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New study: Serotonin not found to be a major player in depression


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Interesting new study.


Serotonin not found to be a major player in depression

New evidence puts into doubt the long-standing belief that a deficiency in serotonin - a chemical messenger in the brain - plays a central role in depression. In the journal ACS Chemical Neuroscience, scientists report that mice lacking the ability to make serotonin in their brains (and thus should have been "depressed" by conventional wisdom) did not show depression-like symptoms.

Donald Kuhn and colleagues at the John D. Dingell VA Medical Center and Wayne State University School of Medicine note that depression poses a major public health problem. More than 350 million people suffer from it, according to the World Health Organization, and it is the leading cause of disability across the globe. In the late 1980s, the now well-known antidepressant Prozac was introduced. The drug works mainly by increasing the amounts of one substance in the brain - serotonin. So scientists came to believe that boosting levels of the signaling molecule was the key to solving depression. Based on this idea, many other drugs to treat the condition entered the picture. But now researchers know that 60 to 70 percent of these patients continue to feel depressed, even while taking the drugs. Kuhn's team set out to study what role, if any, serotonin played in the condition.

To do this, they developed "knockout" mice that lacked the ability to produce serotonin in their brains. The scientists ran a battery of behavioral tests.

Interestingly, the mice were compulsive and extremely aggressive, but didn't show signs of depression-like symptoms. Another surprising finding is that when put under stress, the knockout mice behaved in the same way most of the normal mice did. Also, a subset of the knockout mice responded therapeutically to antidepressant medications in a similar manner to the normal mice. These findings further suggest that serotonin is not a major player in the condition, and different factors must be involved. These results could dramatically alter how the search for new antidepressants moves forward in the future, the researchers conclude.



2000-2004 Celexa 75mg,Klonopin 1mg qd
2004-2014 Effexor XR 75mg, Klonopin 1mg qd
Effexor taper begun June 2014. Currently at ~50% reduction

Reinstated Effexor 75mg qd July 2014..... Contemplating another taper.

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No kidding.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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2012 put on Citalopram and diazepam for 3 months for "depression" after filling in a 3 minute form at the doctors, had a massive reaction with panic attacks and extreme anxiety,never suffered panic attacks or anxiety before citalopram.Told to quit cold turkey which led to two hospital admissions during 2012/2013

December for 6 months Seroquel dosage adjusted up and down 50mg ,150mg ,100mg, caused severe tinnitus ,told to quit cold turkey

2013 January for 12 months Lorazapam given to me like sweets,told to quit cold turkey

2013 May Zoloft for 6 months ,told to quit cold turkey, reinstated 50mg tapered 2nd time over a month (to fast but I survived)messed up my sleep

Zyprexa April 2103 5mg until august 2014 ,dropped by doctor down to 2.5mg for one month went well but sleep was very poor for 3 weeks

End of 2015 I had to reinstate back up to 5mg due to constant insomnia that wouldnt go away Started a slow taper and found an understanding doctor who listened to me while I reduced
May 2016 drug free, sleeping and doing well in life again, it can be done http://survivingantidepressants.org/index.php?/topic/12078-finally-off-zyprexa/

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