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Anbu, 2006 Fluoxetine Withdrawal Syndrome in the Newborn.


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Indian Pediatr. 2006 Jan;43(1):66-9.
Fluoxetine withdrawal syndrome in the newborn.
Anbu AT, Theodore A.

Abstract and free full text at http://www.ncbi.nlm.nih.gov/pubmed/16465011

A term baby was admitted to our neonatal unit with jitteriness, hypertonia, sneezing and fever. Her mother was on 20 mg of fluoxetine throughout her pregnancy. These symptoms which were possibly due to fluoxetine withdrawal lasted only for a short while. We attempt to look at the reported prevalence of this condition in the literature.

From the paper:
"The US Food and Drug administration (FDA) Adverse Event Reporting System(9) recorded 57 instances of SSRI-related neonatal withdrawal syndrome by November 2001."
"The most commonly reported neonatal symptoms include agitation,irritability, impending seizures, hypertonia or hypotonia, hyperreflexia, drowsiness, jitteriness,feeding problems, persistent crying,tachypnoea, temperature instability, acrocyanosis and tremors. In addition fluoxetine toxicity has been observed as scattered petechiae over the face and trunk along with cephalhaematoma(5), marked motor
automatism and skin manifestations(6). It has also been associated with colic(3), lipomeningocele(4), and cardiac arrhythmia(7)."
A., Anbu & A. Thoedore (2006). Fluoxetine Withdrawal Syndrome in the Newborn. Indian Pediatrics, 43, 66-69 : Can be found online at  http://medind.nic.in/ibv/t06/i1/ibvt06i1p66.pdf

Edited by Altostrata
put in Journals format

1988-2012: Prozac @ 60mg (with a few stops and starts)

Fall 2012: Returned to 40mg after discontinuing and horrid withdrawal 

Fall 2013: 40mg Fluoxetine, added 150mg Wellbutrin to treat fatigue 

Winter 2014: Attempting to taper both (too fast)

April 2014: 9mg Fluoxetine + 37.5 Wellbutrin 

Summer 2014: 8 mg Fluoxetine + 0 Wellbutrin (way too fast a drop)

Late summer/Early Fall 2014: Debilitating Withdrawal symptoms 

Fall 2014 - Wellbutrin successfully kicked to the curb but…

Oct- Dec 2014: Panicked reinstatement of Fluoxetine ->30mg - held for 5yrs

Jan 2021: taper to 20mg Fluoxetine  then tapering by 1mg every 2-3 months

Fall 2022 - held at 10mg->December 2022: 9mg->Feb 2023: 8mg ->March 2023: brassmonkey slide begins: 7.8mg -> 7.6 -> 7.4->2 week hold (April)->7.2->7mg->6.8->2 week hold->6.6-> 1-month hold ->(June)-6.5->4-week hold-> (July)-6.4 (discontinued brassmonkey slide and slowed taper)-> (Aug)-6.2->(Sept)-6.0->(Oct)-5.9->(Nov)-5.8->(Dec)-5.7->wave!->(Jan)-5.8->(Feb)-6mg and holding.


My 2014 withdrawal experience: https://rxisk.org/antidepressant-withdrawal-a-prozac-story/


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  • 2 weeks later...

There are many stories like this for many ssri and snri drugs. Sad. 

Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 


There is a crack in everything ..That's how the light gets in :)

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