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Holmaster5000: Klonopin and mirtazapine


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I have been on these drugs for almost two years now. I didn't know how dangerous they were until tried getting off of Klonopin. I had to get back on until I restabilized. Which was recently. Ion plan on getting off Klonopin and remeron, but I've been advised to do Klonopin first.


.5mg clonazepam 3x daily

15mg mirtazapine

About to taper clonazepam

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  • Moderator Emeritus

Hi Holmaster ,  welcome to the site.  You'll find lots of information and support here to help you plan a safe



The recommended tapering rate is no more than 10% at a time , and a hold until the w/d symptoms pass.

Try reading the following links:


Why taper by 10% of my dosage?

Taking multiple psych drugs? Which drug to taper first?

It may be that alternating tapers is better - the klonipin will soften the mirt. withdrawal.


Can you tell us a little more about your taper/reinstatement , and how long you've been stable again for?


If you click FOLLOW at the top right , you'll receive an email each time someone posts here.


Best wishes ,  Fresh

1987-1997 pertofran , prothiaden , Prozac 1997-2002 Zoloft 2002-2004 effexor 2004-2010 Lexapro 40mg

2010-2012Cymbalta 120mg

Sept. 2012 -decreased 90mg in 6months. Care taken over by Dr Lucire in March 2013 , decreased last 30mg at 2mg per week over 3 months. July 21 , 2013- last dose of Cymbalta

Protracted withdrawal syndrome kicked in badly Jan.2014 Unrelenting akathisia until May 2014. Voluntary hosp. admission. Cocktail of Seroquel, Ativan and mirtazapine and I was well enough to go home after 14 days. Stopped all hosp. meds in next few months.

July 2014 felt v.depressed - couldn't stop crying. Started pristiq 50mg. Felt improvement within days and continued to improve, so stayed on 50mg for 8 months.

Began taper 28 Feb. 2015. Pristiq 50mg down to 45mg. Had one month of w/d symptoms. Started CES therapy in March. No w/d symptoms down to 30mg.

October 2015 , taking 25mg Pristiq. Capsules compounded with slow-release additive.

March 2016 , 21mg

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Hi Holmaster, what was your experience with the earlier attempt at getting off Klonopin? Why did you have to reinstate?

1975--first signs of depression

1981--started on imipramine (Tofranil) for IBS and depression

1983-1986--severe depression, rotated through several drugs, on MAOI for one year, eventually back to tricyclics

1986-1994--chronic low grade depression, on tricyclics

1994-96--severe depression, rotated through several drugs inc. Prozax, Effexor, etc..

1996-2013--chronic low grade depression, SAD, on amitryptiline usual dose 12.5-25mg

     flurazepam (Dalmane) as needed for insomnia

2013--developed temazepam (Restoril) dependance for 2 months, tapered off over 1 month

   started bio-identical progesterone 5 mg., depression has lifted completely to this day

March 2016--forced to c/t both amitryptiline and flurazepam, zolpidem not helpful

reinstated small dose (.5 mg) amitryptiline due to stomach issues and tapering w/titration

June 19th--jumped from amitryptiline--drug free!

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