Oaktree1 Posted November 2, 2022 Share Posted November 2, 2022 Some class of a PhD thing called Kenneth Wengler at the Renaissance School of Medicine in Stoneybrook, New York has produced research which claims that the brains of people suffering from 'major depressive disorder' have abnormalities in the blood brain barrier. He and his team apparently applied a new MRI technique called (IDEALS) (i won't bother breaking down the abbreviation because it's a mouthful) and claim that they observed 'disruption' in the blood brain barrier in depressed patients compared with the brains of 'normal' patients i.e. those not suffering from 'major depressive disorder'. Separately researchers from the Image Display, Enhancement, and Analysis (IDEA) group at the University of North Carolina (UNC) say that people with major depression had abnormal patterns of excitation and inhibition at the dorsal lateral prefrontal cortex of the brain. Here is the rest of the article:- "This part of the brain helps govern cognitive control. This includes the regulation of the amygdala, which is involved in expression of emotion. “This suggests that control functions in [major depressive disorder] are impaired, which may lead to elevated responses in the amygdala, resulting in increased anxiety and other negative moods,” Guoshi Li, PhD, a research associate at UNC and study co-author, said in a press statement. The finding supports the longstanding theory that malfunctioning control over the amygdala could result in depressive symptoms. The UNC study also found that recurrent excitation in the thalamus, an area of the central brain that’s also responsible for emotional regulation, was abnormally elevated in people with major depression. The UNC researchers used functional MRI (fMRI) scans and a new multiscale neural model inversion framework that looked at the brain’s microscopic circuitry in context with its larger-scale interactions. “This method allows us to identify impaired connectivity within each brain region, making it a potentially more powerful tool to study the neuromechanism of brain disorders and develop more effective diagnosis and treatment,” Li said. ( Is this bio medical psychiatry's next frontier given that the chemical imbalance theory is now in the bin? I was on Quora recently and had the "mental illness shows up on the scans" thrown at me when I stated that there were no biomarkers for 'mental illness'. So I looked it up and here are the new 'biomarkers' apparently. The link I got this information from is below but there is more of the same all over 'Healthline' a popular wiki style health site too. https://www.openaccessgovernment.org/reasons-behind-depression/78759/ Currently tapering Mirtazapine; previously tapered Cymbalta 30mg from June 2018-Feb 2019 and Seroquel 150mg to zero from Oct-December 2020. Supplements for Hashimoto's disease and histamine issues relating to Mirtazapine: Vitamin D3 1,000mcg, bio-identical HRT, Selenium, Quercetin, Lutein, Zinc, Vitamin C, Omega 3. Mirtazapine Taper: 2021 16th Aug - transitioned to liquid from tablet by dissolving two 15mg tablets into a solution of 15 ml water and 15 ml maple syrup on a starting dose of what I thought was 7.5ml; 17 Sept - 7.31; 24 Sept - 7.13; 15 Oct - 6.95; 6 Nov - 6.78; 21 Nov - 6.61; 5 Dec - 6.51; 2022 - 1 Jan 6.41; 1 Feb - 6.1; 9 Mar - 5.8; 13 Mar - 5.9; 7 Apr - 5.8; 21 Apr - 5.7; 7 May - 5.63; 23 May - 5.55; 8 June 5.50; (got COVID on 12th June so held); 1 July 5.4; 15 July 5.32; 8 Aug 5.2; 15 Aug 5.1; 22 Aug 5; 19 Sept 4.9; 2 Oct 4.81; 13 Oct 4.71; (COVID Booster 17/10/22 so longer hold ); 1 Nov 4.65; 3 Nov 4.60; 10 Nov 4.55; 13 Nov 4.50; 17 Nov 4.45; 20 Nov 4.40; 2 Dec 4.30mg; 9 Dec 4.20mg; I discovered that the volumetric container measured 33ml rather than 30ml in Dec 2022. Following helpful advice from moderator OnMyWay (see her reply of the 5th March) discovered taper with the dilution was 3.8mg (calculated by dividing 30/33 so that every 1ml of solution has 0.90ml of Mirtazapine. 7.50 - 0.90= 6.6ml which was the starting dose on 16th Aug 2021 not 7.5ml). I decided to keep using the solution as I didn't want more change to deal with than I had to. 2023 17 Mar 4.1(3.7); 26 Mar 4.0(3.6); 14 Apr 3.9(3.51)28 Apr 3.8(3.42); 6 Jun 3.7(3.33); 19 Jun 3.6(3.24); 30 Jun 3.5(3.1); 19 Jul 3.4(3.06); 27 Jul 3.35 (3.01); 29 Jul 3.3 (2.97); 4 Aug 3.25 (2.92); 7 Aug 3.2 (2.88); 21 Aug 3.1 (2.79); 14.09 3 (2.7); 29th Sept 2.9(2.61); 15 Oct 2.8(2.52); 30 Oct 10 2.7(2.43); 13 Nov 2.65(2.38); 20 Nov 2.6(2.34); 26 Nov 2.55(2.29); 10 Dec 2.5(2.25); 2024 - 14 Jan 2.45(2.20); 22 Jan 2.40(2.16); 29 Jan 2.35(2.11); 2 Feb 2.3 (2.07);15 Feb 2.25(2.02); 22 Feb 2.21 (1.98); 29 Feb 2.17(1.95); 7 Mar 2.13(1.91); 21 Mar 2.05 (1.84); 31 Mar 2.01 (1.80); 14 Apr 1.90 (1.71); 29 Apr 1.80 (1.62); This is not 'medical advice' - my 'non medical advice' is don't get any more 'medical advice' or you may end up getting more 'medical treatment' i.e more drugs, DSM labels and/or ECT. Please do not PM me thanks. Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted November 5, 2022 Administrator Share Posted November 5, 2022 There are still many theories of depression floating around. Is this study replicable? Probably not, since none of the others are. This is likely a product of the PhD paper mill. I would not get upset about it, hundreds of these studies are produced every year. 1 This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
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