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Singulair experiences?


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I'm tapering off ADs and finally feeling stable. Dr suggested Singulair for allergies. I'm reading about lots of psych side effects. Any experiences?


What is Singulair:

From drugs.com:


Singulair (montelukast) is a leukotriene (loo-koe-TRY-een) inhibitor. Leukotrienes are chemicals your body releases when you breathe in an allergen (such as pollen). These chemicals cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms.


Edited by scallywag
add note about medication in question

43 yr old female. (weaned off Cymbalta 60 replaced with )Meds Prozac 10 mg every other day, Adderall 30mg, klonopin .25.

10/25/14. Prozac 10mg daily, 30 adderall, klonopin .25-.5 daily, fish oil

11/1. Added l arginine/l orthinine

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I just wanted to say welcome. I'm not in the same position as you so I cant really comment, just wanted to tell you that you're mot alone. I'm sure some will be able to advise you better than I can!

All medications::

Xanax (1995-96), Aropax (1995-96), Mellaril (1997-2000), Efexor (1997-2002), Seroquel (2000-now), Lithium Carbonate (2000-now), Avanza (2002-05), Epilim (2005), Seroquel-XR (2000-now), Zyprexa (2002-14), Raberprazole (2000-now prn), Crestor (2009-15), Gabapentin (2009-12), Lamictal (2010-now), Abilify (2011-now) Lyrica (2012-now), Diazepam (2010-now prn), Saphris (2014), Respiridone (2014), Chlorpromazine (2014) Neulatil (07/2016)


Current medications:

Lithium Carbonate 750mg; Seroquel-XR 600mg800mg 04/16, 600mg 04/16, 400mg 04/16, 200mg 04/16, 400mg 04/16, 500mg 04/16; Lamictal 250mg 200mg150mg 04/16; Lyrica 300mg; Abilify 20mg 30mg 11/15 Zoloft 25mg 04/16 ceased after a week due to severe suicidal thoughts; Seroquel 25mg prn; Diazepam 40mg CT Jan 2013, 5mg occasionally, (massive med changes in April 2016 due to a hospital admission).


SupplementsFish oil 4000mgMagnesium 100mg Niacinamide 1000mgSlippery Elm 800mg , B12 1000mcg, Zinc 50mg, B6 100mg, Vitamin D 2000IU, Calcium 1200mgP5P 100mg, Vitamin C 2000mg, Vitamin E 400IU


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Thanks Cali. I sincerely appreciate the welcome. I hope your feeling well.

43 yr old female. (weaned off Cymbalta 60 replaced with )Meds Prozac 10 mg every other day, Adderall 30mg, klonopin .25.

10/25/14. Prozac 10mg daily, 30 adderall, klonopin .25-.5 daily, fish oil

11/1. Added l arginine/l orthinine

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  • 2 years later...

I am facing the decision whether to take Singulair (Montelukast) or not, so if by now anybody has any experiences, I'd love to hear them.

  • 2,5 years of slowly tapering down Cymbalta from 60 mg. Then tried going from 8,44 mg to 1 mg in 8 days. (April 1st 2015). That's when the real hell started. Reinstated. Didn't help. I was added Ativan (2 mg 2 times a day for relentless akathisia that started with jumping Cymbalta). For years had been taking Zopitin 7,5 mg and Stilnox 10 mg for I had not been able to sleep naturally since the 1st day I started Cymbalta). Used to take Xanax occasionally.
  • All of the above were stopped cold turkey when I was hospitalized in the beginning of May 2015.
  • Prior to that I have been on and off the whole spectrum of different AD-s for 15 years (since I was 17).

My introduction.



  • Olanzapine (starting point 2,1 mg): Jan 2016  /---/ April 2018 0 mg. (From 2,1 mg to 0 mg in 1y 3mo).
  • Diazepam (starting at 5 mg) : switching to liquid May 2018;  4,6 mg (June 2018) /---/ 0 mg (Feb 2020) (From 10 to 5 - nobody knows, from 5 to 0 in 1 y 10 mo)
  • Valdoxan (starting at 25 mg): switching to liquid (Feb 2019) /---/ 0 mg (July 2020)


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  • 3 months later...

I've taken Singulair for seasonal allergies for years now, but I have observed since withdrawal it causes me anxiety and sleep disruptions. I'm only speaking for myself. This might not be the same for everyone. I'm just hoping I'll be able to make it through allergy season without it.

(Took Respiradone, Strattera, Celexa, Lexapro, and Pristiq prior to these.)

These were all taken over the course of approximately 10 years

10/7/15 - Fluvoxamine Maleate 100 MG

7/26/16 - Amphetamine Salts 10 MG

10/5/16 - Olanzapine-Fluoxetine 6-25 MG

11/1/16 - Olanzapine 2.5 MG AND Fluoxetine HCL 10 MG

11/08/16 - Amantadine 100 MG AND Aripiprazole 5 MG

11/22/16 - Trazodone 50 MG

12/1/16 - Aripiprazole 5 MG *LAST DOSE - COLD-TURKEYED*

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I have taken it in the past pre-psych drugs and was fine. However, I have also taken zyrtec (cetirizine) my whole life and it is now causing problems and worsening of my drug-induced akathisia and agitation. I have been recommended quercetin by other sufferers but have yet to try it. 

Aug-Dec 2015 Prozac 20mg / Dec 2015-Feb 2016 Prozac 15mg / Feb 2016-May2016 Prozac 20mg

May 2016-June 2016 15mg

June 2016-August 2016 10mg

October 2016-January 2017 15mg, alternating agitation/akathisia sets in --> cold turkey

January 2017 Clonazepam .5mg 

February 2017 Clonazepam 1mg (for a week) then .5mg morning and .25mg evening for about a month. Came down to .25mg morning and evening. 

May 1, 2017 Clonazepam .25mg morning and .125mg evening. // May 20, 2017 Clonazepam .25mg morning and .0625 evening (.3125 total).

early June .28125 // early mid june .25mg // mid june .21875 // late june .1875 // early july .15625 // early mid july .125 

mid july .09375mg // late july .0625 //early August 2017 down to .03125mg once a day, hopped off in mid August

reinstated at .0625mg late August // Oct 16 - updose to .07mg and switch to oral Rosemont solution

Nov 17 2017 reinstate Prozac .5mg // Nov 21 2017 prozac 1.6mg // Dec 18 2017  3mg prozac / fast taper off the reinstatement -- probably completely off early Oct 2018

June 2019 begin tapering off .07mg Clonazepam, Finish taper December 2019

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