Popovic et al, 2015 - Cognitive tolerability following successful long term treatment of major depression and anxiety disorder...

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J Affect Disord. 2015 Mar;173:211-5. doi: 10.1016/j.jad.2014.11.008. Epub 2014 Nov 15.
Cognitive tolerability following successful long term treatment of major depression and anxiety disorders with SSRi antidepressants
Dina Popovic^a, , , 
Eduard Vieta^a, 
Michele Fornaro^b, 
Giulio Perugi^c

Abstract at http://www.ncbi.nlm.nih.gov/pubmed/25462418
 
Background
 
The present study aims to evaluate cognitive tolerability profile of SSRIs in long-term treatment. The secondary aim is to explore differences of side effects profile between patients with major depression (MD) and anxiety disorders (AD).
 
Methods
 
Sixty-seven consecutive patients, successfully treated with SSRIs in monotherapy for at least six months for MD or AD, were assessed for side effects, with a special focus on cognition.
 
Results
 
Over 20% of MD and AD patients in long term treatment with SSRIs reported cognitive symptoms including fatigue, inattentiveness, lack of concentration, memory impairment and apathy. Recall memory impairment, attention deficit and somnolence were most frequently rated as moderate or severe. There were no significant differences in SSRI cognitive side effects profile between MD and AD patients.
 
Limitations
 
Subjective measure of cognitive functioning, limited sample size, lack of a control group.
 
Conclusions
 
A large proportion of depressed and anxious patients treated successfully with SSRIs for over six months reported cognitive, affective, motivational symptoms. These symptoms are likely to represent SSRI side effects rather than residual depressive symptomatology.

Popovic - Cognitive tolerability of SSRI's.pdf

Edited February 23, 2015 by Altostrata
formatted for Journals