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CathleenRSA: desperate to get off venlafaxine


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I found this site by looking for ways to wean off venlafaxine. I have been on it since 2017, and my dose has increased over time to 300mg/ day. I was successful in going cold turkey off both Seroquel and Dopaquel at the end of December last year, but it did require me to take 3 weeks of work to do so. 

I originally landed up on all these meds, as I looked for help to get my off alcohol, and between my Therapist and the Dr, my drinking was primarily to shut out my anxiety. I am 2 years sober this coming December, and have managed to get on top of my anxiety - I just want to get off the Venlafaxine.

I am not sure if I am ready to change my night time meds, which is the Trazadone and Tripiline combined, which has made a huge difference to my sleep for 10 years, and has lowered the amount of migraines I get.

I have just come back from an appointment with my Psychiatrist this morning, where I raised that I wanted to get off the Venlafaxine, as I hate that it controls my entire life, and you cannot miss even a few hours taking your next does, because I get popping electric like flashes, my head feels dizzy or shudders, and my mood just tanks.  My Doc said my only option was to start on another med, Wellbutron, get that working, then start to taper off the Venlafaxine slowly over 5 months, but then she would need to introduce another SSIR. I want to get off the meds - not start some more.

Looking forward to a meaningful journey.

2017 - present : 300mg Venlafaxine

2009-Present: 100mg Trazadone, 10mg Tripiline

2017-2019: 200mg Seroquel XR,  50mg Dopaquel

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  • ChessieCat changed the title to CathleenRSA: desperate to get off venlafaxine
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Welcome to SA, CathleenRSA.


Thanks for completing your drug signature.  Could you add whether the Venlafaxine is immediate release or extended release? Also, is "tripiline" a version of Amitriptyline?


Use this link and press "save."  


Account Settings – Create or Edit a signature.


We don't recommend starting another antidepressant to get off an old antidepressant, and five months to taper off 300mg Venlafaxine is far faster than we recommend.  We recommend tapering no faster than 10% of your current dose every four weeks. Some have to taper more slowly.


Why taper by 10% of my dosage?


This link is specifically about tapering Venlafaxine, including instructions on how to taper to get the nonstandard doses you'll need for your taper.


Tips for tapering off venlafaxine (Effexor)


So you know, there are major drug interactions between Trazodone, Venlafaxine and Amitriptyline.  Getting off the Venlafaxine (very slowly) will be a good step toward reducing these interactions.  


Drug Interactions Checker 


We don't recommend a lot of supplements on SA, as many members report being sensitive to them due to our over-reactive nervous systems, but two supplements that we do recommend are magnesium and omega 3 (fish oil). Many people find these to be calming to the nervous system. 


Magnesium, nature's calcium channel blocker 


Omega-3 fatty acids (fish oil) 


Add in one at a time and at a low dose in case you do experience problems.


This is your Introduction topic, where you can ask questions and connect with other members.  We're glad you found your way here.









Gridley Introduction


Lexapro 20 mg since 2004.  Begin Brassmonkey Slide Taper Jan. 2017.   

End 2017 year 1 of taper at 9.25mg 

End 2018 year 2 of taper at 4.1mg

End 2019 year 3 of taper at 1.0mg  

Oct. 30, 2020  Jump to zero from 0.025mg.  Current dose: 0.000mg

3 year, 10 month taper is 100% complete.


Ativan 1 mg to 1.875mg 1986-2020, two CT's and reinstatements

Nov. 2020, 7-week Ativan-Valium crossover to 18.75mg Valium

Feb. 2021, begin 10%/4 week taper of 18.75mg Valium  

End 2021  year 1 of taper at 6mg

End 2022 year 2 of taper at 2.75mg 

Current dose as of Feb. 25, 2023 2mg

Taper is 89% complete.


Imipramine 75 mg daily since 1986.  Jan-Sept 2016 tapered to 14.4mg  

March 22, 2022: Begin 10%/4 week taper

Aug. 5, 2022: hold at 9.5mg and shift to Valium taper

Taper is 87% complete.  


Supplements: omega-3, vitamins C, E and D3, magnesium glycinate, probiotic, zinc, melatonin .3mg

I am not a medical professional and this is not medical advice but simply information based on my own experience, as well as other members who have survived these drugs.

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