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janep: Mirtazapine Withdrawal

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I will try and make this short. I am a 76 year-old female. I was put on mirtazapine about 2.5 years ago simply for insomnia. I started at 7.5 mg and was quickly increased to 15 mg. It worked beautifully and I also gained weight that I really needed. I stupidly decided to wean myself off because I don't like taking drugs and I have no problems with depression or anxiety. I started at 7.5 mg and was quickly increased to 15 mg. I knew how to do it fairly slowly with liquid and got down to 1 mg with really no problems. At 1 mg insomnia hit and I panicked. I jumped back on. I can't remember if it was to 7.5 mg or 15 mg. I was OK. Then I started titrating again. Nausea and sedation have been the biggest problems. At 1.5 mg. I am suffering badly. I decided to go up to 2 mg and try and stabilize, but I am completely doped,nausea is back and I have no appetite. I cannot afford to lose any more weight.  I know this low dose is causing sedation. so I am not sure if holding at 2 mg is going to help me continue my journey down. I am sorry I took this drug in the first place and even sorrier I decided to try and get off it. Not sure what the answer is at this point since doctors have no clue. 

Edited by Emonda
Name to title


Atorvastatin 80 mg. Just switched March 15, 2024 from many years at 40 mg.

Armour 120 mg. Switched March 19, 2024 from taking Synthroid 88 mg for many years. I have no recollection when I started Synthroid

Mirtazapine liquid equivalent of 2 mg. Started at 15 mg around December 2019.

Zofran when I have nausea that does not abate.

Doctor suggested I take OTC anti-histamine when I can't sleep. That makes me feel worse.


CoQ10/Ubiquinol  200 mg. Several years.

For insomnia, the last week I tried a half dose of Benadryl one day and a Unisom last night - on the suggestion of my GP.



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  • Moderator

Hello @janep.


Could you follow these instructions to fill in your drug signature, that way we can better understand what is happening.


Your first task is to create a drug signature, with the following:


  • All current medication you take, the dose you take, when you started the drug, and when you made dose changes
  • All current supplements you take
  • An accurate history of recent drugs, taken in the last 12-24 months
  • Dates for recent should be written as 7 Oct 2023, or Oct 7 2023, or early Oct 2023, or mid Oct 2023
  • A history of drugs taken 24 months ago and beyond - if applicable
  • Dates for historical drugs can simply be listed as start and stop years
  • Please do not use 07/10/23 // 10/07/23 as this is intepreted differently around the world


  • Please leave out symptoms and diagnoses. See my signature for example of clear and concise information.


Active Monday-Friday UK time



1) Sertraline:

50mg - Oct 2020, 100mg - Dec 2020, 50mg - April 2021, 75mg - May 2021, 50mg - Sep 2021; 55mg - 23 Feb 2024; 60mg - 20 March 2024; Start tapering - 24 April 2024

Current dose: 57.93mg  (15 May 2024)

2) Mirtazapine:

15mg - Nov 2020


Cod liver oil, Magnesium, Vitamin C

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  • Emonda changed the title to janep: Mirtazapine Withdrawal

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