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Hello all from the big island down under. 


Have been on Cymbalta 60mg one capsule per day for approximately 18 months now. GP wants me to stop taking it because of possible liver problems. Has not informed me as to how I should do this nor the possible consequences of withdrawal side effects. Which coincidently I had when starting on Cymbalta at 30mg. This drug has worked wonders for my depression and anxiety. It gave me my life back. As my doctor seems reluctant to offer information hence I am here trying to figure out how I should tackle this.


This morning I opened a capsule and counted those teeny tiny beads which were jumping all over the place. After several counts there were 562 beads in one capsule. It was a horrendous activity so I have decided to go to a compounding pharmacy and have them micro taper by reducing 1 bead per capsule per week until we get down to a reduction of 10%. I will keep you all updated on my progress.


Best wishes to you all. May we all enjoy good health.


mrschompy from Australia

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Hello Mrschompy and welcome to SA,


I'm very glad for you that you found us while still preparing your taper. Your instincts are very good. 


Here you will find more information on tapering Cymbalta (which is indeed tricky to taper...) but it can be done: http://survivingantidepressants.org/index.php?/topic/283-tips-for-tapering-off-cymbalta-duloxetine/


Reduce by micro-taper
The very smallest dose of Cymbalta is one bead. Some people find they can better tolerate a reduction of one bead at a time rather than a 10% decrease. You may be able to make reductions of one bead more frequently; try reducing by one bead a week for a while to see what your tolerance is. See http://survivinganti...or-5-decreases/
Do not reduce by one bead a day. This is too fast, you may develop withdrawal symptoms before you know what's happening.


You will also find a lot of very important information on tapering in general here: http://survivingantidepressants.org/index.php?/topic/300-important-topics-in-the-tapering-forum-and-faq/


Take your time to study the main points and come here should you have any questions. We are all here because doctors know very little about the process. Moreover, we have found their advice, such as the one you got, very harmful. 


Putting your drug history inyour signature will help us to give you more suggestions. This thread describes how you can do that: http://survivingantidepressants.org/index.php?/topic/893-please-put-your-withdrawal-history-in-your-signature/


You will also find a lot of friendly support. Welcome once again.



Current: 9/2022 Xanax 0.08, Lexapro 2

2020 Xanax 0.26 (down from 2 mg in 2013), Lexapro 2.85 mg (down from 5 mg 2013)

Amitriptyline (tricyclic AD) and clonazepam for 3 months to treat headache in 1996 
1999. - present Xanax prn up to 3 mg.
2000-2005 Prozac CT twice, 2005-2010 Zoloft CT 3 times, 2010-2013 Escitalopram 10 mg
went from 2.5 to zero on 7 Aug 2013, bad crash 40 days after
reinstated to 5 mg Escitalopram 4Oct 2013 and holding liquid Xanax every 5 hours
28 Jan 2014 Xanax 1.9, 18 Apr  2015 1 mg,  25 June 2015 Lex 4.8, 6 Aug Lexapro 4.6, 1 Jan 2016 0.64  Xanax     9 month hold

24 Sept 2016 4.5 Lex, 17 Oct 4.4 Lex (Nov 0.63 Xanax, Dec 0.625 Xanax), 1 Jan 2017 4.3 Lex, 24 Jan 4.2, 5 Feb 4.1, 24 Mar 4 mg, 10 Apr 3.9 mg, May 3.85, June 3.8, July 3.75, 22 July 3.7, 15 Aug 3.65, 17 Sept 3.6, 1 Jan 2018 3.55, 19 Jan 3.5, 16 Mar 3.4, 14 Apr 3.3, 23 May 3.2, 16 June 3.15, 15 Jul 3.1, 31 Jul 3, 21 Aug 2.9 26 Sept 2.85, 14 Nov Xan 0.61, 1 Dec 0.59, 19 Dec 0.58, 4 Jan 0.565, 6 Feb 0.55, 20 Feb 0.535, 1 Mar 0.505, 10 Mar 0.475, 14 Mar 0.45, 4 Apr 0.415, 13 Apr 0.37, 21 Apr 0.33, 29 Apr 0.29, 10 May 0.27, 17 May 0.25, 28 May 0.22, 19 June 0.22, 21 Jun updose to 0.24, 24 Jun updose to 0.26

Supplements: Omega 3 + Vit E, Vit C, D, magnesium, Taurine, probiotic 

I'm not a medical professional. Any advice I give is based on my own experience and reading. 

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