Nadia Posted October 12, 2012 Share Posted October 12, 2012 Hi, Was researching and came across Picamilon. Has anyone tried it? Supposedly it has potential as an anxiolytic. GABA itself doesn't cross the blood-brain barrier, but the niacin in the compound helps it across. '94-'08 On/off ADs. Mostly Zoloft & Wellbutrin, but also Prozac, Celexa, Effexor, etc.6/08 quit Z & W after tapering, awful anxiety 3 mos. later, reinstated.11/10 CTed. Severe anxiety 3 mos. later & @ 8 mos. much worse (set off by metronidazole). Anxiety, depression, anhedonia, DP, DR, dizziness, severe insomnia, high serum AM cortisol, flu-like feelings, muscle discomfort.9/11-9/12 Waves and windows of recovery.10/12 Awful relapse, DP/DR. Hydrocortisone?11/12 Improved fairly quickly even though relapse was one of worst waves ever. 1/13 Best I've ever felt. 3/13 A bit of a relapse... then faster and shorter waves and windows. 4/14 Have to watch out for triggers, but feel completely normal about 80% of the time. Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted October 12, 2012 Administrator Share Posted October 12, 2012 I looked into this but it's one of those Russian supplements, so I backed off. A lot of weird supplement research comes out of Russia, I'm very unsure of its quality. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
Nadia Posted October 20, 2012 Author Share Posted October 20, 2012 Hmm... There is someone that says "how to make your own", effectively, by combining niacin and GABA. But I do wonder... like with melatonin and SAMe and 5HTP, etc., it could be worse in the end to mess with what is going on in the brain. I suppose that can be an extreme view... certainly anything we do is a form of brain alteration, from walking to eating to taking fish oil or magnesium. But I guess I'm wary of substances that may upset, rather than encourage, healthy brain homeostasis. '94-'08 On/off ADs. Mostly Zoloft & Wellbutrin, but also Prozac, Celexa, Effexor, etc.6/08 quit Z & W after tapering, awful anxiety 3 mos. later, reinstated.11/10 CTed. Severe anxiety 3 mos. later & @ 8 mos. much worse (set off by metronidazole). Anxiety, depression, anhedonia, DP, DR, dizziness, severe insomnia, high serum AM cortisol, flu-like feelings, muscle discomfort.9/11-9/12 Waves and windows of recovery.10/12 Awful relapse, DP/DR. Hydrocortisone?11/12 Improved fairly quickly even though relapse was one of worst waves ever. 1/13 Best I've ever felt. 3/13 A bit of a relapse... then faster and shorter waves and windows. 4/14 Have to watch out for triggers, but feel completely normal about 80% of the time. Link to comment Share on other sites More sharing options...
antidepressantsNoMore Posted September 23, 2015 Share Posted September 23, 2015 Picamilon is an amino acid derivative related to GABA, used as an ingredient in dietary supplement products. It is said to support relaxation, restful sleep, focus, and positive mood. The supplement GABA is pretty much useless because it has a hard time crossing the Brain Barriar. Picamilon is a derivative of GABA with Vitamin B3. The combination of both molecules makes it easier to cross the Brain barriar and give you results. It is a great anti-anxiety drug and is actually used a prescription in Russia. You can buy it online here legally. I think people should give it a shot. Start out with a low dose 50mg and increase to 200 mg. trintellix 1 mg and rexulti .5mg Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted September 23, 2015 Administrator Share Posted September 23, 2015 Picamilon is not an amino acid. It is a synthetic GABA-ergic drug, developed in Russia, unlicensed in the US and sold as a nutritional supplement. It is popular among recreational drug enthusiasts. There's very little information on the Web available about picamilon other than that supplied by sellers of the supplement. http://www.livestrong.com/article/492571-gaba-supplements-that-pass-the-blood-brain-barrier/ http://www.raysahelian.com/picamilon.html This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
Moderator Emeritus Petunia Posted September 23, 2015 Moderator Emeritus Share Posted September 23, 2015 anM, we already have topic on this supplement, so I joined the topic you started with the original one to keep all the information together. You can buy it online here legally. I think people should give it a shot. Have you tried this yourself? I'm not a doctor. My comments are not medical advise. These are my opinions based on my own experience and what I've learned. Please discuss your situation with a medical practitioner who has knowledge of tapering and withdrawal...if you are lucky enough to find one. My Introduction Thread Full Drug and Withdrawal History Brief Summary Several SSRIs for 13 years starting 1997 (for mild to moderate partly situational anxiety) Xanax PRN ~ Various other drugs over the years for side effects 2 month 'taper' off Lexapro 2010 Short acute withdrawal, followed by 2 -3 months of improvement then delayed protracted withdrawal DX ADHD followed by several years of stimulants and other drugs trying to manage increasing symptoms Failed reinstatement of Lexapro and trial of Prozac (became suicidal) May 2013 Found SA, learned about withdrawal, stopped taking drugs...healing begins. Protracted withdrawal, with a very sensitized nervous system, slowly recovering as time passes Supplements which have helped: Vitamin C, Magnesium, Taurine Bad reactions: Many supplements but mostly fish oil and Vitamin D June 2016 - Started daily juicing, mostly vegetables and lots of greens. Aug 2016 - Oct 2016 Best window ever, felt almost completely recovered Oct 2016 -Symptoms returned - bad days and less bad days. April 2018 - No windows, but significant improvement, it feels like permanent full recovery is close. VIDEO: Where did the chemical imbalance theory come from? VIDEO: How are psychiatric diagnoses made? VIDEO: Why do psychiatric drugs have withdrawal syndromes? VIDEO: Can psychiatric drugs cause long-lasting negative effects? VIDEO: Dr. Claire Weekes Link to comment Share on other sites More sharing options...
Moderator brassmonkey Posted September 23, 2015 Moderator Share Posted September 23, 2015 This site gives a pretty good overview picamilon and doesn't make it sound like it's worth trying. For one thing having only a 1 hour half life makes it pretty useless in the first place, and all the other "benefits" are hearsay and supposition. I wouldn't waste my time or money on it. http://www.calmclinic.com/anxiety/drugs/picamilon 20 years on Paxil starting at 20mg and working up to 40mg. Sept 2011 started 10% every 6 weeks taper (2.5% every week for 4 weeks then hold for 2 additional weeks), currently at 7.9mg. Oct 2011 CTed 15oz vodka a night, to only drinking 2 beers most nights, totally sober Feb 2013. Since I wrote this I have continued to decrease my dose by 10% every 6 weeks (2.5% every week for 4 weeks and then hold for an additional 2 weeks). I added in an extra 6 week hold when I hit 10mg to let things settle out even more. When I hit 3mgpw it became hard to split the drop into 4 parts so I switched to dropping 1mgpw (pill weight) every week for 3 weeks and then holding for another 3 weeks. The 3 + 3 schedule turned out to be too harsh so I cut back to dropping 1mgpw every 4 weeks which is working better. Final Dose 0.016mg. Current dose 0.000mg 04-15-2017 "It's also important not to become angry, no matter how difficult life is, because you can loose all hope if you can't laugh at yourself and at life in general." Stephen Hawking Link to comment Share on other sites More sharing options...
antidepressantsNoMore Posted September 25, 2015 Share Posted September 25, 2015 anM, we already have topic on this supplement, so I joined the topic you started with the original one to keep all the information together. You can buy it online here legally. I think people should give it a shot. Have you tried this yourself? yeah i got 100 grams for 2 dollars, because of a glitch in the companies' website, they gave it to me for 95 percent off. The first week I really liked it but now I'm not so sure. It's cool though because I only spent 2 dollars. It worked at first but it makes me too tired in lower doses and higher doses, too stimulated. I'll just stick with magnesium powder. trintellix 1 mg and rexulti .5mg Link to comment Share on other sites More sharing options...
Reclaiming Posted September 27, 2023 Share Posted September 27, 2023 Happened upon this thread and wanted to say that I started using it about a month ago. It significantly reduced my tinnitus, paresthesia, and overall functioning. I use it routinely now, in addition to GABAergic supplements (primarily magnesium + cofactors / taurine). Oct 2019: Insomnia due to stress, prescribed 50mg trazodone and 50mg sertraline Mar-May 2020: Off sertraline, had a poor reaction. COVID isolation hit. Restarted sertraline 25mg, maintained trazodone June 2020: Used LSD to (I was told) "reset my brain" following isolation, trauma, and difficulty weaning July 2020: Re-started sertraline 25mg, trazodone during subsequent lockdowns Feb 2021: Off sertraline; tried to taper trazodone instead of coming off cold turkey when I had a poor reaction May 2021: Ketamine infusion for suicidality; given Seroquel for sleep; only took a few times Aug 2021: Clonazepam 0.25 mg at sleep and in the morning (0.5 mg total) - maintained for sleep Jan 2022: Tried lamotrigine for two weeks to see if it would stabilize anything. Couldn't fathom being on another drug and stopped. April 2022: Advised to wean off clonazepam to avoid damage. Now, often bedridden, routine bouts of terror/chemical anxiety. My journey: https://brainhack.substack.com/ Link to comment Share on other sites More sharing options...
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