathy vs Functional Sensory Issues


TL1802

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In my introduction, I had noted that my main symptoms of stinging skin, itchy insides, tingling all over the surface of my brain, jitteriness, and sexual dysfunction (lack of sensation, loss of libido, and erectile dysfunction) had started 3 months after my discontinuation of 10mg of Viibryd after 10 months of use and 8 weeks of taper. The appearance of most of these symptoms coincided with my recovery from a very bad cold, though the stinging skin had actually begun 24 hours before the start of the cold.

 

While the tingling on the surface of my brain and jitteriness subsided after 1 year, I am only 50% improved on the stinging skin, itchy insides, and sexual dysfunction after 2 years. In addition, my skin has continued to get drier and I can no longer sweat from my arms and legs. Recently, I came down with another cold and after this recovery, I had to deal with the temporary worsening of my symptoms and noticed that I had lost patches of hair on my legs and that my finger nails began to look unhealthy.

 

These symptoms describe small fiber neuropathy to a t. The issue is, I had a skin biopsy done 18 months ago which came back negative (I was in the 40th percentile for fiber density for my age group, 30 to 39, and small fiber neuropathy isn't diagnosed until you fall below the 10th or 5th percentile). Of course, it's possible that my baseline was actually the 80th percentile.

 

I am having my neurology team repeat the biopsy and also asking for a sweat gland nerve fiber density analysis, which is even more precise and sensitive. I am hoping to answer whether my small fibers were damaged or destroyed by the medication/withdrawal or if I am just dealing with malfunctioning nerves due to receptor adaptations. If there is real damage to the nerves, the question becomes if this was done directly by the medication/withdrawal or if the drug created an autoimmune condition in which my body is attacking my small fiber nerves. What's really interesting is that when I am sick, my neurological symptoms are resolved only to get much worse once I recover from the illness. This makes me think that my body becomes too busy fighting an actual virus and can't attack my nerve cells and then comes back to hit my nervous system once the virus is cleared.

 

I will keep people posted, but wanted to post this to see if any one can relate.

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Interesting @TL1802. I also had some relief of symptoms when I had covid (or flu or whatever) over a year ago. Best sleep I have had for 4 years.... 

Remeron - 2004-2005 (bad withdrawal)

Clonazepam - 2005-2018 (jumped around March)

Olanzapine - 2014- late 2017

Domperidone - 2008-2018

Many drugs in between including Lexapro, other benzos and z-drugs.

Still suffering post-withdrawal from Clonazepam (Klonopin), Olanzapine and Domperidone. 

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  • 2 weeks later...

It gets better with a cold... I've also heard people not getting sick for years after being in WD though this doesn't seem to be the norm. I'm sure antibodies play a significant role but there are also many other factors at play.

Current: Bupropion 450mg, Neurontin 800mg, Klonopin 0.5mg

History:

July 2020: started Cogentin 1mg, Lamictal 50mg, Zoloft 150mg, Zyprexa 5mg (+5mg as needed), Klonopin 0.5mg

November 2020: stopped all meds cold-turkey

February 2021: started Latuda 60mg, Lithium 300mg, Melatonin 5mg, Protonix 40mg, Topamax 25mg

2 weeks later: stopped Topamax, increased Lithium 900mg, started Klonopin 1mg, Lexapro 20mg, Neurontin 400mg

April 2021: started Bupropion 150mg, Revia ?mg

May 2021: stopped ReviaProtonixLexaproincreased Neurontin 800mg, started Celexa 10mg

August 2021: decreased Celexa 5mg (stopped Celexa 2 weeks later), increased Bupropion 300mg

September 2021: increased Latuda 80mg

October 2021: decreased Lithium 600mg for 4 daysLithium 300mg for 4 daysstopped LithiumLatuda

     increased Bupropion 450mg, started Remeron 15mg, decreased Remeron 7.5mg, stopped Remeron

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  • 2 months later...

Undiagnosed small fiber neuropathy or post-Mirtazapine withdrawal induced neuropathy?

 

Since my CT withdrawal 3 years ago, I have been experiencing many of the symptoms listed under autonomic/small fiber neuropathy i.e. damage to the unmyelinated nerve fibers of the autonomic nervous system and somatic neural systems. 

 

My most consistent symptoms are irregular/delayed gut motility (almost like gastroparesis), leg/feet paresthesia (mostly below the knees), and sinus pressure, and it mostly occurs when I go to sleep/wake up. Lying down seems to always get the gut moving. 

 

I have searched through this forum, and it appears that neuropathy like symptoms are another withdrawal effect, and I am wondering if it specifically targets the unmyelinated nerves, including the vagus nerve, which results in slower healing.   

 

I am meeting my gastro next week to check on my GI issues, and an autonomic specialist in Jun, and I am wondering what would rule out actual neuropathy vs withdrawal symptoms?

 

 

Edited by ChessieCat
added Intro topic title before merging with existing topic

Chronic IBS since 1990

Former smoker (1992- Jun 2017)

Prescribed mirtazapine for sleep in Aug 2017 after IBS flare-up following Nicotine cessation.

Mirtazapine 7.5mg 8/17 to 5/18

Mirtazapine 3.75mg 5/18 to 1/19

Off Mirtazapine since 2/19.

Vit B, Vit D+K2 and Magnesium Glycinate as needed.

On Ayurvedic herbs for GI issues - Guduchi since Jul 2020, Indukantham since Oct 2020

On Ashwagandha 1g since Nov 2020

 

 

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Since my CT withdrawal 3 years ago, I have been experiencing many of the symptoms listed under autonomic/small fiber neuropathy i.e. damage to the unmyelinated nerve fibers of the autonomic nervous system and somatic neural systems. 

 

My most consistent symptoms are irregular/delayed gut motility (almost like gastroparesis), leg/feet paresthesia (mostly below the knees), and sinus pressure, and it mostly occurs when I go to sleep/wake up. Lying down seems to always get the gut moving. 

 

I have searched through this forum, and it appears that neuropathy like symptoms are another withdrawal effect, and I am wondering if it specifically targets the unmyelinated nerves, including the vagus nerve, which results in slower healing.   

 

I am meeting my gastro next week to check on my GI issues, and an autonomic specialist in Jun, and I am wondering what would rule out actual neuropathy vs withdrawal symptoms?

Chronic IBS since 1990

Former smoker (1992- Jun 2017)

Prescribed mirtazapine for sleep in Aug 2017 after IBS flare-up following Nicotine cessation.

Mirtazapine 7.5mg 8/17 to 5/18

Mirtazapine 3.75mg 5/18 to 1/19

Off Mirtazapine since 2/19.

Vit B, Vit D+K2 and Magnesium Glycinate as needed.

On Ayurvedic herbs for GI issues - Guduchi since Jul 2020, Indukantham since Oct 2020

On Ashwagandha 1g since Nov 2020

 

 

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Hi everyone! I've been on SSRIs (first paxil, then prozac) for 20 years now, and over that time I've developed 2 persistent, untreatable nerve injuries, and a bizarre twitch that happens in my thigh. (note that the worst of the 2 ongoing nerve injuries is in the same area as the twitch) All of these have defied exhaustive attempts at medical diagnosis or treatment; they have just been called neurological issues of unknown origin. After exploring every conceivable option in standard medicine, alternative medicine, multiple surgeries, and every type of treatment I can possibly think of, I've started wondering if the issues could be caused by the long-term usage of SSRIs.

 

Have anyone else experienced bizarre, untreatable chronic pain issues that were caused by their SSRI usage? (as opposed to withdrawal symptoms from SSRIs) Or has anyone here encountered such information online? I'm wondering if this is something I should pursue.

 

thanks,

Bart

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  • 4 weeks later...

I had the same symptoms that kept worsening with time until I reintroduce a diffrent Antidepressant and restabilized. I felt defeated it was over a year of bedridden misery. I regained some normalcy after reststabilizing on a diffrent AD I don't belive I would have made it without. 

 

I also somehow had a relapse of lyme during this time so some how it effected my immune system. I researched alot and their are just so many unknown variables. I started the 10% taper recently on my new Antidepressant I guess we can keep in touch if you'd like.

2001-2019 Effexor XR 150mg Cross to Zoloft 100mg.

2003-2004 CT Effexor XR 150

09/18/2020 Zoloft 100mg CT Switch Paxil 20mg /Valium 10mg

2020 Paxil 20mg /Valium 10mg/Gabapentin 900mg.

2021 Paxil 20mg /Valium 6mg /Gabapentin 600mg.

Currently:

04/14/2022 Paxil 20mg to 15mg 25% reduction/Valium 3mg/Gabapentin 900mg/Fludrocortisone .01mg 

Paxil: Tablet/Liquid Switch 10% Monthly Drops

5/16 Paxil Liquid 7.4ml/ Valium 3mg/ Gabapentin 900mg, 6/1 Paxil Liquid 6.66ml/ Valium 3mg/ Gabapentin 900mg 6/18 "Switch back to tablets" paxil 10mg+1.66ml/Valium 3mg/Gabapentin 900mg

SupplementsFish Oil, Melatonin 1.5mg, Luracidin.

"Slow  Steady Stable" 💚

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  • 1 year later...

I developed loss of feeling in body after a bad prozac bridge, prozac was added to Effexor to try and get me off it, I was very concerned as I already found Effexor too stimulating and I expressed this tirelessly but psych said she knew what doing and was safe, I said I am ok trazodone for sleep too and she said she knew, she’s the doc. I took the small amount of prozac liquid, she wanted me to take higher, to 112.5mg Effexor and noise increased so much, I couldn’t sit still, was sweating, heart rate up, felt absolutely wild, cried and cried and walked so fast. My body went numb, I stopped it after 4 days, it started on day one but thought maybe this is normal. It got worse as built up. I could feel things before that, I was told it would go, that I must now just cut Effexor fast or wouldn’t deal with me. I was basically ignored about the damage when I saw them, I was lucky I had clonazapam And trazodone for sleep. This was in January and I still have lack of feeling, I don’t know where to turn. I have managed to get off Effexor finally, have benzo to go And trazodone. But I am lost on this lack of feeling, I can’t orgasm or feel down below and this was normal before this bad bridge. I have POTS type issues and I wake with heart going so fast I don’t know why, I’m still on 0.25mg clonazapam rivitrol a year now and trazadone 100mg. Anyone have any insights I am traumatised 

Zopiclone; Xanax 1mg; mogodon Dec 2021 to April 2022. Added Mirtrazapine for two weeks with 25 mcg Amitryptiline right after Mirtrazapine - stopped.  Then Sertraline 25 mg March 2022 for two weeks - still on Xanax and Zopiclone. Hospitalized and put on Effexor xr ven April 2022. Started 37.5 mg increased to 187.5 mg by June, dropped to 150 mg after 3 days. Given Trazadone 100 mg April 2022 at night with Phenergen and 1mg Clonazapam. Added 0.5 mg Clonazapam daytime, but caused drowsiness - dropped 0.5 mg daytime. On Clonazapam, Trazadone and Phenergen 25 mg from April to July 2022. April to current trying to wean Effexor ven xr July 2022 to current down to .25 Clonazapam from 1mg.

Replaced Phenergen with melatonin in July.

July to Aug 2022 Effexor xr down to 112.5 mg - in Sept dropped to 75 mg and reinstated to 112.5 mg. Feb 2023 reduced from 112.5 mg Effexor xr 10 101.5 mg.

At end of Jan 2023 given 5 mg liquid Prozac to add to Effexor - stopped Prozac after 4 days. Still on 100 mg Trazadone and 0.25 mg Clonazapam 

Eltroxin for thyroid since 2006 - taken in the AM.

Ruthie3's intro thread: Ruthie3: Intro

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  • Altostrata changed the title to Drug or Withdrawal Induced Small Fiber Neuropathy vs Autoimmune Neuropathy vs Functional Sensory Issues
  • Administrator

merged similar topics

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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Thank you 🙏 

Zopiclone; Xanax 1mg; mogodon Dec 2021 to April 2022. Added Mirtrazapine for two weeks with 25 mcg Amitryptiline right after Mirtrazapine - stopped.  Then Sertraline 25 mg March 2022 for two weeks - still on Xanax and Zopiclone. Hospitalized and put on Effexor xr ven April 2022. Started 37.5 mg increased to 187.5 mg by June, dropped to 150 mg after 3 days. Given Trazadone 100 mg April 2022 at night with Phenergen and 1mg Clonazapam. Added 0.5 mg Clonazapam daytime, but caused drowsiness - dropped 0.5 mg daytime. On Clonazapam, Trazadone and Phenergen 25 mg from April to July 2022. April to current trying to wean Effexor ven xr July 2022 to current down to .25 Clonazapam from 1mg.

Replaced Phenergen with melatonin in July.

July to Aug 2022 Effexor xr down to 112.5 mg - in Sept dropped to 75 mg and reinstated to 112.5 mg. Feb 2023 reduced from 112.5 mg Effexor xr 10 101.5 mg.

At end of Jan 2023 given 5 mg liquid Prozac to add to Effexor - stopped Prozac after 4 days. Still on 100 mg Trazadone and 0.25 mg Clonazapam 

Eltroxin for thyroid since 2006 - taken in the AM.

Ruthie3's intro thread: Ruthie3: Intro

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  • 3 weeks later...
On 7/6/2023 at 6:49 PM, Ruthie3 said:

I developed loss of feeling in body after a bad prozac bridge, prozac was added to Effexor to try and get me off it, I was very concerned as I already found Effexor too stimulating and I expressed this tirelessly but psych said she knew what doing and was safe, I said I am ok trazodone for sleep too and she said she knew, she’s the doc. I took the small amount of prozac liquid, she wanted me to take higher, to 112.5mg Effexor and noise increased so much, I couldn’t sit still, was sweating, heart rate up, felt absolutely wild, cried and cried and walked so fast. My body went numb, I stopped it after 4 days, it started on day one but thought maybe this is normal. It got worse as built up. I could feel things before that, I was told it would go, that I must now just cut Effexor fast or wouldn’t deal with me. I was basically ignored about the damage when I saw them, I was lucky I had clonazapam And trazodone for sleep. This was in January and I still have lack of feeling, I don’t know where to turn. I have managed to get off Effexor finally, have benzo to go And trazodone. But I am lost on this lack of feeling, I can’t orgasm or feel down below and this was normal before this bad bridge. I have POTS type issues and I wake with heart going so fast I don’t know why, I’m still on 0.25mg clonazapam rivitrol a year now and trazadone 100mg. Anyone have any insights I am traumatised 

Hi Ruthie sorry to hear what you're going through but I have a lot of similar symptoms. Mainly heart stuff I wake with a racing heart and I have physical numbness in my body. Do you get any balance issues like you're on a boat or drunk? I even get it when lying down or sitting. 

Citalopram 10mg sep14-nov14,

cit 20mg nov14-jan15,

cit 40mg jan15 -jan22,

tapered cit 40mg-0mg in 10 days.

mirtazapine 15mg then 30mg jan22-Mar22,

tapered in 1 week.

citalopram 20mg apr22- may22( had a reaction this time, hives everywhere),

no taper cold turkey 

sertraline 50mg then 100mg may22-nov22, tapered in 2 weeks.

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This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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Auto immune group? @Altostrata

36/M, started 10mg escitalopram June 2011

Sept 20th 2021 - increased 10mg to 15mg.
Oct 1st 2021 -November 16th 2021 drug merry go round. Effexor, Zoloft, pristiq.
Nov 22nd 2021 - lexapro 5mg

nov 29th, 2021 - lexapro 10mg

Dec 29th, 2021 - lexapro 15mg

Jan 20th, 2022 - lexapro 20mg

Jan 25th,2022 - lexapro 15mg,Feb 15th,2022 - lexapro 10mg ,Nov 22nd, 2021 - Dec 20th, 2021 -Xanax .25 X2 a day,Dec 20th, 2021 - Jan 16th, 2022 Klonopin .25 daily

2022

,-June 25 - 7.5mg pill, 2.5mg liquid ,-June 28 - 5mg pill, 5mg liquid ,-July 18th - 9.8mg (5mg pill, 4.8mg liquid),-Aug 1 - 9.6mg (5mg pill, 4.6 liquid) ,-Aug 16 - All liquid (9.6MG) ,-Sept 18th - 9.4MG,-Oct 18th - 9.2MG. -Nov 21st - 9MG 2023, April 17th - 8.8MG, May 15th - 8.6MG, June 19th - 8.4MG, Aug 1 - 8.2Mg, Sept 2, 8mg, Oct 9th 7.8mg, Nov 6, 7.6mg, Dec 8th, 7.4mg, Jan 23, 7.2mg Feb 28th 7.1ML, March 13 7ML March 30 6.8ml May 28 6.6ml magnesium, fish oil, b vitamins D3

 

 

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19 hours ago, Conner said:

Auto immune group? @Altostrata

 

What is your question? We do not diagnose, treat, or provide peer support for autoimmune conditions here. Look on Facebook.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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