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How long did it take for you to see any real ‘benefit’ from anti depressants?


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How long did it take for you to see any therapeutic improvement from anti depressants? 
Am interested in people’s experience of how long it took for them to respond to treatment. I myself took them for 7 weeks and didn’t exactly feel better.
But then guidelines suggest 8 to 10 weeks to become effective.

2013-July 1st Citalopram 20mg ()

2013-August 19th ended Citalopram cold turkey

med free.  (Took them for 7 weeks)


When I was a child, I spoke as a child,

I understood as a child, I thought as a child;

But when I became a man,

I put my childish things away.


- 1 Corinthians 13:11


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Everyone is different. I had significant improvement of depression within a week. But lots if people in this forum never had anything but trouble from the meds.

07.2004 Prozac. Greadually increased to 40mg. Good control of depression, but eventually developed muscle spasms and akathesia.

08.2010 Switched to Celexa. Suicidal ideation was constant.  Unable to sleep without ambien.

05.2012 Switched to Zoloft. Absolutely the BEST control of depression but caused severe bloating and rapid weight gain. Acne.

11.00.2012 Returned to Prozac 40mg

04.00.2013 Prozac 40mg + Wellbutrin 150mg

06.25.2013 Prozac 60mg and Wellbutrin 300mg


07.09.2013 Prozac 40mg and Wellbutrin 300mg

07.26.2013 Prozac 40mg and Wellbutrin 150 mg

08.01.2014 Prozac 40mg and Wellbutrin ZERO

08.09.2013 Prozac 30.0 mg

09.13.2013 Prozac 27.5 mg

10.04.2013 Prozac 25.0 mg

10.25.2013 Prozac 22.5 mg

11.15.2013 Prozac 20.0 mg

12.06.2013 Prozac 15.0 mg

12.21.2013 Prozac 10.0 mg


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The first time, I felt some better within a week, much better in 3 months. Huge mistake as all my real issues were left untouched.

1st round Prozac 1989/90, clear depression symptoms. 2nd round Prozac started 1999 when admitted to dr. I was tired. Prozac pooped out, switch to Cymbalta 3/2006. Diagnosed with bipolar disorder due to mania 6/2006--then I was taken abruptly off Cymbalta and didn't know I had SSRI withdrawal. Lots of meds for my intractable "bipolar" symptoms.

Zyprexa started about 9/06, mostly 5mg. Tapered 4/12 through12/29/12

Wellbutrin. XL 300 mg started 1/07, tapered 1/18/13 through 7/8/13

Oxazepam mostly continuously since 6/06, 30mg since 12/12, tapered 1.17.14 through 8.26.15

11/06 Lithium 600mg twice daily, 2.2.14 400mg TID DIY liquid, 2.12.14 1150mg, 3.2.14 1100mg, 3.18.14 1075mg, 4/14 updose to 1100mg, 6.1.14 900 mg capsules 7.8.14 810mg, 8.17.14 725mg, 8.24.24 700mg...10.22.14 487.5mg, 3.9.15 475mg, 4.1.15 462.5mg 4.21.15 450mg 8.11.15 375mg, 11.28.15 362.5mg, back to 375mg four days later, 3.4.16 updose to 475 (too much going on to risk trouble)

9/4/13 Toprol-XL 25mg daily for sudden hypertension, tapered 11.12.13 through 5.3.14, last 10 days or so switched to atenolol

7.4.14 Started Walsh Protocol

56 years old

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Everyone is different. I had significant improvement of depression within a week. But lots if people in this forum never had anything but trouble from the meds.

This describes me. I never had any improvement, but had chronic head/neck pain begin shortly after starting which, years later, was attributed (at least in part) to bruxism caused by SSRIs. Lost everything - my health, ability to work and support myself...life as i knew it.

Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormonesLitigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.<p>2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc).

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Never felt better from them. I was on the russian roulette program for at least a year or more with my doc where we kept trying new drugs and if the side effects were bad we'd try again. That should have been my clue to just not use them. I finally settle on imipramine, tegretol with the benzo klonopin being the only consistent one that we didn't change. Even then, I honest think the only real reason I improved was due to time as a factor and me coping with the actual stress and situation stuff better because I came to accept it than it was the drug. Over the years I've felt full out apathy and very depressed at times. Even suicidal at times. If the med was working, I wouldn't have felt that way. I suspect the med triggered these things more than help them.

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