Administrator Altostrata Posted October 29, 2012 Administrator Share Posted October 29, 2012 (edited) AKA Axoren, Ansial, Bespar, Bespar, Barpil, Buspar, Buspinol, Censpar, Lucelan, Travin Does buspirone have a withdrawal syndrome? Yes indeed it does, despite the "folk wisdom" you might hear from doctors. Withdrawal symptoms from buspirone, like buproprion (Wellbutrin) are only somewhat less likely than other psychiatric drugs. See http://www.everydayhealth.com/health-questions/buspar/what-withdrawal-symptoms-can-i-expect-as-i-end-my-taper-off-buspar Official FDA information at http://www.drugs.com/pro/buspar.html Quote ADVERSE REACTIONS (See also PRECAUTIONS) ....Associated with Discontinuation of Treatment One guide to the relative clinical importance of adverse events associated with BuSpar is provided by the frequency with which they caused drug discontinuation during clinical testing. Approximately 10% of the 2200 anxious patients who participated in the BuSpar premarketing clinical efficacy trials in anxiety disorders lasting 3 to 4 weeks discontinued treatment due to an adverse event. The more common events causing discontinuation included: central nervous system disturbances (3.4%), primarily dizziness, insomnia, nervousness, drowsiness, and lightheaded feeling; gastrointestinal disturbances (1.2%), primarily nausea; and miscellaneous disturbances (1.1%), primarily headache and fatigue. In addition, 3.4% of patients had multiple complaints, none of which could be characterized as primary. And other interesting tidbits: Quote Potential for Withdrawal Reactions in Sedative/Hypnotic/Anxiolytic Drug-Dependent Patients Because BuSpar does not exhibit cross-tolerance with benzodiazepines and other common sedative/hypnotic drugs, it will not block the withdrawal syndrome often seen with cessation of therapy with these drugs. Therefore, before starting therapy with BuSpar, it is advisable to withdraw patients gradually, especially patients who have been using a CNS-depressant drug chronically, from their prior treatment. Rebound or withdrawal symptoms may occur over varying time periods, depending in part on the type of drug, and its effective half-life of elimination. The syndrome of withdrawal from sedative/hypnotic/anxiolytic drugs can appear as any combination of irritability, anxiety, agitation, insomnia, tremor, abdominal cramps, muscle cramps, vomiting, sweating, flu-like symptoms without fever, and occasionally, even as seizures.Possible Concerns Related to Buspirone's Binding to Dopamine Receptors Because buspirone can bind to central dopamine receptors, a question has been raised about its potential to cause acute and chronic changes in dopamine-mediated neurological function (eg, dystonia, pseudo-parkinsonism, akathisia, and tardive dyskinesia). Clinical experience in controlled trials has failed to identify any significant neuroleptic-like activity; however, a syndrome of restlessness, appearing shortly after initiation of treatment, has been reported in some small fraction of buspirone-treated patients. The syndrome may be explained in several ways. For example, buspirone may increase central noradrenergic activity; alternatively, the effect may be attributable to dopaminergic effects (ie, represent akathisia). Reduce by 10% per month to start The 10% rule holds for buspirone, just like other psychiatric drugs: Reduce by 10% per month, calculated on the last dosage. (The amount of the reduction gets progressively smaller.) See Why taper by 10% of my dosage?Cutting up regular buspirone tablets Buspar comes in these dosages: 5 mg, 10mg, 15mg, 30mg tablets. The tablets are scored for splitting. People taking may taper by cutting up the tablets with a pill splitter. It's a good idea to keep the pieces you don't use in a clean pill bottle labeled with the dosage for future use.Use an electronic digital jeweler's scale to weigh small amounts If you are sensitive to dosage changes, you may wish to be more precise in your measurements so you can taper at a measured rate. A digital scale, which can be bought for about $30, is useful. See http://survivingantidepressants.org/index.php?/topic/1596-using-a-digital-scale-to-measure-doses/Use a liquid solution Titrating using a liquid is very good for very small measured decreases in dosage, allowing more precise measurements. Make a solution of buspirone and water yourself Technically, buspirone is water-soluble (MSDS http://www.sciencelab.com/msds.php?msdsId=9925718 ) We don't know how stable a homemade solution would be -- how long it would last at full strength. How to make a liquid: http://survivingantidepressants.org/index.php?/topic/2693-how-to-make-a-liquid-from-tablets-or-capsules/ Have buspirone made into a compounded liquid by a compounding pharmacy (can be expensive). Using a combination of tablets or capsules and liquid Rather than switch directly to an all-liquid dose, you may wish to take part of your dose in liquid and part in lower-dose tablets or capsules, gradually converting to all liquid as you get to lower dosages. This can be very convenient and reduce any problems switching from one form of the drug to another. If your doctor prescribes compounded liquid and tablets or capsules at the same time, most likely he or she will have to indicate "divided doses" in the prescriptions to get the drugs covered by insurance. Have a compounding pharmacy make capsules with custom dosages Compounding pharmacies can weigh buspirone and make up capsules for you of specidic dosages. The only drawback is this can be quite expensive."Bridging" with Prozac or other drugs This should not be necessary with buspirone. We don't know of a substitute. Edited June 13, 2018 by Altostrata updated This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
Loonette Posted November 26, 2013 Share Posted November 26, 2013 I see this is an old post, but I did a search for info on Buspar. I ran out of Buspar on Sunday morning. I was on it since April 2013, after the other medications prescribed by the psychiatrist failed (caused too many negative side effects), those being Wellbutrin and Seroquel. Horrible stuff. The Buspar had no side effects that I could see or feel, but then again, it didn't do anything to help me, either. Supposedly it was being prescribed to me for anxiety. I still felt plenty of anxiety during stressful situations. I'm not sure how normal that even is. I asked my family doctor a few months ago if I could taper off the Buspar, as it seemed to be doing nothing and was a waste of money and who knows what all else it's doing to me negatively, surreptitiously. His response was, "Let's up your dose and see what happens." I reluctantly went with his advice, going from 10 mg twice a day to 15 mg twice a day. I didn't notice any changes for better or worse. Last week, I saw that I was running low on Buspar, so I tried to get an appointment with my doctor. I was told he had no appointments till early December. I asked if there's any way they could squeeze me in, as I'm running out of my prescription Buspar. They said no. Since I already had an appointment scheduled for December 2, I figured all I could do was wait. I took my last Buspar on Sunday morning, which was two halves for a total of 10 mg. So far, nothing seems amiss. Still, I don't know what I don't know, and thus far have not found anything convincing online to assure me I'm going to be okay or if there is anything specific about which I should be aware. This is only my second post on this site. I didn't see an option for me to start a new thread, so please forgive me if I have posted this in the wrong spot. Hoping to find a little support. Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted November 26, 2013 Author Administrator Share Posted November 26, 2013 Loonette, see my response here http://survivingantidepressants.org/index.php?/topic/5300-loonette-coming-off-buspar-buspirone/ This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
Aelius Posted February 24, 2017 Share Posted February 24, 2017 I strongly advise don`t underestimate Buspirone! I thought it was an easy drug to withdraw from. I couldn`t have been mistaken more. I came off it very fast and after about two weeks hell unleashed! Reinstatement didn`t work for me, I had to taper it faster than recommended again. I`ve never had such panic attacks, persistent anxiety and sever depression in my life before! 05/06/2015-05/21/2015 Zoloft C/T, 05/2015-08/2015 Clonazepam 2x0.5mg (reduced to 0 during one month), 05/2015-08/2015 Trazodone 150mg (last month 100mg, reduced to 0 during 7 days), 09/2015-07/2016 Clonazepam reinstated after one month off to 2x0.25mg (benzo free since July 28, 2016), 09/2016 Escitalopram 5mg (10 days), 10/2015-04/2016 Venlafaxine 150mg (3 months) 75mg (3 months) C/T, 01/2016-04/2016 Olanzapine 2.5mg C/T, 04/2016-05/2016 Lamictal 100mg (5 weeks, reduced to 0 during 7 days)), 08/02/2016-08/16/2016 Valdoxan 25mg C/T, 08/23/2016-09/21/2016 Venlafaxine 75 mg (reduced to 0 during 7 days), 07/27/2016-10/10/2016 Buspirone 3x5mg (Oct. 1-3; 5mg-2.5mg-2.5mg,)(Oct.4-5; 2.5mg-2.5mg-2.5mg)(Oct. 6-8; 2.5mg-2.5mg-0)(Oct. 9; 2.5mg-0-0), 10/25/2016 - reinstated Buspirone 3x5mg (Dec.13-19; 5mg-2.5mg-5mg) (Dec.19-Jan.1; 5mg, 2.5mg, 2.5mg) (Jan.2-11; 2.5mg, 2.5mg, 2.5mg) (Jan.2-19;1.67mg, 1.67mg, 1.67mg) (Jan.20-27; 0.83mg, 0.83mg, 0.83mg) (Jan.28-Feb.05; 1mg, 1mg)(Feb.6-0mg) 08/10/2016 - Mirtazapine 30mg (01/26/2017-02/19/2017, 27mg) (02/20/2017-03/05/2017, 25.5mg) (03/06/2017-03/12/2017, 24mg) (03/12/2017-03/19/2017, 23mg) (03/20/2017-04/02/2017, 22mg) (04/03/2017-04/16/2017, 21mg) (04/17/2017-05/12/2017, 20mg) (05/13/2017-05/22/2017, 19mg) (05/23/2017-06/09/2017, 18mg) (06/10/2017-06/16/2017, 17.5mg) (06/17/2017-06/23/2017, 17mg) (06/24/2017-06/30/2017, 16.5mg) (07/01/2017-07/14/2017, 16mg) (07/15/2017-07/23/2017, 15.5mg) (07/24/2017-08/31/2017, 15mg) (09/01/2017-09/10/2017, 14.5mg) (09/11/2017-09/30/2017, 14mg) (10/01/2017-10/26/2017, 13.5mg) (10/27/2017-11/04/2017, 13mg) (11/05/2017-11/18/2017, 12.5mg) (11/19/2017-12/08/2017, 12mg) (12/09/2017-12/15/2017, 11.75mg) (12/16/2017-12/28/2017, 11.5mg) (12/29/2017-01/11/2018, 11mg) (01/12/2018-01/25/2018, 10.5mg) (01/26/2018-02/08/2018, 10mg) (02/09/2018-02/22/2018, 9.5mg) (02/23/2018-03/08/2018, 9mg) (03/09/2018-03/22/2018, 8.5mg) (03/23/2018-04/05/2018, 8mg) (04/06/2018-04/27/2018, 7.5mg) (04/28/2018-05/05/2018, 7.13mg) (05/06/2018-05/17/2018, 7mg) (05/18/201/-05/31/2018, 6.5mg) (06/01/2018-06/14/2018, 6.25mg) (06/15/2018-06/24/2018, 6mg) (06/25/2018-06/30/2018, 5.67mg) (06/31/2018-07/09/2018, 5.5mg) (07/10/2018-07/16/2018, 5.33mg) (07/17/2018-07/23/2018, 5.16mg) (07/24/2018-07/31/2018, 5mg) (08/01/2018-08/14/2018, 4.75mg) (08/15/2018-09/14/2018, 4.50mg) (09/15/2018-10/14/2018, 4.00mg) (10/15/2018-11/26/2018, 3.50mg) (11/27/2018-01/05/2019, 3.0mg) (01/06/2019-01/16/2019, 2.5mg) (01/17/2019-02/08/2019, 2.25mg) (02/09/2019-02/22/2019, 2.13 mg) (02/23/2019-03/07/2019, 2.00 mg) (03/08/2019-04/01/2019, 1.67 mg) (04/02/2019-04/13/2019, 1.5 mg) (04/14/2019-04/26/2019, 1.33 mg) (04/27/2019-05/10/2019, 1.16 mg) (05/11/2019-05/23/2019, 1.0 mg) (05/24/2019-06/02/2019, 0.88 mg) (06/03/2019-06/13/2019, 0.75 mg) (06/14/2019-06/23/2019, 0.63 mg) (06/24/2019-07/03/2019, 0.50 mg) (07/04/2019-07/08/2019, 0.00 mg) (07/09/2019, 0.50 mg) (07/10/2019, 0.00 mg) Psych drugs free since 10th July 2019. Link to comment Share on other sites More sharing options...
Dwell Posted April 9, 2017 Share Posted April 9, 2017 Has anyone done a 10% taper with buspar/buspirone? I'd like to hear how it went! Paxil 20mg started around 2013 dropped to 10 mg at some point dropped to 5mg for 1 week then C/T August 2016. Buspar 10 mg 2x daily started 2013 fluctuating amounts. Tried cylexa 1 week at beginning of August 2016. Tried wellbutrin 1 week after cylexa stopped both. I have been off all meds for around 4- 5 years. Link to comment Share on other sites More sharing options...
Leelo Posted June 13, 2018 Share Posted June 13, 2018 On 2/24/2017 at 4:36 AM, Aelius said: I strongly advise don`t underestimate Buspirone! I thought it was an easy drug to withdraw from. I couldn`t have been mistaken more. I came off it very fast and after about two weeks hell unleashed! Reinstatement didn`t work for me, I had to taper it faster than recommended again. I`ve never had such panic attacks, persistent anxiety and sever depression in my life before! This gave me a little comfort, not that you were in pain of course but that it's not just me. My symptoms came two weeks later as well and I've had hand shakiness for 2 weeks with horrible anxiety, nervousness, depression, gastritis, mild diarrhea, and being twitchy. I've held out for 2 weeks but couldn't take it anymore. I restarted at 5 mg once daily at night. I was originally at 10mg once daily before bed. I have a doctor's appointment Monday and see what he says how to continue. I'm praying I feel better by then. Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted June 13, 2018 Author Administrator Share Posted June 13, 2018 Leelo, please start a topic for yourself in the Introductions forum. You may not need to reinstate more than 5mg. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
Aelius Posted July 6, 2018 Share Posted July 6, 2018 On 6/13/2018 at 4:28 PM, Leelo said: This gave me a little comfort, not that you were in pain of course but that it's not just me. My symptoms came two weeks later as well and I've had hand shakiness for 2 weeks with horrible anxiety, nervousness, depression, gastritis, mild diarrhea, and being twitchy. I've held out for 2 weeks but couldn't take it anymore. I restarted at 5 mg once daily at night. I was originally at 10mg once daily before bed. I have a doctor's appointment Monday and see what he says how to continue. I'm praying I feel better by then. Hi Leelo. Yes, you`not alone in this. I`m sorry what Buspirone has done to you. I`ve been off Buspirone for a year and half and still have serious symptoms. 05/06/2015-05/21/2015 Zoloft C/T, 05/2015-08/2015 Clonazepam 2x0.5mg (reduced to 0 during one month), 05/2015-08/2015 Trazodone 150mg (last month 100mg, reduced to 0 during 7 days), 09/2015-07/2016 Clonazepam reinstated after one month off to 2x0.25mg (benzo free since July 28, 2016), 09/2016 Escitalopram 5mg (10 days), 10/2015-04/2016 Venlafaxine 150mg (3 months) 75mg (3 months) C/T, 01/2016-04/2016 Olanzapine 2.5mg C/T, 04/2016-05/2016 Lamictal 100mg (5 weeks, reduced to 0 during 7 days)), 08/02/2016-08/16/2016 Valdoxan 25mg C/T, 08/23/2016-09/21/2016 Venlafaxine 75 mg (reduced to 0 during 7 days), 07/27/2016-10/10/2016 Buspirone 3x5mg (Oct. 1-3; 5mg-2.5mg-2.5mg,)(Oct.4-5; 2.5mg-2.5mg-2.5mg)(Oct. 6-8; 2.5mg-2.5mg-0)(Oct. 9; 2.5mg-0-0), 10/25/2016 - reinstated Buspirone 3x5mg (Dec.13-19; 5mg-2.5mg-5mg) (Dec.19-Jan.1; 5mg, 2.5mg, 2.5mg) (Jan.2-11; 2.5mg, 2.5mg, 2.5mg) (Jan.2-19;1.67mg, 1.67mg, 1.67mg) (Jan.20-27; 0.83mg, 0.83mg, 0.83mg) (Jan.28-Feb.05; 1mg, 1mg)(Feb.6-0mg) 08/10/2016 - Mirtazapine 30mg (01/26/2017-02/19/2017, 27mg) (02/20/2017-03/05/2017, 25.5mg) (03/06/2017-03/12/2017, 24mg) (03/12/2017-03/19/2017, 23mg) (03/20/2017-04/02/2017, 22mg) (04/03/2017-04/16/2017, 21mg) (04/17/2017-05/12/2017, 20mg) (05/13/2017-05/22/2017, 19mg) (05/23/2017-06/09/2017, 18mg) (06/10/2017-06/16/2017, 17.5mg) (06/17/2017-06/23/2017, 17mg) (06/24/2017-06/30/2017, 16.5mg) (07/01/2017-07/14/2017, 16mg) (07/15/2017-07/23/2017, 15.5mg) (07/24/2017-08/31/2017, 15mg) (09/01/2017-09/10/2017, 14.5mg) (09/11/2017-09/30/2017, 14mg) (10/01/2017-10/26/2017, 13.5mg) (10/27/2017-11/04/2017, 13mg) (11/05/2017-11/18/2017, 12.5mg) (11/19/2017-12/08/2017, 12mg) (12/09/2017-12/15/2017, 11.75mg) (12/16/2017-12/28/2017, 11.5mg) (12/29/2017-01/11/2018, 11mg) (01/12/2018-01/25/2018, 10.5mg) (01/26/2018-02/08/2018, 10mg) (02/09/2018-02/22/2018, 9.5mg) (02/23/2018-03/08/2018, 9mg) (03/09/2018-03/22/2018, 8.5mg) (03/23/2018-04/05/2018, 8mg) (04/06/2018-04/27/2018, 7.5mg) (04/28/2018-05/05/2018, 7.13mg) (05/06/2018-05/17/2018, 7mg) (05/18/201/-05/31/2018, 6.5mg) (06/01/2018-06/14/2018, 6.25mg) (06/15/2018-06/24/2018, 6mg) (06/25/2018-06/30/2018, 5.67mg) (06/31/2018-07/09/2018, 5.5mg) (07/10/2018-07/16/2018, 5.33mg) (07/17/2018-07/23/2018, 5.16mg) (07/24/2018-07/31/2018, 5mg) (08/01/2018-08/14/2018, 4.75mg) (08/15/2018-09/14/2018, 4.50mg) (09/15/2018-10/14/2018, 4.00mg) (10/15/2018-11/26/2018, 3.50mg) (11/27/2018-01/05/2019, 3.0mg) (01/06/2019-01/16/2019, 2.5mg) (01/17/2019-02/08/2019, 2.25mg) (02/09/2019-02/22/2019, 2.13 mg) (02/23/2019-03/07/2019, 2.00 mg) (03/08/2019-04/01/2019, 1.67 mg) (04/02/2019-04/13/2019, 1.5 mg) (04/14/2019-04/26/2019, 1.33 mg) (04/27/2019-05/10/2019, 1.16 mg) (05/11/2019-05/23/2019, 1.0 mg) (05/24/2019-06/02/2019, 0.88 mg) (06/03/2019-06/13/2019, 0.75 mg) (06/14/2019-06/23/2019, 0.63 mg) (06/24/2019-07/03/2019, 0.50 mg) (07/04/2019-07/08/2019, 0.00 mg) (07/09/2019, 0.50 mg) (07/10/2019, 0.00 mg) Psych drugs free since 10th July 2019. Link to comment Share on other sites More sharing options...
Hannahe Posted June 19, 2019 Share Posted June 19, 2019 Does anyone take buspar once a day? If so, does that work for you? I tapered off my morning dose and still taking 2.5 mg at night Originally at 100 mg Zoloft and 150 mg xl Wellbutrin for ten years. Abruptly dropped 50 mg of Zoloft April 2018. Cut Wellbutrin in half (75 mg) for a month in December 2018. Cold turkeyed Wellbutrin January 2019. Reinstated Wellbutrin half of 150 xl (75 mg) in January 2019 and added Xanax. ER visit iv of 5 mg Haloperidol. Finished Xanax taper, cold turkeyed Wellbutrin February 2019 and added 10 mg buspar twice daily. Tapering buspar 50 mg Zoloft at 10:00 am 2.5 mg buspar at 9:00 pm Link to comment Share on other sites More sharing options...
MattNNN Posted July 26, 2023 Share Posted July 26, 2023 I went from 45mg of Buspar to 0mg in only 6 weeks and didn't notice any withdrawal. Then again, I was also on really high doses of Seroquel, Lithium Carbonate, and Zoloft, so maybe that's why I didn't notice anything. -First started taking Seroquel, Zoloft, and Lithium Carbonate in January of 2008 after mother's death. Continued to take these meds for several years. -Had two Zoloft induced manic episodes, one in March 2013 and another in October 2014. -Mostly off meds from October 2014 to April 2015. -Went back on meds (Seroquel, Lithium and Zoloft) in April 2015. Then started to also take Buspar. -Summer 2021: Buspar = 45mg, Lithium Carbonate = 750mg, Seroquel = 350mg, Zoloft = 175mg. // Summer 2022: Buspar = 0mg, Lithium Carbonate = 525mg, Seroquel = 300mg, Zoloft = 87.5mg. // Summer 2023: Buspar = 0mg, Lithium Carbonate = 0mg (replaced with Lithium Orotate), Seroquel = 162.5mg, Zoloft = 37.5mg. -Recent Zoloft Doses -Oct22 to May23: Z = 37.5mg -Jun23: Z = 50mg->37.5mg -Jul23: Z = 34.4mg, Aug23: Z=34.4mg->31.25mg, Sep23: Z= 31.25mg, Oct23: Z =34.4mg, Nov23: Z= 37.5mg, Dec23: Z = 37.5 (switched from night to morning), Apr23: Z = 35.625mg -Recent Seroquel Doses -Dec22: S = 200mg -Jan23 & Feb23: S = 175mg / -Mar23: S = 162.5mg -Apr23: S = 150mg / -May23: S = 156mg / -Jun23-Oct23: S = 162.5mg, Nov23: S = 162.5mg -> 156mg, Dec23: S = 156mg, Apr23: S = 1652.5mg -Also taking: LTheanine, Fish Oil, VitC, D3&K2, GABA, Magnesium Glycinate. -Current Situation: On Feb 5th, my Zoloft dose was 37.5mg, but I was overstimulated by that high dose. I cut the dose down to 35.625mg, but that was too big of a cut so I brought it back up and stayed at 36.25mg for a while. Now I have gotten it back down to 35.625mg. I will stay at this dose until June 1st, then I plan to cut 5mg over the course of the next year. Unfortunately I can't cut it any quicker than that while remaining stable. Link to comment Share on other sites More sharing options...
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