Medved Posted April 3, 2023 Share Posted April 3, 2023 I am really concerned about this. Many articles state that this condition might be permanent. I have it for already 2 years,since stopping Zoloft. Does this go away like all the other WD symptoms or is it a byproduct of withdrawal which will remain chronic? I havent had single positive feeling in 2 years. Plus all the other depression symptoms. Please, all of you that have experience with this, tell me your experiences. Good and bad. Zoloft 09'-10' 50mg Zoloft 50mg May 2019- April 2021, CT but tinkering with doses before CT Link to comment Share on other sites More sharing options...
Peter23 Posted May 11, 2023 Share Posted May 11, 2023 I too have tardive dysphoria after stopping Sertraline and Mirtazapine. I have had it now for several years. Most articles suggest that it MAY BE permanent not that it IS permanent. It might be the case that like Protracted SSRI withdrawal it just takes time for the brain to recover to full functioning. After all the brain is neuroplastic and can recover from many types of insults and injuries. 2000-Venlafaxine 150 mg and Olanzapine 10 mg started 2012- Venlafaxine(tapered off) to Sertraline 150 mg until 2021, added mirtazapine 30 mg until 2019 2018-2023, Oct- Pregabalin, started 150 mg to 600 mg 2019- Diazepam started 6mg 2022- July-restart mirtazapine(unsuccessful) Oct- ECT X 12, Zopliclone 7.5 mg start- present 2023- January, olanzapine decreased to 7.5 mg, Lorazepam 1 mg X 2 weeks, Diazepam increased- 20 mg, some tapering to June-Diazepam 10 mg March- Agomelatine added-25 mg October 9th, 2023 present meds bolded Link to comment Share on other sites More sharing options...
Moderator Onmyway Posted May 13, 2023 Moderator Share Posted May 13, 2023 (edited) While the term "tardive dysphoria" sounds all science-y and diagnosis-y, all it means is "feeling miserable after stopping drugs". There is one author (group) that has written a bunch of articles on it hypothesizing that it's permanent with absolutely no basis for it. For it to be permanent they need to show that it never improves until someone dies. Have they shown that. Not even close. As far as I remember they even show that many people get better within a year. What they have done is that they have observed that some people are still miserable 6 weeks - 4 months after discontinuing ADs. Duh!!! We, here, know that withdrawal, which is all about "feeling miserable" can go for years and in rare cases for decades but it gets better and people heal. So please ignore the fear mongering and demand proof before you work yourself into knots of worry and anxiety 6 weeks after stopping antidepressants. You will get better. Ruminating over poorly written articles will not help the process. Edited May 13, 2023 by Onmyway 3 "Nothing so small as a moment is insurmountable, and moments are all that we have. You have survived every trial and tribulation that life has thrown at you up until this very instant. When future troubles come—and they will come—a version of you will be born into that moment that can conquer them, too." - Kevin Koenig I am not a doctor and this should not be considered medical advice. You can use the information and recommendations provided in whatever way you want and all decisions on your treatment are yours. In the next few weeks I do not have a lot of capacity to respond to questions. If you need a quick answer pls tag or ask other moderators who may want to be tagged. Aug 2000 - July 2003 (ct, 4-6 wk wd) , citalopram 20 mg, xanax prn, wellbutrin for a few months, trazodone prn Dec 2004 - July 2018 citalopram 20 mg, xanax prn (rarely used) Aug 2018 - citalopram 40 mg (self titrated up) September 2018 - January 2019 tapered citalopram - 40/30/20/10/5 no issues until a week after reaching 0 Feb 2019 0.25 xanax - 0.5/day (3 weeks) over to klonopin 0.25 once a day to manage severe wd March 6, reinstated citalopram 2.5 mg (liquid), klonopin 0.25 mg for sleep 2-3 times a week Apr 1st citalopram 2.0 mg (liquid), klonopin 0.25 once a week (off by 4/14/19- no tapering) citalopram (liquid) 4/14/19 -1.8 mg, 5/8/19 - 1.6 mg, 7/27/19 -1.5 mg, 8/15/19 - 1.35, 2/21/21 - 1.1 (smaller drops in between), 6/20/21 - 1.03 mg, 8/7/21- 1.025, 8/11/21 - 1.02, 8/15/21 - 1.015, 9/3/21 - 0.925 (fingers crossed!), 10/8/21 - 0.9, 10/18/21 - 0.875, 12/31/21 - 0.85, 1/7/22 - 0.825, 1/14/22 - 0.8, 1/22/22 - 0.785, 8/18/22 - 0.59, 12/15/2022 - 0.48, 2/15/22 - 0.43, 25/07/23 - 0.25 (mistake), 6/08/23 - 0.33mg Supplements: magnesium citrate and bi-glycinate Link to comment Share on other sites More sharing options...
Moderator Onmyway Posted May 13, 2023 Moderator Share Posted May 13, 2023 On 4/3/2023 at 3:38 PM, Medved said: I am really concerned about this. Many articles state that this condition might be permanent. I have it for already 2 years,since stopping Zoloft. Does this go away like all the other WD symptoms or is it a byproduct of withdrawal which will remain chronic? I havent had single positive feeling in 2 years. Plus all the other depression symptoms. Please, all of you that have experience with this, tell me your experiences. Good and bad. Also @Medvedin your thread you describe having multiple windows post stopping. The two statements are incompatible. "Nothing so small as a moment is insurmountable, and moments are all that we have. You have survived every trial and tribulation that life has thrown at you up until this very instant. When future troubles come—and they will come—a version of you will be born into that moment that can conquer them, too." - Kevin Koenig I am not a doctor and this should not be considered medical advice. You can use the information and recommendations provided in whatever way you want and all decisions on your treatment are yours. In the next few weeks I do not have a lot of capacity to respond to questions. If you need a quick answer pls tag or ask other moderators who may want to be tagged. Aug 2000 - July 2003 (ct, 4-6 wk wd) , citalopram 20 mg, xanax prn, wellbutrin for a few months, trazodone prn Dec 2004 - July 2018 citalopram 20 mg, xanax prn (rarely used) Aug 2018 - citalopram 40 mg (self titrated up) September 2018 - January 2019 tapered citalopram - 40/30/20/10/5 no issues until a week after reaching 0 Feb 2019 0.25 xanax - 0.5/day (3 weeks) over to klonopin 0.25 once a day to manage severe wd March 6, reinstated citalopram 2.5 mg (liquid), klonopin 0.25 mg for sleep 2-3 times a week Apr 1st citalopram 2.0 mg (liquid), klonopin 0.25 once a week (off by 4/14/19- no tapering) citalopram (liquid) 4/14/19 -1.8 mg, 5/8/19 - 1.6 mg, 7/27/19 -1.5 mg, 8/15/19 - 1.35, 2/21/21 - 1.1 (smaller drops in between), 6/20/21 - 1.03 mg, 8/7/21- 1.025, 8/11/21 - 1.02, 8/15/21 - 1.015, 9/3/21 - 0.925 (fingers crossed!), 10/8/21 - 0.9, 10/18/21 - 0.875, 12/31/21 - 0.85, 1/7/22 - 0.825, 1/14/22 - 0.8, 1/22/22 - 0.785, 8/18/22 - 0.59, 12/15/2022 - 0.48, 2/15/22 - 0.43, 25/07/23 - 0.25 (mistake), 6/08/23 - 0.33mg Supplements: magnesium citrate and bi-glycinate Link to comment Share on other sites More sharing options...
PortugueseSea Posted August 12, 2023 Share Posted August 12, 2023 I would say their talks of permanency are about chronicity ; if someone is the throngs of dysphoria for a long time, which is the case with me, it just means your brain hasn't readjusted yet. It might take months to years for it to do so. Why it takes so long is beyond me. I get glimpses of happiness here and tear but the shroud is still going. December 2021 - Metoclopramide started. Akathisia symptoms start; Metoclopramide gets changed to PRN. March 2022 - Akathisia diagnosed; Metoclopramide stopped; Propranolol 10mg x twice a day. Biperiden PRN (0.5mg to 1mg). April 2022 - Tandospirone 30mg (10mg 3x day), Quetiapine 25mg (only taken once, immediate adr). Mirtazapine 7.5mg. . Discontinued Propranolol. May 2022 - Mirtazapine upped to 15mg. Tandospirone cut to 2x 10mg. Low dose Depakote for the month; 100 to 200 to 100 to 0. Mirtazapine cut back to 11.75mg (3/4 of a 15mg pill).June 2022 - Mirtazapine updose to 15mg. Tandospirone, Biperiden discontinued. Klonopin started PRN (0.5mg). September 2022 - Akathisia slowly starts improving, WD/ADR normal sets in in mid September. Hold for 4 months.March 2023 - Off mirtazapine; no Klonopin for 5 months either! Started quercetin (250mg x 2) to soften the histamine rebound. May 2023 - Stopped quercetin and changed from magnesium carbonate to oxide - reacted badly. Reverted back to carbonate. June 2023 - Added fish oil.Current regimen: CALM Magnesium (Carbonate into Citrate) 175mg x2; Vitamin E 268mg x2; Fish oil (100mg Omega3; EPA 30mg; DHA 37mg)x2 Intro thread: https://www.survivingantidepressants.org/topic/27095-portuguesesea-metoclopramide-akathisia-and-mirtazapine/ Link to comment Share on other sites More sharing options...
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